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Journal Articles

Dynamic CTCF binding directly mediates interactions among cis -regulatory elements essential for hematopoiesis

Free
Qian Qi, Li Cheng, Xing Tang, Yanghua He, Yichao Li, Tiffany Yee, Dewan Shrestha, Ruopeng Feng, Peng Xu, Xin Zhou, Shondra Pruett-Miller, Ross C. Hardison, Mitchell J. Weiss, Yong Cheng
Journal: Blood
Blood (2021) 137 (10): 1327–1339.
https://doi.org/10.1182/blood.2020005780
Published: 2021
Includes: Supplemental data
Journal Articles

The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression

Free
Peng Huang, Scott A. Peslak, Xianjiang Lan, Eugene Khandros, Jennifer A. Yano, Malini Sharma, Cheryl A. Keller, Belinda Giardine, Kunhua Qin, Osheiza Abdulmalik, Ross C. Hardison, Junwei Shi, Gerd A. Blobel
Journal: Blood
Blood (2020) 135 (24): 2121–2132.
https://doi.org/10.1182/blood.2020005301
Published: 2020
Includes: Supplemental data
Journal Articles

Site-specific methylation of 18S ribosomal RNA by SNORD42A is required for acute myeloid leukemia cell proliferation

Free
Cornelius Pauli, Yi Liu, Christian Rohde, Chunhong Cui, Daria Fijalkowska, Dennis Gerloff, Carolin Walter, Jeroen Krijgsveld, Martin Dugas, Bayram Edemir, Caroline Pabst, Lutz P. Müller, Fengbiao Zhou, Carsten Müller-Tidow
Journal: Blood
Blood (2020) 135 (23): 2059–2070.
https://doi.org/10.1182/blood.2019004121
Published: 2020
Includes: Supplemental data
Journal Articles

The Neurotransmitter Receptor Gabbr1 Regulates Proliferation and Function of Hematopoietic Stem and Progenitor Cells

Free
Adedamola Elujoba-Bridenstine, MS, Lijian Shao, MD PhD, Katherine Zink, Laura Sanchez, PhD, Brian Cox, PhD, Kostandin Pajcini, PhD, Owen J Tamplin, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3707.
https://doi.org/10.1182/blood-2019-130627
Published: 2019
Journal Articles

gata2 is Required for the runx1 -Independent Hematopoiesis in Zebrafish

Free
Erica Bresciani, PhD, Blake Carrington, Erika M Kwon Kim, PhD, Kai Yu, PhD, Kevin Bishop, Stefania Dell'Orso, PhD, Vittorio Sartorelli, PhD, Raman B. Sood, PhD, Paul P. Liu, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2463.
https://doi.org/10.1182/blood-2019-127334
Published: 2019
Journal Articles

Studying the Role of ETV6 in Megakaryopoiesis and Thrombopoiesis Using a Novel CRISPR-Cas9 Halotag Genome Editing Strategy

Free
Marlie H Fisher, Leila J. Noetzli, PhD, Michael Callaghan, MD, Walter H. Kahr, MDPhDFRCPC, Jesse W Rowley, PhD, Jorge Di Paola, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2468.
https://doi.org/10.1182/blood-2019-131967
Published: 2019
Journal Articles

Preclinical Evaluation of ALS20, a New and Improved Lentiviral Vector for Beta-Globinopathies

Free
Laura Breda, PhD, Valentina Ghiaccio, PhD, Silvia Pires Lourenco, MSc, Danuta Jadwiga Jarocha, PhD, Yasuhiro Ikawa, MD PhD, Naoto Tanaka, PhD, Virginia Guzikowski, Carla Casu, PhD, Kim Smith-Whitley, MD, Janet L. Kwiatkowski, MD MSCE, Stefano Rivella, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2242.
https://doi.org/10.1182/blood-2019-124043
Published: 2019
Journal Articles

