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Anjan Thakurta, PhD
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Journal Articles

Cyclophosphamide Exerts Significant Immunomodulatory Function in Myeloma Patients Treated with Pomalidomide and Dexamethasone

James Croft, BSc, MBBS, MRCP, Andrew Hall, Katrina Walker, Amy L Sherborne, PhD, Kevin Boyd, Mamta Garg, Charlotte Pawlyn, BA, PhD MBBChir, MRCP, FRCPath, Debbie Sherratt, Sadie Reed, PhD, William E Pierceall, Gordon Cook, Anjan Thakurta, PhD, Sarah R Brown, PhD MSc, BSc, Martin Kaiser, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4482.
https://doi.org/10.1182/blood-2018-99-111823
Published: 2018
Journal Articles

Hotspot Mutations in SF3B1 Result in Increased Alternative Splicing in Multiple Myeloma and Activation of Key Cellular Pathways

Michael A Bauer, PhD, Cody Ashby, PhD, Christopher Wardell, PhD, Maria Ortiz, Erin Flynt, Anjan Thakurta, PhD, Gareth Morgan, MD, Brian A Walker, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4454.
https://doi.org/10.1182/blood-2018-99-116858
Published: 2018
Journal Articles

Chromothripsis and Chromoplexy Are Associated with DNA Instability and Adverse Clinical Outcome in Multiple Myeloma

Cody Ashby, PhD, Michael A Bauer, PhD, Yan Wang, Christopher P. Wardell, PhD MSc, BSc, Ruslana G. Tytarenko, MS, Purvi Patel, Erin Flynt, Maria Ortiz, Andrew Dervan, Jake Gockley, PhD, Aneta Mikulasova, PhD, Carolina D. Schinke, MD, Sharmilan Thanendrarajan, MD, Maurizio Zangari, MD, Frits van Rhee, MD PhD, Faith E. Davies, MD, Jonathan J Keats, PhD, Daniel Auclair, PhD, Anjan Thakurta, PhD, Brian A Walker, PhD, Gareth Morgan, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 408.
https://doi.org/10.1182/blood-2018-99-117359
Published: 2018
Journal Articles

Immunome Single Cell Profiling Reveals T Cell Exhaustion with Upregulation of Checkpoint Inhibitors LAG3 and Tigit on Marrow Infiltrating T Lymphocytes in Daratumumab and IMiDs Resistant Patients

Paola Neri, MD, Ranjan Maity, PhD, Ines Tagoug, PhD, Sylvia McCulloch, MD, Peter Duggan, MD, Victor Jimenez-Zepeda, MD, Jason Tay, MD, Anjan Thakurta, PhD, Nizar Bahlis, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 242.
https://doi.org/10.1182/blood-2018-99-117531
Published: 2018
Journal Articles

Single Cell Analysis of Acquired Pomalidomide-Resistance in Multiple Myeloma Cell Lines Reveals Distinct Subclonal Cereblon Mutations and Gene Expression Heterogeneity

Sarah Gooding, Chad C. Bjorklund, Michael Amatangelo, Yan Ren, Mathieu Marella, Suzana Couto, Christopher Park, Sneh Lata, Reshma Nibhani, Fadi Towfic, PhD, Udo Oppermann, Karthik Ramasamy, William E. Pierceall, Paresh Vyas, Anjan Thakurta, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2648.
https://doi.org/10.1182/blood-2018-99-112644
Published: 2018
Journal Articles

Modeling Tumor Microenvironment Interactions of Imid Sensitive and Resistant Cells in 3D Organotypic Culture Models

Aarif Ahsan, PhD, Danny Jeyaraju, Kamlesh Bisht, Patrick R. Hagner, PhD, Chad C. Bjorklund, William E Pierceall, Anjan Thakurta, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5622.
https://doi.org/10.1182/blood-2018-99-118885
Published: 2018
Journal Articles

A High-Risk Multiple Myeloma Group Identified By Integrative Multi-Omics Segmentation of Newly Diagnosed Patients

Maria Ortiz, Fadi Towfic, PhD, Mehmet Kemal Samur, PhD, Erin Flynt, In Sock Jang, PhD, Kai Wang, PhD, Cody Ashby, PhD, Brian A Walker, PhD, Matthew Trotter, PhD, Gareth Morgan, MD, Nikhil Munshi, MD, Anjan Thakurta, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3165.
https://doi.org/10.1182/blood-2018-99-117114
Published: 2018
Journal Articles

Long-Term Follow-up Identifies Double Hit and Key Mutations As Impacting Progression Free and Overall Survival in Multiple Myeloma

