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Journal Articles

Protein expression profiling suggests relevance of noncanonical pathways in isolated pulmonary embolism

Clinical Trials & Observations
Vincent Ten Cate, Jürgen H. Prochaska, Andreas Schulz, Thomas Koeck, Alejandro Pallares Robles, Michael Lenz, Lisa Eggebrecht, Steffen Rapp, Marina Panova-Noeva, H. Ardeschir Ghofrani, F. Joachim Meyer, Christine Espinola-Klein, Karl J. Lackner, Matthias Michal, Alexander K. Schuster, Konstantin Strauch, Alexander M. Zink, Volker Laux, Stefan Heitmeier, Stavros V. Konstantinides, Thomas Münzel, Miguel A. Andrade-Navarro, Kirsten Leineweber, Philipp S. Wild
Journal: Blood
Blood (2021) 137 (19): 2681–2693.
https://doi.org/10.1182/blood.2019004571
Published: 2021
Includes: Supplemental data
Journal Articles

Targeting a cytokine checkpoint enhances the fitness of armored cord blood CAR-NK cells

May Daher, Rafet Basar, Elif Gokdemir, Natalia Baran, Nadima Uprety, Ana Karen Nunez Cortes, Mayela Mendt, Lucila Nassif Kerbauy, Pinaki P. Banerjee, Mayra Shanley, Nobuhiko Imahashi, Li Li, Francesca Lorraine Wei Inng Lim, Mohsen Fathi, Ali Rezvan, Vakul Mohanty, Yifei Shen, Hila Shaim, Junjun Lu, Gonca Ozcan, Emily Ensley, Mecit Kaplan, Vandana Nandivada, Mustafa Bdiwi, Sunil Acharya, Yuanxin Xi, Xinhai Wan, Duncan Mak, Enli Liu, Xin Ru Jiang, Sonny Ang, Luis Muniz-Feliciano, Ye Li, Jing Wang, Shahram Kordasti, Nedyalko Petrov, Navin Varadarajan, David Marin, Lorenzo Brunetti, Richard J. Skinner, Shangrong Lyu, Leiser Silva, Rolf Turk, Mollie S. Schubert, Garrett R. Rettig, Matthew S. McNeill, Gavin Kurgan, Mark A. Behlke, Heng Li, Natalie W. Fowlkes, Ken Chen, Marina Konopleva, Richard E. Champlin, Elizabeth J. Shpall, Katayoun Rezvani
Journal: Blood
Blood (2021) 137 (5): 624–636.
https://doi.org/10.1182/blood.2020007748
Published: 2021
Includes: Supplemental data
Journal Articles

Leukemia Burden in Peripheral Blood Has Negative Impact on CD19-CART Cell Culture and Its Clinical Efficacy in Patients with Refractory or Relapsed B Cell Acute Lymphoblastic Leukemia

Biping Deng, BS, MD, Jing Pan, Shuangyou Liu, Yuehui Lin, Zhaoli Liu, Yunlong Chen, Xiaoming Qu, Yu 'e Zhang, Zhongxin Zhang, Xuansha Niu, Ming Ma, Tong Wu, MD, Alex Hong Chang, Chunrong Tong
Journal: Blood
Blood (2019) 134 (Supplement_1): 1957.
https://doi.org/10.1182/blood-2019-126695
Published: 2019
Journal Articles

Endothelial JAK3 Expression Enhances Pro-Hematopoietic Angiocrine Function of Sinusoidal Endothelial Cells

José Gabriel Barcia Durán, BS
Journal: Blood
Blood (2019) 134 (Supplement_1): 2488.
https://doi.org/10.1182/blood-2019-122449
Published: 2019
Journal Articles

Engineering Naturally Occurring CD7 Negative Cells for the Immunotherapy of CD7 Positive Leukemia

Abdullah Freiwan, MSc, Abishek Vaidya, MS, Caitlin Zebley, MD, Yiping Fan, PhD, Deanna Langfitt, PhD, Benjamin Youngblood, PhD, Maksim Mamonkin, PhD, Stephen Gottschalk, MD, Mireya Paulina Velasquez, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 868.
https://doi.org/10.1182/blood-2019-124903
Published: 2019
Journal Articles

Chimeric Antigen Receptor Modified Memory-like (CAR-ML) NK Cells Exhibit Potent Responses to NK-Resistant Tumors

Melissa M Berrien-Elliott, PhD, Margery Gang, Nancy M Marin Agudelo, PhD, Lynne M Marsala, Mark Foster, Carly Neal, B.S., Wong Pamela, B.S., Wei M Meng, B.S., Maximilian M Schaettler, B.S., Tim Schappe, BS, Todd A Fehniger, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 869.
https://doi.org/10.1182/blood-2019-127546
Published: 2019
Journal Articles

