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Journal Articles

Pediatric hemophagocytic lymphohistiocytosis

Scott W. Canna, Rebecca A. Marsh

Blood (2020) 135 (16): 1332–1343.

https://doi.org/10.1182/blood.2019000936

Published: 2020

Journal Articles

Targeting MDM2 and XIAP By Idasanutlin in Diffuse Large B-Cell Lymphoma

Juan J. Gu, MD PhD, Samuel J. Thompson, Cory Mavis, MSc, Matthew J. Barth, MD, Pallawi Torka, MD, Francisco J. Hernandez-Ilizaliturri, MD

Blood (2019) 134 (Supplement_1): 5301.

https://doi.org/10.1182/blood-2019-129009

Published: 2019

Journal Articles

Role of Disease Mechanism in Hematopoietic Cell Transplantation Outcomes for Hemophagocytic Lymphohistiocytosis

Aleksandra S. Dain, MD, Michelle L. Hermiston, MD PhD, Kristin A. Shimano, MD, Sandhya Kharbanda, MD, Alexis Melton, MD PhD, Jasmeen Dara, MD, James N Huang, MD, Christopher C. Dvorak, MD

Blood (2019) 134 (Supplement_1): 3343.

https://doi.org/10.1182/blood-2019-127397

Published: 2019

Journal Articles

LCL161, an Oral Smac Mimetic/IAP Antagonist for Patients with Myelofibrosis (MF): Novel Translational Findings Among Long-Term Responders in a Phase 2 Clinical Trial

Blood (2018) 132 (Supplement 1): 687.

https://doi.org/10.1182/blood-2018-99-119753

Published: 2018

Journal Articles

Targeting XIAP Via Degradation of MDM-2 By MX69 in Aggressive Lymphomas

Sumera Khan, MSc, MD, Kyle Runckel, BS, Cory Mavis, BSc, MSc, Matthew J. Barth, MD, Francisco J. Hernandez-Ilizaliturri, MD

Blood (2018) 132 (Supplement 1): 5379.

https://doi.org/10.1182/blood-2018-99-118480

Published: 2018

Journal Articles

Memory T Cells from Minor Histocompatibility Antigen-Vaccinated Donors Improve Engraftment with Low Intensity Conditioning

Meng Zhou, Jinling Liu, PhD, Warren D Shlomchik, MD

Blood (2017) 130 (Supplement 1): 4436.

https://doi.org/10.1182/blood.V130.Suppl_1.4436.4436

Published: 2017

Journal Articles

XIAP Knockdown Can Increase the Activity of Caspase 3 and 7, and Restore the Apoptotic Response in Cell Line Models of Rituximab Relapse/Refractory B-Cell Lymphoma

Kyle Runckel, BS, Cory Mavis, BSc, MSc, Francisco J. Hernandez-Ilizaliturri, MD

Blood (2017) 130 (Supplement 1): 1478.

https://doi.org/10.1182/blood.V130.Suppl_1.1478.1478

Published: 2017

Journal Articles

Enhancement of Allo-NK Cell Activity in Myeloid Leukemia Cell Line KG-1a after Combined with Aclacinomycin

Yongbin Ye, MDPhD, Xiaojun Xu, MDPhD, Yanhong Chen, MM, Mingwan Zhang, MM, Dafa Qiu, MM, Ziwen Guo, MB, Huiqing He, MB

Blood (2017) 130 (Supplement 1): 5074.

https://doi.org/10.1182/blood.V130.Suppl_1.5074.5074

Published: 2017

Journal Articles

The XIAP Inhibitor BMT-062789 Displays Anti-Tumor Activity in Cell Line Models of De Novo and Rituximab Relapse/Refractory Lymphoma

Kyle L. Runckel, BS, Cory Mavis, Master, Juan J Gu, PhD, Francisco J. Hernandez-Ilizaliturri, MD

Blood (2016) 128 (22): 5375.

https://doi.org/10.1182/blood.V128.22.5375.5375

Published: 2016

Journal Articles

Induction of Resistance to Proteasome Inhibition Preferentially Switches Survival Dependence from Bcl-2 to XIAP in Preclinical Models of Waldenstrom Macroglobulinemia: Pre-Clinical Rationale for Early Clinical Sequencing of ABT199

