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Chang-xin Shi
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Journal Articles

Genomic mechanisms of resistance to venetoclax in multiple myeloma with t(11;14)(CCND1;IGH)

Available to Purchase
Marcella Kaddoura, Julia Erin Wiedmeier-Nutor, Vikas A Gupta, Tomas Jelinek, Bachisio Ziccheddu, Suganti Shivaram, Hongwei Tang, Rebecca W Owens, Tereza Ševčíková, Rodrigo Fonseca, Michael A. Durante, Benjamin T. Diamond, Logan Zhao, Yuan Xiao Zhu, Chang-Xin Shi, Shannon M Matulis, Constantine S. Mitsiades, Carl Ola Landgren, Saad Z. Usmani, Roman Hajek, Marta Chesi, P. Leif Bergsagel, Esteban Braggio, Lawrence H Boise, Rafael Fonseca, Shaji K Kumar, Francesco Maura, Linda B Baughn
Journal: Blood
Blood blood.2025029996.
https://doi.org/10.1182/blood.2025029996
Published: 2026
Includes: Supplemental data
Journal Articles

An immunostimulatory CELMoD combination overcomes resistance to T-cell engagers caused by a high multiple myeloma burden

Available to Purchase
Erin W. Meermeier, Kirsten Pfeffer, Caleb K. Stein, Meaghen E. Sharik, Megan T. Du, Yuliza Tafoya Alvarado, Chang-Xin Shi, Yuan Xiao Zhu, P. Leif Bergsagel, Marta Chesi
Journal: Blood
Blood (2025) 146 (25): 3072–3085.
https://doi.org/10.1182/blood.2025029215
Published: 2025
Includes: Supplemental data
Journal Articles

Alternate dosing schedules of BCMA-directed T cell engagers display altered pathways of relapse in syngeneic vk*MYC multiple myeloma

Free
Erin Meermeier, Caleb Stein, Meaghen Sharik, Megan Du, Yuan Zhu, Chang-Xin Shi, Kirsten Pfeffer, Keith Abayasiriwardana, Timothy Fisher, Kristin Bompiani-Myers, P. Leif Bergsagel, Marta Chesi
Journal: Blood
Blood (2025) 146 (Supplement 1): 913.
https://doi.org/10.1182/blood-2025-913
Published: 2025
Journal Articles

Retention of immunosuppressive C1Q macrophages following therapeutic interventions imparts negative outcomes across human multiple myeloma studies

Free
Caleb Stein, Erin Meermeier, Taxiarchis Kourelis, Joselle Cook, Yuliza Shotts, Yuan Zhu, Chang-Xin Shi, Kirsten Pfeffer, Meaghen Sharik, P. Leif Bergsagel, Marta Chesi
Journal: Blood
Blood (2025) 146 (Supplement 1): 7481.
https://doi.org/10.1182/blood-2025-7481
Published: 2025
Journal Articles

Pomalidomide promotes activation induced cell death of pre-activated, memory BCMA CAR-T cells in a model of high, but not low, tumor burden multiple myeloma

Free
Kirsten Pfeffer, Yuan Zhu, Chang-Xin Shi, Lorenzo Lindo, Kevin Hay, Erin Meermeier, P. Leif Bergsagel, Marta Chesi
Journal: Blood
Blood (2025) 146 (Supplement 1): 5728.
https://doi.org/10.1182/blood-2025-5728
Published: 2025
Journal Articles

Preclinical evaluation of SWI/SNF targeting agents in multiple myeloma including t(4;14) subtypes

Free
Yusuke Yamashita, Jonathan Patton, Yuliza Shotts, Megan Du, Meaghen Sharik, Kirsten Pfeffer, Yuan Zhu, Chang-Xin Shi, Caleb Stein, Erin Meermeier, Marta Chesi, Lanbo Xiao, Arul Chinnaiyan, Benjamin Barwick, P. Leif Bergsagel
Journal: Blood
Blood (2025) 146 (Supplement 1): 2138.
https://doi.org/10.1182/blood-2025-2138
Published: 2025
Journal Articles

Combination with Cytotoxic Therapy and Checkpoint Blockade Overcomes Primary Resistance to BCMA Bispecific Antibody Therapy and Leads to Durable Remission of Vk*MYC Multiple Myeloma

Free
Erin W Meermeier, Caleb K Stein, Meaghen Sharik, Megan Du, Yuan Xiao Zhu, Chang-Xin Shi, Yuliza Shotts, Maria Josic, Keith Abayasiriwardana, Natalie Bezman, Timothy Fisher, Kristin Bompiani-Myers, Leif Bergsagel, Marta Chesi
Journal: Blood
Blood (2024) 144 (Supplement 1): 358.
https://doi.org/10.1182/blood-2024-210917
Published: 2024
Journal Articles

