Defense-oriented inflammatory reactivity supports survival at younger age but might contribute to health impairments in modern, aging societies. The interleukin-1 (IL-1) cytokines are highly conserved and regulated, pleiotropic mediators of inflammation, essential to respond adequately to infection and tissue damage but also with potential host damaging effects when left unresolved. In this review, we discuss how continuous low-level IL-1 signaling contributes to aging-associated hematopoietic stem and progenitor cell (HSPC) functional impairments and how this inflammatory selective pressure acts as a driver of more profound hematological alterations, such as clonal hematopoiesis of indeterminate potential, and to overt HSPC diseases, like myeloproliferative and myelodysplastic neoplasia as well as acute myeloid leukemia. Based on this, we outline how IL-1 pathway inhibition might be used to prevent or treat inflammaging-associated HSPC pathologies.
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REVIEW ARTICLE|
July 25, 2024
IL-1 in aging and pathologies of hematopoietic stem cells
Francisco Caiado,
Francisco Caiado
Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich, Zurich, Switzerland
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Markus G. Manz
Markus G. Manz
Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich, Zurich, Switzerland
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Blood (2024) 144 (4): 368–377.
Article history
Submitted:
February 28, 2024
Accepted:
May 13, 2024
First Edition:
May 23, 2024
Citation
Francisco Caiado, Markus G. Manz; IL-1 in aging and pathologies of hematopoietic stem cells. Blood 2024; 144 (4): 368–377. doi: https://doi.org/10.1182/blood.2023023105
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