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Journal Articles

FLT3 Is Sumoylated and Localizes to the Nucleus in Acute Myeloid Leukemia

Marisse Asong, MD MSc, Julhash Uddin Kazi, PhD, Lars Ronnstrand, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2733.
https://doi.org/10.1182/blood-2019-127914
Published: 2019
Journal Articles

IPO11 Is Upregulated in Relapsed AML and Supports Survival of Leukemic Stem Cells

Boaz Nachmias, MD PhD, Veronique Voisin, PhD, Rose Hurren, BSc, Xioaming Wang, Neil Maclean, G. Wei Xu, Ayesh K Seneviratne, BSc, MSc, Changjiang Xu, Gary D Bader, Liran I. Shlush, MD, Aaron D Schimmer, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2530.
https://doi.org/10.1182/blood-2019-122284
Published: 2019
Journal Articles

The Metabolic Enzyme Hexokinase 2 Localizes to the Nucleus in AML and Normal Hematopoietic Stem/Progenitor Cells to Maintain Stemness

Geethu Emily Thomas, PhDMSc,BSc, Grace Egan, MD, Laura Garcia Prat, Boaz Nachmias, MD PhD, Jordan M Chin, Fieke W Hoff, BSc, Kerstin Kaufmann, PhD, Rose Hurren, BSc, Marcela Gronda, MSc, Neil MacLean, Xiaoming Wang, Veronique Voisin, PhD, Aaron Botham, Andrea Arruda, Mark D. Minden, MD PhD, Gary D Bader, Steven M. Kornblau, MD, John E. Dick, PhD, Aaron D Schimmer, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2532.
https://doi.org/10.1182/blood-2019-123121
Published: 2019
Journal Articles

Nuclear Import of Janus Kinase 1 Is Mediated By Multiple Alpha Importins and Is Required for the Survival of Diffuse Large B-Cell Lymphoma

Lixin Rui, PhD
Journal: Blood
Blood (2016) 128 (22): 780.
https://doi.org/10.1182/blood.V128.22.780.780
Published: 2016
Journal Articles

XPO1 (Exportin-1) Is a Major Regulator of Human Erythroid Differentiation. Potential Clinical Applications to Decrease Ineffective Erythropoiesis of Beta-Thalassemia

Flavia Guillem, PhD, Michael Dussiot, PhD, Sebastien Causse, PhD, Guillaume Marcion, Emilie-Fleur Gautier, PhD, Julien Rossignol, MD, Jean benoit Arlet, MD PhD, Mathilde Lamarque, MD, Patrick Mayeux, PhD, Frederique Verdier, PhD, Xiuli An, MD PhD, Jean-Antoine Ribeil, MD PhD, Carmen Garrido, PhD, Genevieve Courtois, PhD, Narla Mohandas, D.Sc., Olivier Hermine
Journal: Blood
Blood (2015) 126 (23): 2368.
https://doi.org/10.1182/blood.V126.23.2368.2368
Published: 2015
Journal Articles

The mTOR Kinase Inhibitor AZD-2014 Effectively Reverses XPO1/CRM1 Antagonist KPT-185–induced Glycolysis / Gluconeogenesis, Enhancing Antitumor Effects in Mantle Cell Lymphoma

Yoko Tabe, MD PhD, Masako Harada, PhD, Yuka Miyamae, Hiromichi Matsushita, MD PhD, Kensuke Kojima, MD PhD, Tsutomu Fujimura, Saiko Kazuno, Takashi Ueno, Takashi Miida, MD PhD, Marina Konopleva, MD PhD, Michael Andreeff, MD PhD
Journal: Blood
Blood (2014) 124 (21): 925.
https://doi.org/10.1182/blood.V124.21.925.925
Published: 2014
Journal Articles

Molecular Mechanisms of Antitumor Activity of the Selective Inhibitor of Nuclear Export (SINE) CRM1 Antagonist KPT-185 in Mantle Cell Lymphoma.

