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Ari M. Melnick, MD
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Journal Articles

Computational Systems Biology Models for the Identification of Metabolic Vulnerabilities in Multiple Myeloma

Luis Vitores V. Valcárcel, MSc, Raquel Ordoñez, PhD, Iñigo Apaolaza, MSc, Ana Valcárcel, Leire Garate, Cem Meydan, PhD, Bruno Paiva, PhD, Ari M Melnick, MD, Jesús San-Miguel, Francisco J. Planes, Xabier Agirre, PhD, Felipe Prosper, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3084.
https://doi.org/10.1182/blood-2019-123970
Published: 2019
Journal Articles

Characterization of Complete Lncrnas Transcriptome Reveals Expression of Lncrnas As a Prognostic Factor and Linc-Smilo As a Potential Therapeutic Target in Multiple Myeloma

Arantxa Carrasco, Teresa Ezponda, Cem Meydan, PhD, Luis Vitores Valcárcel, MSc, Raquel Ordoñez, PhD, Marta Kulis, PhD, Leire Garate, Estíbaliz Miranda, Victor Segura, PhD, Elizabeth Guruceaga, Amaia Vilas-Zornoza, PhD, Diego Alignani, PhD, Laura Castro, Marien Pascual, PhD, Ane Amundarain, Halima El Omri, Ruba Yasin, MBBS, MRCP, Maria Jose Calasanz, PhD BSc, Francisco J Planes, Bruno Paiva, PhD, Christopher Mason, PhD, Jesús San-Miguel, Inaki Martin Subero, PhD, Ari M Melnick, MD, Felipe Prosper, MD PhD, Xabier Agirre, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4323.
https://doi.org/10.1182/blood-2019-123008
Published: 2019
Journal Articles

CD25-Dependent Feedback Control of the B-Cell Receptor and Its Oncogenic Mimics in B-Cell Malignancies

Jae-Woong Lee, PhD, Kohei Kume, PhD, Zhengshan Chen, MDPhD, Gang Xiao, PhD, Kadriye Nehir Cosgun, PhD, Lai N Chan, Chun-Wei Chen, PhD, Raju Pillai, MD, Wing C Chan, MD, Stephen J Forman, Larry W Kwak, MD PhD, Francesca Zammarchi, PhD, Patrick Van Berkel, PhD, David M Weinstock, MD, Ari M Melnick, MD, Vu N Ngo, PhD, Huimin Geng, PhD, Selina Luger, MD, Mark R. Litzow, MD, Alexandre Belot, MDPhD, Gulbu Uzel, MD, Michael T McManus, PhD, Elisabeth M. Paietta, PhD, Eric Meffre, PhD, Markus Muschen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 776.
https://doi.org/10.1182/blood-2018-99-117553
Published: 2018
Journal Articles

Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 As a Therapeutic Target for Restoring MHC Expression in Diffuse Large B-Cell Lymphoma

Daisuke Ennishi, MDPhD, Katsuyoshi Takata, MD PhD, Wendy Béguelin, PhD, Gerben Duns, PhD, Anja Mottok, Pedro Farinha, MD PhD, Ali Bashashati, David Scott, Merrill Boyle, BSc, Barbara Meissner, PhD, Susana Ben-Neriah, BSc, Bruce W Woolcock, Adele Telenius, Daniel Lai, Matthew R Teater, PhD, Robert Kridel, PhD MD, Kerry J Savage, BSc, MD MSc, Laurie H Sehn, MD MPH, Ryan D. Morin, PhD BSc MSc, Marco A. Marra, PhD, Sohrab P Shah, Joseph M. Connors, MD, Randy D. Gascoyne, MD, David W. Scott, PhD MD FRACP FRCPA, Ari M Melnick, MD, Christian Steidl, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1560.
https://doi.org/10.1182/blood-2018-99-112010
Published: 2018
Journal Articles

