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Journal Articles

Artesunate Inhibits Graft-Versus-Host Disease in Mice Via a Mechanism of Inducing Mitochondrial Calcium Overloading in Activated T Cells

Ying Wang, PhD, Shan He, PhD, Yongnian Liu, Robert Hooper, PhD, Hongshuang Yu, Yuanyuan Tian, Bui Tien, Bryant M Schultz, John W Elrod, PhD, Jonathan Soboloff, Yi Zhang, MD PhD

Blood (2019) 134 (Supplement_1): 4432.

https://doi.org/10.1182/blood-2019-131115

Published: 2019

Journal Articles

Engineering of CD19-Specific Chimeric Antigen Receptor T Cells with the Integrin CD103 Results in Augmented Therapeutic Efficacy Against Human Lymphoma in a Preclinical Model

Hongxing Sun, PhD, Shan He, PhD, Lijun Meng, PhD, Ying Wang, PhD, Hanghang Zhang, PhD, Yongnian Liu, Jian Wang, MD, Min Tao, MD, Stefan Klaus Barta, MD MRCP, MS, Essel D. Al-Saleem, MD, Henry C. Fung, FRCP, MBBChir, Jean-Pierre Issa, MD, Leizhen Zheng, MD, Yi Zhang, MD

Blood (2018) 132 (Supplement 1): 2050.

https://doi.org/10.1182/blood-2018-99-117354

Published: 2018

Journal Articles

Stim1 Deletion Synthetically Rescues Ezh2-Null Effector T Cells and Alloimmunity

Ying Wang, PhD, Shan He, PhD, Yongnian Liu, Robert Hooper, PhD, Hongshuang Yu, Yuanyuan Tian, Hongxing Sun, PhD, Ran Reshef, MD MSc, Elizabeth O. Hexner, MD MS, Jonathan Soboloff, Yi Zhang, MD

Blood (2018) 132 (Supplement 1): 4533.

https://doi.org/10.1182/blood-2018-99-118720

Published: 2018

Journal Articles

Id3 Is Essential for Mediating Ezh2-Regulated Persistence of Alloreactive T Cells in Gvhd Target Tissues in Mice

Shan He, PhD, Yuanyuan Tian, Yongnian Liu, Ying Wang, Bruce Blazar, MD, Ximi K Wang, Ran Reshef, MD, Yi Zhang, MD

Blood (2017) 130 (Supplement 1): 210.

https://doi.org/10.1182/blood.V130.Suppl_1.210.210

Published: 2017

Journal Articles

The Phosphorylation State of Ezh2 Determines Its Capacity to Maintain CD8 + Memory T Cells for Antitumor Immunity

Shan He, PhD, Yongnian Liu, Lijun Meng, Hongxing SUN, Ying Wang, Yun Ji, Janaki Purushe, BS, Pan Chen, Changhong Li, Jozef Madzo, Jean-Pierre Issa, MD, Jonathan Soboloff, Ran Reshef, MD, Bethany Moore, Luca Gattinoni, Yi Zhang, MD

Blood (2017) 130 (Supplement 1): 4455.

https://doi.org/10.1182/blood.V130.Suppl_1.4455.4455

Published: 2017

Journal Articles

Hsp90 inhibition destabilizes Ezh2 protein in alloreactive T cells and reduces graft-versus-host disease in mice

Qingrong Huang, Shan He, Yuanyuan Tian, Yuting Gu, Pan Chen, Changhong Li, Jiefang Huang, Yongnian Liu, Hongshuang Yu, Min Jin, Shaoyan Hu, Qing Tong, Anqi Ma, Jian Jin, Elizabeth Hexner, Henry Fung, Ran Reshef, Yi Zhang, Yanyun Zhang

Blood (2017) 129 (20): 2737–2748.

https://doi.org/10.1182/blood-2016-08-735886

Published: 2017

Includes: Supplemental data

Journal Articles

Programming of donor T cells using allogeneic δ-like ligand 4–positive dendritic cells to reduce GVHD in mice

Kazuhiro Mochizuki, Lijun Meng, Izumi Mochizuki, Qing Tong, Shan He, Yongnian Liu, Janaki Purushe, Henry Fung, M. Raza Zaidi, Yanyun Zhang, Ran Reshef, Bruce R. Blazar, Hideo Yagita, Shin Mineishi, Yi Zhang

