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Journal Articles

Protein expression profiling suggests relevance of noncanonical pathways in isolated pulmonary embolism

Clinical Trials & Observations
Vincent Ten Cate, Jürgen H. Prochaska, Andreas Schulz, Thomas Koeck, Alejandro Pallares Robles, Michael Lenz, Lisa Eggebrecht, Steffen Rapp, Marina Panova-Noeva, H. Ardeschir Ghofrani, F. Joachim Meyer, Christine Espinola-Klein, Karl J. Lackner, Matthias Michal, Alexander K. Schuster, Konstantin Strauch, Alexander M. Zink, Volker Laux, Stefan Heitmeier, Stavros V. Konstantinides, Thomas Münzel, Miguel A. Andrade-Navarro, Kirsten Leineweber, Philipp S. Wild
Journal: Blood
Blood (2021) 137 (19): 2681–2693.
https://doi.org/10.1182/blood.2019004571
Published: 2021
Includes: Supplemental data
Journal Articles

Targeting a cytokine checkpoint enhances the fitness of armored cord blood CAR-NK cells

May Daher, Rafet Basar, Elif Gokdemir, Natalia Baran, Nadima Uprety, Ana Karen Nunez Cortes, Mayela Mendt, Lucila Nassif Kerbauy, Pinaki P. Banerjee, Mayra Shanley, Nobuhiko Imahashi, Li Li, Francesca Lorraine Wei Inng Lim, Mohsen Fathi, Ali Rezvan, Vakul Mohanty, Yifei Shen, Hila Shaim, Junjun Lu, Gonca Ozcan, Emily Ensley, Mecit Kaplan, Vandana Nandivada, Mustafa Bdiwi, Sunil Acharya, Yuanxin Xi, Xinhai Wan, Duncan Mak, Enli Liu, Xin Ru Jiang, Sonny Ang, Luis Muniz-Feliciano, Ye Li, Jing Wang, Shahram Kordasti, Nedyalko Petrov, Navin Varadarajan, David Marin, Lorenzo Brunetti, Richard J. Skinner, Shangrong Lyu, Leiser Silva, Rolf Turk, Mollie S. Schubert, Garrett R. Rettig, Matthew S. McNeill, Gavin Kurgan, Mark A. Behlke, Heng Li, Natalie W. Fowlkes, Ken Chen, Marina Konopleva, Richard E. Champlin, Elizabeth J. Shpall, Katayoun Rezvani
Journal: Blood
Blood (2021) 137 (5): 624–636.
https://doi.org/10.1182/blood.2020007748
Published: 2021
Includes: Supplemental data
Journal Articles

PD-1 Is Expressed at Low Levels on All Peripheral Blood Natural Killer Cells but Is a Significant Suppressor of NK Function Against PD-1 Ligand Expressing Tumor Targets

Zachary Davis, PhD BS, Martin Felices, PhD, Todd R Lenvik, Sujan Badal, Peter Hinderlie, Bruce R. Blazar, MD, Daniel A. Vallera, PhD, Jeffrey S. Miller, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 621.
https://doi.org/10.1182/blood-2019-127261
Published: 2019
Journal Articles

Deletion of CISH in Human Pluripotent Stem Cell-Derived Natural Killer Cells Enhances Anti-Tumor Activity Via Metabolic Reprogramming

Huang Zhu, PhD, Robert Blum, Zhengming Wu, Zhipeng Meng, PhD, Kun-Liang Guan, PhD, Dan S Kaufman, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 619.
https://doi.org/10.1182/blood-2019-124446
Published: 2019
Journal Articles

Long-Term T Cell Expansion Results in Increased Numbers of Central Memory T Cells with Sustained Functional Properties for Adoptive T Cell Therapy

Stefanie Herda, PhD, Andreas Heimann, MSc, Stefanie Althoff, MSc, Josefine Ruß, Lars Bullinger, Dieter Beule, PhD, Benedikt Obermayer, PhD, Il-Kang Na, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1943.
https://doi.org/10.1182/blood-2019-124736
Published: 2019
Journal Articles

Early Response Observed in Pediatric Patients with Refractory/Relapsed B-Cell Non-Hodgkin Lymphoma Treated with Sequential Chimeric Antigen Receptor T Cells

Wenqun Zhang, MD, Bo Hu, MD, Ling Jing, MD, Jing Yang, MD, Shan Wang, MD, Yang Liu, MD, Juan Du, MD, Yaoliang Ren, MD, Yonghong Zhang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1945.
https://doi.org/10.1182/blood-2019-125753
Published: 2019
Journal Articles

