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Journal Articles

Clonal Hematopoiesis and Genetic Mutations in Individual Patients with Acquired Bone Marrow Failure Diseases

Baixin Ye, Xinhua Du, Li Yan, Qingping Gao, Chunrui Li, MD PhD, Jianfeng Zhou, Xin Yi, Fankai Meng

Blood (2019) 134 (Supplement_1): 937.

https://doi.org/10.1182/blood-2019-125357

Published: 2019

Journal Articles

Comprehensive Transcriptome Profiling of Cryptic CBFA2T3-GLIS2 Fusion-Positive AML Defines Novel Therapeutic Options — a COG and Target Pediatric AML Study

Jenny L. Smith, MSc, MD, Rhonda E. Ries, MA, Marianne T. Santaguida, BSc, PhD, Christos Gekas, PhD, Todd A Alonzo, PhD, Robert B Gerbing, MA, Alan S Gamis, MD MPH, Richard Aplenc, MD PhD, E. Anders Kolb, MD, Tiffany Hylkema, BS, Lisa Eidenschink Brodersen, PhD, Michael R. Loken, PhD, Hamid Bolouri, PhD, Soheil Meshinchi, MD PhD

Blood (2018) 132 (Supplement 1): 881.

https://doi.org/10.1182/blood-2018-99-115544

Published: 2018

Journal Articles

Biomarkers of Overall Survival and Response to Glasdegib and Intensive or Non-Intensive Chemotherapy in Patients with Acute Myeloid Leukemia

Jorge E. Cortes, MD, Akil Merchant, MD, Catriona Jamieson, MD PhD, Daniel A Pollyea, MD, Michael Heuser, MD, Geoffrey Chan, MD, Panpan Wang, Keith A Ching, Jillian Johnson, Thomas O'Brien

Blood (2018) 132 (Supplement 1): 2733.

https://doi.org/10.1182/blood-2018-99-111239

Published: 2018

Journal Articles

Hedgehog Pathway Mutations Drive Oncogenic Transformation in High-Risk T-Cell Acute Lymphoblastic Leukemia

Melissa A. Burns, MD, Zi Wei Liao, Gayle P. Pouliot, MD PhD, Kristen E. Stevenson, MS, Donna S. Neuberg, ScD, Aaron R. Thorner, PhD, Matthew D. Ducar, MS, Emily A. Silverman, Stephen P. Hunger, MD, Mignon L. Loh, MD, Stuart S. Winter, MD, Kimberly P. Dunsmore, MD, Brent Wood, MDPhD, Meenakshi Devidas, PhD, Marian H. Harris, MD PhD, Lewis B. Silverman, MD, Stephen E. Sallan, MD, Alejandro Gutierrez, MD

Blood (2017) 130 (Supplement 1): 367.

https://doi.org/10.1182/blood.V130.Suppl_1.367.367

Published: 2017

Journal Articles

Upregulation of Alternatively Glycosylated Smoothened (SMO) Is Involved in Doxorubicin (DXR) Resistance in Diffuse Large B-Cell Lymphoma

Nitin Agarwal, PhD, Kranthi Kunkalla, MS, Sandra Sanchez, MD, Amineh Vaghefi, MD, Darius Juskevicius, PhD, Alexandar Tzankov, Ramiro E Verdun, PhD, Ralf Landgraf, PhD, Francisco Vega, MD PhD

Blood (2017) 130 (Supplement 1): 3839.

https://doi.org/10.1182/blood.V130.Suppl_1.3839.3839

Published: 2017

Journal Articles

Understanding the Secondary Transformation of JAK2 Myeloproliferative Neoplasms: Genomic Analysis

Ja Min Byun, MD, Byung-Su Kim, MD PhD, Koh Youngil, MD PhD, Sung-Soo Yoon, MD PhD

Blood (2017) 130 (Supplement 1): 2928.

