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Journal Articles

ASXL1 Mutations Are Associated with Widespread and Distinct DNA Methylation Alterations

Nora E Rahmani, MD, Nandini Ramachandra, Tushar D Bhagat, PhD, Shanisha Gordon, Kith Pradhan, PhD, Bianca Rivera Pena, Mohammad Kazemi, Orsi Giricz, PhD, Shahina Maqbool, Raul Olea, Hamid Dolatshad, Vickram Tittrea, Dharamveer Tatwavedi, Shalini Singh, Andrea Pellagatti, Jacqueline Boultwood, Amit Verma, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 2989.
https://doi.org/10.1182/blood-2019-126850
Published: 2019
Journal Articles

Genetic Vulnerabilities of DNMT3A R882H in Myeloid Malignancies

Malgorzata Gozdecka, PhD, Monika Dudek, MSc, Konstantinos Tzelepis, Aristi Damaskou, MSc, Vijay Baskar, PhD, Penny Wright, Graham Duddy, Eshwar Meduri, PhD, Milena Mazan, PhD, Kosuke Yusa, PhD, Brian J. P. Huntly, PhD MRCP, MB, FRCPath, George S. Vassiliou, FRCPath, MRCP, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 111.
https://doi.org/10.1182/blood-2019-126505
Published: 2019
Journal Articles

DNMT3A R882 Alters the Epigenome of Hematopoietic Cells

Amanda M Smith, PhD, Taylor LaValle, BS, Shamika Ketkar, PhD, Sai Mukund Ramakrishnan, MS, Christopher A Miller, PhD, Timothy J Ley, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 112.
https://doi.org/10.1182/blood-2019-129003
Published: 2019
Journal Articles

Precision Medicine Treatment in Older AML: Results of Beat AML Master Trial

Amy Burd, PhD, Ross L. Levine, MD, Amy S. Ruppert, MAS, PhD, Alice S. Mims, MD, Uma Borate, MD, Eytan M. Stein, MD, Prapti A. Patel, MD, Maria R. Baer, MD, Wendy Stock, MD, Michael W. Deininger, William Blum, MD, Gary J. Schiller, MD, Rebecca L. Olin, MD, Mark Litzow, MD, James M. Foran, MD, Tara L. Lin, MD, Brian J Ball, Michael Boyiadzis, MD, Elie Traer, Olatoyosi Odenike, MD, Martha L. Arellano, MD, Alison R. Walker, MD, Vu H. Duong, MD, Robert H. Collins, MD, Nyla A. Heerema, PhD, Jo-Anne Vergilio, MD, TIm Brennan, PhD, Christine Vietz, Molly Vittorio, Leonard Rosenberg, Sonja Marcus, MPH, Ashley Owen Yocum, PhD, Mona Stefanos, MBChB, Brian J. Druker, John C. Byrd, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 175.
https://doi.org/10.1182/blood-2019-130201
Published: 2019
Journal Articles

DNA Methylation Profiling of AML Reveals Epigenetic Subgroups with Distinct Clinical Outcome

Sebastian Vosberg, Paul Kerbs, MSc, Vindi Jurinovic, MSc, Klaus H. Metzeler, MD, Susanne Amler, PhD, Cristina Sauerland, Dennis Görlich, PhD, Wolfgang E. Berdel, MD, Jan Braess, MD, Wolfgang Hiddemann, MD PhD, Karsten Spiekermann, MD, Tobias Herold, MD, Philipp A. Greif, MD PD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2715.
https://doi.org/10.1182/blood-2019-130047
Published: 2019
Journal Articles

Significant Features of DNA Methylation at Bivalent Promotor and Repressed Polycomb Regions in Pediatric AML-the Jccg Study, JPLSG AML-05-

Genki Yamato, Tomoko Kawai, PhD, Norio Shiba, Yusuke Hara, Kentaro Ohki, MD PhD, Taeko Kaburagi, MD, Kenichi Yoshida, MD PhD, Yuichi Shiraishi, PhD, Satoru Miyano, PhD, Nobutaka Kiyokawa, MD PhD, Daisuke Tomizawa, MD PhD, Akira Shimada, MD PhD, Manabu Sotomatsu, MD PhD, Hirokazu Arakawa, MD PhD, Souichi Adachi, MD PhD, Takashi Taga, MD PhD, Keizo Horibe, MD PhD, Seishi Ogawa, MD PhD, Kenichiro Hata, MD PhD, Yasuhide Hayashi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2739.
https://doi.org/10.1182/blood-2019-125025
Published: 2019
Journal Articles

In Vivo Kinetics of Early, Hypomethylating Agent-Induced Methylome and Transcriptome Changes in Primary AML Blasts: Random or Specific?