Results of a Phase 1 Trial of Gda-201, Nicotinamide-Expanded Allogeneic Natural Killer Cells (NAM-NK) in Patients with Refractory Non-Hodgkin Lymphoma (NHL) and Multiple Myeloma (MM)

Veronika Bachanova, MD PhD, David H. McKenna, MD, Xianghua Luo, PhD, Todd E. DeFor, MS, Fiona He, MD, Murali Janakiram, MD MS, Erica D. Warlick, MD, Rose Wangen, Zuzan Cayci, MD, Bartosz Grzywacz, MD, Guy Brachya, PhD, Tony Peled, MSc, Jeffrey S. Miller, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 777.
https://doi.org/10.1182/blood-2019-130476
Published: 2019
Journal Articles

Bnz-1, a Selective γ-Chain Cytokine Inhibitor Has Clinical Activity in Patients with Cutaneous T Cell Lymphoma By Selectively Blocking IL-2, IL-15 and IL-9 Signaling: Results of a Multicenter, Open-Label Phase 1 Trial

Christiane Querfeld, MD PhD, Basem M. William, MRCP,MD, Jonathan E. Brammer, MD, Lubomir Sokol, MD PhD, Yutaka Tagaya, MD PhD, Paul Frohna, MD PhD PharmD, Nazli Azimi, PhD PharmD, Jasmine M. Zain, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1557.
https://doi.org/10.1182/blood-2019-129201
Published: 2019
Journal Articles

Interleukin-15 (IL-5) in Combination with Avelumab in Relapsed/Refractory Mature T-Cell Malignancies

Milos D. Miljkovic, MDMSc, Kevin C Conlon, MD, Sigrid Dubois, PhD, Jennifer Hsu, RN, Jeffrey Schlom, PhD, James Gulley, MD PhD, Thomas A. Waldmann, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1558.
https://doi.org/10.1182/blood-2019-128945
Published: 2019
Journal Articles

Deletion of CISH in Human Pluripotent Stem Cell-Derived Natural Killer Cells Enhances Anti-Tumor Activity Via Metabolic Reprogramming

Huang Zhu, PhD, Robert Blum, Zhengming Wu, Zhipeng Meng, PhD, Kun-Liang Guan, PhD, Dan S Kaufman, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 619.
https://doi.org/10.1182/blood-2019-124446
Published: 2019
Journal Articles

Phase I Clinical Trial of CK0801 (cord blood regulatory T cells) in Patients with Bone Marrow Failure Syndrome (BMF) Including Aplastic Anemia, Myelodysplasia and Myelofibrosis

Tapan M. Kadia, MD, Hongbing Ma, MD PhD, Ke Zeng, MD PhD, Mitsutaka Nishimoto, MD PhD, Mi-Ae Lyu, PhD, Meixian Huang, Musa Yilmaz, MD, Courtney D. DiNardo, MDMSc, Ghayas C. Issa, MD, Simrit Parmar, MBBS, Swami P. Iyer, MD, Parameswaran Hari, MBBS, MD, Naval G. Daver, MD, Elias Jabbour, MD, Gautam M. Borthakur, MD, Srdan Verstovsek, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1221.
https://doi.org/10.1182/blood-2019-127702
Published: 2019
Journal Articles

Tipifarnib Modulates Interferon (IFN)-γ-Inducible Genes in Acute Myeloid Leukemia

Jayakumar Vadakekolathu, PhD, Stephen Reeder, BSc, Clare Coveney, PhD, Sergio Rutella, MDPhDFRCPath
Journal: Blood
Blood (2019) 134 (Supplement_1): 2726.
https://doi.org/10.1182/blood-2019-124717
Published: 2019
Journal Articles

Preclinical Characterization of Prgn-3006 Ultracar-T™ for the Treatment of AML and MDS: Non-Viral, Multigenic Autologous CAR-T Cells Administered One Day after Gene Transfer

Tim Chan, PhD, Xiaohong Ma, Fernando Carvajal-Borda, DVM, Jose Velez, Jacques Plummer, Lindsey Shepard, Rutul R Shah, David A Sallman, MD, Helen Sabzevari, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2660.
https://doi.org/10.1182/blood-2019-130617
Published: 2019
Journal Articles

T Cells Educated By DC/AML Fusions in the Context of 4-1BB Costimulation As a Potent Strategy for Adoptive Cellular Therapy

