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Journal Articles

Enhanced targeting of CML stem and progenitor cells by inhibition of porcupine acyltransferase in combination with TKI

Puneet Agarwal, Bin Zhang, Yinwei Ho, Amy Cook, Ling Li, Fady M. Mikhail, Youzhen Wang, Margaret E. McLaughlin, Ravi Bhatia

Blood (2017) 129 (8): 1008–1020.

https://doi.org/10.1182/blood-2016-05-714089

Published: 2017

Includes: Supplemental data

Journal Articles

Inhibition of CML Stem Cell Renewal By the Porcupine Inhibitor WNT974

Puneet Agarwal, MS, Bin Zhang, PhD, Yinwei Ho, MS, Amy Cook, PhD, Ling Li, PhD, Youzhen Wang, PhD, Margaret E Mclaughlin, MD, Ravi Bhatia, MD

Blood (2015) 126 (23): 54.

https://doi.org/10.1182/blood.V126.23.54.54

Published: 2015

Journal Articles

Osteoblast ablation reduces normal long-term hematopoietic stem cell self-renewal but accelerates leukemia development

Marisa Bowers, Bin Zhang, Yinwei Ho, Puneet Agarwal, Ching-Cheng Chen, Ravi Bhatia

Blood (2015) 125 (17): 2678–2688.

https://doi.org/10.1182/blood-2014-06-582924

Published: 2015

Includes: Supplemental data

Journal Articles

MicroRNA-486 regulates normal erythropoiesis and enhances growth and modulates drug response in CML progenitors

Li-Sheng Wang, Ling Li, Liang Li, Su Chu, Keh-Dong Shiang, Min Li, Hui-Yan Sun, Jun Xu, Feng-Jun Xiao, Guihua Sun, John J. Rossi, YinWei Ho, Ravi Bhatia

Blood (2015) 125 (8): 1302–1313.

https://doi.org/10.1182/blood-2014-06-581926

Published: 2015

Includes: Supplemental data

Journal Articles

Role of Enhanced Microenvironmental Interleukin-1 (IL-1) Expression and Increased IL-1 Responsiveness in Persistence of Leukemia Stem Cells in TKI Treated CML Patients

Bin Zhang, PhD, YinWei Ho, Tinisha McDonald, B.S., Allen Lin, David S Snyder, MD, Vu N. Ngo, PhD, Tessa L. Holyoake, MD PhD, Ravi Bhatia, MD

Blood (2014) 124 (21): 4357.

https://doi.org/10.1182/blood.V124.21.4357.4357

Published: 2014

Journal Articles

Inhibition of CML Stem Cell Growth By Targeting WNT Signaling Using a Porcupine Inhibitor

Puneet Agarwal, MS, Bin Zhang, PhD, YinWei Ho, Amy Cook, PhD, Ling Li, PhD, Youzhen Wang, Margaret McLaughlin, PhD, Ravi Bhatia, MD

Blood (2014) 124 (21): 3130.

https://doi.org/10.1182/blood.V124.21.3130.3130

Published: 2014

Journal Articles

Effective and Selective Elimination of CML Stem Cells Using Novel Ethacrynic Acid Derivatives

Su Chu, MD, YinWei Ho, Guisen Zhao, Tessa L. Holyoake, MD PhD, Samuel Waxman, MD, Yongkui Jing, PhD, Ravi Bhatia, MD

Blood (2014) 124 (21): 4508.

https://doi.org/10.1182/blood.V124.21.4508.4508

Published: 2014

Journal Articles

Contribution of Leukemia-Induced Alterations in Mesenchymal Cell Subpopulations to Altered Regulation of Leukemic and Normal Stem Cells in the CML BM Microenvironment

Bin Zhang, PhD, YinWei Ho, Bijender Kumar, PhD, Ching-Cheng Cheng Chen, PhD, Ravi Bhatia, MD

Blood (2014) 124 (21): 4509.

https://doi.org/10.1182/blood.V124.21.4509.4509

Published: 2014

Journal Articles

Increased p53 Acetylation By SIRT1 Inhibition Is Required for Optimal Activation of p53 Activity and Significantly Enhances the Ability of HDM2 Inhibitors to Target CML LSC

Yann Pierre Kevin Duchartre, PhD, Ling Li, PhD, Tinisha McDonald, B.S., YinWei Ho, Yao-Te Hsieh, Ravi Bhatia, MD

Blood (2014) 124 (21): 4521.

https://doi.org/10.1182/blood.V124.21.4521.4521

Published: 2014

Journal Articles

Role of altered growth factor receptor-mediated JAK2 signaling in growth and maintenance of human acute myeloid leukemia stem cells

Amy M. Cook, Liang Li, Yinwei Ho, Allen Lin, Ling Li, Anthony Stein, Stephen Forman, Danilo Perrotti, Richard Jove, Ravi Bhatia

Blood (2014) 123 (18): 2826–2837.

https://doi.org/10.1182/blood-2013-05-505735

Published: 2014

Includes: Supplemental data

Journal Articles

MJ05, a Novel p53 Activating Compound, Effectively and Selectively Eliminates Human CML Stem/Progenitor Cells

