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Journal Articles

Mll -Partial Tandem Duplication ( Mll -PTD) Causes Pseudohypoxia and Hypermethylation of the Epigenome through Suppression of Mitochondrial Complex II

Asumi Yokota, PhD, Lulu Zhang, PhD, Xiaomei Yan, MD PhD, Xiaomin Feng, MD PhD, Lijun Wen, MS, George Freudiger, Maria Rife, Ally Woeste, Yoshihiro Hayashi, MD PhD, Gang Huang, PhD

Blood (2018) 132 (Supplement 1): 1311.

https://doi.org/10.1182/blood-2018-99-112529

Published: 2018

Journal Articles

LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis

Sara El Ashkar, Juerg Schwaller, Tim Pieters, Steven Goossens, Jonas Demeulemeester, Frauke Christ, Siska Van Belle, Sabine Juge, Nancy Boeckx, Alan Engelman, Pieter Van Vlierberghe, Zeger Debyser, Jan De Rijck

Blood (2018) 131 (1): 95–107.

https://doi.org/10.1182/blood-2017-05-786962

Published: 2018

Includes: Supplemental data

Journal Articles

Defining Acute Myeloid Leukemia Ontogeny in Older Patients

Megan Melody, BA, MS, David A Sallman, MD, Najla Al Ali, M.Sc, Hanadi Ramadan, BA, Ling Zhang, MD, Eric Padron, MD, Kendra Sweet, MD, Martine Extermann, MD, Alan F List, MD, Jeffrey E. Lancet, MD, Rami S. Komrokji, MD

Blood (2017) 130 (Supplement 1): 2594.

https://doi.org/10.1182/blood.V130.Suppl_1.2594.2594

Published: 2017

Journal Articles

Inotuzumab Ozogamicin (InO) for Relapsed/Refractory Acute Lymphoblastic Leukemia (R/R ALL) in the Global Phase 3 INO-VATE Trial: Efficacy By MLL Status

Anjali S. Advani, MD, Elias J. Jabbour, MD, Matthias Stelljes, MD, Wendy Stock, MD, Michaela Liedtke, MD, Nicola Goekbuget, MD, Susan M. O'Brien, MD, Jane Liang White, ScD, Tao Wang, PhD, A. Douglas Laird, PhD, Erik Vandendries, MD PhD, Hagop M. Kantarjian, MD

Blood (2017) 130 (Supplement 1): 2557.

https://doi.org/10.1182/blood.V130.Suppl_1.2557.2557

Published: 2017

Journal Articles

Impact of Bioflavonoid Exposure on DNA Damage Response and of Non-Homologous End Joining (NHEJ) Pathway Repair Proteins in Stem Cells

Anindita Ghosh, MBBS, MSc, Christine Richardson, PhD

Blood (2017) 130 (Supplement 1): 3796.

https://doi.org/10.1182/blood.V130.Suppl_1.3796.3796

Published: 2017

Journal Articles

Therapy-Related ALL Has Distinct Clinical and Pathologic Features Compared to De Novo ALL

Blood (2017) 130 (Supplement 1): 1442.

https://doi.org/10.1182/blood.V130.Suppl_1.1442.1442

Published: 2017

Journal Articles

Reciprocal Regulation of BCL6 and MLL Expression As a Vulnerability in MLL -Rearranged Acute Lymphoblastic Leukemia

Lai N Chan, Christian Hurtz, PhD, Huimin Geng, PhD, Cheryl L. Willman, MD, William L. Carroll, MD, Scott Armstrong, MD PhD, Thomas Arthur Milne, PhD BSc, MSc, Markus Muschen, MD

Blood (2017) 130 (Supplement 1): 1210.

https://doi.org/10.1182/blood.V130.Suppl_1.1210.1210

Published: 2017

Journal Articles

Comparison of MRD Levels and Gene Expression Patterns in MLL-R Versus Non-MLL Infant ALL

Rosemary Sutton, PhD, Tamara Law, BSc (Hons), Nicola C Venn, BSc (Hons), Carol Wadham, PhD, Emily VA Mould, PhD, Murray D Norris, PhD, Rishi S Kotecha, MB ChB FRACP PhD, Rolf Marschalek, PhD, Claus Meyer, PhD, Luciano Dalla-Pozza, MB BS FRACP, Glenn M Marshall, MBBS, MD FRACP, Richard B Lock, PhD, Toby N. Trahair, MBBS FRACP PhD

Blood (2016) 128 (22): 1740.

