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Journal Articles

The endoplasmic reticulum protein SEC22B interacts with NBEAL2 and is required for megakaryocyte α-granule biogenesis

Richard W. Lo, Ling Li, Fred G. Pluthero, Richard Leung, Koji Eto, Walter H. A. Kahr
Journal: Blood
Blood (2020) 136 (6): 715–725.
https://doi.org/10.1182/blood.2019004276
Published: 2020
Includes: Supplemental data
Journal Articles

Factor VIII exhibits chaperone-dependent and glucose-regulated reversible amyloid formation in the endoplasmic reticulum

Juthakorn Poothong, Anita Pottekat, Marina Siirin, Alexandre Rosa Campos, Adrienne W. Paton, James C. Paton, Jacqueline Lagunas-Acosta, Zhouji Chen, Mark Swift, Niels Volkmann, Dorit Hanein, Jing Yong, Randal J. Kaufman
Journal: Blood
Blood (2020) 135 (21): 1899–1911.
https://doi.org/10.1182/blood.2019002867
Published: 2020
Includes: Supplemental data
Journal Articles

Preclinical Validation of Ubiquitin Receptor PSMD4 As Therapeutic Target in Multiple Myeloma

Yan Song, PhD, Ting DU, PhD, Arghya Ray, PhD, Dharminder Chauhan, PhD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4403.
https://doi.org/10.1182/blood-2019-122952
Published: 2019
Journal Articles

Synergistic Effect of Carfilzomib and Metformin in Vascular Plasticity; The Emerging Role of Autophagy

Panagiotis Efentakis, PhD, Ioanna Andreadou, PhD, Panagiota-Efstathia Nikolaou, PhD, Claudius Witzler, Svenja Siemer, Eftathios Kastritis, Philip Wenzel, MD PhD, Meletios A. Dimopoulos, MD, Evangelos Terpos, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3797.
https://doi.org/10.1182/blood-2019-123522
Published: 2019
Journal Articles

Effect of the Unfolded Protein Response and Oxidative Stress on Mutagenesis of CSF3R a Model of Evolution of Severe Congenital Neutropenia to Myelodysplastic Syndrome/Acute Myeloid Leukemia

Adya Sapra, MS, Roman Jaksik, PhD, Sara Biesiadny, Hrishikesh M Mehta, PhD, Marek Kimmel, PhD DSc, Seth J. Corey, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3752.
https://doi.org/10.1182/blood-2019-127401
Published: 2019
Journal Articles

Higher Intensity of Cell Surface Glucose-Regulated Protein 78 (csGRP78) Expression Is Seen in Patients with Early Progressive Disease/Mortality in a Cohort of Relapsed, Refractory Multiple Myeloma Patients Treated with Carfilzomib, Thalidomide and Dexamethasone

Slavisa Ninkovic, MBBS FRACP FRCPA, Simon Harrison, MBBS, MRCP, FRCPath, FRACP, PhD, Lenny Straszkowski, BSci Hons, Giulia Quattrocchi, Wee-Joo Chng, MBBS, PhD, Louise E Purton, PhD, Hang Quach, MBBS, FRACP, FRCPA, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4376.
https://doi.org/10.1182/blood-2019-128190
Published: 2019
Journal Articles

Artesunate Inhibits Graft-Versus-Host Disease in Mice Via a Mechanism of Inducing Mitochondrial Calcium Overloading in Activated T Cells

Ying Wang, PhD, Shan He, PhD, Yongnian Liu, Robert Hooper, PhD, Hongshuang Yu, Yuanyuan Tian, Bui Tien, Bryant M Schultz, John W Elrod, PhD, Jonathan Soboloff, Yi Zhang, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4432.
https://doi.org/10.1182/blood-2019-131115
Published: 2019
Journal Articles

CD244 Marks Non-Functional Hematopoietic Stem Cells with a Mast Cell Signature after Induction of Endoplasmic Reticulum Stress

