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Journal Articles

A master erythroid regulator gets its own GPS

Lily Jun-shen Huang, James J. Bieker
Journal: Blood
Blood (2020) 135 (25): 2209–2210.
https://doi.org/10.1182/blood.2020005882
Published: 2020
Journal Articles

PPM1D and DNMT3A Mutations in Myelodysplasia and Clonal Hematopoiesis

Masanori Motomura, Yoshikage Inoue, Yasunobu Nagata, MD PhD, Tetsuichi Yoshizato, MD PhD, Constance Baer, PhD, Yukihide Momozawa, Niroshan Nadarajah, Yasuhito Nannya, MD PhD, Kenichi Yoshida, MD PhD, Claudia Haferlach, MD, Wolfgang Kern, MD, Yoshiko Atsuta, MD PhD, Yuka Iijima-Yamashita, Yuichi Shiraishi, PhD, Makoto Onizuka, MD PhD, Kenichi Chiba, PhD, Hiroko Tanaka, BA, Hidehiro Itonaga, MD PhD, Yasushi Miyazaki, MD PhD, Keizo Horibe, MD PhD, Masashi Sanada, MD, Yoichiro Kamatani, Michiaki Kubo, MD PhD, Satoru Miyano, PhD, Torsten Haferlach, MD, Seishi Ogawa, MD PhD, Hideki Makishima, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1709.
https://doi.org/10.1182/blood-2019-122032
Published: 2019
Journal Articles

Targeting T-ALL Cells with Potent Activators of the PP2A Protein Phosphatase Tumor Suppressor

Ken Morita, MD PhD, Shuning He, PhD, Radosław P. Nowak, PhD, Jinhua Wang, PhD, Nathanael Gray, PhD, Eric S. Fischer, PhD, A. Thomas Look, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 406.
https://doi.org/10.1182/blood-2019-123573
Published: 2019
Journal Articles

A 14q32.31 Genomic-Imprinted DLK1-DIO3 microrna promotes Leukemogenesis By Inducing Stem Cell Quiescence and Inhibiting NK Cell Anti-Cancer Immunity

Giovannino Silvestri, PhD, Rossana Trotta, PhD, Lorenzo Stramucci, PhD, Shuzhen Wang, PhD, Ann-Kathrin Eisfeld, MD, Bin Zhang, PhD, Klara Srutova, PhD, Gabriel Pineda, PhD, Catriona Jamieson, MD PhD, Fabio Stagno, MD, Paolo Vigneri, MD PhD, Georgios Nteliopoulos, PhD, Martin Guimond, PhD, Peter Hokland, MD DMSc, Michael W. Deininger, Francesco Dazzi, PhD, Dragana Milojkovic, MBBS, MD, Jane Apperley, MB, ChB, MD, Guido Marcucci, MD, Xiaoxuan Fan, PhD, Maria R. Baer, MD, Bruno Calabretta, MD PhD, Danilo Perrotti, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4141.
https://doi.org/10.1182/blood-2019-131113
Published: 2019
Journal Articles

Protein Phosphatase 2A Activation Dependent Down Regulation of PGC1-Alpha and FOXO1 Phosphorylation with OSU-2S in Human Lymphoma Cells

Sohaila Mohamed Khalil, Swagata Goswami, MSc, Xiaokui Mo, PhD MAS, Natarajan Muthusamy, DVM,PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3977.
https://doi.org/10.1182/blood-2019-129224
Published: 2019
Journal Articles

GFI1-Dependent SGPP1 Repression Promotes Growth and Survival of Myeloma Cells

Daniela Nicoleta Petrusca, PhD, Evgeny Berdyshev, PhD, Colin D. Crean, BS, Judith L Anderson, BS, G. David Roodman, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4387.
https://doi.org/10.1182/blood-2019-131106
Published: 2019
Journal Articles

DNA Repair Genes' Expression Abnormalities in De Novo Acute Myelogenous Leukemia (AML): Implications for Targeted Treatment

Frieda Kontsioti, PhD, Eirini Maratou, PhD, Anthi Bouhla, MD, Vassiliki Mpakou, PhD, Konstantinos Gkodopoulos, MD, Georgia Stavroulaki, MD, Eirini Glezou, MD, Thomas Thomopoulos, MD, Efthimia Bazani, MD, Sotirios Papageorgiou, MD PhD, Argiris Symeonidis, MD PhD, George Dimitriadis, MD, Vassiliki Pappa, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5176.
https://doi.org/10.1182/blood-2019-127501
Published: 2019
Journal Articles

