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Issue Archive

Volume 139, Issue 16
April 21 2022
Issue Cover

Table of Contents

EDITORIAL

Introduction to a review series on normal and pathologic erythropoiesis
Mario Cazzola
View Articletitled, Introduction to a review series on normal and pathologic erythropoiesis

BLOOD COMMENTARIES

The rise of Apollo, protector of telomeres
Marcin W. Wlodarski
View Articletitled, The rise of Apollo, protector of telomeres
New immunotherapeutic target in myeloma
Wee Joo Chng
View Articletitled, New immunotherapeutic target in myeloma
Firing up chromatin to forge T-ALL
Mark Y. Chiang
View Articletitled, Firing up chromatin to forge T-ALL
CNS prophylaxis in DLBCL: first do no harm
Craig A. Portell
View Articletitled, CNS prophylaxis in DLBCL: first do no harm
GATA1: function through disorder
John Strouboulis,Antonella E. Ronchi
View Articletitled, GATA1: function through disorder
Blocking (iron) traffic in the gut
Karin E. Finberg
View Articletitled, Blocking (iron) traffic in the gut

PLENARY PAPER

Inherited human Apollo deficiency causes severe bone marrow failure and developmental defects
Laëtitia Kermasson,Dmitri Churikov,Aya Awad,Riham Smoom,Elodie Lainey,Fabien Touzot,Séverine Audebert-Bellanger,Sophie Haro,Lauréline Roger,Emilia Costa,Maload Mouf,Adriana Bottero,Matias Oleastro,Chrystelle Abdo,Jean-Pierre de Villartay,Vincent Géli,Yehuda Tzfati,Isabelle Callebaut,Silvia Danielian,Gabriela Soares,Caroline Kannengiesser,Patrick Revy
View Articletitled, Inherited human Apollo deficiency causes severe bone marrow failure and developmental defects
Supplemental data
The rise of Apollo, protector of telomeres
Marcin W. Wlodarski
View Articletitled, The rise of Apollo, protector of telomeres

REVIEW SERIES

Breakthrough science: hypoxia-inducible factors, oxygen sensing, and disorders of hematopoiesis
Gregg L. Semenza
View Articletitled, Breakthrough science: hypoxia-inducible factors, oxygen sensing, and disorders of hematopoiesis
Introduction to a review series on normal and pathologic erythropoiesis
Mario Cazzola
View Articletitled, Introduction to a review series on normal and pathologic erythropoiesis
Molecular and cellular mechanisms that regulate human erythropoiesis
Alexis L. Caulier,Vijay G. Sankaran
View Articletitled, Molecular and cellular mechanisms that regulate human erythropoiesis
Introduction to a review series on normal and pathologic erythropoiesis
Mario Cazzola
View Articletitled, Introduction to a review series on normal and pathologic erythropoiesis
Ineffective erythropoiesis and its treatment
Mario Cazzola
View Articletitled, Ineffective erythropoiesis and its treatment
Introduction to a review series on normal and pathologic erythropoiesis
Mario Cazzola
View Articletitled, Introduction to a review series on normal and pathologic erythropoiesis

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Unbiased cell surface proteomics identifies SEMA4A as an effective immunotherapy target for myeloma
Georgina S.F. Anderson,Jose Ballester-Beltran,George Giotopoulos,Jose A. Guerrero,Sylvanie Surget,James C. Williamson,Tsz So,David Bloxham,Anna Aubareda,Ryan Asby,Ieuan Walker,Lesley Jenkinson,Elizabeth J. Soilleux,James P. Roy,Ana Teodósio,Catherine Ficken,Leah Officer-Jones,Sara Nasser,Sheri Skerget,Jonathan J. Keats,Peter Greaves,Yu-Tzu Tai,Kenneth C. Anderson,Marion MacFarlane,James E. Thaventhiran,Brian J.P. Huntly,Paul J. Lehner,Michael A. Chapman
View Articletitled, Unbiased cell surface proteomics identifies SEMA4A as an effective immunotherapy target for myeloma
Supplemental data
New immunotherapeutic target in myeloma
Wee Joo Chng
View Articletitled, New immunotherapeutic target in myeloma