Mice Deficient in ß2-Glycoprotein I Have a Delayed Time to Thrombosis

Free
Ravi Kumar Alluri, PhD, Gabriel L Forbes, Suman Kundu, MBA, Alvin H. Schmaier, MD, Keith R McCrae, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2423.
https://doi.org/10.1182/blood-2019-130521
Published: 2019
Journal Articles

Lyn Kinase Contributes to the Reprogramming of Fibroblasts Promoting Chronic Lymphocytic Leukemia Progression

Free
Alexander Frederik Vom Stein, Maximilian Koch, Sebastian Reinarzt, Anna Lucas, Rocio Rebollido-Rios, PhD, Thomas Oellerich, MD, Phuong Hien Nguyen, PhD, Michael Hallek
Journal: Blood
Blood (2019) 134 (Supplement_1): 4283.
https://doi.org/10.1182/blood-2019-129299
Published: 2019
Journal Articles

Homeobox Transcription Factor Hhex Promotes Myeloid Leukemia in Cooperation with Mutant ASXL1

Free
Reina Takeda, MD, Shuhei Asada, MD PhD, Sung-Joon Park, PhD, Akihiko Yokoyama, PhD, Akinori Kanai, PhD, Valeria Visconte, PhD, Courtney Hershberger, BS, Yasutaka Hayashi, MD PhD, Taishi Yonezawa, MSc, Moe Tamura, Tomofusa Fukuyama, MD PhD, Akiko Matsumoto, Satoshi Yamasaki, PhD, Kenta Nakai, PhD, Toshiya Inaba, MD PhD, Tatsuhiro Shibata, MD PhD, Daichi Inoue, MD PhD, Hiroaki Honda, MD PhD, Susumu Goyama, MD PhD, Jaroslaw P. Maciejewski, MD PhD, Toshio Kitamura, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2525.
https://doi.org/10.1182/blood-2019-126663
Published: 2019
Journal Articles

Genome-Scale CRISPR-Cas9 Synthetic Lethal Screening of AML Cell Line Identified Functional Modulators of Etoposide Resistance Predictive of Clinical Outcome in AML Patients

Free
Roya Rafiee, M.Sc., PhD, Amin Sobh, PhD, Abdelrahman H. Elsayed, MSc, Abderrahmane Tagmount, PhD, Chris D Vulpe, MD PhD, Jatinder K Lamba, M.Sc., PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2685.
https://doi.org/10.1182/blood-2019-131312
Published: 2019
Journal Articles

An Integrative Genomic Approach to Examine Mutations and Biological Pathways Associated with Hematological Malignancy Development in DDX41 Mutated Families

Free
Parvathy Venugopal, PhD, Jesse JC Cheah, Leila Eshraghi, PhD, Nur Hezrin Shahrin, PhD, Claire Homan, PhD, Jinghua Feng, PhD, Andreas W Schreiber, PhD, Miriam Fine, Kerry Phillips, Nicola Poplawski, MD, Anna L Brown, PhD, Christopher N Hahn, PhD, Hamish S Scott, PhD FFSc (RCPA)
Journal: Blood
Blood (2019) 134 (Supplement_1): 2686.
https://doi.org/10.1182/blood-2019-131649
Published: 2019
Journal Articles

Diffuse Large B Cell Lymphoma (DLBCL)-Released NM23-H1 Promotes Monocyte Survival and Inflammatory Cytokine Release: A Mechanistic Link between the Dual Impacts of NM23-H1 Expression and Reduced Lymphocyte:Monocyte Ratio in DLBCL Prognosis

Free
Sandro Trova, PhD, Maiss Al-Amere, PhD, Jayna J Mistry, BSc, Zuhal Eraslan, Bader Alhazmi, Joy Harris-Folb, Alessandro Di Maio, Mark T Drayson, MB ChB, PhD FRCPath, Christopher M Bunce, BSc, Stuart A Rushworth, PhD, Farhat Latif Khanim, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2803.
https://doi.org/10.1182/blood-2019-130889
Published: 2019
Journal Articles

