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Journal Articles

Comprehensive Genomic Characterization of Refractory Multiple Myeloma Reveals a Complex Mutational and Structural Landscape Associated with Drug Resistance

Nicola Lehners, MD, Umut H Toprak, Jing Xu, Nagarajan Paramasivam, Daniel Hübschmann, Martina Fröhlich, Nur H Md Hanafiah, Sadaf Mughal, Elias K Mai, MD, Anna Jauch, Jens Hillengass, MD, Roland Eils, Carsten Müller-Tidow, Benedikt Brors, Hartmut Goldschmidt, MD, Matthias Schlesner, Marc S Raab, MD PhD

Blood (2017) 130 (Supplement 1): 266.

https://doi.org/10.1182/blood.V130.Suppl_1.266.266

Published: 2017

Journal Articles

USP7 inhibition alters homologous recombination repair and targets CLL cells independently of ATM/p53 functional status

Blood (2017) 130 (2): 156–166.

https://doi.org/10.1182/blood-2016-12-758219

Published: 2017

Includes: Supplemental data

Journal Articles

Therapeutic Targeting of the Histone Ubiquitination-Methylation Axis in T Cell Leukemia

Panagiotis Ntziachristos, PhD, Kelly Arcipowski, PhD, Carlos Alberto Martinez, Yixing Zhu, Andrew G. Volk, PhD, Suresh Kumar, Paul M Thomas, PhD, Pieter Van Vlierberghe, PhD, Nobuko Hijiya, MD, Stacy Marshall, Jack Wang, Jian Wu, Neil L Kelleher, PhD, John Crispino, PhD MBA

Blood (2016) 128 (22): 1532.

https://doi.org/10.1182/blood.V128.22.1532.1532

Published: 2016

Journal Articles

Inhibition of USP10 Induces Degradation of Oncogenic FLT3: A Novel Approach to Therapy of Leukemia

Sara Buhrlage, PhD, Ellen Weisberg, MD, Nathan Schauer, Jing Yang, PhD, Ilaria Lamberto, PhD, Laura Doherty, Atsushi Nonami, MDPhD, Amanda L. Christie, BS, David M. Weinstock, MD, Richard M. Stone, MD, Nathanael Gray, PhD, James D Griffin, MD

Blood (2016) 128 (22): 524.

https://doi.org/10.1182/blood.V128.22.524.524

Published: 2016

Journal Articles

Usp18 Is Required for Normal Stem Cell Maintenance

Kei-ichiro Arimoto, PhD, Yue Zhang, Ming Yan, PhD, Sayuri Miyauchi, DDS, PhD, Stephanie Weng, PhD, Samuel A. Stoner, Takahiro Shima, MD PhD, Yukiko Komeno, MD PhD, Kentson Lam, MD PhD, Dong-Er Zhang, PhD

Blood (2016) 128 (22): 3863.

https://doi.org/10.1182/blood.V128.22.3863.3863

Published: 2016

Journal Articles

Role of Lncrnas in Early Stage Immunoglobulin Heavy Chain Variable Region (IGHV) Unmutated CLL Disease Progression

Renee C. Tschumper, Susan L. Slager, PhD, Tait D. Shanafelt, MD, Neil E. Kay, MD, Diane F. Jelinek, PhD

Blood (2016) 128 (22): 4364.

https://doi.org/10.1182/blood.V128.22.4364.4364

Published: 2016

Journal Articles

USP47 Is a New Target in Chronic Myelogenous Leukemia

Hu Lei, Chunmin Ma, Zhen Liu, Shenmeng Gao, Li Zhou, Weiwei Wang, Hanzhang Xu, Fenghou Gao, Yingli Wu, Han Liu, PhD

Blood (2015) 126 (23): 1572.

https://doi.org/10.1182/blood.V126.23.1572.1572

Published: 2015

Journal Articles

Small Molecule Inhibitors of USP1 Target ID1 Degradation in Leukemic Cells and Cause Cytotoxicity

Helena Mistry, Ph.D., Grace Hsieh, M.D., Sara Buhrlage, Ph.D, Min Huang, Ph.D., Eunmi Park, Ph.D., Gregory Cuny, Ph.D., Ilene Galinsky, ANP, Richard M. Stone, MD, Nathanael S Gray, PhD, Kalindi Parmar, PhD, Alan D. D'Andrea, MD

Blood (2013) 122 (21): 2906.

https://doi.org/10.1182/blood.V122.21.2906.2906

Published: 2013

Journal Articles

GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1α

Daniela Flügel, Agnes Görlach, Thomas Kietzmann

Blood (2012) 119 (5): 1292–1301.

https://doi.org/10.1182/blood-2011-08-375014

Published: 2012

Includes: Supplemental data

Journal Articles

Regulation of TLR Signaling by USP7.

Yaohong Tan, MD, Ph.D, Joseph D. Rosenblatt, MD, Howard J. Federoff, MD, Ph. D, William J. Bowers, Ph.D, Khaled A. Tolba, MD

Blood (2007) 110 (11): 2300.

https://doi.org/10.1182/blood.V110.11.2300.2300

Published: 2007

Journal Articles

Secondary Bortezomib-Resistance Is Characterized by Upregulation of Proteasomal Subunits and Their Insufficient Inhibition by Bortezomib, Which Can Be Overcome by Alternative Proteasome Inhibitors Combined with Induction of the ER Stress Response.