https://doi.org/10.1182/blood.V130.Suppl_1.2928.2928

Published: 2017

Journal Articles

Characterization of Ex-Vivo PTCH1 Expression Under Tyrosine Kinase Inhibitors Treatment and Determination of Downstream Effectors Oh Hedgehog Pathway in CML

Juan Manuel Alonso Dominguez, MD PhD MSc, Alicia Arenas, PhD, Pilar Llamas, MDPhD, Diego Velasco, Aránzazu García-Raso, PhD, Jose Luis Lopez Lorenzo, MD, Mireia Atance, Rocio N Salgado, PhD, Joaquin Martinez Lopez, MD PhD

Blood (2017) 130 (Supplement 1): 5245.

https://doi.org/10.1182/blood.V130.Suppl_1.5245.5245

Published: 2017

Journal Articles

Drug-Insensitive CML Stem/Progenitor Cells Highly Express Key Regulators of the Hedgehog Pathway and Inhibition of the Hedgehog Pathway Enhances Their Response to TKI Treatment

Kelly A. Turner, BSc, Katharina Rothe, PhD, Adrian Woolfson, MD PhD, Xiaoyan Jiang, MD PhD

Blood (2016) 128 (22): 4236.

https://doi.org/10.1182/blood.V128.22.4236.4236

Published: 2016

Journal Articles

Genetic Sequencing of Adult T-Cell Leukemia/Lymphoma in the Caribbean Population Shows a Distinct Mutational Profile When Compared to the Japanese Cohort

Urvi A Shah, MD, B. Hilda Ye, PhD, Jeff Hall, PhD, Yanhua Wang, MD PhD, Ronald Rice, MD PhD, Rizwan Naeem, MD, Amara Gayathri Nandikolla, MD, Swati Goel, MD, Ioannis Mantzaris, MD, Aditi Shastri, MD, Olga Derman, MD, Noah Kornblum, MD, Ira Braunschweig, MD, Amit Verma, MD, Murali Janakiram, MD

Blood (2016) 128 (22): 1758.

https://doi.org/10.1182/blood.V128.22.1758.1758

Published: 2016

Journal Articles

Phase 2 Trial of Smoothened (SMO) Inhibitor PF-04449913 (PF-04) in Refractory Myelodysplastic Syndromes (MDS)

Jeffrey E. Lancet, MD, Rami S Komrokji, MD, Kendra L. Sweet, MD, Vu H. Duong, MD, Kathy L McGraw, PhD, Ling Zhang, MD, Lisa Ann Nardelli, BS, Zhenjun Ma, PhD, Richard R Reich, PhD, Eric Padron, MD, Alan F List, MD

Blood (2016) 128 (22): 3174.

https://doi.org/10.1182/blood.V128.22.3174.3174

Published: 2016

Journal Articles

Depletion of Ptch2 Activates Canonical and Non-Canonical HH Signaling within the Niche Leading to Myeloproliferation, Stem Cell Exhaustion and Accelerates JAK2V617F Driven Disease

Claudius Klein, Anabel Kuhn, Sandra Kissel, Marie Follo, PhD, Anna Lena Illert, MD, Dietmar Pfeifer, Heike L Pahl, PhD, Robert A.J. Oostendorp, PhD, Justus Duyster, MD, Christine Dierks, MD

Blood (2015) 126 (23): 3593.

https://doi.org/10.1182/blood.V126.23.3593.3593

Published: 2015

Journal Articles

The Alternate Activation of Hedgehog Pathway, Either in CD138+ or in CD138-CD19+ Multiple Myeloma Primary Cells, Impacts on Disease Outcome

Marina Martello, PhD, Daniel Remondini, PhD, Enrica Borsi, PhD, Mauro Procacci, Barbara Santacroce, Annalisa Pezzi, PhD, Angela Flores Dico, Elena Zamagni, Paola Tacchetti, MD, Lucia Pantani, MD, Giulia Marzocchi, PhD, Giovanni Martinelli, MD PhD, Michele Cavo, Carolina Terragna, PhD