Gabriele Greve, Geoffroy Andrieux, Pascal Schlosser, Nadja Blagitko-Dorfs, Hans-Walter Lindemann, MD, Michael Heuser, MD, Andreas Neubauer, Jürgen Krauter, MD, Helmut R. Salih, MD, Gerhard Heil, Carsten Schwänen, Carsten Müller-Tidow, Arnold Ganser, MD, Hartmut Döhner, MD, Dietmar Pfeifer, Björn Hackanson, Olga Grishina, Melanie Boerries, Michael Lübbert
Journal: Blood
Blood (2018) 132 (Supplement 1): 3892.
https://doi.org/10.1182/blood-2018-99-118762
Published: 2018
Journal Articles

Polycomb Group Proteins Recruit TET1 to Remove Aberrant DNA Methylation in Murine Embryonic Stem Cells

Yong Lei, PhD, Margaret A. Goodell, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2571.
https://doi.org/10.1182/blood-2018-99-116841
Published: 2018
Journal Articles

Association of Clinical Epidemiologic Exposures and Overall Survival with Genome-Wide DNA Methylation Profiles in Acute Myeloid Leukemia: Analysis of the Mayo Clinic AML Epidemiology Cohort

César J. Torres-Gutierrez, BS, Michael G. Heckman, Ryan A. Hlady, Rhett P. Ketterling, Lisa Z. Sproat, Kathryn E. Pearce, Elizabeth R. Lesser, Nancy N. Diehl, Laura E. Finn, Liuyan Jennifer Jiang, Keith D. Robertson, James R. Cerhan, MD PhD, James M. Foran, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3987.
https://doi.org/10.1182/blood-2018-99-119386
Published: 2018
Journal Articles

Whole Genome Bisulfite Sequencing (WGBS) Robustly Measures the Pharmacodynamic Effect of Decitabine/Vorinostat Epigenetic Treatment in Relapsed Pediatric ALL Demonstrating Potent Hypomethylation Associated with Upregulation of PRC2 and TP53 Targets

Rumen Kostadinov, PhD, Byunggil Yoo, MS, Midhat S. Farooqi, MD PhD, Shannon Kelley, MS, Erin Guest, MD, Michael J. Burke, MD, Sarah Wheelan, MD PhD, Patrick Brown, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 918.
https://doi.org/10.1182/blood-2018-99-119206
Published: 2018
Journal Articles

The Mantle Cell Lymphoma Response to VCR Protocol Associated with Its Sensitivity to Hypomethylation Regulation-a Collateral Study on VCR Phase I Trial

Jeffrey J Pu, MD PhD, Matthew Nemesure, W. Christopher Ehmann, MD, David F Claxton, MD, Joseph J Drabick, MD, Anna C Salzberg, Yuka I Kawasawa, PhD, Elliot Epner, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5295.
https://doi.org/10.1182/blood-2018-99-118192
Published: 2018
Journal Articles

A Novel Therapy Protocol Improves Outcomes of Hematopoietic Stem Cell Transplantation in Juvenile Myelomonocytic Leukemia Patients Using Hypomethylation of Decitabine

Zhiyong Peng, MD, Xiaoqin Feng, PhD, Huaying Liu, MD, Yuelin He, Jianyun Liao, MD, Xiaoting Liu, Chunfu Li, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5778.
https://doi.org/10.1182/blood-2018-99-114777
Published: 2018
Journal Articles

Molecular profiling reveals immunogenic cues in anaplastic large cell lymphomas with DUSP22 rearrangements