Su Chu, MD, Catherine Drummond, Ling Li, PhD, YinWei Ho, MA, Sonia Lain, Ravi Bhatia, MD

Blood (2013) 122 (21): 1464.

https://doi.org/10.1182/blood.V122.21.1464.1464

Published: 2013

Journal Articles

Pharmacological Inhibition Of The SIRT1 Deacetylase With The Small Molecule Inhibitor Tenovin-6 Enhances Ablation Of FLT3-ITD+ LSC In Combination With TKI Treatment

Ling Li, PhD, Tereza Osdal, MSc, YinWei Ho, MA, Tinisha McDonald, Sookhee Chun, Su Chu, MD, Allen Lin, Cedric Dos Santos, Ph.D, Mihaela Lucia Popa, VMD, Bjorn T Gjertsen, MD PhD, Wenyong Chen, PhD, Sonia Lain, Emmet McCormack, PhD, Ravi Bhatia, MD

Blood (2013) 122 (21): 2685.

https://doi.org/10.1182/blood.V122.21.2685.2685

Published: 2013

Journal Articles

Bone Marrow Osteoblast Ablation Enhances Short-Term Hematopoietic Stem Cells Without Altering Long-Term Hematopoietic Stem Cell Populations and Accelerates Leukemia Development

Marisa Bowers, BA, YinWei Ho, MA, Ravi Bhatia, MD

Blood (2013) 122 (21): 586.

https://doi.org/10.1182/blood.V122.21.586.586

Published: 2013

Journal Articles

Selective Targeting of CML Progenitor/Stem Cells by the Class 1 Histone Deacetylase (HDAC) Inhibitor MS275 in Combination with Imatinib.

Su Chu, MD, YinWei Ho, Ravi Bhatia, MD

Blood (2012) 120 (21): 2791.

https://doi.org/10.1182/blood.V120.21.2791.2791

Published: 2012

Journal Articles

FLT3-ITD+ AML Stem/Progenitor Cells Demonstrate Increased SIRT1 Expression and Enhanced Sensitivity to SIRT1 Inhibition

Ling Li, PhD, Tinisha McDonald, Liang Li, PhD, Sookhee Chun, Cedric Dos Santos, Ph.D, YinWei Ho, Ravi Bhatia, MD

Blood (2012) 120 (21): 1368.

https://doi.org/10.1182/blood.V120.21.1368.1368

Published: 2012

Journal Articles

Dasatinib Enhances Targeting of Human AML Leukemia Stem Cells by Chemotherapeutic Agents Via Activation of p53

Cedric Dos Santos, Ph.D, Tinisha McDonald, YinWei Ho, Liu Hongjun, Allen Lin, Stephen J Forman, MD, Kuo Ya-Huei, Ph.D, Ravi Bhatia, MD

Blood (2012) 120 (21): 3590.

https://doi.org/10.1182/blood.V120.21.3590.3590

Published: 2012

NARROW

Enhanced targeting of CML stem and progenitor cells by inhibition of porcupine acyltransferase in combination with TKI

Inhibition of CML Stem Cell Renewal By the Porcupine Inhibitor WNT974

Osteoblast ablation reduces normal long-term hematopoietic stem cell self-renewal but accelerates leukemia development

MicroRNA-486 regulates normal erythropoiesis and enhances growth and modulates drug response in CML progenitors

Role of Enhanced Microenvironmental Interleukin-1 (IL-1) Expression and Increased IL-1 Responsiveness in Persistence of Leukemia Stem Cells in TKI Treated CML Patients

Inhibition of CML Stem Cell Growth By Targeting WNT Signaling Using a Porcupine Inhibitor

Effective and Selective Elimination of CML Stem Cells Using Novel Ethacrynic Acid Derivatives

Contribution of Leukemia-Induced Alterations in Mesenchymal Cell Subpopulations to Altered Regulation of Leukemic and Normal Stem Cells in the CML BM Microenvironment

Increased p53 Acetylation By SIRT1 Inhibition Is Required for Optimal Activation of p53 Activity and Significantly Enhances the Ability of HDM2 Inhibitors to Target CML LSC

Role of altered growth factor receptor-mediated JAK2 signaling in growth and maintenance of human acute myeloid leukemia stem cells

MJ05, a Novel p53 Activating Compound, Effectively and Selectively Eliminates Human CML Stem/Progenitor Cells

Pharmacological Inhibition Of The SIRT1 Deacetylase With The Small Molecule Inhibitor Tenovin-6 Enhances Ablation Of FLT3-ITD+ LSC In Combination With TKI Treatment

Bone Marrow Osteoblast Ablation Enhances Short-Term Hematopoietic Stem Cells Without Altering Long-Term Hematopoietic Stem Cell Populations and Accelerates Leukemia Development

Selective Targeting of CML Progenitor/Stem Cells by the Class 1 Histone Deacetylase (HDAC) Inhibitor MS275 in Combination with Imatinib.

FLT3-ITD+ AML Stem/Progenitor Cells Demonstrate Increased SIRT1 Expression and Enhanced Sensitivity to SIRT1 Inhibition

Dasatinib Enhances Targeting of Human AML Leukemia Stem Cells by Chemotherapeutic Agents Via Activation of p53

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American Society of Hematology

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American Society of Hematology

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