Blood (2015) 126 (23): 2961.

https://doi.org/10.1182/blood.V126.23.2961.2961

Published: 2015

Journal Articles

Measurement of PTCH1 Expression at Diagnosis Is an Appropriate Tool for Tyrosine Kinase Inhibitors Selection in Chronic Myeloid Leukemia Patients in Chronic Phase

Juan Manuel Alonso-Dominguez, MD, Felipe Casado, MariaTeresa Gómez Casares, MDPhD, Ismael Buno, Francisca Ferrer-Marin, Eduardo Anguita, MD PhD, Alicia Arenas, Rafael Del Orbe, MD, Rosa M. Ayala, MD PhD, Pilar Llamas, MD, Pedro Sanchez-Godoy, MD, Carmen Burgaleta, MD, Valentín García-Gutierrez, Juan Luis Steegmann, MD PhD, Joaquin Martinez-Lopez

Blood (2015) 126 (23): 2791.

https://doi.org/10.1182/blood.V126.23.2791.2791

Published: 2015

Journal Articles

A Genome-Wide Association Study of Myeloma Survival in Utah Uncovers Germline Variants That May Influence Survival of Multiple Myeloma Patients

Karen Curtin, PhD, Yi Zhao, MS, Donglei Hu, PhD, Guido J Tricot, MD PhD, Elad Ziv, MD, Djordje Atanackovic, MD, Nicola J Camp, PhD

Blood (2015) 126 (23): 2993.

https://doi.org/10.1182/blood.V126.23.2993.2993

Published: 2015

Journal Articles

The Signature Program, a Distinctive Tissue Agnostic Trial Model for Molecularly Pre-Selected Hematological and Solid Tumor Patients

Frank Giles, MD MB, FRCPI, FRCPath, Sarina A. Piha-Paul, MD, Alexander I. Spira, PhD MD FACP, Fadi Braiteh, MD CPI, Julio Antonio Peguero, MD, Daniel L. Spitz, MD FACP, James A. Knost, MD, Lee Schwartzberg, MD FACP, Steven Stein, MD, August J. Salvado, MD, Claudia Lebedinsky, MD, Barinder Kang, PhD, Eric Slosberg, PhD

Blood (2014) 124 (21): 4818.

https://doi.org/10.1182/blood.V124.21.4818.4818

Published: 2014

Journal Articles

Aberrant Hedgehog Pathway Activity Marks Clinical MDS Progression and Accelerates Leukemic Transformation in Vivo

Lukasz P Gondek, MD PhD, Yiting Lim, PhD, Hideki Makishima, MD PhD, Qiuju Wang, MA, Jaroslaw P. Maciejewski, MD PhD FACP, Peter D Aplan, MD, Amy E. DeZern, MD MHS, William Matsui, MD

Blood (2014) 124 (21): 528.

https://doi.org/10.1182/blood.V124.21.528.528

Published: 2014

Journal Articles

Incidence of Germline Mutations in Cancer-Predisposition Genes in Children with Hematologic Malignancies: a Report from the Pediatric Cancer Genome Project

Blood (2014) 124 (21): 127.

https://doi.org/10.1182/blood.V124.21.127.127

Published: 2014

Journal Articles

Transcriptional Regulation Of GLI1 , Potential New Therapeutic Target For Diffuse Large B-Cell Lymphoma

Nitin K Agarwal, PhD, Kranthi Kunkalla, MS, David H Hawke, PhD, Yadong Liu, MD, Changju Qu, MD PhD, Francisco Vega, MD, PhD

Blood (2013) 122 (21): 2513.

https://doi.org/10.1182/blood.V122.21.2513.2513

Published: 2013

Journal Articles

Improved Efficacy Of Combination Of JAK2 and Hedgehog Inhibitors In Myelofibrosis

Neha Bhagwat, B.S., Matthew D Keller, B.S., Raajit K. Rampal, M.D., Ph.D., Kaitlyn Shank, B.S., Elisa de Stanchina, PhD, Kristine Rose, PhD, Dereck Amakye, MD, Ross L. Levine, MD