Sharoon Akhtar, MPhil, Aneel Paulus, MDMS, Kelara Samuel, Hassan Yousaf, Davitte Cogen, Vivek Roy, MD, Taimur Sher, MD, James M. Foran, MD, Candido E. Rivera, MD, Gerardo Colon-Otero, MD, Sikander Ailawadhi, MD, Asher Alban Chanan-Khan, MD

Blood (2015) 126 (23): 4839.

https://doi.org/10.1182/blood.V126.23.4839.4839

Published: 2015

Journal Articles

The Novel Technique of Genetically Engineered Patient-Derived Xenografts (GEPDX) Reveals That the X-Linked Inhibitor of Apoptosis Protein (XIAP) Plays an Essential Role for Maintenance and Growth of Patients' Acute Lymphoblastic Leukemia In Vivo

Michela Carlet, PhD, Jenny Vergalli, M.Sc., Cornelia Finkenzeller, M.Sc., Michaela Grunert, PhD, Irmela Jeremias, MD

Blood (2015) 126 (23): 2632.

https://doi.org/10.1182/blood.V126.23.2632.2632

Published: 2015

Journal Articles

Targeting the X-Linked Inhibitor of Apoptosis Protein (XIAP) Can Promote Tumor Cell Death, and Increase the Cytotoxic Effects of Chemotherapy Agents in in Vitro and In Vivo Models of Rituximab-Resistant Lymphoma

Kyle L. Runckel, BS, Cory Mavis, MSc, Joseph Skitzki, Juan J Gu, PhD, Francisco J. Hernandez-Ilizaliturri, MD, Myron S. Czuczman, MD

Blood (2015) 126 (23): 590.

https://doi.org/10.1182/blood.V126.23.590.590

Published: 2015

Journal Articles

Therapy Personalization Using Predictive Simulation Approach with Ex-Vivo Clinical Validations

Nicole A Doudican, PhD, Ravi Vij, MD, Mark A Fiala, BS, CCRP, Justin King, Shireen Vali, PhD, Kabya Basu, Ansu Kumar, Neeraj Kumar Singh, Zeba Sultana, Taher Abbasi, MS, Amitabha Mazumder, MD

Blood (2014) 124 (21): 2232.

https://doi.org/10.1182/blood.V124.21.2232.2232

Published: 2014

Journal Articles

Inhibition of Akt signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy

Anniek B. van der Waart, Noortje M. P. van de Weem, Frans Maas, Cynthia S. M. Kramer, Michel G. D. Kester, J. H. Frederik Falkenburg, Nicolaas Schaap, Joop H. Jansen, Robbert van der Voort, Luca Gattinoni, Willemijn Hobo, Harry Dolstra

Blood (2014) 124 (23): 3490–3500.

https://doi.org/10.1182/blood-2014-05-578583

Published: 2014

Includes: Supplemental data

Journal Articles

Inability to resolve specific infection generates innate immunodeficiency syndrome in Xiap −/− mice

Wan-Chen Hsieh, Ya-Ting Chuang, I-Hsuan Chiang, Shu-Ching Hsu, Shi-Chuen Miaw, Ming-Zong Lai

Blood (2014) 124 (18): 2847–2857.

https://doi.org/10.1182/blood-2014-03-564609

Published: 2014

Includes: Supplemental data

Journal Articles

cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner

W. Wei-Lynn Wong, James E. Vince, Najoua Lalaoui, Kate E. Lawlor, Diep Chau, Aleksandra Bankovacki, Holly Anderton, Donald Metcalf, Lorraine O’Reilly, Philipp J. Jost, James M. Murphy, Warren S. Alexander, Andreas Strasser, David L. Vaux, John Silke

Blood (2014) 123 (16): 2562–2572.

https://doi.org/10.1182/blood-2013-06-510743

Published: 2014

Includes: Supplemental data

Journal Articles

cIAPs and XIAP reduce RIPKs to silence

Arnaud Jacquel, Patrick Auberger

Blood (2014) 123 (16): 2445–2446.

https://doi.org/10.1182/blood-2014-02-555771

Published: 2014

Journal Articles

Inhibition Of The Immunoproteasome Subunit LMP7 Decreases Alloresponses In Both MHC-Mismatched and miHA-Disparate Murine Models Of Graft Versus Host Disease

Jennifer Matos, PhD, Zheng Yang, Eugenia Dziopa, Leah Dziopa, Christopher J. Kirk, Ph.D, Robert Korngold, PhD, Jenny Zilberberg, Ph.D.