Proof of Concept for Repair of Sickle Cell Disease By Non-Myeloablative MHC Disparate T Cell Depleted HSCT Combined with Donor-Derived Veto Cells

Aloukick Kumar Singh, PhD, Elias Schetzen, PhD, Esther BACHAR Lustig, PhD, Wei-Hsin Liu, M.Sc, Raj Kumar Yadav, PhD, Sandeep Kumar Yadav, PhD, Kathryn McGinnis, M.Sc, Yair Reisner, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1919.
https://doi.org/10.1182/blood-2019-124594
Published: 2019
Journal Articles

Development of CD38 CAR Engineered Human Placental Hematopoietic Stem Cell Derived Natural Killer Cells (PNK-CAR38) As Allogeneic Cancer Immunotherapy

Srinivas Somanchi, PhD, Xuan Guo, PhD, Shuyang He, PhD, Rohit Mathur, PhD, Andrea Difiglia, BS, Hemlata Rana, MS, Weifang Ling, PhD, James Edinger, PhD, Gunnar F. Kaufmann, PhD, Jerome B. Zeldis, MD PhD, Henry Ji, PhD, Robert Hariri, MD PhD, Xiaokui Zhang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2070.
https://doi.org/10.1182/blood-2019-129539
Published: 2019
Journal Articles

Cytokine-Induced Memory-like (ML) NK Cells Persist for > 2 Months Following Adoptive Transfer into Leukemia Patients with a MHC-Compatible Hematopoietic Cell Transplant (HCT)

Jennifer A Foltz, PhD, Melissa M Berrien-Elliott, PhD, Carly Neal, B.S., Mark Foster, Ethan McClain, Tim Schappe, BS, Sweta Desai, Michelle Becker-Hapak, BS, Amanda F Cashen, MD, Todd A Fehniger, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1954.
https://doi.org/10.1182/blood-2019-126004
Published: 2019
Journal Articles

Leukemia Burden in Peripheral Blood Has Negative Impact on CD19-CART Cell Culture and Its Clinical Efficacy in Patients with Refractory or Relapsed B Cell Acute Lymphoblastic Leukemia

Biping Deng, BS, MD, Jing Pan, Shuangyou Liu, Yuehui Lin, Zhaoli Liu, Yunlong Chen, Xiaoming Qu, Yu 'e Zhang, Zhongxin Zhang, Xuansha Niu, Ming Ma, Tong Wu, MD, Alex Hong Chang, Chunrong Tong
Journal: Blood
Blood (2019) 134 (Supplement_1): 1957.
https://doi.org/10.1182/blood-2019-126695
Published: 2019
Journal Articles

NKG2C + CD57 + Natural Killer Cells May Play an Important Role in Maintaining Virus-Specific Immune Reconstitution Post-Allogeneic HSCT

Debora Basilio Basilio-Queiros, MSc, Susanne Luther, Arnold Ganser, MD, Eva M Weissinger, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1939.
https://doi.org/10.1182/blood-2019-121914
Published: 2019
Journal Articles

Combining CAR Engineering and CIS Checkpoint Deletion in NK Cells for the Treatment of B Cell Hematologic Malignancies

May Daher, MD, Rafet Basar, MD, Elif Gokdemir, BS, Natalia Baran, PhDMD, Nadima Uprety, MS, Mayela Carolina Mendt, PhD, Lucila Kerbauy, MD, Mayra Shanley, PhD, Ana Karen Nunez Cortes, MD, Li Li, MD, Pinaki P Banerjee, PhD, Vakul Mohanty, PhD, Junjun Lu, Gonca Ozcan, MD, Emily Ensley, BS, Vandana Nandivada, BS, MS, Mecit Kaplan, MS, Mustafa H Bdaiwi, MD, Enli Liu, MD, Sonny Ang, PhD, Ken Chen, PhD, Marina Y Konopleva, MD PhD, Richard E. Champlin, MD, Elizabeth J. Shpall, MD, Katayoun Rezvani, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1936.
https://doi.org/10.1182/blood-2019-126739
Published: 2019
Journal Articles

Identifying miRNA Biomarkers and Predicted Targets Associated with Venous Thromboembolism in Colorectal Cancer Patients

