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Journal Articles

Identification and Validation of Predictive Biomarkers to CD19- and BCMA-Specific CAR T-Cell Responses in CAR T-Cell Precursors

Free
Meng Wang, BS, Iulian Pruteanu, PhD, Adam D. Cohen, MD, Alfred L Garfall, MD, Michael C. Milone, Lifeng Tian, PhD, Vanessa E. Gonzalez, Saar Gill, MD MRCP, FRCPath, Noelle V. Frey, MD, David M. Barrett, Marco Ruella, MD, Simon F Lacey, PhD, Jakub Svoboda, MD, Elise A. Chong, MD, Joseph A Fraietta, PhD, Megan Davis, PhD, Sunita D Nasta, MD, Bruce L Levine, PhD, Don L. Siegel, MD PhD, Shannon L. Maude, MD PhD, Stephen J. Schuster, MD, Edward A. Stadtmauer, MD FACP, Stephan Grupp, MD PhD, David L. Porter, MD, Carl H June, MD, J. Joseph Melenhorst, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 622.
https://doi.org/10.1182/blood-2019-122513
Published: 2019
Journal Articles

CD20-TCB, a Novel T-Cell-Engaging Bispecific Antibody, Induces T-Cell-Mediated Killing in Relapsed or Refractory Non-Hodgkin Lymphoma: Biomarker Results From a Phase I Dose-Escalation Trial

Free
Ann-Marie E Bröske, PhD, Ian James, PhD, Anton Belousov, PhD, Enrique Gomez, PhD, Marta Canamero, MD PhD, Chia-Huey Ooi, PhD, Nils Grabole, PhD, Sabine Wilson, PhD, Koorosh Korfi, PhD, Nicole A Kratochwil, PhD, Peter N Morcos, PharmD, Cristiano Ferlini, MD, Denise Thomas, MSc, Natalie Dimier, PhD, Tom Moore, MBChB, Marina Bacac, PhD, Martin Weisser, MD, Michael Dickinson, MBBS,FRACP,FRCPA
Journal: Blood
Blood (2019) 134 (Supplement_1): 5319.
https://doi.org/10.1182/blood-2019-123979
Published: 2019
Journal Articles

NLRP6 in Donor T Cells Separately Regulates CD4 and CD8 Mediated Graft-Versus-Host Disease in Experimental Murine BMT

Free
Masahiro Suto, Eri Matsuki, MD, Erika Sekiguchi, Hiroya Tamaki, MD PhD, Isao Tawara, MD PhD, Grace Chen, MD PhD, Kenichi Ishizawa, MD PhD, Pavan Reddy, Tomomi Toubai
Journal: Blood
Blood (2019) 134 (Supplement_1): 1926.
https://doi.org/10.1182/blood-2019-123875
Published: 2019
Journal Articles

A GUT Microbiota Score Predicting for ACUTE GRAFT-Versus-Host Disease

Free
Lijie Han, PhD, Jie Peng, MD, Ke Zhao, MD, Zhiping Fan, MD, Hua Jin, Haiyan Zhang, MD, Hui Sun, Qifa Liu, MD, Zhongxing Jiang, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1991.
https://doi.org/10.1182/blood-2019-126518
Published: 2019
Journal Articles

Aberrant SYK Expression As a Potential Therapeutic Target in T/NK Cell Neoplasms

Free
Jing-Ping Zhang, PhD, Qi Gao, MLS, Alexander Chan, MD, Wenbin Xiao, MD PhD, Sary El Daker, PhD, Mikhail Roshal, MD PhD, Ahmet Dogan, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3978.
https://doi.org/10.1182/blood-2019-130406
Published: 2019
Journal Articles

The Lymphoma Tumor Microenvironment Influences Toxicity after CD19 CAR T Cell Therapy

Free
Michael D. Jain, MD PhD, Rawan Faramand, MD, Verena Staedtke, MD PhD, Renyuan Bai, MBBS, Sae Bom Lee, Hiroshi Kotani, MD PhD, Kayla Reid, Kristen Spitler, Julio Chavez, Bijal Shah, MD, Christina A Bachmeier, PharmD, Marian Dam, ARNP, Brigett Brandjes, PA, Ricardo J Gonzalez, MD, John E Mullinax, MD PhD, Xuefeng Wang, PhD, Mohammad Hussaini, MD, Frederick L. Locke, MD, Marco L. Davila, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4105.
https://doi.org/10.1182/blood-2019-127305
Published: 2019
Journal Articles