LYMPHOID NEOPLASIA

Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology in T-ALL
Mateusz Antoszewski,Nadine Fournier,Gustavo A. Ruiz Buendía,Joao Lourenco,Yuanlong Liu,Tara Sugrue,Christelle Dubey,Marianne Nkosi,Colin E.J. Pritchard,Ivo J. Huijbers,Gabriela C. Segat,Sandra Alonso-Moreno,Elisabeth Serracanta,Laura Belver,Adolfo A. Ferrando,Giovanni Ciriello,Andrew P. Weng,Ute Koch,Freddy Radtke
View Articletitled, Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology in T-ALL
Supplemental data
Firing up chromatin to forge T-ALL
Mark Y. Chiang
View Articletitled, Firing up chromatin to forge T-ALL
Timing of high-dose methotrexate CNS prophylaxis in DLBCL: a multicenter international analysis of 1384 patients
Matthew R. Wilson,Toby A. Eyre,Amy A. Kirkwood,Nicole Wong Doo,Carole Soussain,Sylvain Choquet,Nicolás Martinez-Calle,Gavin Preston,Matthew Ahearne,Elisabeth Schorb,Marie-Pierre Moles-Moreau,Matthew Ku,Chiara Rusconi,Jahanzaib Khwaja,Mayur Narkhede,Katharine L. Lewis,Teresa Calimeri,Eric Durot,Loïc Renaud,Andreas Kiesbye Øvlisen,Graham McIlroy,Timothy J. Ebsworth,Johnathan Elliot,Anna Santarsieri,Laure Ricard,Nimish Shah,Qin Liu,Adam S. Zayac,Francesco Vassallo,Laure Lebras,Louise Roulin,Naelle Lombion,Kate Manos,Ruben Fernandez,Nada Hamad,Alberto Lopez-Garcia,Deirdre O'Mahony,Praveen Gounder,Nathalie Forgeard,Charlotte Lees,Kossi Agbetiafa,Tim Strüßmann,Thura Win Htut,Aline Clavert,Hamish Scott,Anna Guidetti,Brett R. Barlow,Emmanuelle Tchernonog,Jeffery Smith,Fiona Miall,Christopher P. Fox,Chan Y. Cheah,Tarec Christoffer El Galaly,Andrés J.M. Ferreri,Kate Cwynarski,Pamela McKay
View Articletitled, Timing of high-dose methotrexate CNS prophylaxis in DLBCL: a multicenter international analysis of 1384 patients
Supplemental data
CNS prophylaxis in DLBCL: first do no harm
Craig A. Portell
View Articletitled, CNS prophylaxis in DLBCL: first do no harm

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Impaired p47phox phosphorylation in neutrophils from patients with p67phox-deficient chronic granulomatous disease
Sahra Amel Belambri,Viviana Marzaioli,Margarita Hurtado-Nedelec,Coralie Pintard,Shiyu Liang,Yezhou Liu,Tarek Boussetta,Marie-Anne Gougerot-Pocidalo,Richard D. Ye,Pham My-Chan Dang,Jamel El-Benna
View Articletitled, Impaired p47phox phosphorylation in neutrophils from patients with p67phox-deficient chronic granulomatous disease
Supplemental data

