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Achim Heinecke
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Journal Articles

Comparison of Treatment Strategies in Patients over 60 Years with AML: Final Analysis of a Prospective Randomized German AML Intergroup Study

Dietger Niederwieser, MD, Verena Sophia Hoffmann, Dr., Markus Pfirrmann, PhD, Haifa Kathrin Al-Ali, MD, Sebastian Schwind, MD, Vladan Vucinic, MD, Rainer Krahl, PhD, Christoph Kahl, Hans-Heinrich Wolf, MD, Ute Kreibich, Prof., Detlef Hähling, Ute Hegenbart, MD, Carsten Hirt, Norma Peter, MD, Axel Florschuetz, Kolja Reifenrath, Antje Schulze, Niklas Zojer, MD, Sebastian Scholl, Christian Junghanss, MD, Wolfram Pönisch, Simone Heyn, MD, Herbert G. Sayer, Andreas Hochhaus, MD, Thomas Heinicke, MD, Thomas Fischer, MD, Alwin Krämer, MD, Peter Dreger, MD, Georg Maschmeyer, MD, Utz Krug, Maria Christina Sauerland, MSc, Achim Heinecke, Rüdiger Hehlmann, MD, Eva Lengfelder, MD, Wolfgang Hiddemann, MD, Hubert Serve, MD, Carsten Müller-Tidow, Wolfgang E Berdel, MD, Thomas Büchner
Journal: Blood
Blood (2016) 128 (22): 1066.
https://doi.org/10.1182/blood.V128.22.1066.1066
Published: 2016
Journal Articles

Up-Front Randomization 10 Years Later: The AML Cooperative Group Strategy

Thomas Buchner, MD, Wolfgang E. Berdel, MD, Bernhard J. Woermann, MD, Maria Cristina Sauerland, MSc, Achim Heinecke, PhD, Utz Krug, MD, Wolfgang Hiddemann, MD
Journal: Blood
Blood (2014) 124 (21): 2267.
https://doi.org/10.1182/blood.V124.21.2267.2267
Published: 2014
Journal Articles

A Combined Molecular and Clinical Prognostic Index For Relapse and Survival In Cytogenetically Normal AML (PINA)

Friederike Pastore, MD, Annika Dufour, PhD, Tobias Benthaus, MD, Klaus H. Metzeler, MD, Kati Maharry, MAS, Stephanie Schneider, PhD, Bianka Ksienzyk, Gudrun Mellert, Evelyn Zellmeier, Purvi M. Kakadia, PhD, Michael Unterhalt, M.D. Ph.D., Michaela Feuring-Buske, MD, Christian Buske, MD, Jan Braess, MD, Cristina Sauerland, MSc, Achim Heinecke, PhD, Utz Krug, MD, Wolfgang E. Berdel, MD, Thomas Büchner, MD, Bernhard J. Woermann, MD, Wolfgang Hiddemann, MD, Stefan K. Bohlander, MD, Guido Marcucci, MD, Karsten Spiekermann, MD, Clara D. Bloomfield, MD, Eva Hoster, PhD
Journal: Blood
Blood (2013) 122 (21): 1303.
https://doi.org/10.1182/blood.V122.21.1303.1303
Published: 2013
Journal Articles

Acute Myeloid Leukemia: The Outcome Is Determined By Age, Genetic Group, White Blood Cell Count, Lactate Dehydrogenase, Rather Than By Chemotherapy Intensity

Thomas Buchner, MD, Wolfgang E. Berdel, MD, Utz Krug, MD, Claudia Haferlach, MD, Susanne Schnittger, PhD, Torsten Haferlach, MD, Carsten Mueller-Tidow, MD, Matthias Stelljes, MD, Rolf M. Mesters, MD, Hubert Serve, MD, Jan Braess, MD, Karsten Spiekermann, MD, Peter Staib, MD, Andreas Grueneisen, MD, Albrecht Reichle, MD, Leopold Balleisen, MD, Hartmut Eimermacher, MD, Aristoteles Giagounidis, MD, PhD, Herbert Rasche, MD, Eva Lengfelder, M.D. Ph.D., Andreas Faldum, MD, Maria Cristina Sauerland, MSc, Achim Heinecke, PhD, Rüdiger Hehlmann, MD, Bernhard J. Woermann, MD, Wolfgang Hiddemann, MD
Journal: Blood
Blood (2013) 122 (21): 1447.
https://doi.org/10.1182/blood.V122.21.1447.1447
Published: 2013
Journal Articles