Valgardur Sigurdsson, PhD, Shuhei Koide, PhD, Visnja Radulovic, PhD, Els Mansell, PhD, Mark Van Der Garde, MSc, PhD, Tiit Örd, PhD, Tonis Örd, PhD, Kenichi Miharada, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2474.
https://doi.org/10.1182/blood-2019-128239
Published: 2019
Journal Articles

The GPR68/BCL2 Axis Remodels Metabolism in AML By Relocating Calcium

Xiaofei He, B.S., Caleb Hawkins, B.S., Lauren Lawley, B.S., Mark Wunderlich, MS, Benjamin Mizukawa, Xiang-ming Zha, PhD, Stephanie Halene, MD, Jing Fang, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2661.
https://doi.org/10.1182/blood-2019-125455
Published: 2019
Journal Articles

EHMT2 Inhibitor BIX-01294 Induces Endoplasmic Reticulum Stress Mediated Apoptosis and Autophagy in Diffuse Large B Cell Lymphoma Cells

Linyan Xu, PhD, Xiang Gao, Wei Sang, MD, Dongmei Yan, Xuguang Song, Feng Zhu, Kailin Xu, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2787.
https://doi.org/10.1182/blood-2019-127653
Published: 2019
Journal Articles

PKR-like Endoplasmic Reticulum Kinase Mediates Apoptosis Induced By Pharmacological AMP-Activated Protein Kinase Activation in Acute Myeloid Leukemia

Laury Poulain, PhD, Adrien Grenier, MD PhD, Johanna Mondesir, MD, Arnaud Jacquel, PhD, Claudie Bosc, Lucille Stuani, PhD, Rudy Birsen, MD, Sarah Mouche, Justine Decroocq, MD, Fetta Mazed, PhD, Benoit Viollet, PhD, Patrick Auberger, PhD, Pierre Sujobert, MD PhD, Didier Bouscary, MD PhD, Jean-Emmanuel Sarry, PhD, Jerome Tamburini, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2552.
https://doi.org/10.1182/blood-2019-123364
Published: 2019
Journal Articles

Inhibition of TLR4 Signaling Affects Mitochondrial Fitness Overcoming Bortezomib Resistance in Myeloma Plasma Cells

Cesarina Giallongo, PhD, Daniele Tibullo, PhD, Giuseppina Camiolo, Fabrizio Puglisi, Daniela Cambria, Alessandro Barbato, Nunziatina Laura Parrinello, PhD, Alessandra Romano, MD PhD, Concetta Conticello, MD, Angela Amorini, PhD, Giovanni Li Volti, MD PhD, Giuseppe Lazzarino, Giuseppe A. Palumbo, MD PhD, Francesco Di Raimondo, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3073.
https://doi.org/10.1182/blood-2019-129812
Published: 2019
Journal Articles

A Phase 1b Dose Escalation Trial of Carfilzomib in Combination with Bendamustine and Rituximab in Patients with Relapsed or Refractory Non-Hodgkin Lymphoma

Swetha Kambhampati, MD, Bita Fakhri, MDMPH, Weiyun Ai, MD PhD, Lawrence D Kaplan, MD, Joseph Tuscano, MD, Matthew J. Wieduwilt, MD PhD, Akshay Sudhindra, MD, Jimmy Hwang, PhD, Jesika Reiner, MPH, Michelle Martinelli, Charlie Aoun, BS, Teresa Ta, Diem Le, Michelle Padilla, Erika Crawford, Charalambos Andreadis, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2828.
https://doi.org/10.1182/blood-2019-123279
Published: 2019
Journal Articles

Blockade of Ubiquitin Receptor Rpn13 in Plasmacytoid Dendritic Cells Enhances Anti-Myeloma Immunity

Arghya Ray, PhD, Yan Song, PhD, Ting DU, PhD, Dharminder Chauhan, PhD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3098.
https://doi.org/10.1182/blood-2019-122901
Published: 2019
Journal Articles

Carfilzomib Induces Cardiotoxicity Via ß5/ß2-Specific Proteasome Subunit Inhibition Pattern

