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Journal Articles

LP-118, a Novel BCL2 Inhibitor, Shows Potent in Vitro Anti-Myeloma Activity

Rodrigo Fonseca, Yuan Xiao Zhu, P. Leif Bergsagel, Marta Chesi, Akhilesh Pandey, Kiran Mangalaparthi, Yi Chen, Felai Tan, Stephen P. Anthony, Yu Chen, Yue Shen, Bing Dai, Esteban Braggio, Rafael Fonseca
Journal: Blood
Blood (2022) 140 (Supplement 1): 7129–7130.
https://doi.org/10.1182/blood-2022-167372
Published: 2022
Journal Articles

Synergistic Immunostimulatory Effects and Therapeutic Benefit of Combined T Cell Engager and Cytotoxic Therapy in a Multiple Myeloma Preclinical Model

Erin Meermeier, Caleb K Stein, Meaghen E Sharik, Yuan Xiao Zhu, Megan T Du, Seth J Welsh, Chang-Xin Shi, Matthew L Wheeler, P. Leif Bergsagel, Marta Chesi
Journal: Blood
Blood (2022) 140 (Supplement 1): 7056–7057.
https://doi.org/10.1182/blood-2022-167668
Published: 2022
Journal Articles

Newly Diagnosed, Untreated, Multiple Myeloma (MM) Patient Samples Already Harbor Cereblon (CRBN) Exon 10 Deletions Associated with Drug Resistance

Yuan Xiao Zhu, Gregory J Ahmann, Laura Ann Bruins, Mariano Arribas, Xianfeng Chen, Marta Chesi, P. Leif Bergsagel, Rafael Fonseca, Lisa M. Rimsza
Journal: Blood
Blood (2022) 140 (Supplement 1): 4187–4188.
https://doi.org/10.1182/blood-2022-157316
Published: 2022
Journal Articles

Chronic Lymphocytic Leukemia in African Ancestry Population Is Characterized By Increased Telomere Erosion

Cecilia Bonolo De Campos, Chantal McCabe, Laura Ann Bruins, Daniel R. O'Brien, Sochilt Brown, Cristine Allmer, Yuan Xiao Zhu, Kari G Rabe, Sameer A. Parikh, Neil E. Kay, James R. Cerhan, Laura Z Rassenti, Richard R. Furman, J. Brice Weinberg, Danielle Brander, Marta Chesi, Susan L. Slager, Esteban Braggio
Journal: Blood
Blood (2022) 140 (Supplement 1): 4135–4136.
https://doi.org/10.1182/blood-2022-170944
Published: 2022
Journal Articles

IMiDs Synergize with EP300 Inhibition to Disrupt the Ikzf/MYC/IRF4 Axis in Multiple Myeloma

Seth J Welsh, Benjamin G Barwick, Erin Meermeier, Daniel Riggs, Chang-Xin Shi, Yuan Xiao Zhu, Meaghen E Sharik, Megan T Du, Victoria Marie Garbitt, Caleb K Stein, Joachim L Petit, Nathalie Meurice, Rodrigo Fonseca, Kennedi Todd, Sochilt Brown, Yuliza Tafoya Alvarado, Zachary Hammond, Nicklus Cuc, Courtney Wittenberg, Camille Herzog, Lawrence H. Boise, Nizar J. Bahlis, Paola Neri, W. Michael Kuehl, Marta Chesi, P. Leif Bergsagel
Journal: Blood
Blood (2022) 140 (Supplement 1): 12997.
https://doi.org/10.1182/blood-2022-169920
Published: 2022
Journal Articles

Identifying Mechanisms Associated with Venetoclax Resistance in Multiple Myeloma (MM)

Yuan Xiao Zhu, Laura Ann Bruins, Joseph Ahmann, Cecilia Bonolo De Campos, Esteban Braggio, Xianfeng Chen, Mariano Arribas, Susie Darvish, Gregory J Ahmann, Rafael Fonseca
Journal: Blood
Blood (2021) 138 (Supplement 1): 2668.
https://doi.org/10.1182/blood-2021-153747
Published: 2021
Journal Articles

The Contribution of Proteasome Subunits to Myeloma Cell Viability and Proteasome Inhibitor Sensitivity

Chang-Xin Shi, PhD, Yuan Xiao Zhu, PhD, Laura Ann Bruins, BS, Cecilia Bonolo De Campos, PhD, William Stewart, Esteban Braggio, PhD, A Keith Stewart, M.B. Ch.B.
Journal: Blood
Blood (2019) 134 (Supplement_1): 4337.
https://doi.org/10.1182/blood-2019-127149
Published: 2019
Journal Articles

