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Journal Articles

Active DNA Demethylation Mediated By GADD45β Is Essential during G-CSF Triggered Granulocytic Differentiation

Perihan Mir, Maksim Klimiankou, Narges Aghaallaei, Betuel Findik, Frederic Thalheimer, Susanne Wingert, Michael A. Rieger, Thomas Thumberger, Cornelia Zeidler, Baubak Bajoghli, Karl Welte, Julia Skokowa, MD PhD

Blood (2019) 134 (Supplement_1): 211.

https://doi.org/10.1182/blood-2019-128508

Published: 2019

Journal Articles

Whole Genome Bisulfite Sequencing of 63 Primary AML Samples Identifies a Unique DNA Hypermethylation Signature for Mutant IDH1/2 Cases That Is Different from That of TET2 Mutant AML

Ellie Wilson, BS, Nichole Helton, Catrina Fronick, BS, Robert Fulton, MS, John S. Welch, MD PhD, Timothy J Ley, MD, David H Spencer, MD

Blood (2019) 134 (Supplement_1): 3755.

https://doi.org/10.1182/blood-2019-122340

Published: 2019

Journal Articles

Epigenetic Profile of Treg-like Cells Induced By Mesenchymal Stem Cells in Vitro Resembles That of Natural Treg

Rita I Azevedo, PhD, Ekaterina Minskaia, PhD, Cláudia Lobato da Silva, PhD, Ana Fernandes Platzgummer, PhD, Ana I.S. Vieira, MSc, Joaquim M.S. Cabral, PhD, Joao F Lacerda, MD PhD

Blood (2018) 132 (Supplement 1): 2578.

https://doi.org/10.1182/blood-2018-99-112452

Published: 2018

Journal Articles

Molecular profiling reveals immunogenic cues in anaplastic large cell lymphomas with DUSP22 rearrangements

Blood (2018) 132 (13): 1386–1398.

https://doi.org/10.1182/blood-2018-03-838524

Published: 2018

Includes: Supplemental data

Journal Articles

Characterization and Targeting TET2-Mutant HSPCs and AML

Yusuke Nakauchi, MD PhD, Daniel Thomas, MD PhD, Andreas Reinisch, MD PhD, Rajiv Sharma, PhD, David Cruz, BS, M. Ryan Corces, PhD, Ravi Majeti, MD PhD

Blood (2017) 130 (Supplement 1): 2509.

https://doi.org/10.1182/blood.V130.Suppl_1.2509.2509

Published: 2017

Journal Articles

Acute Deletion of Tet2 or Tet3 Transiently Dysregulate Murine Erythropoiesis

Aishwarya Swaminathan, PhD, Daniel Hidalgo, MA, Hien Nguyen, Scott Shaffer, Maria Figueroa, Jian Xu, PhD, Merav Socolovsky, MBBS, PhD

Blood (2017) 130 (Supplement 1): 11.

https://doi.org/10.1182/blood.V130.Suppl_1.11.11

Published: 2017

Journal Articles

Vitamin C Stabilizes Foxp3 Expression in Induced Treg Cells By Targeted DNA Demethylation and Prevents Murine Model of Acute Graft Versus Host Disease

Hidenori Kasahara, MD, Shinichiro Okamoto, MD PhD, Takashi Sekiya, PhD, Akihiko Yoshimura, PhD

Blood (2017) 130 (Supplement 1): 70.

https://doi.org/10.1182/blood.V130.Suppl_1.70.70

Published: 2017

Journal Articles

Aid is a key regulator of myeloid/erythroid differentiation and DNA methylation in hematopoietic stem/progenitor cells

Hiroyoshi Kunimoto, Anna Sophia McKenney, Cem Meydan, Kaitlyn Shank, Abbas Nazir, Franck Rapaport, Benjamin Durham, Francine E. Garrett-Bakelman, Elodie Pronier, Alan H. Shih, Ari Melnick, Jayanta Chaudhuri, Ross L. Levine

Blood (2017) 129 (13): 1779–1790.

https://doi.org/10.1182/blood-2016-06-721977

Published: 2017

Includes: Supplemental data

Journal Articles

DNMT3A Mutations Enhance CpG Mutagenesis through Deregulation of the Active DNA Demethylation Pathway