PLATELETS AND THROMBOPOIESIS

Deletion of platelet CLEC-2 decreases GPIbα-mediated integrin αIIbβ3 activation and decreases thrombosis in TTP
Bojing Shao,Christopher Hoover,Huiping Shi,Yuji Kondo,Robert H. Lee,Junmei Chen,Xindi Shan,Jianhua Song,J. Michael McDaniel,Meixiang Zhou,Samuel McGee,Karen Vanhoorelbeke,Wolfgang Bergmeier,José A. López,James N. George,Lijun Xia
View Articletitled, Deletion of platelet CLEC-2 decreases GPIbα-mediated integrin αIIbβ3 activation and decreases thrombosis in TTP
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Congenital anemia reveals distinct targeting mechanisms for master transcription factor GATA1
Leif S. Ludwig,Caleb A. Lareau,Erik L. Bao,Nan Liu,Taiju Utsugisawa,Alex M. Tseng,Samuel A. Myers,Jeffrey M. Verboon,Jacob C. Ulirsch,Wendy Luo,Christoph Muus,Claudia Fiorini,Meagan E. Olive,Christopher M. Vockley,Mathias Munschauer,Abigail Hunter,Hiromi Ogura,Toshiyuki Yamamoto,Hiroko Inada,Shinichiro Nakagawa,Shuichi Ohzono,Vidya Subramanian,Roberto Chiarle,Bertil Glader,Steven A. Carr,Martin J. Aryee,Anshul Kundaje,Stuart H. Orkin,Aviv Regev,Timothy L. McCavit,Hitoshi Kanno,Vijay G. Sankaran
View Articletitled, Congenital anemia reveals distinct targeting mechanisms for master transcription factor GATA1
Supplemental data
GATA1: function through disorder
John Strouboulis,Antonella E. Ronchi
View Articletitled, GATA1: function through disorder
Modulation of the HIF2α-NCOA4 axis in enterocytes attenuates iron loading in a mouse model of hemochromatosis
Nupur K. Das,Chesta Jain,Amanda Sankar,Andrew J. Schwartz,Naiara Santana-Codina,Sumeet Solanki,Zhiguo Zhang,Xiaoya Ma,Sanjana Parimi,Liangyou Rui,Joseph D. Mancias,Yatrik M. Shah
View Articletitled, Modulation of the HIF2α-NCOA4 axis in enterocytes attenuates iron loading in a mouse model of hemochromatosis
Supplemental data
Blocking (iron) traffic in the gut
Karin E. Finberg
View Articletitled, Blocking (iron) traffic in the gut

THROMBOSIS AND HEMOSTASIS

Natural history of PF4 antibodies in vaccine-induced immune thrombocytopenia and thrombosis
Brian Craven,William Lester,Sara Boyce,Will Thomas,Angela Kanny,Claire Davies,Sue Pavord,Joannes Hermans,Michael Makris,Emily Bart-Smith,Sarah Arnott,Beverley J. Hunt,Pavel Chudakou,Anthony Calvert,Deepak Singh,Marie Scully
View Articletitled, Natural history of PF4 antibodies in vaccine-induced immune thrombocytopenia and thrombosis
Supplemental data

LETTERS TO BLOOD

De novo and relapsed immune thrombocytopenia after COVID-19 vaccines: results of French safety monitoring
Guillaume Moulis,Etienne Crickx,Laure Thomas,Nathalie Massy,Matthieu Mahévas,Marie-Blanche Valnet-Rabier,Marina Atzenhoffer,Marc Michel,Bertrand Godeau,Haleh Bagheri,Francesco Salvo
View Articletitled, De novo and relapsed immune thrombocytopenia after COVID-19 vaccines: results of French safety monitoring
Supplemental data
Immune-mediated thrombotic thrombocytopenic purpura following COVID-19 vaccination
Adrien Picod,Jean-Michel Rebibou,Antoine Dossier,Bérengère Cador,David Ribes,Claire Vasco-Moynet,Caroline Stephan,Mathieu Bellal,Alain Wynckel,Pascale Poullin,Edwige Péju,Laure Ricard,Jean-Emmanuel Kahn,Raïda Bouzid,Ygal Benhamou,Bérangère Joly,Agnès Veyradier,Paul Coppo
View Articletitled, Immune-mediated thrombotic thrombocytopenic purpura following COVID-19 vaccination
SARS-CoV-2 vaccination and immune thrombotic thrombocytopenic purpura
Hridaya Shah,Ann Kim,Senthil Sukumar,Marshall Mazepa,Ruhail Kohli,Evan M. Braunstein,Robert A. Brodsky,Spero Cataland,Shruti Chaturvedi
View Articletitled, SARS-CoV-2 vaccination and immune thrombotic thrombocytopenic purpura
Supplemental data

BLOOD WORK

Pure erythroid leukemia evolved from JAK2V617F-positive polycythemia vera: blast phase transformation along erythroid line
Yue Zhao,Endi Wang
View Articletitled, Pure erythroid leukemia evolved from <em>JAK2</em><sup>V617F</sup>-positive polycythemia vera: blast phase transformation along erythroid line

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

Human Apollo deficiency causes IBMFS
CME
View Articletitled, Human Apollo deficiency causes IBMFS
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