CRISPR-Cas9 Screen Identifies XPO7 As a Potential Therapeutic Target for TP53 -Mutated AML

Free
Yuichiro Semba, MD PhD, Takuji Yamauchi, MD PhD, Fumihiko Nakao, MD, Jumpei Nogami, PhD, Matthew C. Canver, MD PhD, Luca Pinello, PhD, Daniel E. Bauer, MD PhD, Koichi Akashi, MD PhD, Takahiro Maeda, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3784.
https://doi.org/10.1182/blood-2019-129623
Published: 2019
Journal Articles

Characterizing Dyskeratosis Congenita Caused By Parn Mutations in the Zebrafish

Free
Anna Cordeiro, PhD, Adam P Deveau, MSc, Santhosh Dhanraj, PhD, Yigal Dror, MDFRCPC, Jason Berman, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3744.
https://doi.org/10.1182/blood-2019-130147
Published: 2019
Journal Articles

Targeting Activated Signaling Pathways for the Treatment of IKZF1 -Deleted B Lymphoblastic Leukemia

Free
Rohit Gupta, BA, Jason H. Rogers, MS, Xin Long, PhD, Geraldo Medrano, BS, Jaime M. Reyes, BS, Michele Redell, MD PhD, Zachary T Ball, PhD, Margaret Goodell, PhD, Rachel E. Rau, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3789.
https://doi.org/10.1182/blood-2019-127209
Published: 2019
Journal Articles

Targeting Salt-Inducible Kinase 3 As a Therapeutic Approach for Acute Myeloid Leukemia

Free
Shan Lin, Yusuke Tarumoto, Jinhua Wang, PhD, Joseph Milazzo, Yali Xu, Nathanael Gray, Christopher Vakoc, Kimberly Stegmaier, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3941.
https://doi.org/10.1182/blood-2019-125278
Published: 2019
Journal Articles

A Gain of Function Mutation in the NSD2 Histone Methyltransferase Drives Glucocorticoid Resistance Via Blocking Receptor Auto-Induction and BIM/Bmf Expression in ALL

Free
Jianping Li, MD, Catalina Troche, PhD, Julia Hlavka Zhang, BS, Jonathan Shrimp, PhD, Jacob S. Roth, PhD, Duohui Jing, PhD, Alok Swaroop, PhD, Marta Kulis, Jon Oyer, PhD, Christine Will, MS, Daphne Dupere-Richer, PhD, Alberto Riva, PhD, Crissandra Pipe, LATG, Amin Sobn, PhD, Sharon Norton, MS, Richard Lynn Bennett, PhD, Min Shen, PhD, Matthew D. Hall, PhD, Richard B. Lock, PhD, Jonathan D. Licht, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3758.
https://doi.org/10.1182/blood-2019-126910
Published: 2019
Journal Articles

Improved Anti-Tumor Response of Chimeric Antigen Receptor T Cell (CART) Therapy after GM-CSF Inhibition Is Mechanistically Supported By a Novel Direct Interaction of GM-CSF with Activated Carts

Free
Michelle J. Cox, Charles J. Kuhlmann, Rosalie M. Sterner, Reona Sakemura, MD PhD, Sutapa Sinha, PhD, Raphael Mwangi, MS, Nancy Scott, MS, Mehrdad Hefazi, MD, Omar Ahmed, Dale Chappell, Cameron Durrant, Claudia Manriquez Roman, Kendall J. Schick, Erin E. Tapper, Paulina Horvei, MD, Michael W. Ruff, MD, Sameer A. Parikh, MD, Neil E. Kay, MD, Saad S. Kenderian, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3868.
https://doi.org/10.1182/blood-2019-129349
Published: 2019
Journal Articles

Germline Mutations Predispose to Familial Myeloproliferative Neoplasms

Free
Stephanie Berg, DO, Manuel O. Diaz, MD, Sucha Nand, MD, Jiwang Zhang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2969.
https://doi.org/10.1182/blood-2019-124805
Published: 2019