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Journal Articles

Overexpression and Targeted Activation of the Protein Phosphatases SHP-1 Abrogates Survival Pathways in Large Granular Lymphocyte Leukemia (LGLL)

Mario Angelo Pagano, Elena Tibaldi, Giulia Calabretto, Antonella Teramo, Luca Dell'Amico, Gabriella Donà, Gregorio Barilà, Cristina Vicenzetto, Vanessa Rebecca Gasparini, Valentina Trimarco, Monica Facco, Francesco Piazza, Gianpietro Semenzato, Anna Maria Brunati, Renato Zambello

Blood (2019) 134 (Supplement_1): 2798.

https://doi.org/10.1182/blood-2019-129883

Published: 2019

Journal Articles

The Gp1ba-Cre transgenic mouse: a new model to delineate platelet and leukocyte functions

Zoltan Nagy, Timo Vögtle, Mitchell J. Geer, Jun Mori, Silke Heising, Giada Di Nunzio, Ralph Gareus, Alexander Tarakhovsky, Arthur Weiss, Benjamin G. Neel, Guillaume E. Desanti, Alexandra Mazharian, Yotis A. Senis

Blood (2019) 133 (4): 331–343.

https://doi.org/10.1182/blood-2018-09-877787

Published: 2019

Includes: Supplemental data

Journal Articles

SHP-1 As a Negative Regulator of FLT3 Associated Aberrant Signaling and a New Potential Target to FLT3-ITD Mutation

Tongjuan Li, MD PhD, Dan Li, Lei Zhao, MD, Jue Wang, MD PhD, Zhen Shang, MD PhD, Yicheng Zhang, MD PhD, Liang Huang, MD PhD, Jianfeng Zhou, PhD

Blood (2018) 132 (Supplement 1): 4051.

https://doi.org/10.1182/blood-2018-99-115793

Published: 2018

Journal Articles

Ptpn6 Inhibits IL-1 Release from Neutrophils By Regulation of Caspase-8- and Ripk3/Mlkl-Dependent Forms of Cell Death

Mary Speir, PhD, Joanne A O'Donnell, PhD, Alyce A Chen, PhD, Akshay A D'Cruz, PhD, Ben A Croker, PhD

Blood (2018) 132 (Supplement 1): 274.

https://doi.org/10.1182/blood-2018-99-120197

Published: 2018

Journal Articles

Reduced Expression of DOCK4 Leads to Increased Protein Phosphorylation and Migration of Hematopoietic Stem/Progenitor Cells

Sriram Sundaravel, MS, Wen Liang-Kuo, PhD, Hui Liu, MS, Jong Jeong, PhD, Gaurav Choudhary, PhD, Tushar Damodar Bhagat, PhD, Shanisha Gordon, Amit Verma, MD, Amittha Wickrema, PhD

Blood (2018) 132 (Supplement 1): 2563.

https://doi.org/10.1182/blood-2018-99-114320

Published: 2018

Journal Articles

Divergent Evolutionary Trajectories of Erk- and Stat5-Activating Lesions in Acute Lymphoblastic Leukemia

Lai N Chan, Seyedmehdi Shojaee, PhD, Christian Hurtz, PhD, Franziska Auer, PhD, Zhengshan Chen, MDPhD, Kadriye Nehir Cosgun, PhD, Huimin Geng, PhD, Teresa Sadras, PhD, Deborah L White, PhD, Markus Muschen, MD

Blood (2018) 132 (Supplement 1): 568.

https://doi.org/10.1182/blood-2018-99-115536

Published: 2018

Journal Articles

The Persistent Survival of MPN Cells to JAK2 Inhibition Is Dependent on SHP2 Activity, Which May Provide a Therapeutic Target to Enhance Current Anti-MPN Therapies

Garima Pandey, Guolin Zhang, Narmin Amin, Lucia Mazzacurati, Eric B. Haura, Gary W. Reuther, PhD

Blood (2018) 132 (Supplement 1): 3064.

https://doi.org/10.1182/blood-2018-99-118641

Published: 2018

Journal Articles

SHP1 Deficiency Is Responsible for the Constitutive Activation of the BCR Pathway in GCB DLBCL