Myeloma Cells Addicted to Glutamine for Biomass Production Are Sensitive to Lenalidomide

Sinto Chirackal, PhD, Esteban Braggio, PhD, Rahman Atiqur, PhD, Gregory J Ahmann, BS, Yuan Xiao Zhu, PhD, A. Keith Stewart, MB, ChB, Marta Chesi, PhD, P. Leif Bergsagel, MD, Rafael Fonseca, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4410.
https://doi.org/10.1182/blood-2019-124967
Published: 2019
Journal Articles

Lenalidomide, Pomalidomide and CC-220 Resistant Multiple Myeloma: Confirmation of Role of CRBN/IRF4 Axis and Identification of Multiple Disruption Mechanisms

Yuan Xiao Zhu, PhD, Chang-Xin Shi, PhD, Laura Ann Bruins, BS, Xuewei Wang, PhD, Daniel Riggs, PhD, Brooke Porter, Jonathan Ahmann, BS, Esteban Braggio, PhD, P. Leif Bergsagel, MD, A. Keith Stewart, MBChB, MBA
Journal: Blood
Blood (2017) 130 (Supplement 1): 4369.
https://doi.org/10.1182/blood.V130.Suppl_1.4369.4369
Published: 2017
Journal Articles

PIKfyve Inhibitors for the Treatment of Multiple Myeloma

Cecilia Bonolo De Campos, PhD, Yuan Xiao Zhu, PhD, Chang-Xin Shi, PhD, Laura Ann Bruins, BS, Joachim L Petit, PhD, Alysia N Polito, BS, Meaghen E Sharik, BS, Caleb K Stein, MS, Gregory J Ahmann, BS, Ilsel D Lopez Armenta, BS, Nikolai Sepetov, PhD, Sergei Romanov, PhD, P. Leif Bergsagel, MD, Marta Chesi, PhD, Nathalie Meurice, PhD, A. Keith Stewart, MBChB, MBA
Journal: Blood
Blood (2017) 130 (Supplement 1): 4423.
https://doi.org/10.1182/blood.V130.Suppl_1.4423.4423
Published: 2017
Journal Articles

Lenalidomide Inhibits Thioredoxin Reductase (TrxR) in Multiple Myeloma (MM) Cells but Direct Inhibition of Trxr and Thioredoxin (Trx) Can Bypass Requirement of Cereblon (CRBN)

Sinto Sebastian Chirackal, PhD, Esteban Braggio, PhD, Yuan Xiao Zhu, PhD, Chang-Xin Shi, PhD, Scott Van Wier, Gregory Ahmann, Veronica Gonzalez-Calle, MD, Marta Chesi, PhD, Leif Bergsagel, MD, Keith Stewart, M.B., Ch.B., Rafael Fonseca, MD
Journal: Blood
Blood (2016) 128 (22): 4482.
https://doi.org/10.1182/blood.V128.22.4482.4482
Published: 2016
Journal Articles

Targeted sequencing of refractory myeloma reveals a high incidence of mutations in CRBN and Ras pathway genes

Clinical Trials & Observations
K. Martin Kortüm, Elias K. Mai, Nur H. Hanafiah, Chang-Xi Shi, Yuan-Xiao Zhu, Laura Bruins, Santiago Barrio, Patrick Jedlowski, Maximilian Merz, Jing Xu, Robert A. Stewart, Mindaugas Andrulis, Anna Jauch, Jens Hillengass, Hartmut Goldschmidt, P. Leif Bergsagel, Esteban Braggio, A. Keith Stewart, Marc S. Raab
Journal: Blood
Blood (2016) 128 (9): 1226–1233.
https://doi.org/10.1182/blood-2016-02-698092
Published: 2016
Includes: Supplemental data
Journal Articles

Targeted Sequencing of Relapsed/Refractory Myeloma Patients Identifies an Enrichment of Mutations in Cereblon and MAPK Pathways

Elias Karl Mai, MD, K. Martin Kortuem, MD, Nur Hanafiah, Santiago Barrio, Laura Ann Bruins, Maximilian Merz, MD, Jing Xu, Koenuel Pashayeva, MD, Yuan-Xiao Zhu, Chang-Xin Shi, PhD, R. Alexander Stewart, Patrick Jedlowski, Mindaugas Andrulis, MD, Anna Jauch, Prof., Jens Hillengass, MD, Hartmut Goldschmidt, MD, P. Leif Bergsagel, MD PhD, Esteban Braggio, PhD, A. Keith Stewart, MD, Marc Steffen Raab, MD PhD
Journal: Blood
Blood (2015) 126 (23): 723.
https://doi.org/10.1182/blood.V126.23.723.723
Published: 2015
Journal Articles

