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Journal Articles

Proteomic Profiling and Mechanistic Investigating of a Novel Anti-Cancer Small Molecule Inhibitor of Sec61

Yu Qian, PhD, Henry W.B. Johnson, PhD, Christopher J. Kirk, PhD, Eric Lowe, BS, Dustin McMinn, PhD, Beatriz Millare, BS, Tony Muchamuel, MS, Jinhai Wang, PhD

Blood (2019) 134 (Supplement_1): 2076.

https://doi.org/10.1182/blood-2019-125988

Published: 2019

Journal Articles

CD244 Marks Non-Functional Hematopoietic Stem Cells with a Mast Cell Signature after Induction of Endoplasmic Reticulum Stress

Valgardur Sigurdsson, PhD, Shuhei Koide, PhD, Visnja Radulovic, PhD, Els Mansell, PhD, Mark Van Der Garde, MSc, PhD, Tiit Örd, PhD, Tonis Örd, PhD, Kenichi Miharada, PhD

Blood (2019) 134 (Supplement_1): 2474.

https://doi.org/10.1182/blood-2019-128239

Published: 2019

Journal Articles

Targeting the Activating Mutations of NOTCH1 in T-Cell Lymphoblastic Leukemia with a New SERCA Inhibitor CAD204520

Matteo Marchesini, PhD, Andrea Gherli, Anna Montanaro, Samuel Kitara, Claudia Sorrentino, Luca Pagliaro, Anne-Marie Lund Winter, Chiara Rompietti, Donatella Stilli, Federica Rizzi, Kimberly Stegmaier, MD, Paolo Sportoletti, William Dalby-Brown, Giovanni Roti

Blood (2019) 134 (Supplement_1): 407.

https://doi.org/10.1182/blood-2019-125616

Published: 2019

Journal Articles

The Unfolded Protein Response Causes Prothrombotic Transformation of Pancreatic Cancer Linking Tumor Progression with Cancer-Associated Thrombosis

Oluwatoyosi Muse, PhD, Rushad Patell, MD, Christian Peters, PhD, Sol Schulman, MD PhD, Emale Darzi, MS, Calvin Schuster, BA, Ling Huang, PhD, Shibani Mukherjee, PhD, Senthil Muthuswamy, PhD, Jeffrey I. Zwicker, MD, Robert C. Flaumenhaft, MD PhD

Blood (2019) 134 (Supplement_1): 632.

https://doi.org/10.1182/blood-2019-123544

Published: 2019

Journal Articles

Autonomous Ca 2+ Oscillations Reflect Oncogenic Signaling in B-ALL Cells

Kohei Kume, PhD, Liting Chen, PhD, Jaewoong Lee, PhD, Markus Müschen, MD PhD

Blood (2019) 134 (Supplement_1): 1253.

https://doi.org/10.1182/blood-2019-130708

Published: 2019

Journal Articles

Transcriptomic and Metabolomic Profiling Identifies Calcium-Dependent Signaling Mechanisms As a Novel and Exploitable Target to Overcome Anti-CD20 Resistance in Non-Hodgkin Lymphoma (NHL)

Ravi Dashnamoorthy, PhD, Saheli Sarkar, PhD, Afshin Beheshti, PhD, Maisarah Mokhtar, B.S, Tali Konry, PhD, Michael Levin, PhD, Andrew M. Evens, DO, MSc

Blood (2019) 134 (Supplement_1): 1511.

https://doi.org/10.1182/blood-2019-126539

Published: 2019

Journal Articles

A New Therapeutic Hypothesis: Nonsense-Mediated Decay Is an Exploitable Target in Multiple Myeloma

Alexander Leeksma, MD, Ingrid A.M. Derks, Brett Garrick, Torsten Trowe, Aldo Jongejan, PhD, Perry Moerland, PhD, Arnon P. Kater, MD, Eric Eldering, PhD, Ellen Filvaroff, PhD

Blood (2018) 132 (Supplement 1): 1937.

https://doi.org/10.1182/blood-2018-99-114801

Published: 2018

Journal Articles

NR4A3 Suppresses Lymphomagenesis I n Vitro and In Vivo by Induction of Similar Patterns of Pro-Apoptotic Genes like NR4A1

Alexander JA Deutsch, PhD, Beate Rinner, Martin Pichler, Karoline Fechter, Hildegard T. Greinix, MD, Chenguang Wang, Christine Beham-Schmid, MD, Peter Neumeister, MD

Blood (2016) 128 (22): 2728.

https://doi.org/10.1182/blood.V128.22.2728.2728

Published: 2016

Journal Articles

Conditional Expression of Mutant ELANE Produces Unfolded Protein Response but Fails to Promote Cell Death or Differentiation Block: What Is the Mechanism for Severe Congenital Neutropenia?

