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Journal Articles

CML: new tools to answer old questions

Free
George Giotopoulos, Brian J. P. Huntly
Journal: Blood
Blood (2020) 135 (26): 2327–2328.
https://doi.org/10.1182/blood.2020005599
Published: 2020
Journal Articles

Development of Reference Control Material for the Evaluation of the Cepheid Prototype * Xpert® BCR-ABL P190 Ultra Assay

Free
Yuanyuan Liu, PhD, Tran Tran, BS, Phat Nguyen, BSc, Huilin Wei, MD PhD, Gwo-Jen Day, PhD, Lin Yuan, MS
Journal: Blood
Blood (2019) 134 (Supplement_1): 5213.
https://doi.org/10.1182/blood-2019-128856
Published: 2019
Journal Articles

Efficacy of OR21, a Novel Oral Demethylating Agent in Chronic Myeloid Leukemia

Free
Kazuharu Kamachi, MD, Hiroshi Ureshino, MD, Nao Yoshida, MD, Yuki Kurahashi, Tatsuro Watanabe, PhD, Seiji Okada, MD PhD, Shinya Kimura, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5365.
https://doi.org/10.1182/blood-2019-125460
Published: 2019
Journal Articles

BCR-ABL and Src Family Kinases Induce YAP Tyrosine Phosphorylation Resulting in Survivin and Cyclin D1 Expression in Chronic Myeloid Leukemia Cells

Free
Toshiyuki Hori, MD PhD, Kenta Moriyama, MS
Journal: Blood
Blood (2019) 134 (Supplement_1): 5366.
https://doi.org/10.1182/blood-2019-124643
Published: 2019
Journal Articles

The Platelet Millionaire: A Rare Cause of Thrombocytosis in an Adolescent

Free
Ritika Walia, MD, Theresa Sepulveda, MD, Sharon Wretzel, MD, Philip H Brandt, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5391.
https://doi.org/10.1182/blood-2019-129278
Published: 2019
Journal Articles

Determine White Blood Cell Count (WBCC) Limits and ABL Ct Cut-Off with ABL Copy Number (CN) Calibration for the Xpert® BCR-ABL Ultra Assay

Free
Huilin Wei, MD PhD, Krupa Shridhar, Gwo-Jen Day, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5367.
https://doi.org/10.1182/blood-2019-130899
Published: 2019
Journal Articles

The Role of Hypoxia on ABL Tyrosine Kinase Inhibitor Resistant Chronic Myeloid Leukemia Cells

Free
Seiichi Okabe, MD PhD, Yuko Tanaka, MD PhD, Mitsuru Moriyama, Akihiko Gotoh, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5369.
https://doi.org/10.1182/blood-2019-129768
Published: 2019
Journal Articles

The Frequency of Calr and MPL Gene Mutations in Jak2 V617F - Positive Chronic Myeloproliferative Neoplasms in Russia

Free
Tatiana V Makarik, PhD, Adhamjon O Abdullaev, MD PhD, Sergei M. Kulikov, PhD, Elena E Nikulina, Svetlana A Treglazova, Irina N Subortseva, MD, Alla M. Kovrigina, MD PhD, Anait L. Melikyan, MD PhD, Andrey B Sudarikov, PhD DSc, Valery G. Savchenko, MD PhD academician
Journal: Blood
Blood (2019) 134 (Supplement_1): 5400.
https://doi.org/10.1182/blood-2019-124767
Published: 2019
Journal Articles

Post-Transplant Maintenance Treatment with Ponatinib for Philadelphia Chromosome Positive Leukemia

Free
Yuya Kishida, MD, Yuho Najima, MD PhD, Yuki Otsuka, MD, Kenya Toma, MD, Atsushi Wada, MD, Hiroto Adachi, MD, Ryosuke Konuma, MD, Tatsuya Konishi, Akihito Nagata, Yuta Yamada, MD, Ryohei Nagata, MD, Atsushi Marumo, MD, Junichi Mukae, MD, Yuma Noguchi, MD, Kyoko Inamoto, MD, Takashi Toya, MD PhD, Aiko Igarashi, MD, Takeshi Kobayashi, MD, Kazuhiko Kakihana, MD PhD, Hisashi Sakamaki, MD PhD, Kazuteru Ohashi, MD PhD, Noriko Doki, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5694.
https://doi.org/10.1182/blood-2019-128031
Published: 2019
Journal Articles