Ann S. Kim, BA, Matthew F Kalady, MD, Jennifer DeVecchio, Kahraman Tanriverdi, Jane E. Freedman, MD, John Barnard, PhD, Tae Hyun Hwang, PhD, Alok A Khorana, MD, Keith R McCrae, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3643.
https://doi.org/10.1182/blood-2019-127585
Published: 2019
Journal Articles

Abnormal Cytokine Production By Mast Cell Cultures from Sickle Cell Anemia Patients in Response to Inflammatory Stimuli and to Co-Culture with Eosinophils

Myriam Salazar-Terreros, PhDMSc, Kleber Yotsumoto Fertrin, MD PhD, Nicolas Moreno Reyes, PhD, Fernando Ferreira Costa, MD PhD, Carla F. Franco-Penteado, BSc, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3566.
https://doi.org/10.1182/blood-2019-129509
Published: 2019
Journal Articles

Human Interleukin 15 (IL15) Humanized NCG Mice Support the Human Natural Killer Cells Reconstitution and Development

Cunxiang Ju, PhD, Mingkun Zhang, Dan Wu, Jing Tang, PhD, Shuai Li, Jing Zhao, PhD, Demin Wang, PhD, Xiang Gao, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4871.
https://doi.org/10.1182/blood-2019-123661
Published: 2019
Journal Articles

Gene Editing and mRNA-Based Therapy: Two Complementary Therapeutic Approaches for the Treatment of Patients with Xmen Disease

Julie Brault, PhD PharmD, Ezekiel Bello, Ronald J. Meis, PhD, Taylor Liu, Sherry M. Koontz, BS, Kennichi Dowdell, PhD, Linhong Li, PhD, Cornell Allen, MS, Narda Theobald, BS, Janet Lee, BS, Aaron B. Clark, BS, Juan C. Ravell, MD, Michael Lenardo, MD, Gary A. Dahl, PhD, Harry L. Malech, MD, Suk See De Ravin, MD, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4637.
https://doi.org/10.1182/blood-2019-129062
Published: 2019
Journal Articles

Bnz-1, a Selective γ-Chain Cytokine Inhibitor Has Clinical Activity in Patients with Cutaneous T Cell Lymphoma By Selectively Blocking IL-2, IL-15 and IL-9 Signaling: Results of a Multicenter, Open-Label Phase 1 Trial

Christiane Querfeld, MD PhD, Basem M. William, MRCP,MD, Jonathan E. Brammer, MD, Lubomir Sokol, MD PhD, Yutaka Tagaya, MD PhD, Paul Frohna, MD PhD PharmD, Nazli Azimi, PhD PharmD, Jasmine M. Zain, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1557.
https://doi.org/10.1182/blood-2019-129201
Published: 2019
Journal Articles

Interleukin-15 (IL-5) in Combination with Avelumab in Relapsed/Refractory Mature T-Cell Malignancies

Milos D. Miljkovic, MDMSc, Kevin C Conlon, MD, Sigrid Dubois, PhD, Jennifer Hsu, RN, Jeffrey Schlom, PhD, James Gulley, MD PhD, Thomas A. Waldmann, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1558.
https://doi.org/10.1182/blood-2019-128945
Published: 2019
Journal Articles

Engineering High Affinity and Cleavage Resistant CD16 to Augment ADCC of Placental Hematopoietic Stem Cells-Derived Natural Killer Cells

Xuan Guo, PhD, Srinivas Somanchi, PhD, Rohit Mathur, PhD, Shuyang He, PhD, Qian Ye, PhD, Andrea Difiglia, BS, Salvatore Rotondo, MS, Hemlata Rana, MS, Weifang Ling, PhD, James Edinger, PhD, Robert Hariri, MD PhD, Xiaokui Zhang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1576.
https://doi.org/10.1182/blood-2019-127009
Published: 2019
Journal Articles

A Novel Class of Bifunctional Immunotherapeutic That Exploits a Universal Antibody Binding Terminus (uABT) to Recruit Endogenous Antibodies to Cell Expressing CD38 Demonstrate In Vivo efficacy in Three Distinct Animal Models

Anna Bunin, PhD, Katy McGrath, BS, Ann Marie Rossi, MS, Matthew Welsch, PhD, Christian Vidal, PhD, David Trinh, BA, David Spiegel, MD, PhD, Luca Rastelli, PhD, Enrique Alvarez, DVM
Journal: Blood
Blood (2019) 134 (Supplement_1): 1820.
https://doi.org/10.1182/blood-2019-130838
Published: 2019