Hrishikesh M Mehta, PhD, Arighno Das, BA, Ralph Kamel, MD, Marshall Horwitz, MD PhD, Seth Corey, MD MPH

Blood (2016) 128 (22): 3899.

https://doi.org/10.1182/blood.V128.22.3899.3899

Published: 2016

Journal Articles

N-RasG12D-Mediated Dysregulation of IRE1alpha-Xbp1s Signaling Promotes Pre-Leukemic Hematopoietic Stem Cell Expansion

Lu Liu, PhD, Meiling Zhao, MS, Kevin B Yang, Xi Jin, PhD, Gina Ney, MD PhD, Juan Del Valle, BS, PhD, Takao Iwawaki, PhD, Qing Li, MD PhD

Blood (2016) 128 (22): 567.

https://doi.org/10.1182/blood.V128.22.567.567

Published: 2016

Journal Articles

The Carboxy-Terminal Domain of Calreticulin (CALR) Exports the Glucocorticoid Receptor (GR) from the Nucleus to the Cytoplasm of Human Erythroid Cells Resetting Their Stress Response

Anna Rita Migliaccio, PhD, Mario Falchi, PhD, Lilian Varricchio, PhD, Fabrizio Martelli, PhD, Francesca Masiello, MS, Manuela Marra, PhD, Orietta Picconi, Agostino Tafuri, MD, Gabriella Girelli, MD, Carolyn F. Whitsett, MD

Blood (2016) 128 (22): 545.

https://doi.org/10.1182/blood.V128.22.545.545

Published: 2016

Journal Articles

The MAP3K Apoptosis Signal-Regulating Kinase 1 (ASK1) Functions As a Calcium-Dependent Regulator of Platelet Activation Downstream of the G(α) q -PLC Signaling Axis

Randall J. Derstine, M.S., Meghna U. Naik, M.Sc., Ulhas P. Naik, PhD FAHA

Blood (2016) 128 (22): 3720.

https://doi.org/10.1182/blood.V128.22.3720.3720

Published: 2016

Journal Articles

Leukemia-Specific Delivery of Mutant NOTCH1 Targeted Therapy

Giovanni Roti, MD PhD, Jun Qi, PhD, Samuel Kitara, Anthony C. Varca, Marta Sanchez-Martin, PhD, Andrew L. Kung, MD PhD, Adolfo A. Ferrando, MD PhD, James E. Bradner, MD, Kimberly Stegmaier, MD

Blood (2016) 128 (22): 889.

https://doi.org/10.1182/blood.V128.22.889.889

Published: 2016

Journal Articles

C-Jun Regulates ER Stress Signaling to Promote Chemotherapy Resistance in Acute Myeloid Leukemia

Chun Zhou, PhD, Daniela Di Marcantonio, PhD, Esteban Martinez, Nehal Solanki-Patel, Suraj Peri, PhD, Claudia Scholl, Stefan Fröhling, David L. Wiest, PhD, Stephen Matthew Sykes, PhD

Blood (2015) 126 (23): 2464.

https://doi.org/10.1182/blood.V126.23.2464.2464

Published: 2015

Journal Articles

Therapeutic Synergy from Combined Inhibition of the SERCA Channel and MAPK Signaling Pathway in MAPK-Dependent Leukemia

Meng Wang, MD PhD MRCP, Ugur Eskiocak, PhD, Michalis Agathokleous, PhD, Stacy Yuan, Charles Crawley, MD(London) FRCP FCPath, Sean J. Morrison, PhD

Blood (2015) 126 (23): 1264.

https://doi.org/10.1182/blood.V126.23.1264.1264

Published: 2015

Journal Articles

Crispr Sgrnas Genome-Wide Screen Identifies the Proteasome Regulatory Subunit PSMC6 As a Bortezomib Resistance Gene in Human Multiple Myeloma Cells

Chang-Xin Shi, PhD, Klaus M Kortum, MD, Yuan Xiao Zhu, PhD, Patrick Jedlowski, Esteban Braggio, PhD, Laura Ann Bruins, Patrick G. Votruba, M.S., Moulun Luo, PhD, Robert A. Stewart, Jonathan M. Ahmann, A. Keith Stewart

Blood (2015) 126 (23): 450.

https://doi.org/10.1182/blood.V126.23.450.450

Published: 2015

Journal Articles

NR4A3 Possesses Tumor Suppressive Properties like NR4A1 By Regulating Pro-Apoptotic Genes in Aggressive Lymphomas and Serves As a Potential Drug Target for Lymphoma Therapy

Alexander JA Deutsch, PhD, Beate Rinner, PhD, Kerstin Wenzl, MSc, Katharina Troppan, MD, Beata Pursche, Hildegard T. Greinix, MD, Christine Beham-Schmid, MD, Peter Neumeister, MD

Blood (2015) 126 (23): 2674.

