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Journal Articles

The miR-185/PAK6 axis predicts therapy response and regulates survival of drug-resistant leukemic stem cells in CML

Hanyang Lin, Katharina Rothe, Min Chen, Andrew Wu, Artem Babaian, Ryan Yen, Jonathan Zeng, Jens Ruschmann, Oleh I. Petriv, Kieran O'Neill, Tobias Maetzig, David J. H. F. Knapp, Naoto Nakamichi, Ryan Brinkman, Inanc Birol, Donna L. Forrest, Carl Hansen, R. Keith Humphries, Connie J. Eaves, Xiaoyan Jiang
Journal: Blood
Blood (2020) 136 (5): 596–609.
https://doi.org/10.1182/blood.2019003636
Published: 2020
Includes: Supplemental data
Journal Articles

A topological view of human CD34 + cell state trajectories from integrated single-cell output and proteomic data

David J. H. F. Knapp, Colin A. Hammond, Fangwu Wang, Nima Aghaeepour, Paul H. Miller, Philip A. Beer, Davide Pellacani, Michael VanInsberghe, Carl Hansen, Sean C. Bendall, Garry P. Nolan, Connie J. Eaves
Journal: Blood
Blood (2019) 133 (9): 927–939.
https://doi.org/10.1182/blood-2018-10-878025
Published: 2019
Includes: Supplemental data
Journal Articles

Global Transcriptome Profiling Identifies a Key Mir-185-PAK6 Axis That Promotes Survival of Leukemic Stem Cells and Drug-Insensitive Blasts in BCR-ABL + Human Leukemia

Andrew Wu, BSc, Lin Hanyang, PhD, Katharina Rothe, PhD, Min Chen, MD PhD, Jens Ruschmann, PhD, Oleh Petriv, PhD, Kieran O'Neill, PhD, Tobias Maetzig, MD, David Knapp, PhD, Naoto Nakamichi, MD PhD, Ryan Brinkman, PhD, Inanc Birol, PhD, Donna L Forrest, MD, Carl Hansen, PhD, R. Keith Humphries, MD PhD, Connie J. Eaves, PhD, Xiaoyan Jiang, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 931.
https://doi.org/10.1182/blood-2018-99-113559
Published: 2018
Journal Articles

Distinct signaling programs control human hematopoietic stem cell survival and proliferation

David J. H. F. Knapp, Colin A. Hammond, Nima Aghaeepour, Paul H. Miller, Davide Pellacani, Philip A. Beer, Karen Sachs, Wenlian Qiao, WeiJia Wang, R. Keith Humphries, Guy Sauvageau, Peter W. Zandstra, Sean C. Bendall, Garry P. Nolan, Carl Hansen, Connie J. Eaves
Journal: Blood
Blood (2017) 129 (3): 307–318.
https://doi.org/10.1182/blood-2016-09-740654
Published: 2017
Includes: Supplemental data
Journal Articles

Identification and Characterization of New Microrna Biomarkers and Target Genes in Drug-Insensitive CD34+ CML Stem/Progenitor Cells Using Global Comparative RNA-Seq Analyses

Hanyang Lin, BSc, MSc, Jonathan Zeng, Katharina Rothe, BSc, MSc, Jens Ruschmann, PhD, Oleh Petriv, PhD, Kieran O'Neill, PhD, Tobias Maetzig, PhD, David Knapp, BSc, Ryan R. Brinkman, PhD, Inanc Birol, PhD, Donna L. Forrest, MD, Carl Hansen, PhD, Connie J. Eaves, PhD, R. Keith Humphries, MD PhD, Xiaoyan Jiang, MDPhD
Journal: Blood
Blood (2015) 126 (23): 1567.
https://doi.org/10.1182/blood.V126.23.1567.1567
Published: 2015
Journal Articles

Identification of New microRNA Biomarkers and Candidate Target Genes in Primitive CML Cells Using Global Comparative RNA analyses

Hanyang Lin, Katharina Rothe, Jens Ruschmann, Oleh Petriv, Kieran O'Neill, David J.H.F. Knapp, Ryan R. Brinkman, Inanc Birol, Donna L. Forrest, MD, Carl Hansen, Connie J Eaves, R. Keith Humphries, MD PhD, Xiaoyan Jiang
Journal: Blood
Blood (2014) 124 (21): 3133.
https://doi.org/10.1182/blood.V124.21.3133.3133
Published: 2014