Mathijs A. Sanders, PhD, Annelieke Zeilemaker, Adil al Hinai, Remco Hoogenboezem, François G. Kavelaars, BSc, Melissa Rijken, Eric M.J. Bindels, PhD, Bob Löwenberg, MD PhD, Peter J.M. Valk, PhD

Blood (2016) 128 (22): 1076.

https://doi.org/10.1182/blood.V128.22.1076.1076

Published: 2016

Journal Articles

Changes in Killer-Cell Immunoglobulin-like Receptor (KIR) Expression on NK Cells Following DNA Demethylation By Azacitidine in Relapsed and Refractory Lymphomas

Runa Shrestha, MD, Ahmad Al-Attar, MD, John W Hayslip, MD, Lutz T Charles, MD, Emily Dressler, PhD, Jabbour Hossam, MD, Maryam F Zia, MD, Hayder Saeed, MD, Amit Goldberg, MD, Gregory Monohan, MD, Roger Herzig, MD, Roger A Fleischman, MD, PhD, Gerhard Hildebrandt, MD, Shams A Shakil, MD, PhD

Blood (2016) 128 (22): 5296.

https://doi.org/10.1182/blood.V128.22.5296.5296

Published: 2016

Journal Articles

De Novo DNA Methylation Is Associated with Granulopoiesis and Megakaryopoiesis but Not Erythropoiesis

Jens Lichtenberg, PhD, Elisabeth F. Heuston, PhD, Stacie M. Anderson, NIH Intramural Sequencing Center, Cheryl A. Keller, PhD, Ross C. Hardison, PhD, David M. Bodine, PhD

Blood (2016) 128 (22): 3868.

https://doi.org/10.1182/blood.V128.22.3868.3868

Published: 2016

Journal Articles

Multivariate Analysis Identifies Significant Correlations Between Baseline Biomarkers, DNA Demethylation and Clinical Responses in 122 Patients Treated in a Phase 1/2, Study of Guadecitabine (SGI-110), in the Treatment of Relapsed/Refractory Acute Myeloid Leukemia (r/r AML)

Srikanth Gottipati, PhD, Shashank Rohatagi, PhD, Woonbok Chung, PhD, Pietro Taverna, PhD, Hagop M. Kantarjian, MD, Gail J. Roboz, MD, Patricia L. Kropf, MD, Mohammad Azab, MD, Jean-Pierre Issa, MD

Blood (2015) 126 (23): 2594.

https://doi.org/10.1182/blood.V126.23.2594.2594

Published: 2015

Journal Articles

Novel Functional Roles for Ten-Eleven-Translocation 2 (Tet2) in Normal and Leukemic Growth of Mast Cells

Raghuveer Mali, PhD, Holly Rene Martin, PhD, Baskar Ramdas, PhD, Lakshmi Palam, PhD, Valeria Visconte, PhD, Tiu Ramon, MD, Helmut Hanenberg, MD, Mingjiang Xu, MD PhD, Reuben Kapur, PhD

Blood (2015) 126 (23): 775.

https://doi.org/10.1182/blood.V126.23.775.775

Published: 2015

Journal Articles

Impact of TET2 Deficiency on Iron Metabolism in Erythroblasts: A Potential Link to Ring Sideroblast Formation

Kyoko Inokura, MD, Tohru Fujiwara, MD PhD, Yoko Okitsu, MD PhD, Noriko Fukuhara, MD PhD, Yasushi Onishi, MD PhD, Kenichi Ishizawa, MD PhD, Kazuya Shimoda, MD PhD, Hideo Harigae, MD PhD

Blood (2014) 124 (21): 750.

https://doi.org/10.1182/blood.V124.21.750.750

Published: 2014

Journal Articles

Dnmt3a and Tet2 interact to Repress differentiation lineage-specific transcriptional factors in Hematopoietic Stem Cells By the Regulation of Epigenome

Xiaotian Zhang, BS, Mira Jeong, PhD, Jianzhong Su, Myung Gon Ko, PhD, Yun Huang, PhD, Hyun Jung Park, Anjana Rao, PhD, Wei Li, PhD, Margaret A. Goodell, PhD

Blood (2014) 124 (21): 242.

https://doi.org/10.1182/blood.V124.21.242.242

Published: 2014

Journal Articles

TET2 Regulates CD8 + T Cell Differentiation

Shannon A. Carty, MD, Mercy Gohil, Gary A Koretzky, MD PhD, Martha S Jordan, PhD

Blood (2014) 124 (21): 1423.

