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Journal Articles

Paraoxonase 2 Enables Initiation of B-ALL By Subverting Metabolic Gatekeeper Functions

Lili Pan, MD, Chao Hong, PhD, Gang Xiao, PhD, Huimin Geng, PhD, Shaoyuan Wang, MD, Markus Müschen, MD PhD

Blood (2019) 134 (Supplement_1): 746.

https://doi.org/10.1182/blood-2019-125171

Published: 2019

Journal Articles

Modulation of Donor Graft By the Steroidal Lactone Withaferin A Alleviates Post-Transplant Acute GVHD Via Nrf-2 Independent T-Reg Induction

Vikram Gota, MD, Miten Mehta, PhD, Dievya Gohil, MSc, Dhruv Jha, M.Pharm, Rajiv Kumar, MBBS, MD DM, Beamon Agarwal, MD PhD, Deepak Sharma, PhD, Santosh Sandur, PhD, Navin Khattry, MD DM, Anuradha Majumdar, PhD

Blood (2017) 130 (Supplement 1): 3174.

https://doi.org/10.1182/blood.V130.Suppl_1.3174.3174

Published: 2017

Journal Articles

Cytoplasmic Phospholipase A2 Is Essential in GPVI Signaling Initiated Procoagulant Platelet Formation

Andaleb Kholmukhamedov, MD, Janecke Rae, Shawn M. Jobe, MD PhD

Blood (2017) 130 (Supplement 1): 1068.

https://doi.org/10.1182/blood.V130.Suppl_1.1068.1068

Published: 2017

Journal Articles

PON2 Exemplifies a Unique Dependency of B Cell Lineage ALL Cells on Detoxifying Lactonases

Gang Xiao, PhD, Chao Hong, PhD, Huimin Geng, PhD, Markus Muschen, MD

Blood (2017) 130 (Supplement 1): 882.

https://doi.org/10.1182/blood.V130.Suppl_1.882.882

Published: 2017

Journal Articles

Parthenolide and DMAPT Induce Cell Death in Chronic Myeloid Leukemia Cells Via Generation of Reactive Oxygen Species

Gabriela Flores-López, PhD Candidate, Hector Mayani, PhD, María Antonieta Chávez-Gonzalez, PhD

Blood (2016) 128 (22): 4242.

https://doi.org/10.1182/blood.V128.22.4242.4242

Published: 2016

Journal Articles

Combining BCL-2 Inhibitors with Parthenolide to Treat Childhood Acute Lymphoblastic Leukaemia

Paraskevi Diamanti, BSc, PhD, William J Barendt, BSc, Benjamin C Ede, BSc, Charlotte V. Cox, BSc, Allison Blair, PhD BSc

Blood (2015) 126 (23): 2531.

https://doi.org/10.1182/blood.V126.23.2531.2531

Published: 2015

Journal Articles

Dual Targeting of NOXA/MCL-1 Synergistically Induces Cell Death in Mantle Cell Lymphoma (MCL) Cells

Elisabeth Höring, German Ott, MD, Christine Bayha, Kleih Markus, Matthias C. Voehringer, MD, Heiko van Der Kuip, Walter E. Aulitzky, MD

Blood (2015) 126 (23): 2757.

https://doi.org/10.1182/blood.V126.23.2757.2757

Published: 2015

Journal Articles

Foxo 3a Signaling Mediates Apoptosis in Lymphoma Cells By the Diterpenoid Lactone Andrographolide (Andro), the Active Component of Andrographis Paniculata

Shuo Yang, Bo Ding, Fei Ying, Jana Svetlichnaya, Austin Tom, Sheila Prachand, Yanzhuang Wang, Leo I Gordon, MD FACP

Blood (2015) 126 (23): 2760.

https://doi.org/10.1182/blood.V126.23.2760.2760

Published: 2015

Journal Articles

Selectively Targeting Mutated NOTCH1 with a Folate-Thapsigargin Derivative

Giovanni Roti, MD, Jun Qi, PhD, Angela Su, B.S., Antony Varca, B.S., Jon C Aster, MD PhD, James E. Bradner, Kimberly Stegmaier, MD

Blood (2014) 124 (21): 2158.

https://doi.org/10.1182/blood.V124.21.2158.2158

Published: 2014

Journal Articles

ALDH Genes and Reactive Aldehydes Play Important Roles in HSCs and Leukemia and May Be Exploited to Treat AML