Rebecca A. Luchtel, Surendra Dasari, Naoki Oishi, Martin Bjerregård Pedersen, Guangzhen Hu, Karen L. Rech, Rhett P. Ketterling, Jagmohan Sidhu, Xueju Wang, Ryohei Katoh, Ahmet Dogan, N. Sertac Kip, Julie M. Cunningham, Zhifu Sun, Saurabh Baheti, Julie C. Porcher, Jonathan W. Said, Liuyan Jiang, Stephen Jacques Hamilton-Dutoit, Michael Boe Møller, Peter Nørgaard, N. Nora Bennani, Wee-Joo Chng, Gaofeng Huang, Brian K. Link, Fabio Facchetti, James R. Cerhan, Francesco d’Amore, Stephen M. Ansell, Andrew L. Feldman
Journal: Blood
Blood (2018) 132 (13): 1386–1398.
https://doi.org/10.1182/blood-2018-03-838524
Published: 2018
Includes: Supplemental data
Journal Articles

Novel Role of CEBPβ As a Transcriptional Repressor of Transposable Elements

Devi Thiagarajan, Stephen Capone, BS, Anthony Colombo, Timothy Junius Triche, Jr., PhD, Giridharan Ramsingh, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 771.
https://doi.org/10.1182/blood.V130.Suppl_1.771.771
Published: 2017
Journal Articles

CLLU1 Expression Is Not Confined to Chronic Lymphocytic Leukemia Cells; Putative Role of Gene-Body Hypomethylation in Regulating Splice Variant-Specific Transcriptional Dynamics

Spyros Ioannis Papamichos, MD PhD, Eleftheria Lamprianidou, Chryssoula Kordella, Anna Christoforidou, Zoe Bezirgiannidou, Ioannis Kotsianidis, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4979.
https://doi.org/10.1182/blood.V130.Suppl_1.4979.4979
Published: 2017
Journal Articles

The Landscape of Circular RNAs in Drug Resistant TCF3 -Rearranged Childhood Leukemia

Cai Chen, Daniel Picard, M.Sc., Nan Qin, PhD, Cyrill Schipp, MSc, Michael Gombert, PhD, Sebastian Ginzel, M.Sc., Jianda Hu, Prof MDPhD, Arndt Borkhardt, Prof MD, Marc Remke, Ute Fischer, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1432.
https://doi.org/10.1182/blood.V130.Suppl_1.1432.1432
Published: 2017
Journal Articles

DUSP22 Rearrangements Identify a Molecularly Distinct Type of Anaplastic Large Cell Lymphoma Characterized By DNA Hypomethylation and Lack of Activated STAT3

Rebecca Boddicker, PhD, Surendra Dasari, PhD, Naoki Oishi, MD PhD, Guangzhen Hu, PhD, Jagmohan Sidhu, MD, Julie Cunningham, PhD, Zhifu Sun, MD, Saurabh Baheti, MS, Julie C Porcher, Stephen M Ansell, MD PhD, Nabila Nora Bennani, MD, James R. Cerhan, MD PhD, Andrew L Feldman, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1456.
https://doi.org/10.1182/blood.V130.Suppl_1.1456.1456
Published: 2017
Journal Articles

Hypomethylation of Decitabine Improved Outcomes of Hematopoietic Stem Cell Transplantation in Children with Juvenile Myelomonocytic Leukemia

Zhiyong Peng, MD, Xiaoqin Feng, PhD, Yuelin He, Yuchen Lin, Jianyun Liao, Xuedong Wu, MD, Jiaqi Chen, MD, Chunfu Li, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3232.
https://doi.org/10.1182/blood.V130.Suppl_1.3232.3232
Published: 2017
Journal Articles

Attenuation of Apoptosis Stimulating Protein of p53-1 (ASPP1) Associates with Therapy Failure in Acute Myeloid Leukemia (AML)

Marcus M. Schittenhelm, Max Kaiser, Gunnar Blumenstock, Kerstin Maria Kampa-Schittenhelm, MD
Journal: Blood
Blood (2016) 128 (22): 1556.
https://doi.org/10.1182/blood.V128.22.1556.1556
Published: 2016
Journal Articles

Interclonal and Intraclonal Heterogeneity in Patients with IDH1/2 Mutation

Wanlong Ma, BS, Maya Thangavelu, PhD, Ivan De Dios, BS, Vincent Funari, PhD, Maher Albitar, MD
Journal: Blood
Blood (2016) 128 (22): 1689.
https://doi.org/10.1182/blood.V128.22.1689.1689
Published: 2016