Acute Myeloid Leukemia: Longterm Outcome Predicted by Age and Genetic Groups

Thomas Buchner, MD, Wolfgang E. Berdel, MD, Utz Krug, Claudia Haferlach, MD, Susanne Schnittger, PhD, Matthias Stelljes, MD, Gerda Silling, MD, Peter Staib, MD, Andreas Grueneisen, MD, Albrecht Reichle, Leopold Balleisen, MD, Hartmut Eimermacher, MD, Aristoteles Giagounidis, MD, Herbert Rasche, MD, Eva Lengfelder, MD, Cristina Sauerland, MSc, Achim Heinecke, PhD, Bernhard Josef Woermann, MD, Wolfgang Hiddemann, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 1509.
https://doi.org/10.1182/blood.V120.21.1509.1509
Published: 2012
Journal Articles

Allogeneic Stem Cell Transplantation Versus Conventional Postremission Therapy for Acute Myeloid Leukemia in First Complete Remission: A Matched Pairs Analysis

Matthias Stelljes, MD, Utz Krug, Dietrich Beelen, Jan Braess, MD, Maria Cristina Sauerland, Achim Heinecke, PhD, Tim Sauer, MD, Petra Tschanter, MD, Gabriela B. Thoennissen, MD, Hans-Jochem Kolb, MD, Albrecht Reichle, Ernst Holler, MD, Rainer Schwerdtfeger, Renate Arnold, MD, Christof Scheid, MD, Carsten Müller-Tidow, Bernhard J. Woermann, MD, Wolfgang Hiddemann, MD, PhD, Wolfgang E. Berdel, MD, Thomas Büchner, MD
Journal: Blood
Blood (2012) 120 (21): 1974.
https://doi.org/10.1182/blood.V120.21.1974.1974
Published: 2012
Journal Articles

The FLT3 ITD mRNA level has a high prognostic impact in NPM1 mutated, but not in NPM1 unmutated, AML with a normal karyotype

Brief Report
Friederike Schneider, Eva Hoster, Michael Unterhalt, Stephanie Schneider, Annika Dufour, Tobias Benthaus, Gudrun Mellert, Evelyn Zellmeier, Purvi M. Kakadia, Stefan K. Bohlander, Michaela Feuring-Buske, Christian Buske, Jan Braess, Achim Heinecke, Maria C. Sauerland, Wolfgang E. Berdel, Thomas Büchner, Bernhard J. Wörmann, Wolfgang Hiddemann, Karsten Spiekermann
Journal: Blood
Blood (2012) 119 (19): 4383–4386.
https://doi.org/10.1182/blood-2010-12-327072
Published: 2012
Includes: Supplemental data
Journal Articles

Front Line Treatment of Elderly Patients with Acute Promyelocytic Leukemia: Long-Term Results of the German AML Cooperative Group

Eva Lengfelder, MD, Benjamin Hanfstein, MD, Claudia Haferlach, Jan Braess, MD, Utz Krug, MD, Karsten Spiekermann, MD, Torsten Haferlach, Karl-Anton Kreuzer, Hubert Serve, MD, Heinz A. Horst, MD, Susanne Schnittger, Philipp Erben, Bernhard J Woermann, Wolfgang E. Berdel, Maria-Christina Sauerland, Achim Heinecke, Wolf-Karsten Hofmann, Rüdiger Hehlmann, Wolfgang Hiddemann, MD, Thomas Buchner, MD
Journal: Blood
Blood (2011) 118 (21): 425.
https://doi.org/10.1182/blood.V118.21.425.425
Published: 2011
Journal Articles

Outcome of Myelodysplastic Syndrome Treated with Intensive Chemotherapy within the AMLCG99 Trial

Utz Krug, MD, Carsten Muller-Tidow, MD, Matthias Stelljes, Maria Cristina Sauerland, MSc, Achim Heinecke, Ph.D., Claudia Haferlach, MD, Susanne Schnittger, PhD, Torsten Haferlach, MD, Jan Braess, MD, Karsten Spiekermann, MD, Sarah Volpert, PhD, Peter Staib, Andreas Grüneisen, MD, Wolfgang Kern, MD, Albrecht Reichle, MD, Wolf-Dieter Ludwig, Leopold Balleisen, MD, Hartmut Eimermacher, MD, Carlo Aul, MD, Herbert Rasche, MD, Eva Lengfelder, MD, Eckhard Thiel, Joachim Kienast, Hubert Serve, MD, Bernhard Josef Woermann, MD, Wolfgang Hiddemann, MD, Wolfgang E. Berdel, Thomas Buchner, MD
Journal: Blood
Blood (2011) 118 (21): 2773.
https://doi.org/10.1182/blood.V118.21.2773.2773
Published: 2011
Journal Articles

Sorafenib In Combination with Standard Induction and Consolidation Therapy In Elderly AML Patients: Results From a Randomized, Placebo-Controlled Phase II Trial