Phase 1 Trial of K0706, a Novel Oral BCR-ABL1 Tyrosine Kinase Inhibitor (TKI): In Patients with Chronic Myelogenous Leukemia (CML) and Phildelphia Positive Acute Lymphoblastic Leukemia (Ph+ ALL) Failing ≥ 3 Prior TKI Therapies: Initial Safety and Efficacy

Free
Jorge E. Cortes, MD, Dong-Wook Kim, Franck E Nicolini, MD PhD, Tapan Saikia, MD, Aude Charbonnier, Jane F. Apperley, MD FRCP, FRCPath, MB, Krishna Rathnam, Michael W. Deininger, Hugues De Lavallade, Navin Khattry, MD DM MDcal Oncology, Andrew Whiteley, MD, Michael J. Mauro, MD, Gregor Verhoef, MD PhD, Carlo Gambacorti-Passerini, MD, Alessandro Lucchesi, MD, Shashikant Apte, MD FRCPA, Granacher Nikki, Siu-Long Yao, MD, Mudgal Kothekar, MD, Jayasree Sreenivasan, Msc, Bimba HV, MD, Geetanjali Chimote, MBBS, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4158.
https://doi.org/10.1182/blood-2019-129751
Published: 2019
Journal Articles

Real-Life Outcomes of Ponatinib Treatment in Patients with Chronic Myeloid Leukemia (CML) and Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ ALL): Data from a Nationwide Belgian Registry

Free
Timothy Devos, MD PhD, Violaine Havelange, Koen Theunissen, Stef Meers, Fleur Samantha Benghiat, Alain Gadisseur, Gaëtan Vanstraelen, Marc André, Benjamin Bailly, Nikki Granacher, Philippe Lewalle, Ann De Becker, Koen Van Eygen, Marie Lejeune, Dries Deeren, MD PhD, Gianfilippo Nifosi, Agnes Triffet, Inge Vrelust, Julie Bekaert, Michael Beck, Dominik Selleslag
Journal: Blood
Blood (2019) 134 (Supplement_1): 4161.
https://doi.org/10.1182/blood-2019-127923
Published: 2019
Journal Articles

Predicting the Long-Term Efficacy of Ifnα in JAK2 V617F and Calr -Mutated MPN Patients

Free
Amandine Tisserand, Robert Noble, PhD, Matthieu Mosca, PhD, Christophe Marzac, MD, Gaelle Vertenoeil, MD, Hugo Campario, PharmD, Mira El-Khoury, PhD, Caroline Marty, PhD, Philippe Rameau, Nicole Casadevall, MD, Eric Solary, MD PhD, Florence Pasquier, MD PhD, Hana Raslova, PhD, Bruno Cassinat, PharmD, PhD, Stefan N Constantinescu, MD PhD, Jean-Jacques Kiladjian, MD PhD, Francois Girodon, MD PhD, Michael Hochberg, PhD, Villeval Jean-Luc, PhD, William Vainchenker, MD PhD, Isabelle Plo
Journal: Blood
Blood (2019) 134 (Supplement_1): 4196.
https://doi.org/10.1182/blood-2019-127903
Published: 2019
Journal Articles

Activation of AKT/mTOR Pathway in Ph+ Acute Lymphoblastic Leukemia (ALL) Leads to Non-Mutational Resistance

Free
Afsar Ali Mian, BSc, MPhil, PhD, Usva Zafar, BSc, Oliver Ottmann, Prof, MD, Martin Ruthardt, MD, El-Nasir M A Lalani, BSc MBChB FRCPath PhDFHEA
Journal: Blood
Blood (2019) 134 (Supplement_1): 2570.
https://doi.org/10.1182/blood-2019-130898
Published: 2019
Journal Articles

Health Insurance Status Impacts Rates of Overall Survival in Philadelphia-Positive Acute Lymphoblastic Leukemia

Free
Jeremy Chang, MD, Sherry Zhang, MD, Mojtaba Akhtari, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2581.
https://doi.org/10.1182/blood-2019-123738
Published: 2019
Journal Articles

Combination of Dasatinib and Pediatric-Inspired Regimens in Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: A Single-Center Prospective Study

Free
Zhang Guang ji, Sr., master, Jianxiang Wang, MD, Ying Wang, Hui Wei, MD, Yingchang Mi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2583.
https://doi.org/10.1182/blood-2019-126480
Published: 2019
Journal Articles