Blood (2013) 122 (21): 666.

https://doi.org/10.1182/blood.V122.21.666.666

Published: 2013

Journal Articles

Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma

Simona Blotta, Jana Jakubikova, Teresa Calimeri, Aldo M. Roccaro, Nicola Amodio, Abdel Kareem Azab, Umberto Foresta, Constantine S. Mitsiades, Marco Rossi, Katia Todoerti, Stefano Molica, Fortunato Morabito, Antonino Neri, Piersandro Tagliaferri, Pierfrancesco Tassone, Kenneth C. Anderson, Nikhil C. Munshi

Blood (2012) 120 (25): 5002–5013.

https://doi.org/10.1182/blood-2011-07-368142

Published: 2012

NARROW

Clonal Hematopoiesis and Genetic Mutations in Individual Patients with Acquired Bone Marrow Failure Diseases

Comprehensive Transcriptome Profiling of Cryptic CBFA2T3-GLIS2 Fusion-Positive AML Defines Novel Therapeutic Options — a COG and Target Pediatric AML Study

Biomarkers of Overall Survival and Response to Glasdegib and Intensive or Non-Intensive Chemotherapy in Patients with Acute Myeloid Leukemia

Hedgehog Pathway Mutations Drive Oncogenic Transformation in High-Risk T-Cell Acute Lymphoblastic Leukemia

Upregulation of Alternatively Glycosylated Smoothened (SMO) Is Involved in Doxorubicin (DXR) Resistance in Diffuse Large B-Cell Lymphoma

Understanding the Secondary Transformation of JAK2 Myeloproliferative Neoplasms: Genomic Analysis

Characterization of Ex-Vivo PTCH1 Expression Under Tyrosine Kinase Inhibitors Treatment and Determination of Downstream Effectors Oh Hedgehog Pathway in CML

Drug-Insensitive CML Stem/Progenitor Cells Highly Express Key Regulators of the Hedgehog Pathway and Inhibition of the Hedgehog Pathway Enhances Their Response to TKI Treatment

Genetic Sequencing of Adult T-Cell Leukemia/Lymphoma in the Caribbean Population Shows a Distinct Mutational Profile When Compared to the Japanese Cohort

Phase 2 Trial of Smoothened (SMO) Inhibitor PF-04449913 (PF-04) in Refractory Myelodysplastic Syndromes (MDS)

Depletion of Ptch2 Activates Canonical and Non-Canonical HH Signaling within the Niche Leading to Myeloproliferation, Stem Cell Exhaustion and Accelerates JAK2V617F Driven Disease

The Alternate Activation of Hedgehog Pathway, Either in CD138+ or in CD138-CD19+ Multiple Myeloma Primary Cells, Impacts on Disease Outcome

Measurement of PTCH1 Expression at Diagnosis Is an Appropriate Tool for Tyrosine Kinase Inhibitors Selection in Chronic Myeloid Leukemia Patients in Chronic Phase

A Genome-Wide Association Study of Myeloma Survival in Utah Uncovers Germline Variants That May Influence Survival of Multiple Myeloma Patients

The Signature Program, a Distinctive Tissue Agnostic Trial Model for Molecularly Pre-Selected Hematological and Solid Tumor Patients

Aberrant Hedgehog Pathway Activity Marks Clinical MDS Progression and Accelerates Leukemic Transformation in Vivo

Incidence of Germline Mutations in Cancer-Predisposition Genes in Children with Hematologic Malignancies: a Report from the Pediatric Cancer Genome Project

Transcriptional Regulation Of GLI1 , Potential New Therapeutic Target For Diffuse Large B-Cell Lymphoma

Improved Efficacy Of Combination Of JAK2 and Hedgehog Inhibitors In Myelofibrosis

Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma

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American Society of Hematology

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American Society of Hematology

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