Hubert Serve, Ruth Wagner, Cristina Sauerland, Uta Brunnberg, Utz Krug, Markus Schaich, Oliver G. Ottmann, Justus Duyster, Hannes Wandt, Wolfgang Herr, Aristoteles A.N. Giagounidis, Andreas Neubauer, Albrecht Reichle, Walter E. Aulitzky, Richard Noppeney, Igor Wolfgang Blau, Volker Kunzmann, Norbert Schmitz, Karl-Anton Kreuzer, Alwin Krämer, Christian Brandts, Björn Steffen, Achim Heinecke, Christian Thiede, Carsten Müller-Tidow, Gerhard Ehninger, Wolfgang E. Berdel
Journal: Blood
Blood (2010) 116 (21): 333.
https://doi.org/10.1182/blood.V116.21.333.333
Published: 2010
Journal Articles

Estimating the Chances of Older AML Patients to Achieve a Complete Remission Upon Intensive Induction Chemotherapy - An AMLCG and SAL Study

Utz O Krug, MD, Christian Rohde, Ph.D., Achim Heinecke, Ph.D., Maria Cristina Sauerland, Anja Koschmieder, Christoph Röllig, Markus Schaich, MD, Christian Thiede, Michael Kramer, Jan Braess, M.D., Karsten Spiekermann, MD, Torsten Haferlach, MD, Claudia Haferlach, MD, Gerhard Ehninger, Prof., Bernhard Josef Woermann, MD, Wolfgang E. Berdel, Wolfgang Hiddemann, MD, Thomas Buchner, Carsten Müller-Tidow
Journal: Blood
Blood (2010) 116 (21): 2696.
https://doi.org/10.1182/blood.V116.21.2696.2696
Published: 2010
Journal Articles

A New Molecular and Clinical Prognostic Score for Risk Stratification in CN-AML.

Friederike Schneider, Annika Dufour, Tobias Benthaus, Stephanie Schneider, Gudrun Mellert, Evelyn Zellmeier, Stefan K Bohlander, Michael Unterhalt, Michaela Feuring-Buske, Christian Buske, Jan Braess, Maria Cristina Sauerland, Achim Heinecke, Wolfgang Berdel, Thomas Buechner, Bernhard Wörmann, Wolfgang Hiddemann, Karsten Spiekermann, Eva Hoster
Journal: Blood
Blood (2009) 114 (22): 2635.
https://doi.org/10.1182/blood.V114.22.2635.2635
Published: 2009
Journal Articles

Long-Term Results in Patients with Acute Myeloid Leukemia (AML): The Influence of High-Dose AraC, G-CSF Priming, Autologous Transplantation, Prolonged Maintenance, Age, History, Cytogenetics, and Mutation Status. Data of the AMLCG 1999 Trial.

Thomas Buchner, Wolfgang E. Berdel, Claudia Haferlach, Susanne Schnittger, PhD, Torsten Haferlach, Hubert Serve, Carsten Müller-Tidow, Jan Braess, Karsten Spiekermann, Joachim Kienast, Rolf Mesters, Sarah Volpert, Peter Staib, Andreas Grüneisen, Wolfgang Kern, MD, Albrecht Reichle, Wolf-Dieter Ludwig, Georg Maschmeyer, Leopold Balleisen, Hartmut Eimermacher, Carlo Aul, Aristoteles Giagounidis, Herbert Rasche, Rüdiger Hehlmann, Eva Lengfelder, Wolfgang Köpcke, Utz O. Krug, Maria Cristina Sauerland, Achim Heinecke, Bernhard J Woermann, Wolfgang Hiddemann
Journal: Blood
Blood (2009) 114 (22): 485.
https://doi.org/10.1182/blood.V114.22.485.485
Published: 2009
Journal Articles

High Expression of Lymphoid Enhancer-Binding Factor 1 ( LEF1 ) Is a Novel, Favorable Prognostic Marker in Cytogenetically Normal AML and Is Associated with Upregulation of T-Lymphoid Lineage Markers in AML Blasts.

Klaus H. Metzeler, Bernhard Heilmeier, Konstantin Petropoulos, Maria C. Sauerland, Achim Heinecke, Wolfgang E Berdel, Thomas Buechner, Jan Braess, Karsten Spiekermann, Michaela Feuring-Buske, Wolfgang Hiddemann, Stefan K Bohlander, Christian Buske
Journal: Blood
Blood (2009) 114 (22): 398.
https://doi.org/10.1182/blood.V114.22.398.398
Published: 2009
Journal Articles

Loss of Structural Maintenance of Chromosomes 1A Protein Expression Is Associated with a Poor Prognosis in Acute Myelogenous Leukemia.

