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Journal Articles

Pivotal role of PDK1 in megakaryocyte cytoskeletal dynamics and polarization during platelet biogenesis

Sascha Geue, Katja Aurbach, Mailin-Christin Manke, Georgi Manukjan, Patrick Münzer, David Stegner, Caroline Brähler, Britta Walker-Allgaier, Melanie Märklin, Carla E. Borst, Leticia Quintanilla-Fend, Dominik Rath, Tobias Geisler, Helmut R. Salih, Peter Seizer, Florian Lang, Bernhard Nieswandt, Meinrad Gawaz, Harald Schulze, Irina Pleines, Oliver Borst
Journal: Blood
Blood (2019) 134 (21): 1847–1858.
https://doi.org/10.1182/blood.2019000185
Published: 2019
Includes: Multimedia, Supplemental data
Journal Articles

Selective Targeting of Histone Deacetylase 11 Disables Metabolism of Myeloproliferative Neoplasms

Vasundhara Sharma, PhD, Lanzhu Yue, MD, Nathan P. Horvat, MDCandidate, Agni Christodoulidou, PhD, Afua Adutwumwa Akuffo, PhDCandidate, Mathew Beatty, PhD, Cem Murdun, MS, Julia Billington, PhDCandidate, William E Goodheart, MS, PhDCandidate, Eva Sahakian, PhD, Ling Zhang, MD, John J. Powers, BS, Narmin E. Amin, Que T. Lambert-Showers, Lancia Darville, PhD, Javier Pinilla Ibarz, MD PhD, Gary W. Reuther, Jennifer Lee, PhD, Xiaozhang Zheng, PhD, Pui Yee Ng, PhD, Mathew W. Martin, PhD, Gary C. Marshall, PhD, John M. Koomen, PhD, Ross L. Levine, MD, Amit Verma, MBBS, H. Leighton Grimes, PhD, Eduardo Sotomayor, MD, Zonghong Shao, MD, Kenneth Wright, PhD, Pearlie K. Epling-Burnette
Journal: Blood
Blood (2019) 134 (Supplement_1): 474.
https://doi.org/10.1182/blood-2019-127235
Published: 2019
Journal Articles

Decline in Insulin-like Growth Factor-1 (IGF1) from Aged Mesenchymal Stromal Cells Is a Targetable Mechanism to Rescue Hematopoietic Stem Cell Aging

Kira Young, PhD, Elizabeth Eudy, BS, Matthew Loberg, BA, Rebecca Bell, BA, Jennifer Trowbridge, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 526.
https://doi.org/10.1182/blood-2019-124534
Published: 2019
Journal Articles

Anticancer Activity of a Highly Potent Small Molecule Tubulin Polymerization Inhibitor, AB8939

Martine Humbert, PhD, Armelle Goubard, PhD, Colin Mansfield, PhD, Olivier Hermine, MD PhD, Patrice Dubreuil, PhD, The AB8939 Study Group
Journal: Blood
Blood (2019) 134 (Supplement_1): 2075.
https://doi.org/10.1182/blood-2019-122540
Published: 2019
Journal Articles

Super-Resolution Immunofluorescence Imaging of Platelet Granules

Maurice Swinkels, MSc, BSc, Johan A. Slotman, PhD, Frank W.G. Leebeek, MD PhD, Jan Voorberg, PhD, Ruben Bierings, PhD, Gerard Jansen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3613.
https://doi.org/10.1182/blood-2019-124353
Published: 2019
Journal Articles

In Vivo Evaluation of Mesothelin As a Therapeutic Target in Pediatric Acute Myeloid Leukemia

Anilkumar Gopalakrishnapillai, PhD, Allison Kaeding, MD, Christoph Schatz, PhD, Anette Sommer, PhD, Soheil Meshinchi, MD PhD, E. Anders Kolb, MD, Sonali Barwe, PhD MSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 1370.
https://doi.org/10.1182/blood-2019-123794
Published: 2019
Journal Articles