Overexpression and Targeted Activation of the Protein Phosphatases SHP-1 Abrogates Survival Pathways in Large Granular Lymphocyte Leukemia (LGLL)

Mario Angelo Pagano, Elena Tibaldi, Giulia Calabretto, Antonella Teramo, Luca Dell'Amico, Gabriella Donà, Gregorio Barilà, Cristina Vicenzetto, Vanessa Rebecca Gasparini, Valentina Trimarco, Monica Facco, Francesco Piazza, Gianpietro Semenzato, Anna Maria Brunati, Renato Zambello
Journal: Blood
Blood (2019) 134 (Supplement_1): 2798.
https://doi.org/10.1182/blood-2019-129883
Published: 2019
Journal Articles

Ibrutinib Selects for Cells with Elevated Reactive Oxygen Species and Downregulated Phosphatases

Nathan Camp, PhD, Meghan Garrett, Ajay K. Gopal, MD, Richard James, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3795.
https://doi.org/10.1182/blood-2019-124454
Published: 2019
Journal Articles

Significance of Abnormalities of PPM1D in Myeloproliferative Neoplasms

Bridget Marcellino, MD PhD, Joseph Tripodi, Michal Bar-Natan, MD, Harry Fruchtman, Noushin Farnoud, PhD, Min Lu, PhD, Heidi E. Kosiorek, MS, Amylou C. Dueck, PhD, Raajit K. Rampal, MD PhD, John Mascarenhas, MD, Vesna Najfeld, PhD, Ronald Hoffman, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4207.
https://doi.org/10.1182/blood-2019-129565
Published: 2019
Journal Articles

The Role of PPM1D Mutations in Lenalidomide Resistance and Progression in Patients with MDS and Deletion of Chromosome 5q

Victoria Panagiota, MD, Manja Meggendorfer, PhD, Anne Sophie Kubasch, MD, Razif Gabdoulline, Jan Krönke, MD, Rabia Shahswar, Anna Mies, Christian Kandziora, MD, Piroska Klement, Johannes Schiller, Gudrun Göhring, MD, Claudia Haferlach, MD, Christina Ganster, Katayoon Shirneshan, Annika Gutermuth, Christian Thiede, MD, Ulrich Germing, MD, Thomas Schroeder, Guido Kobbe, Sabrina Klesse, Christian Koenecke, Brigitte Schlegelberger, MD PhD, Nicolaus Kroeger, MD, Detlef Haase, MD PhD, Konstanze Döhner, MD, Wolfgang R. Sperr, Peter Valent, Arnold Ganser, MD, Felicitas Thol, MD, Torsten Haferlach, MD, Uwe Platzbecker, Michael Heuser, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4360.
https://doi.org/10.1182/blood-2018-99-114026
Published: 2018
Journal Articles

Inhibition of WIP1 Phosphatase in Multiple Myeloma Overcomes Bortezomib Resistance and Promotes Cell Death Via ER Stress-Induced Apoptotic JNK/c-Jun Signaling and Downregulation of Inhibitors of Apoptosis Proteins (IAPs)

Katia Beider, Evgenia Rosenberg, Valeria Voevoda, Hanna Bitner, Yaarit Sirovsky, Hila Magen, MD, Olga Ostrovsky, PhD, Avichai Shimoni, MD, Michael Milyavsky, PhD, Amnon Peled, Arnon Nagler, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1366.
https://doi.org/10.1182/blood-2018-99-114652
Published: 2018
Journal Articles

Aberrant Level of Estrogen Correlates with Defective Thrombopoiesis during Pregnancy in Patients with Immune Thrombocytopenia

Qi Chen, Xiao Liu, Jing-Zhong Zhao, Chen-Cong Wang, Ya-Nan Wang, Jing Xue, Jia-Min Zhang, MD, Xiao-Lu Zhu, Yun He, Qian-Ming Wang, Hai-Xia Fu, Lan-Ping Xu, Kai-Yan Liu, Xiao-Jun Huang, MD, Xiaohui Zhang, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1047.
https://doi.org/10.1182/blood.V130.Suppl_1.1047.1047
Published: 2017
Journal Articles

Direct-Acting Small Molecule Activators of PP2A (SMAPs) in Myeloid Malignancies: Understanding Mechanisms of Cytotoxicity to Inform Rational Combinatorial Therapeutic Strategies