Combination of Nilotinib and Pegylated Interferon Alfa-2B Results in High Rates of MR4.5 at 24 Months - Primary Analysis of the ALLG CML 11 Pinnacle Study

Free
David T Yeung, PhDBSc,FRACP,FRCPA,MBBS, Naranie Shanmuganathan, MBBS FRACP FRCPA, Andrew Grigg, Ilona Cunningham, MBBS FRACP FRCPA, Jake Shortt, FRACP,FRCPA,PhD, Philip Rowling, MBBS FRACP FRCPA, John Reynolds, PhD, Rosemary Anne Harrup, MBBS, FRACP, FRCPA, David M Ross, MD PhD, David Kipp, MBBS,FRCPA,FRACP, Anthony K Mills, FRACP, FRCPA, MBBS, Christopher K Arthur, MBBS FRACP FRCPA, Anthony P Schwarer, MD MBBS (Hons), FRACP, FRCPA, Kathryn Jackson, MBBS FRACP FRCPA, Nicholas Viiala, MBBS FRACP FRCPA, Robert Weinkove, MD, Agnes S. M. Yong, MD PhD, Deborah L. White, PhD FFSc (RCPA), Susan Branford, PhD, Timothy P. Hughes, MDMBBS,FRACP,FRCPA, On Behalf of the ALLG
Journal: Blood
Blood (2019) 134 (Supplement_1): 2926.
https://doi.org/10.1182/blood-2019-125740
Published: 2019
Journal Articles

BCR-ABL1 qPCR-Based Doubling Time within the First 6 Months after Imatinib Discontinuation Is a Predictive of Successful TKI Treatment-Free Remission

Free
Georgina S. Daher-Reyes, MD, Isabelle Bence-Bruckler, MD, Lambert Busque, MD, Donna L. Forrest, MD, Lynn Savoie, MD, Mary-Margaret Keating, MD, Robert Delage, MD, Anargyros Xenocostas, MD FRCPC, Elena Liew, MDBSc,FRCPC, Pierre Laneuville, MD FRCPC, Kristjan Paulson, MD, Jeffrey H. Lipton, MD PhD, Suzanne Kamel-Reid, BA, MA, PhD FACMG, Brian Leber, MD, Dennis Dong Hwan Kim, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2933.
https://doi.org/10.1182/blood-2019-131454
Published: 2019
Journal Articles

Interim Analysis of a Prospective Multicentre Study Using Next Generation Sequencing for Kinase Domain Mutational Analysis in CML Patients on First or Subsequent TKI Therapy

Free
Hugues De Lavallade, Sophie Jackson, BSc, Heather Oakervee, BSc, MBBS, MD MRCP, FRCPath, Sebastian Francis, MBChB, MRCP, Edward Belsham, FRCPath, MB, Paul Cahalin, MA MRCP FRCPath, Joanne Ewing, PhDBMBS BSc FRPATH, Jenny Byrne, MD PhD, Kate Rothwell, BA MB BChir, PhD, Sandra Hassan, MBBS, MRCP, FRCPath, MDRes), Srinivas Pillai, MBBS,MD MRCP, FRCPath, Priyanka Mehta, Anshu Garg, MBBS,MDMRCP,FRCPath, Mhairi Copland, PhD MBBChir, FRCP, FRCPath, Oliver Ottmann, Prof, MD, Deepti Radia, Patrick Harrington, MRCP, FRCPath, Rachel Greig, Nicholas Lea, PhD, Michael Thompson, Aytug Kizilors, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2935.
https://doi.org/10.1182/blood-2019-129825
Published: 2019
Journal Articles

Reveal the Neutrophil: Elucidating the Role of a Neutrophil-Specific JAK2-V617F Mutation

Free
Tobias Ronny Haage, MD, Andreas Johann Müller, Priyadharshini Arunachalam, Thomas Fischer, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2965.
https://doi.org/10.1182/blood-2019-122660
Published: 2019
Journal Articles

TNFR1 Blockade Rather then TNFR2 Blockade Reduces Chronic Inflammation in JAK2 +/V617F Mice

Free
Peter Müller, PhD, Bärbel Edelmann-Stephan, PhD, Fabian Richter, PhD, Klaus Pfizenmaier, PhD, Thomas Fischer, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2966.
https://doi.org/10.1182/blood-2019-127997
Published: 2019