Binu K Sasi, PhD, Sven Turkalj, BS, Hilal Kalkan, BS, Fabiola Porro, MS, Engin Bojnik, PhD, Beata Pyrzynska, PhD, Abdessamad Zerrouqi, PhD, Malgorzata Bobrowicz, PhD, Magdalena Winiarska, PhD, Valdemar Priebe, MS, Francesco Bertoni, MD, Larry Mansouri, PhD, Richard Rosenquist, MD PhD, Dimitar G Efremov, MD PhD

Blood (2018) 132 (Supplement 1): 2860.

https://doi.org/10.1182/blood-2018-99-118120

Published: 2018

Journal Articles

Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis

Mitchell J. Geer, Johanna P. van Geffen, Piraveen Gopalasingam, Timo Vögtle, Christopher W. Smith, Silke Heising, Marijke J. E. Kuijpers, Bibian M. E. Tullemans, Gavin E. Jarvis, Johannes A. Eble, Mark Jeeves, Michael Overduin, Johan W. M. Heemskerk, Alexandra Mazharian, Yotis A. Senis

Blood (2018) 132 (13): 1413–1425.

https://doi.org/10.1182/blood-2017-10-802975

Published: 2018

Includes: Supplemental data

Journal Articles

A Dominant Negative SHP-2 Which Abrogates PD-1 Signalling Pathways and Restores Function of Cytotoxic CAR T Cells

Vania Baldan, PhD, Priyanka Ghongane, MSc, Evangelia Kokalaki, PhD, Wen Chean Lim, PhD, Shimobi Onuoha, PhD, Shaun Paul Cordoba, PhD, Simon Thomas, PhD, Martin Pule, MD PhD

Blood (2017) 130 (Supplement 1): 3190.

https://doi.org/10.1182/blood.V130.Suppl_1.3190.3190

Published: 2017

Journal Articles

ITIM receptors: more than just inhibitors of platelet activation

Carmen H. Coxon, Mitchell J. Geer, Yotis A. Senis

Blood (2017) 129 (26): 3407–3418.

https://doi.org/10.1182/blood-2016-12-720185

Published: 2017

Includes: Supplemental data

Journal Articles

BCL6 Is Critical to Overcome Oncogene-Induced Senescence in RAS-Mediated B Cell Transformation

Lai N Chan, PhD, Christian Hurtz, PhD, Gang Xiao, PhD, Seyedmehdi Shojaee, PhD, Rebecca Caeser, Huimin Geng, PhD, Ari Melnick, MD, Markus Müschen, MD PhD

Blood (2016) 128 (22): 438.

https://doi.org/10.1182/blood.V128.22.438.438

Published: 2016

Journal Articles

Modulating platelet reactivity through control of RGS18 availability

Peisong Ma, Kristy Ou, Andrew J. Sinnamon, Hong Jiang, David P. Siderovski, Lawrence F. Brass

Blood (2015) 126 (24): 2611–2620.

https://doi.org/10.1182/blood-2015-04-640037

Published: 2015

Includes: Supplemental data

Journal Articles

BCR Signalosome-Oriented Phosphotyrosine Profiling of CLL

Yueming Chang, MD PhD, Jeffrey S Wasser, MD, Adam Boruchov, MD, Bruce J Mayer, PhD, Kazuya Machida, MDPhD

Blood (2015) 126 (23): 4128.

https://doi.org/10.1182/blood.V126.23.4128.4128

Published: 2015

Journal Articles

Human Transcription Factor KLF3 Maintains T Lymphocyte Quiescent Phenotype Via Inhibiting SHP-1 Expression

Fang Fang, Mangju Wang, MD, Quan Qiu, Dingfang Bu, Wei Liu, MD, Ying Zhang, Yongjin Shi, Xuzhen Lv, Ping Zhu, MD

Blood (2015) 126 (23): 3426.

https://doi.org/10.1182/blood.V126.23.3426.3426

Published: 2015

Journal Articles

Differential Signaling through p190 and p210 Forms of BCR-ABL Fusion Proteins Revealed By Proteomic Analysis

Jevon Cutler, Rahia Tahir, Jingnan Han, Raja Sekhar Nirujogi, Tai-Chung Huang, MD, Xianrong Wong, Saradhi Mallampati, Xiaoping Sun, MD PhD, Patrick Brown, MD, Karen Reddy, PhD, Akhilesh Pandey, MD PhD

Blood (2015) 126 (23): 3651.