https://doi.org/10.1182/blood.V128.22.1740.1740

Published: 2016

Journal Articles

Pluripotent Reprogramming of Human AML Resets Leukemic Behavior and Models Therapeutic Targeting of Subclones

Mark Ping Chao, MD PhD, Gentles Andrew, PhD, Chatterjee Susmita, MS, Andreas Reinisch, MDPhD, M. Ryan Corces, PhD, Jinfeng Shen, PhD, Morganti Rachel, Rahul Singha, PhD, Daniel Haag, PhD, Marius Wernig, PhD, Joseph Wu, MD PhD, Ravi Majeti, MD PhD

Blood (2016) 128 (22): 575.

https://doi.org/10.1182/blood.V128.22.575.575

Published: 2016

Journal Articles

Clinical Outcome, Molecular and Gene Expression Analysis of 20 MLL-Rearranged AML from a Single Institution

Sergio Burillo-Sanz, PhD, Rosario Morales-Camacho, MD PhD, MT Vargas, Prof., Javier Sánchez, PhD, Jose Raul Garcia-Lozano, MD PhD, Teresa Caballero-Velazquez, MD PhD, Concepcion Prats-Martin, MD, Olga Perez, MD, Ricardo Bernal, MD PhD, Jose A. Perez-Simon, MD, PhD

Blood (2015) 126 (23): 4943.

https://doi.org/10.1182/blood.V126.23.4943.4943

Published: 2015

Journal Articles

Novel Myelodysplastic Syndromes-like Mouse Models By Cooperating Genetic/Epigenetic Mutations Reveal the Critical Role of HIF-1α for Disease Development

Yoshihiro Hayashi, MD PhD, Yue Zhang, MD, Xiaomei Yan, MD PhD, Goro Sashida, MD PhD, Zefeng Xu, MD, Yunzhu Dong, Hironori Harada, MD PhD, Zhijian Xiao, MD, Gang Huang, PhD

Blood (2014) 124 (21): 362.

https://doi.org/10.1182/blood.V124.21.362.362

Published: 2014

Journal Articles

Genome Engineering to Prospectively Investigate the Pathogenesis of MLL-AF9 Acute Leukemia

Corina Buechele, MD, Erin H. Breese, MDPhD, Dominik Schneidawind, MD, Matthew H. Porteus, MD PhD, Michael L. Cleary, MD

Blood (2014) 124 (21): 883.

https://doi.org/10.1182/blood.V124.21.883.883

Published: 2014

Journal Articles

Targeted Resequencing of MLL -PTD Positive AML Patients Reveals a High Prevalence of Co-Ocurring Mutations in Epigenetic Regulator Genes

Sylvia Herold, PhD, Thoralf Stange, Matthias Kuhn, Ingo Roeder, MD, Christoph Röllig, MD, Gerhard Ehninger, MD, Christian Thiede, MD

Blood (2014) 124 (21): 1035.

https://doi.org/10.1182/blood.V124.21.1035.1035

Published: 2014

Journal Articles

Value of EVI1 Gene Expression Level in Adult Acute Lymphoblastic Leukemia (ALL): A Study from the Group for Research on Adult ALL (GRAALL)

Claire Abbal, Raouf Ben Abdelali, Marina Lafage, Françoise Huguet, Thibaut Leguay, Olivier Spertini, Nicolas Boissel, Claude Gardin, Carlos Graux, Jean-Michel Cayuela, Marie-Laure Boulland, Nathalie Grardel, Anne Bouvier, Michel Duchosal, MD, Véronique Lhéritier, Yves Chalandon, Vahid Asnafi, MDPhD, Norbert Ifrah, Hervé Dombret, MD PhD

Blood (2014) 124 (21): 1081.

https://doi.org/10.1182/blood.V124.21.1081.1081

Published: 2014

Journal Articles

Presence of MLL Gene Rearrangements in Infant Acute Leukemia Could be Predicted By Tumor cells’ Immunophenotype

Alexander Popov, MD PhD, Grigory Tsaur, MD PhD, Tatiana Verzhbitskaya, MD PhD, Olga Streneva, MD PhD, Egor Shorikov, MD PhD, Leonid Saveliev, MD PhD, Larisa Fechina, MD PhD

Blood (2014) 124 (21): 5359.

https://doi.org/10.1182/blood.V124.21.5359.5359

Published: 2014

Journal Articles

Detection of Rearrangements of Mixed Lineage Leukemia Gene and Its clinical relevance

Weihong Chen, MD, Jiacai Zhuo, Xin Du

Blood (2014) 124 (21): 5339.

