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Issue Archive

Volume 4, Issue 21
November 10 2020
Blood Advances Cover Image for Volume 4, Issue 21

Table of Contents

EXCEPTIONAL CASE REPORT

B-lymphoblastic leukemia arising in a patient with chronic neutrophilic leukemia
Clinical Trials & Observations
Craig S. Boddy,Brent T. Tan,Joseph Aoki
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STIMULUS REPORTS

Outcome of patients with IDH1/2-mutated post–myeloproliferative neoplasm AML in the era of IDH inhibitors
Clinical Trials & Observations
Helen T. Chifotides,Lucia Masarova,Mansour Alfayez,Naval Daver,Yesid Alvarado,Elias Jabbour,Marina Konopleva,Hagop M. Kantarjian,Keyur P. Patel,Courtney D. DiNardo,Srdan Verstovsek
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CD34 expression does not correlate with immunophenotypic stem cell or progenitor content in human cord blood products
Sruthi Mantri,Andreas Reinisch,Beruh T. Dejene,Deirdre J. Lyell,David L. DiGiusto,Rajni Agarwal-Hashmi,Ravindra Majeti,Kenneth I. Weinberg,Matthew H. Porteus
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Supplemental data
Bone marrow dendritic cell aggregates associate with systemic immune dysregulation in chronic myelomonocytic leukemia
Abhishek A. Mangaonkar,Kaaren K. Reichard,Moritz Binder,Giacomo Coltro,Terra L. Lasho,Ryan M. Carr,April Chiu,Vivian Negron,Mehrdad Hefazi,Theodora Anagnostou,Michael M. Timm,James W. Hiebert,Jose C. Villasboas,Wilson I. Gonsalves,Naseema Gangat,Mithun Shah,Hassan B. Alkhateeb,Aref Al-Kali,Michelle A. Elliott,Kebede H. Begna,Alexandra P. Wolanskyj-Spinner,Mark R. Litzow,William J. Hogan,Stephen M. Ansell,Animesh Pardanani,Ayalew Tefferi,Mrinal M. Patnaik
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Supplemental data
Epigenetic silencing of HTLV-1 expression by the HBZ RNA through interference with the basal transcription machinery
Hélène Gazon,Pradeep Singh Chauhan,Florent Porquet,Gabriela Brunsting Hoffmann,Roberto Accolla,Luc Willems
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Supplemental data

REVIEW ARTICLES

Handling challenging questions in the management of chronic myeloid leukemia: when is it safe to stop tyrosine kinase inhibitors?
Clinical Trials & Observations
Delphine Rea
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Which patients are at high risk of recurrent venous thromboembolism (deep vein thrombosis and pulmonary embolism)?
Clinical Trials & Observations
Fionnuala Ní Áinle,Barry Kevane
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CLINICAL TRIALS AND OBSERVATIONS

The design of a Bayesian platform trial to prevent and eradicate inhibitors in patients with hemophilia
Clinical Trials & Observations
Marnie Bertolet,Maria M. Brooks,Margaret V. Ragni
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Supplemental data
Efficacy and safety of carfilzomib-based regimens in frail patients with relapsed and/or refractory multiple myeloma
Clinical Trials & Observations
Thierry Facon,Ruben Niesvizky,Maria-Victoria Mateos,David Siegel,Cara Rosenbaum,Sara Bringhen,Katja Weisel,P. Joy Ho,Heinz Ludwig,Shaji Kumar,Kenneth Wang,Mihaela Obreja,Zhao Yang,Zandra Klippel,Khalid Mezzi,Amanda Goldrick,Christina Tekle,Meletios A. Dimopoulos
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Supplemental data
Secondary CNL after SAA reveals insights in leukemic transformation of bone marrow failure syndromes
Clinical Trials & Observations
Laurent Schmied,Patricia A. Olofsen,Pontus Lundberg,Alexandar Tzankov,Martina Kleber,Jörg Halter,Mario Uhr,Peter J. M. Valk,Ivo P. Touw,Jakob Passweg,Beatrice Drexler
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Supplemental data
A phase 3 randomized study of 5-azacitidine maintenance vs observation after transplant in high-risk AML and MDS patients
Clinical Trials & Observations
Betül Oran,Marcos de Lima,Guillermo Garcia-Manero,Peter F. Thall,Ruitao Lin,Uday Popat,Amin M. Alousi,Chitra Hosing,Sergio Giralt,Gabriela Rondon,Glenda Woodworth,Richard E. Champlin
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HEALTH SERVICES AND OUTCOMES