Comprehensive Integration of Whole Genome, Transcriptome and Methylation Profiling Reveals Novel Gene Dysregulation Including IL15, SOCS6 and CARD11 Associated with MYD88 and CXCR4 Genotype Status in WM

Zachary R Hunter, PhD, Gloria G Chan, MS, Cristina Jimenez, PhD, Nickolas Tsakmaklis, Lian Xu, MS, Jiaji G Chen, Maria Demos, Amanda Kofides, Manit Munshi, MS, Maria Luisa Guerrera, MD, Xia Liu, MD, Guang Yang, PhD, Jorge J. Castillo, MD, Ari M Melnick, MD, Steven P Treon, MD PhD FRCP
Journal: Blood
Blood (2018) 132 (Supplement 1): 1563.
https://doi.org/10.1182/blood-2018-99-119828
Published: 2018
Journal Articles

Heat Shock Factor 1 Reprograms the DLBCL Microenvironment to Evade Immune Surveillance and Support Tumor Growth

Jude M Phillip, DPhil, Maria Nieves Calvo Vidal, PhD, Maria Victoria Revuelta, PhD, Nahuel Zamponi, PhD, Stephen Sloan, Benet Pera Gresely, PhD, Tharu Fernando, PhD, Wayne Tam, MD PhD, Giorgio Inghirami, MD, Lawrence Bonassar, PhD, Ari M. Melnick, MD, Leandro Cerchietti, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2854.
https://doi.org/10.1182/blood-2018-99-117774
Published: 2018
Journal Articles

BAP1 Loss Results in EZH2-Dependent Transformation in Myelodysplastic Syndromes

Lindsay M LaFave, PhD, Wendy Béguelin, PhD, Richard Koche, PhD, Matt Teater, Efthymia Papalexi, Barbara Spitzer, MD, Sarah Knutson, PhD, John Campbell, PhD, Heike Keilhack, PhD, Paul M Thomas, PhD, Neil L Kelleher, PhD, Omar Abdel-Wahab, Ari M. Melnick, MD, Scott A. Armstrong, MD PhD, Ross L. Levine, MD
Journal: Blood
Blood (2015) 126 (23): 713.
https://doi.org/10.1182/blood.V126.23.713.713
Published: 2015
Journal Articles

Transcriptome Sequencing Reveals Thousands of Novel Long Non-Coding RNAs in B-Cell Lymphoma

Akanksha Verma, Yanwen Jiang, PhD, Lauren Fairchild, Wei Du, BS, Ari M. Melnick, MD, Olivier Elemento
Journal: Blood
Blood (2015) 126 (23): 2427.
https://doi.org/10.1182/blood.V126.23.2427.2427
Published: 2015
Journal Articles

BCL6 Orchestrates Tfh Differentiation Via Multiple Distinct Mechanisms

Katerina Hatzi, PhD, J. Philip Nance, PhD, Mark Kroenke, PhD, Elias K. Haddad, PhD, Ari M. Melnick, MD, Shane Crotty, PhD
Journal: Blood
Blood (2014) 124 (21): 4137.
https://doi.org/10.1182/blood.V124.21.4137.4137
Published: 2014
Journal Articles

AG-221, a Small Molecule Mutant IDH2 Inhibitor, Remodels the Epigenetic State of IDH2-Mutant Cells and Induces Alterations in Self-Renewal/Differentiation in IDH2-Mutant AML Model in Vivo

Alan H. Shih, MDPhD, Kaitlyn R Shank, B.S., Cem Meydan, Andrew M. Intlekofer, MD PhD, Patrick Ward, Craig B. Thompson, MD, Ari M Melnick, MD, Jeremy Travins, Kim Straley, Camelia Gliser, Katherine Yen, Ross L Levine, MD
Journal: Blood
Blood (2014) 124 (21): 437.
https://doi.org/10.1182/blood.V124.21.437.437
Published: 2014
Journal Articles