Identification of FAM46C As a Multiple Myeloma Repressor

Yuan Xiao Zhu, PhD, Chang-Xin Shi, PhD, Patrick Jedlowski, Klaus Martin Kortum, Laura Ann Bruins, Jonathan Ahmann, Esteban Braggio, PhD, Xuewei Wang, A. Keith Stewart
Journal: Blood
Blood (2015) 126 (23): 836.
https://doi.org/10.1182/blood.V126.23.836.836
Published: 2015
Journal Articles

Immunomodulatory Drugs Inhibit H 2 O 2 Decomposition in Multiple Myeloma Cells and Its Mediated Cytotoxicity Is Determined By Cellular Antioxidative Capacity

Sinto Sebastian Chirackal, PhD, Yuan Xiao Zhu, PhD, Esteban Braggio, PhD, Chang-Xin Shi, PhD, Sonali Panchabhai, MBBS, Gregory Ahmann, BS, Scott A. Van Wier, BS, Marta Chesi, PhD, Leif Bergsagel, MD PhD, Keith Stewart, MD, Rafael Fonseca, MD
Journal: Blood
Blood (2015) 126 (23): 2475.
https://doi.org/10.1182/blood.V126.23.2475.2475
Published: 2015
Journal Articles

Crispr Sgrnas Genome-Wide Screen Identifies the Proteasome Regulatory Subunit PSMC6 As a Bortezomib Resistance Gene in Human Multiple Myeloma Cells

Chang-Xin Shi, PhD, Klaus M Kortum, MD, Yuan Xiao Zhu, PhD, Patrick Jedlowski, Esteban Braggio, PhD, Laura Ann Bruins, Patrick G. Votruba, M.S., Moulun Luo, PhD, Robert A. Stewart, Jonathan M. Ahmann, A. Keith Stewart
Journal: Blood
Blood (2015) 126 (23): 450.
https://doi.org/10.1182/blood.V126.23.450.450
Published: 2015
Journal Articles

RNA interference screening identifies lenalidomide sensitizers in multiple myeloma, including RSK2

Yuan Xiao Zhu, Hongwei Yin, Laura A. Bruins, Chang-Xin Shi, Patrick Jedlowski, Meraj Aziz, Chris Sereduk, Klaus Martin Kortuem, Jessica E. Schmidt, Mia Champion, Esteban Braggio, A. Keith Stewart
Journal: Blood
Blood (2015) 125 (3): 483–491.
https://doi.org/10.1182/blood-2014-05-577130
Published: 2015
Includes: Supplemental data
Journal Articles

Ikaros Degradation Efficiency Correlates with Response of Multiple Myeloma (MM) Cells to IMiD Therapy and Is Blocked By Proteasome Inhibitors

Chang-Xin Shi, PhD, Yuan Xiao Zhu, PhD, Patrick Jedlowski, Laura Bruins, Martin Kortuem, MD, A. Keith Stewart, MD
Journal: Blood
Blood (2014) 124 (21): 2247.
https://doi.org/10.1182/blood.V124.21.2247.2247
Published: 2014
Journal Articles

Identification of cereblon-binding proteins and relationship with response and survival after IMiDs in multiple myeloma

Yuan Xiao Zhu, Esteban Braggio, Chang-Xin Shi, K. Martin Kortuem, Laura A. Bruins, Jessica E. Schmidt, Xiu-Bao Chang, Paul Langlais, Moulun Luo, Patrick Jedlowski, Betsy LaPlant, Kristina Laumann, Rafael Fonseca, P. Leif Bergsagel, Joseph Mikhael, Martha Lacy, Mia D. Champion, A. Keith Stewart
Journal: Blood
Blood (2014) 124 (4): 536–545.
https://doi.org/10.1182/blood-2014-02-557819
Published: 2014
Includes: Supplemental data
Journal Articles

A Synthetic Lethality Druggable Genome RNAi Screen Identifies Genes Mediating Sensitivity To Lenalidomide In Multiple Myeloma Including RSK2

Yuan Xiao Zhu, Ph.D., Laura Bruins, Chang-Xin Shi, Ph.D., Jessica Schmidt, Chris Sereduk, Mia Champion, Ph.D., Esteban Braggio, Ph.D., Holly Yin, Ph.D., A. Keith Stewart, MBChB
Journal: Blood
Blood (2013) 122 (21): 3084.
https://doi.org/10.1182/blood.V122.21.3084.3084
Published: 2013