Yoko Tabe, MD, PhD, Kensuke Kojima, MD, PhD, Linhua Jin, PhD, Takashi Miida, MD, PhD, Sharon Shacham, PhD MBA, Michael Kauffman, MD, PhD, Michael Andreeff, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2438.
https://doi.org/10.1182/blood.V120.21.2438.2438
Published: 2012
Journal Articles

Results of a Phase I Dose Escalation Study of the Novel, Oral CRM1 Selective Inhibitor of Nuclear Export (SINE) KPT-335 in Dogs with Spontaneous Non-Hodgkin's Lymphomas (NHL)

Sharon Shacham, PhD MBA, Sandra Barnard, BVSc, William Kisseberth, DVM, PhD, Daisuke Ito, DVM PhD, Kiersten Jensen, Antonella Borgotti, DVM MS, Michael Henson, DVM PhD, Heather Wilson, DVM, Dilara McCauley, PhD, Jaime Modiano, DVM PhD, Michael Kauffman, MD, PhD, Cheryl London, DVM PhD
Journal: Blood
Blood (2012) 120 (21): 161.
https://doi.org/10.1182/blood.V120.21.161.161
Published: 2012
Journal Articles

MicroRNA-96 Inhibits Fetal Hemoglobin Expression During Erythropoiesis

Imane Azzouzi, Jeannine Winkler, Jean-Claude Fauchère, André P Gerber, Markus Stoffel, Markus Schmugge, MD, Oliver Speer
Journal: Blood
Blood (2010) 116 (21): 3220.
https://doi.org/10.1182/blood.V116.21.3220.3220
Published: 2010
Journal Articles

Exportin 7 (RanBP16) Plays An Essential Role In Terminal Erythroid Differentiation

Shilpa Hattangadi, MD, Karly Burke, Harvey Lodish
Journal: Blood
Blood (2010) 116 (21): 3877.
https://doi.org/10.1182/blood.V116.21.3877.3877
Published: 2010
Journal Articles

Importin-β1 and Nucleus Transporter Chromosome Region Maintenance 1 (CRM1) Constitute the Nucleocytoplasmic Transport System of STAT3 in Blood-Derived CLL Cells.

Inbal Hazan-Halevy, PhD., David Harris, Zhiming Liu, Alessandra Ferrajoli, MD., Michael J Keating, M.D., Zeev Estrov, MD
Journal: Blood
Blood (2008) 112 (11): 1059.
https://doi.org/10.1182/blood.V112.11.1059.1059
Published: 2008
Journal Articles

TGFβ Activates p53 Via PP2A in Hematopoietic Cells.

Rishu Takimoto, MD, PhD, Junji Kato, MD, PhD, Koichi Takada, MD, PhD, Daisuke Takahari, MD, Yoshiro Niitsu
Journal: Blood
Blood (2006) 108 (11): 4335.
https://doi.org/10.1182/blood.V108.11.4335.4335
Published: 2006
Journal Articles

Nuclear Localization in the Biology of the CD40 Receptor in Normal and Neoplastic Human B Lymphocytes.

Yen-Chiu Lin-Lee, Ph.D., Yun-Houng Chen, Ph.D., Lan Pham, M.S., Archito Tamayo, M.S., Lingchen Fu, M.D., Linda Yoshimura, M.S., Richard J. Ford, M.D.Ph.D.
Journal: Blood
Blood (2004) 104 (11): 246.
https://doi.org/10.1182/blood.V104.11.246.246
Published: 2004
Journal Articles

A Novel p53-PP2A Signaling Pathway Is Responsible for Regulation of Hematopoiesis Induced by TGFß.

Rishu Takimoto, MD/PhD, Junji Kato, MD/PhD, Koichi Takada, MD/PhD, Daisuke Takahari, MD, Yoshiro Niitsu, MD/PhD
Journal: Blood
Blood (2004) 104 (11): 4327.
https://doi.org/10.1182/blood.V104.11.4327.4327
Published: 2004