Mirna-181a expression Lead to Longer Animal Survival and Slower Tumor-Growth Rate in Diffuse Large B-Cell Lymphoma Xenograft Models

Goldi A Kozloski, PhD, Xiaoyu Jiang, PhD, Shruti Bhatt, PhD, Rita Shaknovich, MD PhD, Ari M Melnick, MD, Izidore S Lossos, MD
Journal: Blood
Blood (2014) 124 (21): 2963.
https://doi.org/10.1182/blood.V124.21.2963.2963
Published: 2014
Journal Articles

Conditional Loss of Dnmt3a Results in Myeloproliferation and Liver-Specific Myeloid Expansion

Olga A Guryanova, MD PhD, Yen Lieu, PhD, Kaitlyn R Shank, B.S., Sharon Rivera, PhD, Francine E Garrett-Bakelman, MD PhD, Jacob Glass, MD PhD, Matthew D Keller, B.S., Suveg Pandey, B.S., Daniel Tovbin, Abby R Weinstein, Julie Teruya-Feldstein, MD, Omar Abdel-Wahab, MD, Christopher E Mason, PhD, Ari M Melnick, MD, Siddhartha Mukherjee, MD PhD, Ross L. Levine, MD
Journal: Blood
Blood (2014) 124 (21): 364.
https://doi.org/10.1182/blood.V124.21.364.364
Published: 2014
Journal Articles

DNA Hydroxymethylation Profiling Reveals That WT1 Mutations Result in Loss of TET2 Function in Acute Myeloid Leukemia

Raajit K. Rampal, MD PhD, Altuna Alkalin, Jozef Madzo, PhD, Aparna Vasanthakumar, BSc, MSc, PhD, Elodie Pronier, PhD, Jay P. Patel, Yushan Li, Jihae Ahn, BS, Omar Abdel-Wahab, MD, Alan H. Shih, MDPhD, Chao Lu, Patrick Ward, Jennifer J Tsai, MD, Todd Hricik, Jacob Tallman, Valeria Tosello, PhD, Xinyang Zhao, PhD, Danette Daniels, Qing Dai, Luisa Ciminio, Iannis Aifantis, PhD, Chuan He, PhD, François Fuks, Martin S. Tallman, MD, Adolfo A. Ferrando, MD PhD, Stephen Nimer, MD, Elisabeth Paietta, PhD, Craig B. Thompson, MD, Jonathan D. Licht, MD, Christopher E Mason, PhD, Lucy A Godley, MD PhD, Ari M Melnick, MD, Maria E Figueroa, MD, Ross L Levine, MD
Journal: Blood
Blood (2014) 124 (21): 365.
https://doi.org/10.1182/blood.V124.21.365.365
Published: 2014
Journal Articles

Hyperactive Ptpn11 Mutations Alters Leukemic Stem Cell Frequency through Mcl-1 Overexpression

Lili Chen, PhD, Wei Chen, PhD, Maria Mysliwski, Justin Serio, James Ropa, Fardokht Abulwerdi, Rebecca J. Chan, MD PhD, Jay P. Patel, Martin S. Tallman, MD, Elisabeth M. Paietta, PhD, Ari M Melnick, MD, Ross L. Levine, MD, Omar Abdel-Wahab, MD, Zaneta Nikolovska-Coleska, PhD, Andrew G. Muntean, PhD
Journal: Blood
Blood (2014) 124 (21): 3565.
https://doi.org/10.1182/blood.V124.21.3565.3565
Published: 2014
Journal Articles

Msi2 Maintains the MLL Leukemia Stem Cell Regulatory Program

Sun Mi Park, PhD, Mithat Gönen, PhD, Ly P. Vu, PhD, Gerard Minuesa, PhD, Patrick Tivnan, Trevor Barlowe, James Taggart, Yuheng Lu, Raquel P Deering, PhD, Nir Hacohen, PhD, Maria Figueroa, MD, Elisabeth M. Paietta, PhD, Martin S. Tallman, MD, Ari M. Melnick, MD, Ross L. Levine, MD, Christina Leslie, PhD, Christopher J Lengner, PhD, Michael G Kharas, PhD
Journal: Blood
Blood (2014) 124 (21): 836.
https://doi.org/10.1182/blood.V124.21.836.836
Published: 2014
Journal Articles