https://doi.org/10.1182/blood.V126.23.2674.2674

Published: 2015

Journal Articles

Selectively Targeting Mutated NOTCH1 with a Folate-Thapsigargin Derivative

Giovanni Roti, MD, Jun Qi, PhD, Angela Su, B.S., Antony Varca, B.S., Jon C Aster, MD PhD, James E. Bradner, Kimberly Stegmaier, MD

Blood (2014) 124 (21): 2158.

https://doi.org/10.1182/blood.V124.21.2158.2158

Published: 2014

Journal Articles

A Small Molecule, Shikonin, Dually Functions As a Proteasome Inhibitor and a Necroptosis Inducer In Multiple Myeloma Cells

Naoko Wada, MD, Yawara Kawano, MD, PhD, Shiho Fujiwara, MD, Yoshitaka Kikukawa, MD, PhD, Yutaka Okuno, MD, PhD, Hiroaki Mitsuya, MD, PhD, Hiroyuki Hata, MD, PhD

Blood (2013) 122 (21): 3172.

https://doi.org/10.1182/blood.V122.21.3172.3172

Published: 2013

Journal Articles

Bim-Targeting Therapy Circumvents Adaptive Bortezomib-Resistance In Myeloma Through a Novel Cross-Link Between Autophagy and Apoptosis

Shuang Chen, MD/PhD, Yun Dai, MD, PhD, Yu Zhang, PhD, Liang Zhou, MD/PhD, Hui Lin, MD, Xin-Yan Pei, Robert Z. Orlowski, M.D., Ph.D., Steven Grant, MD

Blood (2013) 122 (21): 601.

https://doi.org/10.1182/blood.V122.21.601.601

Published: 2013

NARROW

Proteomic Profiling and Mechanistic Investigating of a Novel Anti-Cancer Small Molecule Inhibitor of Sec61

CD244 Marks Non-Functional Hematopoietic Stem Cells with a Mast Cell Signature after Induction of Endoplasmic Reticulum Stress

Targeting the Activating Mutations of NOTCH1 in T-Cell Lymphoblastic Leukemia with a New SERCA Inhibitor CAD204520

The Unfolded Protein Response Causes Prothrombotic Transformation of Pancreatic Cancer Linking Tumor Progression with Cancer-Associated Thrombosis

Autonomous Ca 2+ Oscillations Reflect Oncogenic Signaling in B-ALL Cells

Transcriptomic and Metabolomic Profiling Identifies Calcium-Dependent Signaling Mechanisms As a Novel and Exploitable Target to Overcome Anti-CD20 Resistance in Non-Hodgkin Lymphoma (NHL)

A New Therapeutic Hypothesis: Nonsense-Mediated Decay Is an Exploitable Target in Multiple Myeloma

NR4A3 Suppresses Lymphomagenesis I n Vitro and In Vivo by Induction of Similar Patterns of Pro-Apoptotic Genes like NR4A1

Conditional Expression of Mutant ELANE Produces Unfolded Protein Response but Fails to Promote Cell Death or Differentiation Block: What Is the Mechanism for Severe Congenital Neutropenia?

N-RasG12D-Mediated Dysregulation of IRE1alpha-Xbp1s Signaling Promotes Pre-Leukemic Hematopoietic Stem Cell Expansion

The Carboxy-Terminal Domain of Calreticulin (CALR) Exports the Glucocorticoid Receptor (GR) from the Nucleus to the Cytoplasm of Human Erythroid Cells Resetting Their Stress Response

The MAP3K Apoptosis Signal-Regulating Kinase 1 (ASK1) Functions As a Calcium-Dependent Regulator of Platelet Activation Downstream of the G(α) q -PLC Signaling Axis

Leukemia-Specific Delivery of Mutant NOTCH1 Targeted Therapy

C-Jun Regulates ER Stress Signaling to Promote Chemotherapy Resistance in Acute Myeloid Leukemia

Therapeutic Synergy from Combined Inhibition of the SERCA Channel and MAPK Signaling Pathway in MAPK-Dependent Leukemia

Crispr Sgrnas Genome-Wide Screen Identifies the Proteasome Regulatory Subunit PSMC6 As a Bortezomib Resistance Gene in Human Multiple Myeloma Cells

NR4A3 Possesses Tumor Suppressive Properties like NR4A1 By Regulating Pro-Apoptotic Genes in Aggressive Lymphomas and Serves As a Potential Drug Target for Lymphoma Therapy

Selectively Targeting Mutated NOTCH1 with a Folate-Thapsigargin Derivative

A Small Molecule, Shikonin, Dually Functions As a Proteasome Inhibitor and a Necroptosis Inducer In Multiple Myeloma Cells

Bim-Targeting Therapy Circumvents Adaptive Bortezomib-Resistance In Myeloma Through a Novel Cross-Link Between Autophagy and Apoptosis

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American Society of Hematology

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American Society of Hematology

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