https://doi.org/10.1182/blood.V124.21.5339.5339

Published: 2014

Journal Articles

The Outcome of Childhood Acute Lymphoblastic Leukemia with MLL Gene Rearrangement Treated with the Protocol (CCLG-ALL2008)

Yina SUN, Yi-huan Chai, MD, Hai-long He, MD, Jun LU, Yi WANG, Wen-li Zhao, Pei-fang Xiao, Jun-jie Fan, Shaoyan Hu, MD PhD

Blood (2014) 124 (21): 5243.

https://doi.org/10.1182/blood.V124.21.5243.5243

Published: 2014

Journal Articles

Oncogenetics and minimal residual disease are independent outcome predictors in adult patients with acute lymphoblastic leukemia

Blood (2014) 123 (24): 3739–3749.

https://doi.org/10.1182/blood-2014-01-547695

Published: 2014

Includes: Supplemental data

Journal Articles

Cytogenetic and Molecular Genetic Characterization Of MLL -PTD Positive AML In Comparison To MLL -Translocated AML

Claudia Haferlach, MD, Alexander Kohlmann, PhD, Wolfgang Kern, MD, Torsten Haferlach, MD, Susanne Schnittger, PhD

Blood (2013) 122 (21): 2557.

https://doi.org/10.1182/blood.V122.21.2557.2557

Published: 2013

Journal Articles

Backtracking Of The Genetic Events Preceding Acute Leukemia Diagnosis

Olga Zimmermannova, Marketa Zaliova, Ester Mejstrikova, Eva Fronkova, Marie Jarosova, Zuzana Zemanova, Libuse Lizcova, Halima A Al-Shehhi, Anthony V. Moorman, Ajay J Vora, Claus Meyer, Rolf Marschalek, Jan Stary, Jan Trka, Ondrej Hrusak, Jan Zuna

Blood (2013) 122 (21): 2562.

https://doi.org/10.1182/blood.V122.21.2562.2562

Published: 2013

NARROW

Mll -Partial Tandem Duplication ( Mll -PTD) Causes Pseudohypoxia and Hypermethylation of the Epigenome through Suppression of Mitochondrial Complex II

LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis

Defining Acute Myeloid Leukemia Ontogeny in Older Patients

Inotuzumab Ozogamicin (InO) for Relapsed/Refractory Acute Lymphoblastic Leukemia (R/R ALL) in the Global Phase 3 INO-VATE Trial: Efficacy By MLL Status

Impact of Bioflavonoid Exposure on DNA Damage Response and of Non-Homologous End Joining (NHEJ) Pathway Repair Proteins in Stem Cells

Therapy-Related ALL Has Distinct Clinical and Pathologic Features Compared to De Novo ALL

Reciprocal Regulation of BCL6 and MLL Expression As a Vulnerability in MLL -Rearranged Acute Lymphoblastic Leukemia

Comparison of MRD Levels and Gene Expression Patterns in MLL-R Versus Non-MLL Infant ALL

Pluripotent Reprogramming of Human AML Resets Leukemic Behavior and Models Therapeutic Targeting of Subclones

Clinical Outcome, Molecular and Gene Expression Analysis of 20 MLL-Rearranged AML from a Single Institution

Novel Myelodysplastic Syndromes-like Mouse Models By Cooperating Genetic/Epigenetic Mutations Reveal the Critical Role of HIF-1α for Disease Development

Genome Engineering to Prospectively Investigate the Pathogenesis of MLL-AF9 Acute Leukemia

Targeted Resequencing of MLL -PTD Positive AML Patients Reveals a High Prevalence of Co-Ocurring Mutations in Epigenetic Regulator Genes

Value of EVI1 Gene Expression Level in Adult Acute Lymphoblastic Leukemia (ALL): A Study from the Group for Research on Adult ALL (GRAALL)

Presence of MLL Gene Rearrangements in Infant Acute Leukemia Could be Predicted By Tumor cells’ Immunophenotype

Detection of Rearrangements of Mixed Lineage Leukemia Gene and Its clinical relevance

The Outcome of Childhood Acute Lymphoblastic Leukemia with MLL Gene Rearrangement Treated with the Protocol (CCLG-ALL2008)

Oncogenetics and minimal residual disease are independent outcome predictors in adult patients with acute lymphoblastic leukemia

Cytogenetic and Molecular Genetic Characterization Of MLL -PTD Positive AML In Comparison To MLL -Translocated AML

Backtracking Of The Genetic Events Preceding Acute Leukemia Diagnosis

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American Society of Hematology

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