https://doi.org/10.1182/blood.V126.23.3651.3651

Published: 2015

Journal Articles

Loss-of-Function Missense Mutations in Tyrosine Phosphatase PTPN6 Deregulate STAT3 Signaling in Diffuse Large B-Cell Lymphoma

Christos Demosthenous, Guangzhen Hu, PhD, Thomas E Witzig, MD, Mamta Gupta, PhD

Blood (2014) 124 (21): 707.

https://doi.org/10.1182/blood.V124.21.707.707

Published: 2014

Journal Articles

Plasma DNA Methylation of p16 and shp1 in Patients with B-Cell Non-Hodgkin Lymphoma

Rong Fu, PhD, Xiaoshuang Chen, Zonghong Shao, MD

Blood (2014) 124 (21): 5369.

https://doi.org/10.1182/blood.V124.21.5369.5369

Published: 2014

Journal Articles

Tyrosine Phosphatase SHP-1 Acts As a Key Regulator Of Alloresponses In Primary Murine T Cells

Christian Kardinal, Ph.D., Jessica Herbst, Ulf Diekmann, M.Sc., Martin G. Sauer, MD

Blood (2013) 122 (21): 3489.

https://doi.org/10.1182/blood.V122.21.3489.3489

Published: 2013

Journal Articles

Memory B Cells Display Changes In The Expression Pattern Of Genes Related To Cell Survival In Elderly Individuals

Alicia Baez, Isabel Alvarez-Laderas, Jose Ignacio Piruat, Ph.D, Teresa Caballero-Velazquez, Africa Millan-Ucles, María Victoria Barbado, Ph.D, Mayte Medrano, Estefania Garcia-Guerrero, Luis Ignacio Sanchez-Abarca, Ph.D., Jose Antonio Perez-Simón, MD, PhD, Ildefonso Espigado

Blood (2013) 122 (21): 4893.

https://doi.org/10.1182/blood.V122.21.4893.4893

Published: 2013

NARROW

Overexpression and Targeted Activation of the Protein Phosphatases SHP-1 Abrogates Survival Pathways in Large Granular Lymphocyte Leukemia (LGLL)

The Gp1ba-Cre transgenic mouse: a new model to delineate platelet and leukocyte functions

SHP-1 As a Negative Regulator of FLT3 Associated Aberrant Signaling and a New Potential Target to FLT3-ITD Mutation

Ptpn6 Inhibits IL-1 Release from Neutrophils By Regulation of Caspase-8- and Ripk3/Mlkl-Dependent Forms of Cell Death

Reduced Expression of DOCK4 Leads to Increased Protein Phosphorylation and Migration of Hematopoietic Stem/Progenitor Cells

Divergent Evolutionary Trajectories of Erk- and Stat5-Activating Lesions in Acute Lymphoblastic Leukemia

The Persistent Survival of MPN Cells to JAK2 Inhibition Is Dependent on SHP2 Activity, Which May Provide a Therapeutic Target to Enhance Current Anti-MPN Therapies

SHP1 Deficiency Is Responsible for the Constitutive Activation of the BCR Pathway in GCB DLBCL

Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis

A Dominant Negative SHP-2 Which Abrogates PD-1 Signalling Pathways and Restores Function of Cytotoxic CAR T Cells

ITIM receptors: more than just inhibitors of platelet activation

BCL6 Is Critical to Overcome Oncogene-Induced Senescence in RAS-Mediated B Cell Transformation

Modulating platelet reactivity through control of RGS18 availability

BCR Signalosome-Oriented Phosphotyrosine Profiling of CLL

Human Transcription Factor KLF3 Maintains T Lymphocyte Quiescent Phenotype Via Inhibiting SHP-1 Expression

Differential Signaling through p190 and p210 Forms of BCR-ABL Fusion Proteins Revealed By Proteomic Analysis

Loss-of-Function Missense Mutations in Tyrosine Phosphatase PTPN6 Deregulate STAT3 Signaling in Diffuse Large B-Cell Lymphoma

Plasma DNA Methylation of p16 and shp1 in Patients with B-Cell Non-Hodgkin Lymphoma

Tyrosine Phosphatase SHP-1 Acts As a Key Regulator Of Alloresponses In Primary Murine T Cells

Memory B Cells Display Changes In The Expression Pattern Of Genes Related To Cell Survival In Elderly Individuals

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American Society of Hematology

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American Society of Hematology

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