https://doi.org/10.1182/blood.V124.21.1423.1423

Published: 2014

Journal Articles

DNA Demethylation By Activation-Induced Cytidine Deaminase in B Cell Lymphoma

Yang Xi, PhD, Velizar Shivarov, MD, PhD, Gur Yaari, PhD, Steven Kleinstein, PhD, Matthew P. Strout, MD, PhD

Blood (2014) 124 (21): 3549.

https://doi.org/10.1182/blood.V124.21.3549.3549

Published: 2014

Journal Articles

Systems Biology and Epigenetic Mechanisms in Erythropoiesis

Merav Socolovsky, MBBS, PhD

Blood (2013) 122 (21): SCI-11.

https://doi.org/10.1182/blood.V122.21.SCI-11.SCI-11

Published: 2013

Journal Articles

TET Proteins and Histone Modifications in Hematopoiesis

Kristian Helin, PhD, Kasper D. Rasmusssen, Marianne T. Pedersen, Guangshuai Jia, Kristine Williams, Jens V. Johansen, Paul A.C. Cloos, Olivier A. Bernard, Jesper Christensen

Blood (2013) 122 (21): SCI-19.

https://doi.org/10.1182/blood.V122.21.SCI-19.SCI-19

Published: 2013

Journal Articles

T-Cell-Mediated Suppression: From Bench to Bedside

Maria Grazia Roncarolo, MD, Manuela Battaglia, PhD, Rosa Bacchetta, MD, Megan Levings, PhD, Silvia Gregori, PhD

Blood (2013) 122 (21): SCI-37.

https://doi.org/10.1182/blood.V122.21.SCI-37.SCI-37

Published: 2013

NARROW

Active DNA Demethylation Mediated By GADD45β Is Essential during G-CSF Triggered Granulocytic Differentiation

Whole Genome Bisulfite Sequencing of 63 Primary AML Samples Identifies a Unique DNA Hypermethylation Signature for Mutant IDH1/2 Cases That Is Different from That of TET2 Mutant AML

Epigenetic Profile of Treg-like Cells Induced By Mesenchymal Stem Cells in Vitro Resembles That of Natural Treg

Molecular profiling reveals immunogenic cues in anaplastic large cell lymphomas with DUSP22 rearrangements

Characterization and Targeting TET2-Mutant HSPCs and AML

Acute Deletion of Tet2 or Tet3 Transiently Dysregulate Murine Erythropoiesis

Vitamin C Stabilizes Foxp3 Expression in Induced Treg Cells By Targeted DNA Demethylation and Prevents Murine Model of Acute Graft Versus Host Disease

Aid is a key regulator of myeloid/erythroid differentiation and DNA methylation in hematopoietic stem/progenitor cells

DNMT3A Mutations Enhance CpG Mutagenesis through Deregulation of the Active DNA Demethylation Pathway

Changes in Killer-Cell Immunoglobulin-like Receptor (KIR) Expression on NK Cells Following DNA Demethylation By Azacitidine in Relapsed and Refractory Lymphomas

De Novo DNA Methylation Is Associated with Granulopoiesis and Megakaryopoiesis but Not Erythropoiesis

Multivariate Analysis Identifies Significant Correlations Between Baseline Biomarkers, DNA Demethylation and Clinical Responses in 122 Patients Treated in a Phase 1/2, Study of Guadecitabine (SGI-110), in the Treatment of Relapsed/Refractory Acute Myeloid Leukemia (r/r AML)

Novel Functional Roles for Ten-Eleven-Translocation 2 (Tet2) in Normal and Leukemic Growth of Mast Cells

Impact of TET2 Deficiency on Iron Metabolism in Erythroblasts: A Potential Link to Ring Sideroblast Formation

Dnmt3a and Tet2 interact to Repress differentiation lineage-specific transcriptional factors in Hematopoietic Stem Cells By the Regulation of Epigenome

TET2 Regulates CD8 + T Cell Differentiation

DNA Demethylation By Activation-Induced Cytidine Deaminase in B Cell Lymphoma

Systems Biology and Epigenetic Mechanisms in Erythropoiesis

TET Proteins and Histone Modifications in Hematopoiesis

T-Cell-Mediated Suppression: From Bench to Bedside

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American Society of Hematology

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ASH Publications

American Society of Hematology

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