Thomas Ruckrich, Jeannette Gogel, Marianne Kraus, Huib Ovaa, Christoph Driessen

Blood (2006) 108 (11): 2583.

https://doi.org/10.1182/blood.V108.11.2583.2583

Published: 2006

Journal Articles

The Ubiquitin Specific Peptidase 42 Gene ( USP42) Is Recurrently Involved as a Fusion Gene with RUNX1 in Acute Myeloid Leukemia with the t(7;21)(p22;q22) Cryptic Translocation.

Amelie Giguere, Sawcene Hazourli, Douja Meftah, Raouf Fetni, Pierre Chagnon, Josee Hebert

Blood (2006) 108 (11): 4273.

https://doi.org/10.1182/blood.V108.11.4273.4273

Published: 2006

Journal Articles

Acquired Bortezomib (Velcade®)-Resistance Is Accompanied by Downmodulation of Proteasome Activity and Upregulation of Tripeptidyl Peptidase II (TPPII) and a Ubiquitin-Specific Protease.

Christoph Driessen, Jeanette Gogel, Marianne Kraus, Huib Ovaa, Alexander Beck, Thomas Rückrich

Blood (2005) 106 (11): 3375.

https://doi.org/10.1182/blood.V106.11.3375.3375

Published: 2005

Journal Articles

Activity Profiling of Proteasome Subunits and Deubiquitinating Enzymes in Human Hematopoetic Malignancies.

Christoph Driessen, Marianne Kraus, Jeanette Gogel, Alexander Beck, Winfried Kammer, Huib Ovaa, Herman Overkleeft, Thomas Rückrich

Blood (2005) 106 (11): 617.

https://doi.org/10.1182/blood.V106.11.617.617

Published: 2005

Journal Articles

Gene Expression Profiling of Myeloma Cells at Diagnosis Can Predict Response to Therapy with Thalidomide and Dexamethasone Combination.

Shaji Kumar, MD, Philip R. Greipp, MD, Jessica Haug, MD, Michael Kline, PhD, Wee Joo Chng, Emily Blood, MS, Leif Bergsagel, MD, John A. Lust, MD, Morie A. Gertz, MD, Rafael Fonseca, MD, S. Vincent Rajkumar, MD

Blood (2005) 106 (11): 508.

https://doi.org/10.1182/blood.V106.11.508.508

Published: 2005

Journal Articles

Quantitative Proteomic Profiling of Primary Cutaneous CD30+ T-Cell Lymphoma Progression.

Kalpana S. Reddy, MD, David K. Crockett, Marshall E. Kadin, MD, Kojo S.J. Elenitoba-Johnson, MD, Megan S. Lim, MD, PhD

Blood (2004) 104 (11): 2270.

https://doi.org/10.1182/blood.V104.11.2270.2270

Published: 2004

NARROW

Comprehensive Genomic Characterization of Refractory Multiple Myeloma Reveals a Complex Mutational and Structural Landscape Associated with Drug Resistance

USP7 inhibition alters homologous recombination repair and targets CLL cells independently of ATM/p53 functional status

Therapeutic Targeting of the Histone Ubiquitination-Methylation Axis in T Cell Leukemia

Inhibition of USP10 Induces Degradation of Oncogenic FLT3: A Novel Approach to Therapy of Leukemia

Usp18 Is Required for Normal Stem Cell Maintenance

Role of Lncrnas in Early Stage Immunoglobulin Heavy Chain Variable Region (IGHV) Unmutated CLL Disease Progression

USP47 Is a New Target in Chronic Myelogenous Leukemia

Small Molecule Inhibitors of USP1 Target ID1 Degradation in Leukemic Cells and Cause Cytotoxicity

GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1α

Regulation of TLR Signaling by USP7.

Secondary Bortezomib-Resistance Is Characterized by Upregulation of Proteasomal Subunits and Their Insufficient Inhibition by Bortezomib, Which Can Be Overcome by Alternative Proteasome Inhibitors Combined with Induction of the ER Stress Response.

The Ubiquitin Specific Peptidase 42 Gene ( USP42) Is Recurrently Involved as a Fusion Gene with RUNX1 in Acute Myeloid Leukemia with the t(7;21)(p22;q22) Cryptic Translocation.

Acquired Bortezomib (Velcade®)-Resistance Is Accompanied by Downmodulation of Proteasome Activity and Upregulation of Tripeptidyl Peptidase II (TPPII) and a Ubiquitin-Specific Protease.

Activity Profiling of Proteasome Subunits and Deubiquitinating Enzymes in Human Hematopoetic Malignancies.

Gene Expression Profiling of Myeloma Cells at Diagnosis Can Predict Response to Therapy with Thalidomide and Dexamethasone Combination.

Quantitative Proteomic Profiling of Primary Cutaneous CD30+ T-Cell Lymphoma Progression.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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