Maura Gasparetto, MD, Craig T. Jordan, PhD, Mohammad Minhajuddin, Daniel A Pollyea, MD, MS, Vasilis Vasilou, Philip Reigan, PhD, R. Keith Humphries, MD, PhD, Clayton A. Smith, MD, FRCPC

Blood (2013) 122 (21): 2893.

https://doi.org/10.1182/blood.V122.21.2893.2893

Published: 2013

Journal Articles

Targeting The Mitochondrial ClpP As a Novel Therapeutic Strategy For Acute Myeloid Leukemia

Alicia Cole, PhD, Zezhou Wang, PhD, Rachel Mattson, Etienne Coyaud, PhD, Rose Hurren, Marcela Gronda, MSc, Fengshu Lin, PhD, Neil Maclean, BSc, Elisa Leung, BSc, Yihua Qiu, MD, Nianxiang Zhang, PhD, Kevin R. Coombes, PhD, Mark D. Minden, MD PhD, Walid A. Houry, PhD, Zenyaho Hao, PhD, Steven M. Kornblau, MD, Brian Raught, PhD, Aaron Schimmer, PhD, MD

Blood (2013) 122 (21): 3937.

https://doi.org/10.1182/blood.V122.21.3937.3937

Published: 2013

Journal Articles

Targeting the Mammalian Mitochondrial Clpp (mClpP) As a Novel Therapeutic Strategy for Acute Myeloid Leukemia

Alicia Cole, PhD, Zezhou Wang, PhD, Rachel Mattson, Rose Hurren, BSc, Fengshu Lin, PhD, Marcela Gronda, MSc, Neil Maclean, BSc, Methvin Isaac, PhD, Elisa Leung, BSc., Mohan Babu, PhD, Mahadeo A. Sukhai, PhD, Walid A. Houry, PhD, Aaron D. Schimmer, MD

Blood (2012) 120 (21): 3603.

https://doi.org/10.1182/blood.V120.21.3603.3603

Published: 2012

Journal Articles

The Diterpenoid Lactone Andrographolide Induces Reactive Oxygen Species (ROS) Dependent Apoptosis in ATRA Sensitive and Resistant APL Cell Lines.

Shuo Yang, PhD, Jessica K. Altman, MD, Sheila Prachand, MS, Austin Tom, BS, Bo Ding, BS, Brent Wu, Leonidas C. Platanias, MD, PhD, Leo I. Gordon, MD

Blood (2012) 120 (21): 2446.

https://doi.org/10.1182/blood.V120.21.2446.2446

Published: 2012

Journal Articles

Targeting Redox Homeostasis As a Means to Selectively Eradicate Primary Human Leukemia Cells,

Shanshan Pei, Kevin Callahan, PhD, Mohammad Minhajuddin, PhD, Marlene Balys, Sarah Neering, Cheryl Corbett, Michael W. Becker, MD, Jane L. Liesveld, MD, Fred Hagen, PhD, Alan E Friedman, PhD, Peter Crooks, PhD, Craig T. Jordan, PhD

Blood (2011) 118 (21): 3506.

https://doi.org/10.1182/blood.V118.21.3506.3506

Published: 2011

Journal Articles

Small Compound 6- O -Angeloylplenolin Induces Mitotic Arrest and Exhibits Therapeutic Potential In Multiple Myeloma

Ying Liu, Xiaoqin Chen, Yongxian Cheng, Guangbiao Zhou, MD, PhD

Blood (2010) 116 (21): 5043.

https://doi.org/10.1182/blood.V116.21.5043.5043

Published: 2010

Journal Articles

Investigating Drug Resistance In Leukemia Initiating Cell Populations.

Paraskevi Diamanti, BSc, PhD, Charlotte Victoria Cox, BSc, Allison Blair, PhD, BSc

Blood (2010) 116 (21): 1570.

https://doi.org/10.1182/blood.V116.21.1570.1570

Published: 2010

Journal Articles

Genetic Screen to Isolate “Lariat” Peptides for Characterizing ABL Kinase Activity and Conformation

V.M. Bharathikumar, Kris Barreto, Marciano D. Reis, MD, John F. Decoteau, MD, C. Ronald Geyer

Blood (2010) 116 (21): 438.

https://doi.org/10.1182/blood.V116.21.438.438

Published: 2010

Journal Articles

Bryostatin Enhances the Cytotoxic Effects of Anti-CD22 Immunotoxins in CLL by Two Distinct Mechanisms: Implications for a Sequential Therapy.