Utz O. Krug, MD, Claudia Hömme, PhD, Nicola Tidow, PhD, Horst Buerger, MD, Gabriele Koehler, MD, Achim Heinecke, PhD, Thomas Buchner, MD, Wolfgang E Berdel, MD, Steffen Koschmieder, MD, Carsten Mueller-Tidow, MD
Journal: Blood
Blood (2009) 114 (22): 4693.
https://doi.org/10.1182/blood.V114.22.4693.4693
Published: 2009
Journal Articles

A Novel Risk Score Predicts the Likelihood of a Complete Remission After Intensive Induction Therapy in Older AML Patients.

Utz O. Krug, MD, Achim Heinecke, PhD, Anja Koschmieder, MD, Matthias Stelljes, MD, Maria Cristina Sauerland, PhD, Wolfgang E Berdel, MD, Bernhard J Woermann, MD, Wolfgang Hiddemann, MD, Thomas Buchner, MD, Carsten Müller-Tidow, MD
Journal: Blood
Blood (2009) 114 (22): 327.
https://doi.org/10.1182/blood.V114.22.327.327
Published: 2009
Journal Articles

NPM1 but not FLT3-ITD mutations predict early blast cell clearance and CR rate in patients with normal karyotype AML (NK-AML) or high-risk myelodysplastic syndrome (MDS)

Brief Report
Friederike Schneider, Eva Hoster, Michael Unterhalt, Stephanie Schneider, Annika Dufour, Tobias Benthaus, Gudrun Mellert, Evelin Zellmeier, Stefan K. Bohlander, Michaela Feuring-Buske, Christian Buske, Jan Braess, Susanne Fritsch, Achim Heinecke, Maria C. Sauerland, Wolfgang E. Berdel, Thomas Buechner, Bernhard J. Woermann, Wolfgang Hiddemann, Karsten Spiekermann
Journal: Blood
Blood (2009) 113 (21): 5250–5253.
https://doi.org/10.1182/blood-2008-09-172668
Published: 2009
Includes: Supplemental data
Journal Articles

Dose-dense induction with sequential high-dose cytarabine and mitoxantone (S-HAM) and pegfilgrastim results in a high efficacy and a short duration of critical neutropenia in de novo acute myeloid leukemia: a pilot study of the AMLCG

Clinical Trials & Observations
Jan Braess, Karsten Spiekermann, Peter Staib, Andreas Grüneisen, Bernhard Wörmann, Wolf-Dieter Ludwig, Hubert Serve, Albrecht Reichle, Rudolf Peceny, Daniel Oruzio, Christoph Schmid, Xaver Schiel, Marcus Hentrich, Christina Sauerland, Michael Unterhalt, Michael Fiegl, Wolfgang Kern, Christian Buske, Stefan Bohlander, Achim Heinecke, Herrad Baurmann, Dietrich W. Beelen, Wolfgang E. Berdel, Thomas Büchner, Wolfgang Hiddemann
Journal: Blood
Blood (2009) 113 (17): 3903–3910.
https://doi.org/10.1182/blood-2008-07-162842
Published: 2009
Journal Articles

Older Age Is An Independent Risk Factor in AML

Thomas Buchner, Wolfgang E. Berdel, Claudia Haferlach, Susanne Schnittger, Torsten Haferlach, MD, Hubert Serve, Carsten Müller-Tidow, Jan Braess, Karsten Spiekermann, Joachim Kienast, Rolf Mesters, Sarah Volpert, Peter Staib, Andreas Grüneisen, Wolfgang Kern, Albrecht Reichle, Wolf-Dieter Ludwig, Georg Maschmeyer, Ludwig Balleisen, Hartmut Eimermacher, Carlo Aul, Aristoteles Giagounidis, Herbert Rasche, Ruediger Hehlmann, Eva Lengfelder, Wolfgang Koepcke, Utz O. Krug, Maria Cristina Sauerland, Achim Heinecke, Bernhard Josef Woermann, Wolfgang Hiddemann, MD
Journal: Blood
Blood (2008) 112 (11): 555.
https://doi.org/10.1182/blood.V112.11.555.555
Published: 2008
Journal Articles

Age-Dependent Frequencies of NPM-1/FLT3-ITD Mutations in Patients with Normal Karyotype AML

Friederike Schneider, Eva Hoster, Michael Unterhalt, Stephanie Schneider, Annika Dufour, Tobias Benthaus, Gudrun Mellert, Evelyn Zellmeier, Stefan K. Bohlander, Michaela Feuring-Buske, Christian Buske, Jan Braess, Achim Heinecke, Maria C. Sauerland, Wolfgang E. Berdel, Thomas Buechner, Wolfgang Hiddemann, Karsten Spiekermann
Journal: Blood
Blood (2008) 112 (11): 2531.
https://doi.org/10.1182/blood.V112.11.2531.2531
Published: 2008