Cody Ashby, PhD, Eileen Boyle, Ruslana G. Tytarenko, MS, Hongwei Wang, MS, Adam Rosenthal, MS, Purvi Patel, Yan Wang, Shayu Deshpande, Maria Ortiz, Erin Flynt, Antje Hoering, PhD, Sharmilan Thanendrarajan, MD, Carolina D. Schinke, MD, Maurizio Zangari, MD, Frits van Rhee, MD PhD, Bart Barlogie, MD PhD, Anjan Thakurta, PhD, Gareth Morgan, MD, Brian A Walker, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 110.
https://doi.org/10.1182/blood-2018-99-113045
Published: 2018
Journal Articles

Landscape of Recurrent Mutations in Non-Coding Genome with Functional Implications in Newly-Diagnosed Multiple Myeloma

Mehmet Kemal Samur, PhD, Chandraditya Chakraborty, PhD, Raphael Szalat, MD, Anil Aktas Samur, PhD, Mariateresa Fulciniti, PhD, Michael A Lopez, Masood A. Shammas, PhD, Paul Richardson, Florence Magrangeas, PhD, Stephane Minvielle, PhD, Philippe Moreau, Michel Attal, Anjan Thakurta, PhD, Kenneth Anderson, MD, Giovanni Parmigiani, Hervé Avet-Loiseau, MDPhD, Nikhil Munshi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 190.
https://doi.org/10.1182/blood-2018-190
Published: 2018
Journal Articles

Immune Profiling of Relapsed or Refractory Multiple Myeloma Patients Treated with Pomalidomide and Low-Dose Dexamethasone in Combination with Daratumumab

William E. Pierceall, Nizar Bahlis, MD, David S Siegel, MD PhD, Gary J. Schiller, MD, Christy J. Samaras, DO, Michael Sebag, MD PhD, Jesus G. Berdeja, MD, Siddhartha Ganguly, MD, Jeffrey V Matous, MD, Kevin Song, MD, Christopher S. Seet, MD, Giampaolo Talamo, Shanti Srinivas, Mirelis Acosta-Rivera, Michael Bar, Donald P. Quick, MD, Bertrand Anz, Gustavo Fonseca, Donna Reece, Weiyuan Chung, Natalya Serbina, Faiza Zafar, MPAS, Amit Agarwal, MD PhD, Anjan Thakurta, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2012.
https://doi.org/10.1182/blood-2018-99-111554
Published: 2018
Journal Articles

Mechanistic Insights of Pomalidomide Activity in Combination with Bortezomib and Dexamethasone in Multiple Myeloma and Immune Cells

Mark Katz, Chad C. Bjorklund, Anjan Thakurta, PhD, Natalya Serbina
Journal: Blood
Blood (2018) 132 (Supplement 1): 1934.
https://doi.org/10.1182/blood-2018-99-118829
Published: 2018
Journal Articles

Iberdomide (CC-220) Has Synergistic Anti-Tumor and Immunostimulatory Activity Against Multiple Myeloma in Combination with Both Bortezomib and Dexamethasone, or in Combination with Daratumumab in Vitro

Michael Amatangelo, Chad C. Bjorklund, Jian Kang, Ann Polonskaia, Sridevi Viswanatha, Anjan Thakurta, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1935.
https://doi.org/10.1182/blood-2018-99-113383
Published: 2018
Journal Articles

FOXM1 Is Associated with Development of Therapeutic Resistance in Multiple Myeloma

Michael Amatangelo, PhD, Maria Ortiz, Paola Neri, MD, Fadi Towfic, PhD, Chad Bjorklund, Jian Kang, Erica Sternberg, Nizar J. Bahlis, MD, Matthew Trotter, PhD, Anjan Thakurta, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1261.
https://doi.org/10.1182/blood.V130.Suppl_1.1261.1261
Published: 2017
Journal Articles

Identification of Novel Oncogenes and Tumor Suppressor Genes in Newly Diagnosed Multiple Myeloma

Brian A Walker, PhD, Christopher P. Wardell, PhD, Konstantimos Mavrommatis, PhD, Cody Cody Ashby, PhD, Michael Bauer, PhD, Mehmet Kemal Samur, PhD, Fadi Towfic, PhD, Maria Ortiz, Erin Flynt, PhD, Matthew Trotter, PhD, Anjan Thakurta, PhD, Nikhil Munshi, MD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 60.
https://doi.org/10.1182/blood.V130.Suppl_1.60.60
Published: 2017
Journal Articles

Single Cell Resolution Profiling Defines the Innate and Adaptive Immune Repertoires Modulated By Daratumumab and IMiDs Treatment in Multiple Myeloma (MM)

Paola Neri, MD, Ranjan Maity, PhD, Ines Tagoug, PhD, Peter Duggan, MD FRCPC, Sylvia McCulloch, MD, Victor Jimenez-Zepeda, MD, Jason Tay, MD FRCPC, Lawrence H. Boise, PhD, Anjan Thakurta, PhD, Nizar J. Bahlis, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 123.
https://doi.org/10.1182/blood.V130.Suppl_1.123.123
Published: 2017
Journal Articles