Blood (2013) 122 (21): 4472.

https://doi.org/10.1182/blood.V122.21.4472.4472

Published: 2013

Journal Articles

Ex Vivo Generation Of Functional Plasmacytoid and Myeloid Dendritic Cells Is Strongly Promoted By The Aryl Hydrocarbon Receptor Antagonist Stemregenin 1

Soley Thordardottir, MSc, Hangalapura Basav N., PhD, Tim Hutten, MSc, Marta Cossu, MSc, Jan Spanholtz, PhD, Nicolaas PM Schaap, MD, PhD, Timothy Radstake, MD, PhD, Robbert van der Voort, PhD, Harry Dolstra, PhD

Blood (2013) 122 (21): 2025.

https://doi.org/10.1182/blood.V122.21.2025.2025

Published: 2013

Journal Articles

Allogeneic hematopoietic cell transplantation for XIAP deficiency: an international survey reveals poor outcomes

Blood (2013) 121 (6): 877–883.

https://doi.org/10.1182/blood-2012-06-432500

Published: 2013

NARROW

Pediatric hemophagocytic lymphohistiocytosis

Targeting MDM2 and XIAP By Idasanutlin in Diffuse Large B-Cell Lymphoma

Role of Disease Mechanism in Hematopoietic Cell Transplantation Outcomes for Hemophagocytic Lymphohistiocytosis

LCL161, an Oral Smac Mimetic/IAP Antagonist for Patients with Myelofibrosis (MF): Novel Translational Findings Among Long-Term Responders in a Phase 2 Clinical Trial

Targeting XIAP Via Degradation of MDM-2 By MX69 in Aggressive Lymphomas

Memory T Cells from Minor Histocompatibility Antigen-Vaccinated Donors Improve Engraftment with Low Intensity Conditioning

XIAP Knockdown Can Increase the Activity of Caspase 3 and 7, and Restore the Apoptotic Response in Cell Line Models of Rituximab Relapse/Refractory B-Cell Lymphoma

Enhancement of Allo-NK Cell Activity in Myeloid Leukemia Cell Line KG-1a after Combined with Aclacinomycin

The XIAP Inhibitor BMT-062789 Displays Anti-Tumor Activity in Cell Line Models of De Novo and Rituximab Relapse/Refractory Lymphoma

Induction of Resistance to Proteasome Inhibition Preferentially Switches Survival Dependence from Bcl-2 to XIAP in Preclinical Models of Waldenstrom Macroglobulinemia: Pre-Clinical Rationale for Early Clinical Sequencing of ABT199

The Novel Technique of Genetically Engineered Patient-Derived Xenografts (GEPDX) Reveals That the X-Linked Inhibitor of Apoptosis Protein (XIAP) Plays an Essential Role for Maintenance and Growth of Patients' Acute Lymphoblastic Leukemia In Vivo

Targeting the X-Linked Inhibitor of Apoptosis Protein (XIAP) Can Promote Tumor Cell Death, and Increase the Cytotoxic Effects of Chemotherapy Agents in in Vitro and In Vivo Models of Rituximab-Resistant Lymphoma

Therapy Personalization Using Predictive Simulation Approach with Ex-Vivo Clinical Validations

Inhibition of Akt signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy

Inability to resolve specific infection generates innate immunodeficiency syndrome in Xiap −/− mice

cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner

cIAPs and XIAP reduce RIPKs to silence

Inhibition Of The Immunoproteasome Subunit LMP7 Decreases Alloresponses In Both MHC-Mismatched and miHA-Disparate Murine Models Of Graft Versus Host Disease

Ex Vivo Generation Of Functional Plasmacytoid and Myeloid Dendritic Cells Is Strongly Promoted By The Aryl Hydrocarbon Receptor Antagonist Stemregenin 1

Allogeneic hematopoietic cell transplantation for XIAP deficiency: an international survey reveals poor outcomes

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American Society of Hematology

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American Society of Hematology

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