Gender differences in question-asking at the 2019 American Society of Hematology Annual Meeting
Saira Moazzam,Lynn Onstad,Heather O’Leary,Ariela Marshall,Ifeyinwa Osunkwo,Emily Du,Tamara Dunn,Julianne Dunlap,Bill Reed,Selina Luger,Stephanie J. Lee
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Decisional involvement and information preferences of patients with hematologic malignancies
Kah Poh Loh,Mazie Tsang,Thomas W. LeBlanc,Anthony Back,Paul R. Duberstein,Supriya Gupta Mohile,Ronald M. Epstein,Heidi D. Klepin,Michael W. Becker,Areej El-Jawahri,Stephanie J. Lee
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HEMATOPOIESIS AND STEM CELLS

Abortive γδTCR rearrangements suggest ILC2s are derived from T-cell precursors
Samuel B. Shin,Bernard C. Lo,Maryam Ghaedi,R. Wilder Scott,Yicong Li,Melina Messing,Diana Canals Hernaez,Jessica Cait,Taka Murakami,Michael R. Hughes,Kevin B. Leslie,T. Michael Underhill,Fumio Takei,Kelly M. McNagny
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Supplemental data
FOXO activity adaptation safeguards the hematopoietic stem cell compartment in hyperglycemia
Vinothini Govindarajah,Jung-Mi Lee,Michael Solomon,Bryan Goddard,Ramesh Nayak,Kalpana Nattamai,Hartmut Geiger,Nathan Salomonis,Jose A. Cancelas,Damien Reynaud
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Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Public and private human T-cell clones respond differentially to HCMV antigen when boosted by CD3 copotentiation
Laura R. E. Becher,Wendy K. Nevala,Shari Lee Sutor,Megan Abergel,Michele M. Hoffmann,Christopher A. Parks,Larry R. Pease,Adam G. Schrum,Svetomir N. Markovic,Diana Gil
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Supplemental data
Real-world evidence of tisagenlecleucel for pediatric acute lymphoblastic leukemia and non-Hodgkin lymphoma
Clinical Trials & Observations
Marcelo C. Pasquini,Zhen-Huan Hu,Kevin Curran,Theodore Laetsch,Frederick Locke,Rayne Rouce,Michael A. Pulsipher,Christine L. Phillips,Amy Keating,Matthew J. Frigault,Dana Salzberg,Samantha Jaglowski,Joshua P. Sasine,Joseph Rosenthal,Monalisa Ghosh,Daniel Landsburg,Steven Margossian,Paul L. Martin,Manali K. Kamdar,Peiman Hematti,Sarah Nikiforow,Cameron Turtle,Miguel-Angel Perales,Patricia Steinert,Mary M. Horowitz,Amy Moskop,Lida Pacaud,Lan Yi,Raghav Chawla,Eric Bleickardt,Stephan Grupp
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Supplemental data