Jessica Liegel, MD, Dina Stroopinsky, PhD, Haider Ghiasuddin, Adam Morin, Marzia Capelletti, PhD MMSc, Shira Orr, PhD, Maryam Rahimian, MD, Lina Bisharat, Shufen Meng, MD, Myrna Nahas, MD, Matthew Weinstock, MD, Donald Kufe, MD, Jacalyn Rosenblatt, MD, David E. Avigan, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2673.
https://doi.org/10.1182/blood-2019-131491
Published: 2019
Journal Articles

Local Manufacture of CD19 CAR-T Cells Using an Automated Closed-System: Robust Manufacturing and High Clinical Efficacy with Low Toxicities

Olga Molostova, MD, Larisa Shelikhova, MD, Dina Schneider, PhD, Rimma Khismatullina, MD, Yakov Muzalevsky, Alexey Kazachenok, Liane Preussner, Georg Rauser, Julia Abugova, Elena Kurnikova, Dmitriy Pershin, Viktoria Zubachenko, Alexander Popov, MD PhD, Olga Illarionova, MD, Natalia Miakova, MD PhD, Dmitry Litvinov, MD, Galina Novichkova, MD PhD, Alexey A. Maschan, MD, Rimas Orentas, PhD, Boro Dropulic, PhD, Michael Maschan, MDMSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 2625.
https://doi.org/10.1182/blood-2019-130370
Published: 2019
Journal Articles

Phase 1 Trial of Human IL-15 (rhIL-15) and Obinutuzumab for Relapsed and Refractory Chronic Lymphocytic Leukemia

Milos D. Miljkovic, MDMSc, Kevin C Conlon, MD, Jennifer Hsu, RN, Clare Sun, MD, Adrian Wiestner, MD PhD, Thomas A. Waldmann, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3052.
https://doi.org/10.1182/blood-2019-130807
Published: 2019
Journal Articles

Gene Expression and Cytokine Analyses Identify Markers of Progression from CLL-like Monoclonal B-Cell Lymphocytosis to Chronic Lymphocytic Leukemia

Gonzalo Blanco, PhD, Anna Puiggros, PhD, Barbara Sherry, PhD, Lara Nonell, Eulalia Puigdecanet, Pui Yan Chiu, Yasmine Kieso, MSCR, Gerardo Ferrer, PhD, Magdalena Arnal, María Rodríguez-Rivera, Eva Gimeno, MD PhD, Eugenia Abella, Kanti R Rai, MD, Pau Abrisqueta, MD PhD, Xavier Calvo, MD PhD, Francesc Bosch, MD PhD, Ana Ferrer, MD PhD, Nicholas Chiorazzi, MD, Blanca Espinet, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3027.
https://doi.org/10.1182/blood-2019-122038
Published: 2019
Journal Articles

NKTR-255, a Polymer-Conjugated IL-15 Enhances Antibody-Dependent Cellular Cytotoxicity Mediated By NK Cells in a B Cell Lymphoma Model

Takahiro Miyazaki, Saul Kivimäe, Marlene Hennessy, Rhoneil Pena, Phi Quach, Andrew Moffet, Wildaliz Nieves, Ping Zhang, Mario Q. Marcondes, MD PhD, Loui Madakamutil, Jonathan Zalevsky
Journal: Blood
Blood (2019) 134 (Supplement_1): 5302.
https://doi.org/10.1182/blood-2019-127771
Published: 2019
Journal Articles

Relative Depletion of Soluble Interleukin 6 Receptors Abolished the Development of Cytokine Release Syndrome after CART19/22 and Lenalidomide Treatment for Lymphoma

Caixia Li, Changfeng Zhang, PhD, Xiaochen Chen, Ying Zhang, Jia Chen, MD, Liqing Kang, Xiaoyan Lou, Jin Zhou, Xiangping Zong, Zhen Yang, Jiaqi Li, Wei Qi, Lei Yu, Depei Wu, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5313.
https://doi.org/10.1182/blood-2019-126821
Published: 2019
Journal Articles

A Novel Class of Bifunctional Immunotherapeutic That Exploits a Universal Antibody Binding Terminus (uABT) to Recruit Endogenous Antibodies to Cell Expressing CD38 Demonstrate In Vivo efficacy in Three Distinct Animal Models

Anna Bunin, PhD, Katy McGrath, BS, Ann Marie Rossi, MS, Matthew Welsch, PhD, Christian Vidal, PhD, David Trinh, BA, David Spiegel, MD, PhD, Luca Rastelli, PhD, Enrique Alvarez, DVM
Journal: Blood
Blood (2019) 134 (Supplement_1): 1820.
https://doi.org/10.1182/blood-2019-130838
Published: 2019