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Yunyu Spence
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Journal Articles

Stable Factor IX Activity Following AAV-Mediated Gene Transfer in Patients with Severe Hemophilia B

Andrew Davidoff, MD, Edward GD Tuddenham, MBBS, FRCP, FRCPath, PhD, Savita Rangarajan, MBBS, FRCP, FRCPath, Cecilia Rosales, PhD, Jenny McIntosh, PhD, Pratima Chowdary, MBBS, FRCP, FRCPath, Anne Riddell, BSc, Bertil Glader, MD, PhD, Pradip Rustagi, MD, Catherine Ng, MS, Mark Kay, MD, PhD, Junfang Zhou, MD, Yunyu Spence, PhD, Christopher Morton, B.S., James Allay, PhD, Susan Sleep, PhD, Etiena Basner-Tschakarjan, MD, Federico Mingozzi, PhD., Katherine A. High, MD, John T. Gray, PhD, Ulrike M. Reiss, MD, Arthur W. Nienhuis, MD, Amit C Nathwani, MBChB, FRCP, FRCPath, PhD
Journal: Blood
Blood (2012) 120 (21): 752.
https://doi.org/10.1182/blood.V120.21.752.752
Published: 2012
Journal Articles

AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage

Christopher Binny, Jenny McIntosh, Marco Della Peruta, Hanna Kymalainen, Edward G. D. Tuddenham, Suzanne M. K. Buckley, Simon N. Waddington, John H. McVey, Yunyu Spence, Christopher L. Morton, Adrian J. Thrasher, John T. Gray, Francis J. Castellino, Alice F. Tarantal, Andrew M. Davidoff, Amit C. Nathwani
Journal: Blood
Blood (2012) 119 (4): 957–966.
https://doi.org/10.1182/blood-2011-09-377630
Published: 2012
Includes: Supplemental data
Journal Articles

Adeno-Associated Viral Vector Mediated Gene Transfer for Hemophilia B

Amit C Nathwani, MBChB, FRCP, FRCPath, PhD, Edward GD Tuddenham, MBBS, FRCP, FRCPath, PhD, Savita Rangarajan, MBBS, FRCP, FRCPath, Cecilia Rosales, PhD, Jenny H McIntosh, PhD, David C Linch, MD FMedSci, Pratima Chowdary, MBBS, FRCP, FRCPath, Anja Griffioen, Anne Riddell, BSc, Jun Pie, BSN, Chris Harrington, BSN, James O’Beirne, MBBS, FRCP, MD EDIC, Keith Smith, BSc, MSc, C.Biol, John Pasi, MBChB, PhD, FRCP, FRCPath, Bertil Glader, MD PhD, Pradip Rustagi, MD, Catherine Ng, MS, Mark Kay, MD, PhD, Junfang Zhou, MD, Yunyu Spence, PhD, Christopher Morton, BS, James Allay, PhD, John Coleman, Susan Sleep, PhD, John M Cunningham, MD, Etiena Basner-Tschakarjan, MD, Federico Mingozzi, PhD, Katherine A. High, MD, John T. Gray, PhD, Ulrike M. Reiss, MD, Arthur W. Nienhuis, MD, Andrew Davidoff, MD
Journal: Blood
Blood (2011) 118 (21): 5.
https://doi.org/10.1182/blood.V118.21.5.5
Published: 2011
Journal Articles

Safe and efficient transduction of the liver after peripheral vein infusion of self-complementary AAV vector results in stable therapeutic expression of human FIX in nonhuman primates

Amit C. Nathwani, John T. Gray, Jenny McIntosh, Catherine Y. C. Ng, Junfang Zhou, Yunyu Spence, Melanie Cochrane, Elaine Gray, Edward G. D. Tuddenham, Andrew M. Davidoff
Journal: Blood
Blood (2006) 109 (4): 1414–1421.
https://doi.org/10.1182/blood-2006-03-010181
Published: 2006
Journal Articles

Self-complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and nonhuman primate liver

Amit C. Nathwani, John T. Gray, Catherine Y. C. Ng, Junfang Zhou, Yunyu Spence, Simon N. Waddington, Edward G. D. Tuddenham, Geoffrey Kemball-Cook, Jenny McIntosh, Mariette Boon-Spijker, Koen Mertens, Andrew M. Davidoff
Journal: Blood
Blood (2006) 107 (7): 2653–2661.
https://doi.org/10.1182/blood-2005-10-4035
Published: 2006
Includes: Supplemental data
Journal Articles

Sex significantly influences transduction of murine liver by recombinant adeno-associated viral vectors through an androgen-dependent pathway

Andrew M. Davidoff, Catherine Y. C. Ng, Junfang Zhou, Yunyu Spence, Amit C. Nathwani
Journal: Blood
Blood (2003) 102 (2): 480–488.
https://doi.org/10.1182/blood-2002-09-2889
Published: 2003