Neddylation Pathway Regulates Treg Differentiation and T Cell Function in Chronic Lymphocytic Leukemia (CLL) Ex Vivo and Murine In Vivo Studies

Free
Scott R Best, BS, Vi Lam, Nur Bruss, BS, Taylor Hashiguchi Rowland, BS, Adam S. Kittai, MD, Tingting Liu, Allison J Berger, PhD, Alexey Danilov, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4313.
https://doi.org/10.1182/blood-2019-123600
Published: 2019
Journal Articles

Anti-CD6 Monoclonal Antibody Itolizumab Efficiently Inhibits T Cell Proliferation after in Vitro TCR Stimulation in the Setting of Acute Graft Versus Host Disease

Free
Benedetta Rambaldi, MD, Carol Reynolds, PhD, Sharmila Chamling Rai, BSc, Takeru Asano, MD PhD, Yohei Arihara, MD PhD, Mahasweta Gooptu, MD, John Koreth, MBBS, DPhil, Corey Cutler, MD MPH, FRCPC, Sarah Nikiforow, MD PhD, Vincent T. Ho, MD, Edwin P. Alyea, III, MD, Joseph H. Antin, MD, Rizwan Romee, MD PhD, Robert J. Soiffer, MD, Domenico Russo, MD, Jeanette Ampudia, BSc, Cherie Tracy Ng, PhD MPH, Stephen Connelly, PhD MBA, Jerome Ritz, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4517.
https://doi.org/10.1182/blood-2019-125721
Published: 2019
Journal Articles

Frequency of Marrow Infiltrating PD-1 Expressing CD4 Effectors Following Autologous Stem Cell Transplant (ASCT) for Multiple Myeloma Is Prognostic for Clinical Outcome

Free
Nouf Alrasheed, Lydia Lee, Huw Richards, William Wilson, Oliver C Cohen, MBBS, BSc, FRCPath, Selina J Chavda, Jake Henry, Andrew Furness, Melody Chin, Daria Galas-Filipowicz, Charalampia Kyriakou, Neil K Rabin, Sergio A Quezada, Kwee Yong
Journal: Blood
Blood (2019) 134 (Supplement_1): 4368.
https://doi.org/10.1182/blood-2019-126682
Published: 2019
Journal Articles

Stanozolol and Danazol Have Different Effects on Hematopoiesis in Murine Model of Immune-Mediated Bone Marrow Failure

Free
Hongmin Li, MD, Zhangbiao Long, MD, Bing Han, Zhao Wang, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2506.
https://doi.org/10.1182/blood-2019-126318
Published: 2019
Journal Articles

Immune Phenotyping of Cytotoxic T-Cells Reveals a Novel Population of TIM3 Expressing Cells That Lack PD1 and Are Associated with Good Outcomes in Marginal Zone Lymphoma

Free
Theodora Anagnostou, MD, Zhi-Zhang Yang, MD, Hyojin Kim, PhD, Shahrzad Jalali, PhD, Jose C Villasboas, Hongyan Wu, PhD, Tammy Price-Troska, BS, Anne J Novak, PhD, Stephen M Ansell, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2790.
https://doi.org/10.1182/blood-2019-127757
Published: 2019
Journal Articles

Long Term Responses to Venetoclax and Ibrutinib in Mantle Cell Lymphoma Are Associated with Immunological Recovery and Prognostic Changes in Inflammatory Biomarkers

Free
Joanne Davis, PhD, Sasanka M Handunnetti, MBBS, Chia Sharpe, Gillian Turner, Mary Ann Anderson, MBBS, PhD FRACP, FRCPA, Andrew W. Roberts, MBBS, PhD, John F. Seymour, MBBS, PhD FRACP, Constantine S. Tam, MBBS, MD, David Ritchie, MD PhD, Rachel Koldej
Journal: Blood
Blood (2019) 134 (Supplement_1): 2791.
https://doi.org/10.1182/blood-2019-122974
Published: 2019
Journal Articles

Intra-Tumoral CD8+ T-Cells in Follicular Lymphoma Contain Large Clonal Expansions That Are Amenable to Dual-Checkpoint Blockade

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Karthik Nath, MBBS, Soi C. Law, Muhammed B. Sabdia, Lilia Merida De Long, Mohamed Shanavas, MD, Joshua W.D. Tobin, MD, Jay Gunawardana, PhD, Frank Vari, PhD, Sarah-Jane Halliday, Annette Hernandez, BS, Donna Cross, Robert J. Bird, FRACP,FRCP,FRCPA,MBBS,MRCP, Colm Keane, MD, Maher K. Gandhi, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2793.
https://doi.org/10.1182/blood-2019-130050
Published: 2019
Journal Articles