Ingo Ringshausen, Thomas Decker, Viola Biberacher, Christian Meyer zum Buschenfelde, Madlen Oelsner, Michaela Wagner, Christian Bogner, Christian Peschel, MD

Blood (2009) 114 (22): 3429.

https://doi.org/10.1182/blood.V114.22.3429.3429

Published: 2009

Journal Articles

Analysis of the Anti-Leukemia Mechanism of Parthenolide.

ShanShan Pei, Monica L. Guzman, PhD, Shama Nasim, Lei Shi, Peter A Crooks, PhD, Craig T. Jordan, PhD

Blood (2009) 114 (22): 2734.

https://doi.org/10.1182/blood.V114.22.2734.2734

Published: 2009

Journal Articles

Induction of Noxa Via Generation of Reactive Oxygen Species Plays a Key Role in Induction of CLL Cell Apoptosis by Two Novel p53-Independent Cytotoxic Agents.

Andrew Steele, BSc, MSc, PhD, Archibald G Prentice, MBChB, FRCP, FRCPath, Anastasios Chanalaris, A. Victor Hoffbrand, DM, FRCP, FRCPath, DSc, Kate Cwynarski, Ranmohan Wickremasinghe

Blood (2009) 114 (22): 2752.

https://doi.org/10.1182/blood.V114.22.2752.2752

Published: 2009

NARROW

Paraoxonase 2 Enables Initiation of B-ALL By Subverting Metabolic Gatekeeper Functions

Modulation of Donor Graft By the Steroidal Lactone Withaferin A Alleviates Post-Transplant Acute GVHD Via Nrf-2 Independent T-Reg Induction

Cytoplasmic Phospholipase A2 Is Essential in GPVI Signaling Initiated Procoagulant Platelet Formation

PON2 Exemplifies a Unique Dependency of B Cell Lineage ALL Cells on Detoxifying Lactonases

Parthenolide and DMAPT Induce Cell Death in Chronic Myeloid Leukemia Cells Via Generation of Reactive Oxygen Species

Combining BCL-2 Inhibitors with Parthenolide to Treat Childhood Acute Lymphoblastic Leukaemia

Dual Targeting of NOXA/MCL-1 Synergistically Induces Cell Death in Mantle Cell Lymphoma (MCL) Cells

Foxo 3a Signaling Mediates Apoptosis in Lymphoma Cells By the Diterpenoid Lactone Andrographolide (Andro), the Active Component of Andrographis Paniculata

Selectively Targeting Mutated NOTCH1 with a Folate-Thapsigargin Derivative

ALDH Genes and Reactive Aldehydes Play Important Roles in HSCs and Leukemia and May Be Exploited to Treat AML

Targeting The Mitochondrial ClpP As a Novel Therapeutic Strategy For Acute Myeloid Leukemia

Targeting the Mammalian Mitochondrial Clpp (mClpP) As a Novel Therapeutic Strategy for Acute Myeloid Leukemia

The Diterpenoid Lactone Andrographolide Induces Reactive Oxygen Species (ROS) Dependent Apoptosis in ATRA Sensitive and Resistant APL Cell Lines.

Targeting Redox Homeostasis As a Means to Selectively Eradicate Primary Human Leukemia Cells,

Small Compound 6- O -Angeloylplenolin Induces Mitotic Arrest and Exhibits Therapeutic Potential In Multiple Myeloma

Investigating Drug Resistance In Leukemia Initiating Cell Populations.

Genetic Screen to Isolate “Lariat” Peptides for Characterizing ABL Kinase Activity and Conformation

Bryostatin Enhances the Cytotoxic Effects of Anti-CD22 Immunotoxins in CLL by Two Distinct Mechanisms: Implications for a Sequential Therapy.

Analysis of the Anti-Leukemia Mechanism of Parthenolide.

Induction of Noxa Via Generation of Reactive Oxygen Species Plays a Key Role in Induction of CLL Cell Apoptosis by Two Novel p53-Independent Cytotoxic Agents.

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American Society of Hematology

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American Society of Hematology

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