Blood (2016) 127 (25): 3270–3280.

https://doi.org/10.1182/blood-2015-05-644476

Published: 2016

Includes: Supplemental data

Journal Articles

Pharmacological Inhibition of Hsp90 Destabilizes the Histone Methyltransferase Ezh2 in Alloreactive T Cells and Reduces Graft-Versus-Host Disease While Retaining Anti-Leukemic Effects in Mice

Qingrong Huang, Shan He, Yuanyuan Tian, Changhong Li, Yuting Gu, Pan Chen, Jiefang Huang, Yongnian Liu, Min Jin, Qi Cao, Ran Reshef, MD, Yi Zhang, Yanyun Zhang

Blood (2015) 126 (23): 234.

https://doi.org/10.1182/blood.V126.23.234.234

Published: 2015

Journal Articles

Programming of Donor T Cells Using Allogeneic Delta-like Ligand 4-Positive Dendritic Cells to Reduce Gvhd but Retain GVL Activity

Kazuhiro Mochizuki, MD PhD, Lijun Meng, Izumi Mochizuki, MD, Qing Tong, MD, Shan He, Yongnian Liu, Janaki Purushe, Hongxing Sun, Henry Fung, Raza Zaidi, Ran Reshef, MD, Bruce R. Blazar, MD, Hideo Yagita, PhD, Shin Mineishi, MD, Yi Zhang

Blood (2015) 126 (23): 233.

https://doi.org/10.1182/blood.V126.23.233.233

Published: 2015

Journal Articles

The histone methyltransferase Ezh2 is a crucial epigenetic regulator of allogeneic T-cell responses mediating graft-versus-host disease

Shan He, Fang Xie, Yongnian Liu, Qing Tong, Kazuhiro Mochizuki, Philip E. Lapinski, Ram-Shankar Mani, Pavan Reddy, Izumi Mochizuki, Arul M. Chinnaiyan, Shin Mineishi, Philip D. King, Yi Zhang

Blood (2013) 122 (25): 4119–4128.

https://doi.org/10.1182/blood-2013-05-505180

Published: 2013

Includes: Supplemental data

Journal Articles

The Epigenetic Regulator Ezh2 Is An Effective Target For Controlling Th1 Cell-Mediated Acquired Aplastic Anemia In Mice

Qing Tong, MD, Shan He, PhD, Fang Xie, Amanda Wong, Kazuhiro Mochizuki, MD, PhD, Yongnian Liu, MS, Izumi Mochizuki, MD, Shin Mineishi, MD, Yi Zhang, MD, PhD

Blood (2013) 122 (21): 2467.

https://doi.org/10.1182/blood.V122.21.2467.2467

Published: 2013

Journal Articles

The Histone Methyltransferase Ezh2 Is a Crucial Epigenetic Regulator Of Allogeneic T Cell Responses and Graft-Versus-Host Disease In Mice

Shan He, PhD, Fang Xie, Yongnian Liu, MS, Qing Tong, MS, Kazuhiro Mochizuki, MD, PhD, Philip E Lapinski, PhD, Pavan Reddy, MD, Izumi Mochizuki, MD, Arul M. Chinnaiyan, MD, PhD, Shin Mineishi, MD, Philip D King, PhD, Yi Zhang, MD, PhD

Blood (2013) 122 (21): 137.

https://doi.org/10.1182/blood.V122.21.137.137

Published: 2013

Journal Articles

Identification of Previously Uncharacterized Delta 4-Positive Inflammatory Plasmacytoid Dendritic Cells That Play Important Roles in Eliciting Graft-Versus-Host Disease in Mice

Kazuhiro Mochizuki, MD, PhD, Fang Xie, MD, Shan He, PhD, Qing Tong, MS, Yongnian Liu, MS, Yajun Guo, MD, PhD, Koji Kato, MD, PhD, Hideo Yagita, PhD, Shin Mineishi, Yi Zhang, MD, PhD

Blood (2012) 120 (21): 337.

https://doi.org/10.1182/blood.V120.21.337.337

Published: 2012

Journal Articles

Histone Methyltransferase Ezh2 Controls T-Cell Immunity by Regulating Bioenergetic Metabolism