Genome-Wide microRNA Expression Profiling in Molecular Subgroups of Peripheral T-Cell Lymphoma Identified Role of Mir-126 in T-Cell Lymphomagenesis

Free
Waseem Lone, PhD, Alyssa Bouska, PhD, Tyler Herek, BS,MS, Catalina Amador, MD, Mallick Saumyaranajn, MD, Yu Jiayu, Tayla Heavican, Stefano A. Pileri, MD PhD, Timothy McKeithan, MD PhD, Wing C. Chan, MD, Javeed Iqbal, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2767.
https://doi.org/10.1182/blood-2019-129327
Published: 2019
Journal Articles

Intravital Imaging of Bright Cyan-Fluorescent AML Model Reveals Impact of CXCR4 Inhibitor on AML and Immune Cell Dynamics

Free
Tomasz Zal, PhD, Mateusz Rytelewski, PhD, Rodrigo Jacamo, PhD, Malgorzata Anna Zal, MSc, Meenakshi Shanmugasundaram, Michael Andreeff, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2674.
https://doi.org/10.1182/blood-2019-131945
Published: 2019
Journal Articles

Evaluation of T-Cell Compartment By Complex Multiparameter Flow Cytometry Reveals Distinct Patterns of T-Cell Exhaustion in DLBCL, FL and HL Patients

Free
Alexis Vallée, Mitra Shourian, PhD, Nathalie Johnson, MD, Hélène Decaluwe
Journal: Blood
Blood (2019) 134 (Supplement_1): 2806.
https://doi.org/10.1182/blood-2019-130647
Published: 2019
Journal Articles

Phase 1 Results of CNCT19: CD19 CAR Constructed of a New Anti-CD19 Chimeric Antigen Receptor in Relapsed or Refractory Acute Lymphoblastic Leukemia

Free
Runxia Gu, Fang Liu, Dehui Zou, MD, Bingcheng Liu, Wei Liu, Xiaojuan Chen, MD, Kaiqi Liu, Ye Guo, MD, Xiaoyuan Gong, Rui Lv, Xia Chen, Chunlin Zhou, Mengjun Zhong, Yingxi Xu, Huijun Wang, Hui Wei, MD, Yingchang Mi, MD, Lugui Qiu, MD PhD, Lulu Lv, Min Wang, MD, Ying Wang, MD, Xiaofan Zhu, MD, Jianxiang Wang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2622.
https://doi.org/10.1182/blood-2019-125342
Published: 2019
Journal Articles

Cross Talk between the Immune Compartment and the Tumor Cells in Myelodysplastic Syndromes (MDS)

Free
Camille Bigenwald, MD, Amir Horowitz, PhD, Shyamala C. Navada, MD, Rosalie Odchimar-Reissig, RN, Richa Rai, PhD, Stella Melana, PhD, Erin P. Demakos, RN, Miriam Merad, MD, Lewis R. Silverman, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2986.
https://doi.org/10.1182/blood-2019-124887
Published: 2019
Journal Articles

Modulation of the IL-6/STAT3 Signaling Axis in CD4 + T Cells As a Potential Immune Mechanism of Action of Azacytidine in High-Risk Myelodysplastic Syndromes

Free
Eleftheria Lamprianidou, Chrysoula Kordella, Anastasiya Kazachenka, Emmanouela Zoulia, Elsa Bernard, PhD, Anastasia Filia, Stamatia Laidou, Theodoros P. Vassilakopoulos, MD PhD, Sotirios Papageorgiou, MD PhD, Vassiliki Pappa, MD, Athanasios Galanopoulos, MD PhD, Nora-Athina Viniou, MD PhD, Evangelia Nakou, Anastasia Hadzidimitriou, PhD, George Kassiotis, Elli Papaemmanuil, PhD, Ioannis Mitroulis, Ioannis Kotsianidis
Journal: Blood
Blood (2019) 134 (Supplement_1): 2988.
https://doi.org/10.1182/blood-2019-126504
Published: 2019
Journal Articles

Single-Antibody Detection of T-Cell Receptor Beta Chain Monotypia Resolves Uncertainties in the Identification and Quantitation of Sézary Cells By Routine Flow Cytometry: Towards Accurate and Unequivocal Blood Staging of Cutaneous T-Cell Lymphomas

Free
Pedro Horna, MD, Min Shi, MD PhD, Dragan Jevremovic, MD PhD, Horatiu Olteanu, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2848.
https://doi.org/10.1182/blood-2019-129477
Published: 2019