A Virtual B Cell Lymphoma Model to Predict Effective Combination Therapy

Wei Du, BA, Rebecca Goldstein, BA, Yanwen Jiang, PhD, Omar Aly, BA, Leandro Cerchietti, MD, Ari M. Melnick, MD, Olivier Elemento, PhD
Journal: Blood
Blood (2014) 124 (21): 928.
https://doi.org/10.1182/blood.V124.21.928.928
Published: 2014
Journal Articles

BCL6 Mediates a Stress Tolerance Phenotype through Its BTB Domain

Tharu M Fernando, MS, Shao Ning Yang, MS, Chuanxin Huang, PhD, Gabriela Chiosis, PhD, Leandro Cerchietti, MD, Ari M. Melnick, MD
Journal: Blood
Blood (2014) 124 (21): 567.
https://doi.org/10.1182/blood.V124.21.567.567
Published: 2014
Journal Articles

PTEN Is Essential for Normal Cytokine Signaling and Oncogenic Transformation of Pre-B Cells

Seyedmehdi Shojaee, PhD, Valeria Cazzaniga, Hilde Schjerven, PhD, Maike Buchner, PhD, Christian Hurtz, PhD, Huimin Geng, PhD, Andreas Hochhaus, MD, Giovanni Cazzaniga, PhD, Ari M Melnick, MD, Steven M. Kornblau, MD, Thomas G Graeber, PhD, Markus Muschen, MD PhD
Journal: Blood
Blood (2014) 124 (21): 262.
https://doi.org/10.1182/blood.V124.21.262.262
Published: 2014
Journal Articles

Targeting BCL6 and Germinal Centers (GCs) in Chronic Graft-Versus-Host Disease (cGVHD) Using Direct and Epigenomic Therapies

Ryan P Flynn, Katelyn Goodman, Jun Qi, PhD, Du Jing, Angela Panoskaltsis-Mortari, PhD, Zhang Yi, Chen Dong, PhD, Xindong Liu, Kelli P A MacDonald, PhD, Geoffrey R Hill, MD, Jonathan S Serody, MD, William J Murphy, PhD, Leo Luznik, MD, Ivan Maillard, MD PhD, John Koreth, MBBS, DPhil, Corey S Cutler, MD MPH, Robert J Soiffer, MD, Joseph H. Antin, MD, Jerome Ritz, MD, Ari M Melnick, MD, James E. Bradner, MD, Bruce R. Blazar, MD
Journal: Blood
Blood (2014) 124 (21): 535.
https://doi.org/10.1182/blood.V124.21.535.535
Published: 2014
Journal Articles

The Significance of GADD45A Promoter DNA Hypermethylation in AML: Association with IDH1/2 and TET2 Mutation

Michelle Perugini, PhD, Saumya E Samaraweera, PhD, Anna L Brown, PhD, Nik Cummings, BSc, Silke Danner, Ing Soo Tiong, MBChB, Francine E Garrett-Bakelman, MD PhD, Martin P. Carroll, MD, Michael W. Becker, MD, Stephen S. Chung, MD, Christopher Y. Park, MD PhD, Christopher E Mason, PhD, Monica L. Guzman, PhD, Ross L. Levine, MD, Ari M Melnick, MD, Luen Bik To, MBBS, PhD, Andrew H Wei, MBBS, PhD, Ian D Lewis, MBBS, PhD, Richard J D'Andrea, PhD
Journal: Blood
Blood (2014) 124 (21): 69.
https://doi.org/10.1182/blood.V124.21.69.69
Published: 2014