Max A Mendez-Lopez, MD, Andrej Besse, PhD, Bogdan Florea, PhD, Christian Zuppinger, PhD, Herman Overkleeft, PhD, Christoph Driessen, MD, Lenka Besse, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3110.
https://doi.org/10.1182/blood-2019-127987
Published: 2019
Journal Articles

The Factor VIII Variant X5 Enhances Hemophilia a Gene Therapy Efficiency By Its Improved Secretion

Franziska Horling, PhD, Johannes Lengler, PhD, Wenjing Cao, PhD, Biao Dong, PhD, Bagirath Gangadharan, Maurus De La Rosa, PhD, Werner Hoellriegl, PhD, Birgit M Reipert, PhD, Friedrich Scheiflinger, Weidong Xiao, PhD, Hanspeter Rottensteiner
Journal: Blood
Blood (2019) 134 (Supplement_1): 3356.
https://doi.org/10.1182/blood-2019-126489
Published: 2019
Journal Articles

Personalized Ubiquitination Signatures for Predicting Response to Proteasome Inhibitor-Based Therapy of MM Patients

Haim Tsubery, PhD, Lerman Gali, PhD, Kronenfeld Gali, MSc, Itamar Sela, PhD, Yifat Merbl, PhD, Ayelet Itzhaki-Alfia, PhD, Svetlana Trestman, MD, Yael C Cohen, MD, Irit Avivi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3371.
https://doi.org/10.1182/blood-2019-125274
Published: 2019
Journal Articles

Systematic Characterization of Genes Representing Preferential Molecular Vulnerabilities for Myeloma Cells Compared to Other Neoplasias - Implications for the Biology and Therapeutic Targeting of Myeloma

Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD PhD, Sondra L. Downey-Kopyscinski, PhD, Geoffrey Matthews, PhD, Hu Yiguo, PhD, Michal Sheffer, PhD, Eugen Dhimolea, PhD, Olga Dashevsky, PhD, Sara Gandolfi, MD, Joshua Dempster, PhD, Robin M. Meyers, PhD, Jordan Bryan, James M. McFarland, Johanna Brueggenthies, Huihui Tang, PhD, Megan Bariteau, BSc, Minasri Borah, Quinlan L Sievers, PhD, Benjamin Ebert, MD, Brian Glassner, PhD, Christopher J. Ott, PhD, Nicholas P Kwiatkowski, PhD, John G Doench, PhD, Daniel Auclair, Joan Levy, PhD, Lawrence H. Boise, PhD, Jonathan J Keats, PhD, Jonathan D. Licht, MD, Richard Groen, Nathanael Gray, Aedin Culhane, PhD, William C. Hahn, MD PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4407.
https://doi.org/10.1182/blood-2019-130901
Published: 2019
Journal Articles

The Ire of IRE1α: Overexpression of IRE1α at Myeloma Diagnosis Is Associated with Decreased Survival While Downregulation of IRE1α Expression Is Predictive of Therapy Resistance

Scott R. Goldsmith, MD, Mark A. Fiala, BS, Mark A. Schroeder, MD, Tanya M. Wildes, MD, Armin Ghobadi, MD, Ravi Vij, MBBS, Keith E. Stockerl-Goldstein, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4351.
https://doi.org/10.1182/blood-2019-131135
Published: 2019
Journal Articles

Targeting the p62-ZZ/N-End Rule Pathway in Multiple Myeloma Overcomes Proteasome Inhibitor-Resistance Via Induction of Necroptosis and Enhances the Bone Anabolic Effects of Proteasome Inhibitors

Silvia Marino, PhD, Daniela Nicoleta Petrusca, PhD, Edward Simpson, PhD, Judith L Anderson, BS, Xiang-Qun Xie, PhDMD,MBA, Yunlong Liu, PhD, John Chirgwin, PhD, G. David Roodman, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4391.
https://doi.org/10.1182/blood-2019-131865
Published: 2019