Brentuximab Vedotin in Front-Line Therapy of Hodgkin Lymphoma (HL) and CD30-Expressing Peripheral T-Cell Lymphoma (PTCL) in Adults Age 60 and Above

Christopher A. Yasenchak, MD, Rodolfo Bordoni, MD, Victor Yazbeck, MD, Dipti Patel-Donnelly, MD, Timothy Larson, MD, Trevor Newhook, MS, Linda Ho, Matthew Mei, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2852.
https://doi.org/10.1182/blood-2019-122968
Published: 2019
Journal Articles

Distinct Bone Marrow Microenvironment Abnormalities in MDS and MPN with Fibrosis

Cao Sy Luan, MS, Yoshiaki Takahoko, MS, Hidekazu Nishikii, MD PhD, Naoshi Obara, MD PhD, Tatsuhiro Sakamoto, MD PhD, Takayasu Kato, MD PhD, Keiichiro Hattori, MD PhD, Ryota Matsuoka, MD PhD, Shingo Sakashita, MD PhD, Yasuhito Nannya, MD PhD, Hideki Makishima, MD PhD, Mamiko Sakata-Yanagimoto, MD PhD, Seishi Ogawa, MD PhD, Shigeru Chiba, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2976.
https://doi.org/10.1182/blood-2019-129423
Published: 2019
Journal Articles

Exploitation of a Newly Characterized Metabolic-Cytoskeletal Axis for Effective Combination Therapy of Iron Restricted Anemia

Adam N Goldfarb, MD, Katie Freeman, BA, Alejandro Ariel Gru, MD, Zollie White, III, MS, Lorrie L Delehanty, BS
Journal: Blood
Blood (2019) 134 (Supplement_1): 2233.
https://doi.org/10.1182/blood-2019-129172
Published: 2019
Journal Articles

KIFC1 Mediates Centrosome Clustering Prior to Proplatelet Formation from Megakaryocytes

Adrian R. Wilkie, PhD, Leila J. Noetzli, PhD, Genevieve Couldwell, Anthony R. Sciaudone, Anjana Ray, PhD, Kellie R. Machlus, PhD, Joseph E. Italiano, Jr., BS, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 721.
https://doi.org/10.1182/blood-2019-130803
Published: 2019
Journal Articles

ATRA Could Correct the Defective S1P-Mediated Cytoskeletal Reorganization in Proplatelet Formation of ITP

Qiu-Sha Huang, Jing Xue, Chen-Cong Wang, Ya-Zhen Qin, Lan-Ping Xu, Kaiyan Liu, Xiao-Jun Huang, MD, Xiao-Hui Zhang
Journal: Blood
Blood (2019) 134 (Supplement_1): 218.
https://doi.org/10.1182/blood-2019-126384
Published: 2019
Journal Articles

A Phase 2 Study of Retreatment with Brentuximab Vedotin in Patients with cHL, sALCL or Other CD30-Expressing PTCL

Sairah Ahmed, MD, Julie Lisano, PharmD, Trevor Newhook, MS
Journal: Blood
Blood (2019) 134 (Supplement_1): 4054.
https://doi.org/10.1182/blood-2019-121523
Published: 2019
Journal Articles

AB8939, a Microtubule-Destabilizing Agent with Potential to Overcome Multidrug Resistance, Is Active across the Range (M0-M7) of Acute Myeloid Leukemia Subtypes

Armelle Goubard, PhD, Martine Humbert, PhD, Colin Mansfield, PhD, Olivier Hermine, MD PhD, Patrice Dubreuil, PhD, The AB8939 Study Group
Journal: Blood
Blood (2019) 134 (Supplement_1): 5154.
https://doi.org/10.1182/blood-2019-127021
Published: 2019
Journal Articles

Ex vivo Engineering of Platelets

Koji Eto, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): SCI-6.
https://doi.org/10.1182/blood-2019-121116
Published: 2019
Journal Articles

MiR-193a Is a Negative Regulator of Hematopoietic Stem Cells and Promotes Anti-Leukemic Effects in Acute Myeloid Leukemia