Christopher B Ryder, Goutham Narla, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2517.
https://doi.org/10.1182/blood.V130.Suppl_1.2517.2517
Published: 2017
Journal Articles

SF3B1 Mutation Causes Aberrant Splicing and Downregulation of PPP2R5A in Chronic Lymphocytic Leukemia

Qimei Han, MBBS, Libin Deng, PhD, Lirong Pei, Jeong-Hyeon Choi, PhD, Victor Jin, PhD, Huidong Shi
Journal: Blood
Blood (2017) 130 (Supplement 1): 2477.
https://doi.org/10.1182/blood.V130.Suppl_1.2477.2477
Published: 2017
Journal Articles

Agonist-Induced Signaling and Integrin-Mediated Function in Murine Platelets Is Distinctly Regulated By the α Isoform of the Catalytic Subunit of Protein Phosphatase 1

Tanvir Khatlani, PhD, Subhashree Pradhan, PhD, Qi Da, PhD, K. Vinod Vijayan, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1023.
https://doi.org/10.1182/blood.V130.Suppl_1.1023.1023
Published: 2017
Journal Articles

Reprogramming Cell-Signaling By Delivering the Catalytic Domain of Ptpgr Ameliorates Anemia of β-Thalassemia

Alessandro Mattè, PhD, Elisabetta Beneduce, Michela Mirenda, PhD, Roberta Russo, Achille Iolascon, MD PhD, Antonella Pantaleo, PhD, Francesco Turrini, MD PhD, Angela Siciliano, Enrica Federti, PhD, Serge Cedrick, Anne Janin, PhD, Christophe Leboeuf, Carlo Laudanna, MD, Lucia De Franceschi, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2219.
https://doi.org/10.1182/blood.V130.Suppl_1.2219.2219
Published: 2017
Journal Articles

Salubrinal Mediated Fetal Hemoglobin Induction through the eIF2α-ATF4 Signaling Pathway

Nicole Hope Lopez, BS, Biaoru Li, MD PhD, Levi Makala, DVM, MBA, PhD, Betty S. Pace, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2235.
https://doi.org/10.1182/blood.V130.Suppl_1.2235.2235
Published: 2017
Journal Articles

The Bone Marrow Niche Uses Mir-300 As a Biological Rheostat to Selectively Control Stem Cell-Driven Malignant Hematopoiesis and Innate Anti-Cancer Immunity

Giovannino Silvestri, PhD, Lorenzo Stramucci, PhD, Justin Ellis, Jason Harb, PhD, Paolo Neviani, PhD, Bin Zhang, PhD, Klara Srutova, PhD, Carlo Gambacorti-Passerini, MD, Gabriel Pineda, PhD, Catriona Jamieson, MD PhD, Bruno Calabretta, MD PhD, Fabio Stagno, MD PhD, Paolo Vigneri, MD PhD, G. Nteliopoulos, Philippa May, Alistair Reid, BSc, PhD, Ramiro Garzon, MD, Denis-Claude Roy, MD, Martin Guimond, PhD, Peter Hokland, MD, Michael W. Deininger, MD PhD, Garrett Fitzgerald, MD, Chris Harman, MD, Francesco Dazzi, PhD, Dragana Milojkovic, MBBS, PhD, Jane F. Apperley, FRCP, FRCPath, MD MBChB, Guido Marcucci, MD, Jianfei Qi, PhD, Kateřina Machová Poláková, PhD, Xiaoxuan Fan, PhD, Maria R. Baer, MD, Rossana Trotta, PhD, Danilo Perrotti, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 45.
https://doi.org/10.1182/blood.V130.Suppl_1.45.45
Published: 2017
Journal Articles

PPM1D Mutations and up Modulation Phenocopy TP53 Lesions in Myeloid Neoplasms

Reem Elagooz, MS, MD, Mai Aly, MD MS, Cassandra M. Hirsch, BS, Bartlomiej P. Przychodzen, MSc, Teodora Kuzmanovic, BA, Tomas Radivoyevitch, Valeria Visconte, PhD, Sudipto Mukherjee, MD PhD MPH, Hetty E. Carraway, MD MBA, Mikkael A. Sekeres, MD MS, Aziz Nazha, MD, Jaroslaw P. Maciejewski, PhD MD FACP, Yasunobu Nagata, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4233.
https://doi.org/10.1182/blood.V130.Suppl_1.4233.4233
Published: 2017