Shan He, PhD, Fang Xie, MD, Qing Tong, MS, Kazuhiro Mochizuki, MD, PhD, Yongnian Liu, MS, Philip E Lapinski, PhD, Shin Mineishi, Ram Shankar Mani, MD, Victor E Marquez, Arul M. Chinnaiyan, MD, PhD, Philip D King, PhD, Yi Zhang, MD, PhD

Blood (2012) 120 (21): 953.

https://doi.org/10.1182/blood.V120.21.953.953

Published: 2012

Journal Articles

Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cells

Shan He, Jina Wang, Koji Kato, Fang Xie, Sooryanarayana Varambally, Shin Mineishi, Rork Kuick, Kazuhiro Mochizuki, Yongnian Liu, Evelyn Nieves, Ram-Shankar Mani, Arul M. Chinnaiyan, Victor E. Marquez, Yi Zhang

Blood (2012) 119 (5): 1274–1282.

https://doi.org/10.1182/blood-2011-06-364422

Published: 2012

Includes: Supplemental data

Journal Articles

Inhibition of Histone Methylation Arrests Ongoing Graft-Versus-Host Diseases in Mice by Selectively Inducing Apoptosis of Alloreactive Effector T Cells

Shan He, PhD, Jina Wang, MD, Koji Kato, MD, PhD, Fang Xie, MD, Sooryanarayana Varambally, MD, Shin Mineishi, MD, Rork Kuick, MS, Kazuhiro Mochizuki, MD, Yongnian Liu, MS, Evelyn Nieves, PhD, Ram Mani, MD, Arul M. Chinnaiyan, MD, PhD, Victor E. Marquez, PhD, Yi Zhang, MD, PhD

Blood (2011) 118 (21): 820.

https://doi.org/10.1182/blood.V118.21.820.820

Published: 2011

NARROW

Artesunate Inhibits Graft-Versus-Host Disease in Mice Via a Mechanism of Inducing Mitochondrial Calcium Overloading in Activated T Cells

Engineering of CD19-Specific Chimeric Antigen Receptor T Cells with the Integrin CD103 Results in Augmented Therapeutic Efficacy Against Human Lymphoma in a Preclinical Model

Stim1 Deletion Synthetically Rescues Ezh2-Null Effector T Cells and Alloimmunity

Id3 Is Essential for Mediating Ezh2-Regulated Persistence of Alloreactive T Cells in Gvhd Target Tissues in Mice

The Phosphorylation State of Ezh2 Determines Its Capacity to Maintain CD8 + Memory T Cells for Antitumor Immunity

Hsp90 inhibition destabilizes Ezh2 protein in alloreactive T cells and reduces graft-versus-host disease in mice

Programming of donor T cells using allogeneic δ-like ligand 4–positive dendritic cells to reduce GVHD in mice

Pharmacological Inhibition of Hsp90 Destabilizes the Histone Methyltransferase Ezh2 in Alloreactive T Cells and Reduces Graft-Versus-Host Disease While Retaining Anti-Leukemic Effects in Mice

Programming of Donor T Cells Using Allogeneic Delta-like Ligand 4-Positive Dendritic Cells to Reduce Gvhd but Retain GVL Activity

The histone methyltransferase Ezh2 is a crucial epigenetic regulator of allogeneic T-cell responses mediating graft-versus-host disease

The Epigenetic Regulator Ezh2 Is An Effective Target For Controlling Th1 Cell-Mediated Acquired Aplastic Anemia In Mice

The Histone Methyltransferase Ezh2 Is a Crucial Epigenetic Regulator Of Allogeneic T Cell Responses and Graft-Versus-Host Disease In Mice

Identification of Previously Uncharacterized Delta 4-Positive Inflammatory Plasmacytoid Dendritic Cells That Play Important Roles in Eliciting Graft-Versus-Host Disease in Mice

Histone Methyltransferase Ezh2 Controls T-Cell Immunity by Regulating Bioenergetic Metabolism

Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cells

Inhibition of Histone Methylation Arrests Ongoing Graft-Versus-Host Diseases in Mice by Selectively Inducing Apoptosis of Alloreactive Effector T Cells

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American Society of Hematology

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ASH Publications

American Society of Hematology

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