Kathrin Krowiorz, Raj Bhayadia, Razan Jammal, Caroline Pabst, Nicole Pochert, MSc, Christoph Rueß, MSc, Christina Miller, Konstanze Döhner, MD, Tobias Maetzig, PhD, Hartmut Döhner, MD, Lars Bullinger, MD, Stephan Emmrich, PhD MSc, Dirk Heckl, PhD, Vera Martins, Reinhild Rösler, PhD, Sebastian Wiese, PhD, R. Keith Humphries, MD PhD, Arefeh Rouhi, PhD, Jan-Henning Klusmann, Florian Kuchenbauer, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2627.
https://doi.org/10.1182/blood-2018-99-116256
Published: 2018
Journal Articles

Combination of Momelotinib and Citarinostat Show Strong Synergistic Effect in Lymphoid Cell Lines Co-Targeting JAK2/STAT3 and HDAC6

Maria Cosenza, MS, Monica Civallero, PhD, Stefano Sacchi, MD, Samantha Pozzi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3506.
https://doi.org/10.1182/blood-2018-99-116468
Published: 2018
Journal Articles

Mitochondrial Regulation Is Essential for Erythroid Nuclear Clearance

Raymond Liang, PhD, Vijay Menon, PhD, Miao Lin, Msc, Roberta Nowak, Velia M. Fowler, PhD, Geoffrey Girnun, Saghi Ghaffari, MDPhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 843.
https://doi.org/10.1182/blood-2018-99-120063
Published: 2018
Journal Articles

Targeting CD45 with an Amanitin Antibody-Drug Conjugate Effectively Depletes Human HSCs and Immune Cells for Transplant Conditioning

Rahul Palchaudhuri, PhD, Bradley R Pearse, PhD, Jennifer L Proctor, BS, Sharon L. Hyzy, MS, Sharon Aslanian, MS, Sean M McDonough, MS, Ganapathy Sarma, PhD, Melissa L. Brooks, BS, Anjali Bhat, MS, Danielle Ladwig, MS, Molly A McShea, MS, Nathan M Kallen, BA, Qing Li, PhD, Rajiv Panwar, PhD, Junia Dushime, BS, Pranoti Sawant, MS, Hillary L Adams, MS, Patrick C. Falahee, PhD, Tahirih L Lamothe, Andrew D Gabros, Lena Kien, BS, Geoff Gillard, PhD, Charlotte F McDonagh, PhD, Anthony E. Boitano, PhD, Michael P. Cooke, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4526.
https://doi.org/10.1182/blood-2018-99-117167
Published: 2018
Journal Articles

Efficacy of a New Small-Molecule Inhibitor of Histone Deacetylase 6 (HDAC6) in Preclinical Models of B-Cell Lymphoma and Acute Myeloid Leukemia

Montserrat Perez-Salvia, PhD, Aldaba Eneko, Vara Yosu, Fabre Myriam, Ferrer Cristina, Masdeu Carme, Zubia Aizpea, San Sebastian Eider, Otaegui Dorleta, Llinàs-Arias Pere, Rosselló-Tortella Margalida, Berdasco Maria, Setien Fernando, Moutinho Catia, Villanueva Alberto, Eva González-Barca, MD PhD, Josep Muncunill, MSc, Jose Tomas Navarro, MD PhD, Miguel Angel Piris, PhD MD, Cossio Fernando, Manel Esteller, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5383.
https://doi.org/10.1182/blood-2018-99-111578
Published: 2018
Journal Articles

Elucidation of the IMiDs-Resistant Mechanism and Development of the Overcoming Drugs Inducing CRBN Independent G2/M Cell Cycle Arrest in Myeloma Cells

Ryo Uozaki, Shuji Aida, Takasi Yamagughi, Tomofumi Yamamoto, BPharm, Sho Kashiwazaki, Hiroshi Yanagawa, Daiju Ichikawa, Maiko Matsushita, Yutaka Hattori
Journal: Blood
Blood (2018) 132 (Supplement 1): 4451.
https://doi.org/10.1182/blood-2018-99-115909
Published: 2018