MYELOID NEOPLASIA

Whole transcriptome sequencing detects a large number of novel fusion transcripts in patients with AML and MDS
Anna Stengel,Rabia Shahswar,Torsten Haferlach,Wencke Walter,Stephan Hutter,Manja Meggendorfer,Wolfgang Kern,Claudia Haferlach
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Supplemental data
CD200 expression marks leukemia stem cells in human AML
Jenny M. Ho,Stephanie M. Dobson,Veronique Voisin,Jessica McLeod,James A. Kennedy,Amanda Mitchell,Liqing Jin,Kolja Eppert,Gary Bader,Mark D. Minden,John E. Dick,Jean C. Y. Wang
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Supplemental data
Genetic factors rather than blast reduction determine outcomes of allogeneic HCT in BCR-ABL–negative MPN in blast phase
Clinical Trials & Observations
Vikas Gupta,James A. Kennedy,Jose-Mario Capo-Chichi,Soyoung Kim,Zhen-Huan Hu,Edwin P. Alyea,Uday R. Popat,Ronald M. Sobecks,Bart L. Scott,Aaron T. Gerds,Rachel B. Salit,H. Joachim Deeg,Ryotara Nakamura,Wael Saber
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Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

The transition of M-CSF–derived human macrophages to a growth-promoting phenotype
Kajal Hamidzadeh,Ashton T. Belew,Najib M. El-Sayed,David M. Mosser
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Supplemental data

THROMBOSIS AND HEMOSTASIS

Frequency of venous thromboembolism in 6513 patients with COVID-19: a retrospective study
Clinical Trials & Observations
Jason B. Hill,David Garcia,Mark Crowther,Bryan Savage,Shira Peress,Kevin Chang,Steven Deitelzweig
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Incidence of VTE in asymptomatic children with deficiencies of antithrombin, protein C, and protein S: a prospective cohort study
Clinical Trials & Observations
Daniela Tormene,Elena Campello,Chiara Simion,Giacomo Turatti,Michelangelo Marobin,Claudia Maria Radu,Anna Pontarin,Paolo Prandoni,Paolo Simioni
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Created using Biorender

A genetic modifier of venous thrombosis in zebrafish reveals a functional role for fibrinogen AαE in early hemostasis
Cristina Freire,Richard J. Fish,Rui Vilar,Corinne Di Sanza,Steven J. Grzegorski,Catherine E. Richter,Jordan A. Shavit,Marguerite Neerman-Arbez
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Supplemental data
Activated platelet-based inhibition of fibrinolysis via thrombin-activatable fibrinolysis inhibitor activation system
Yuko Suzuki,Hideto Sano,Liina Mochizuki,Naoki Honkura,Tetsumei Urano
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Supplemental data

TRANSFUSION MEDICINE

Elevated plasma levels of syndecan-1 and soluble thrombomodulin predict adverse outcomes in thrombotic thrombocytopenic purpura
Ruinan Lu,Jingrui Sui,X. Long Zheng
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Supplemental data
Processing methods and storage duration impact extracellular vesicle counts in red blood cell units
Clementine Gamonet,Maxime Desmarets,Guillaume Mourey,Sabeha Biichle,Sophie Aupet,Caroline Laheurte,Anne François,Eric Resch,Frédéric Bigey,Delphine Binda,Laurent Bardiaux,Christian Naegelen,Nadine Marpaux,Fanny Angelot Delettre,Philippe Saas,Pascal Morel,Pierre Tiberghien,Jacques Lacroix,Gilles Capellier,Chrystelle Vidal,Francine Garnache-Ottou
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Supplemental data
Pathogen-reduced PRP blocks T-cell activation, induces Treg cells, and promotes TGF-β expression by cDCs and monocytes in mice
Johnson Q. Tran,Marcus O. Muench,Rachael P. Jackman
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Supplemental data

COMMENTARY

In response to “American Society of Hematology 2020 guidelines for treating newly diagnosed acute myeloid leukemia in older adults”
Pavan Reddy,on behalf of the Board of Directors of the American Society for Transplantation and Cellular Therapy,Stella Davies,on behalf of the Board of Directors of the American Society for Transplantation and Cellular Therapy,Navneet Majhail,on behalf of the Board of Directors of the American Society for Transplantation and Cellular Therapy,Brenda Sandmaier,on behalf of the Board of Directors of the American Society for Transplantation and Cellular Therapy,Parameswaran Hari,on behalf of the Board of Directors of the American Society for Transplantation and Cellular Therapy,Corey Cutler,on behalf of the Board of Directors of the American Society for Transplantation and Cellular Therapy
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All Issues

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