Immune Profile of Patients (pts) with Relapsed and/or Refractory Multiple Myeloma (RRMM) Treated with Pomalidomide (POM) + Low-Dose Dexamethasone (LoDEX) + Daratumumab (DARA) in the Second Line Immediately after Lenalidomide (LEN)

Xiaozhong Qian, Kathryn Newhall, PhD, Mark Tometsko, Chad Bjorklund, Jianglin Ma, Nizar J. Bahlis, MD, David Siegel, MD PhD, Gary J. Schiller, MD, Christy Samaras, Michael Sebag, MD PhD, Jesus G. Berdeja, MD, Siddhartha Ganguly, MD, Jeffrey V. Matous, MD, Kevin W Song, MD, Christopher S. Seet, Giampaolo Talamo, Shanthi Srinivas, Mirelis Acosta-Rivera, Michael Bar, Donald Quick, Bertrand Anz, Gustavo Fonseca, Donna Reece, MD FRCP(C), Jorge Mouro, MS, Amit Agarwal, MD PhD, Faiza Zafar, MPAS, Anjan Thakurta, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1888.
https://doi.org/10.1182/blood.V130.Suppl_1.1888.1888
Published: 2017
Journal Articles

Clonal Heterogeneity in Differentiation Response and Resistance to the IDH2 Inhibitor Enasidenib in Acute Myeloid Leukemia

Lynn Quek, FRCPath, DPhil, MBBS, Muriel David, Alison Kennedy, MSc, Marlen Metzner, MSc, Michael Amatangelo, PhD, Alan H. Shih, MD PhD, Bilyana Stoilova, PhD, Dimitris Karamitros, PhD, Cyril Quivoron, Mael Heiblig, MD, Christophe Willekens, MD, Veronique Saada, Andrew Peniket, Olivier Bernard, Sam Agresta, MD, Katharine Yen, Eytan M. Stein, MD, Stephane De Botton, Anjan Thakurta, PhD, Ross L. Levine, MD, Virginie Penard-Lacronique, PhD, Paresh Vyas, DPhil, FRCP, FRCPath, MRCP, MRCPath
Journal: Blood
Blood (2017) 130 (Supplement 1): 724.
https://doi.org/10.1182/blood.V130.Suppl_1.724.724
Published: 2017
Journal Articles

MYC Rearrangements in Multiple Myeloma Are Complex, Can Involve More Than Five Different Chromosomes, and Correlate with Increased Expression of MYC and a Distinct Downstream Gene Expression Pattern

Aneta Mikulasova, PhD, Cody Cody Ashby, PhD, Ruslana G. Tytarenko, MS, Michael Bauer, PhD, Konstantimos Mavrommatis, PhD, Christopher P. Wardell, PhD, Matthew Trotter, PhD, Shayu Deshpande, Owen W. Stephens, Erming Tian, PhD MBA, Graham Jackson, Faith E. Davies, MD, Anjan Thakurta, PhD, Nikhil Munshi, MD, Gareth J. Morgan, MD PhD, Brian A Walker, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 65.
https://doi.org/10.1182/blood.V130.Suppl_1.65.65
Published: 2017
Journal Articles

Correlative Analyses of Cereblon ( CRBN ), cMYC , IRF4 , BLIMP1 , and XBP1 with Clinical Outcomes in Stratus (MM-010), a Phase 3b Study of Pomalidomide (POM) + Low-Dose Dexamethasone (LoDEX) in Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM)

Xiaozhong Qian, Meletios A. Dimopoulos, Michael Amatangelo, PhD, Chad Bjorklund, Katja C. Weisel, Enrique M. Ocio, MDPhD, Xin Yu, Teresa Peluso, Lars Sternas, Mohamed Zaki, Philippe Moreau, MDPhD, Anjan Thakurta, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3109.
https://doi.org/10.1182/blood.V130.Suppl_1.3109.3109
Published: 2017
Journal Articles

Higher Expression of Nuclear Cereblon in Bone Marrow Biopsies of Patients with Multiple Myeloma Included in the HOVON-87/Nmsg-18 Trial May be Associated with Longer PFS and OS

Ruth Wester, King Hong Lam, MD PhD, Mark van Duin, PhD, Suzana Couto, Yan Ren, Maria Wang, PhD, Bronno van der Holt, Berna Beverloo, PhD, Heleen Visser-Wisselaar, Alex Nigg, Max Qian, Anjan Thakurta, PhD, Annemiek Broyl, MD PhD, Sonja Zweegman, MD PhD, Pieter Sonneveld, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3052.
https://doi.org/10.1182/blood.V130.Suppl_1.3052.3052
Published: 2017