Celmod-Dexamethasone Combination Overcomes Primary Resistance to T Cell Engagers Caused By High Tumor Burden in a Human CRBN + Preclinical Model of Multiple Myeloma

Free
Erin W Meermeier, Meaghen Sharik, Megan Du, Caleb K Stein, Yuan Xiao Zhu, Chang-Xin Shi, Yuliza Shotts, Leif Bergsagel, Marta Chesi
Journal: Blood
Blood (2024) 144 (Supplement 1): 356.
https://doi.org/10.1182/blood-2024-212225
Published: 2024
Journal Articles

Abundance of C1q Expressing Macrophages Promotes Resistance to Modern Therapy

Free
Caleb K Stein, Erin W Meermeier, Yuliza Shotts, Yuan Xiao Zhu, Chang-Xin Shi, Kirsten Pfeffer, Megan Du, Meaghen Sharik, Leif Bergsagel, Marta Chesi
Journal: Blood
Blood (2024) 144 (Supplement 1): 3275.
https://doi.org/10.1182/blood-2024-212331
Published: 2024
Journal Articles

IMiDs Synergize with EP300 Inhibition to Disrupt the Ikzf/MYC/IRF4 Axis in Multiple Myeloma

Free
Seth J Welsh, Benjamin G Barwick, Erin Meermeier, Daniel Riggs, Chang-Xin Shi, Yuan Xiao Zhu, Meaghen E Sharik, Megan T Du, Victoria Marie Garbitt, Caleb K Stein, Joachim L Petit, Nathalie Meurice, Rodrigo Fonseca, Kennedi Todd, Sochilt Brown, Yuliza Tafoya Alvarado, Zachary Hammond, Nicklus Cuc, Courtney Wittenberg, Camille Herzog, Lawrence H. Boise, Nizar J. Bahlis, Paola Neri, W. Michael Kuehl, Marta Chesi, P. Leif Bergsagel
Journal: Blood
Blood (2022) 140 (Supplement 1): 12997.
https://doi.org/10.1182/blood-2022-169920
Published: 2022
Journal Articles

Synergistic Immunostimulatory Effects and Therapeutic Benefit of Combined T Cell Engager and Cytotoxic Therapy in a Multiple Myeloma Preclinical Model

Free
Erin Meermeier, Caleb K Stein, Meaghen E Sharik, Yuan Xiao Zhu, Megan T Du, Seth J Welsh, Chang-Xin Shi, Matthew L Wheeler, P. Leif Bergsagel, Marta Chesi
Journal: Blood
Blood (2022) 140 (Supplement 1): 7056–7057.
https://doi.org/10.1182/blood-2022-167668
Published: 2022
Journal Articles

Disrupting Ectopic Super-Enhancers to Treat Multiple Myeloma

Free
Seth Welsh, Daniel Riggs, Erin Meermeier, Chang-Xin Shi, Victoria Garbitt, Meaghen E Sharik, Megan Du, Kennedi Todd, Zachary Hammond, Sochilt Brown, Caleb K Stein, Paola Neri, Nizar J. Bahlis, Benjamin G Barwick, Larry H. Boise, W. Michael Kuehl, Marta Chesi, P. Leif Bergsagel
Journal: Blood
Blood (2021) 138 (Supplement 1): 1593.
https://doi.org/10.1182/blood-2021-147551
Published: 2021
Journal Articles

The Contribution of Proteasome Subunits to Myeloma Cell Viability and Proteasome Inhibitor Sensitivity

Free
Chang-Xin Shi, PhD, Yuan Xiao Zhu, PhD, Laura Ann Bruins, BS, Cecilia Bonolo De Campos, PhD, William Stewart, Esteban Braggio, PhD, A Keith Stewart, M.B. Ch.B.
Journal: Blood
Blood (2019) 134 (Supplement_1): 4337.
https://doi.org/10.1182/blood-2019-127149
Published: 2019
Journal Articles

Lenalidomide, Pomalidomide and CC-220 Resistant Multiple Myeloma: Confirmation of Role of CRBN/IRF4 Axis and Identification of Multiple Disruption Mechanisms

Free
Yuan Xiao Zhu, PhD, Chang-Xin Shi, PhD, Laura Ann Bruins, BS, Xuewei Wang, PhD, Daniel Riggs, PhD, Brooke Porter, Jonathan Ahmann, BS, Esteban Braggio, PhD, P. Leif Bergsagel, MD, A. Keith Stewart, MBChB, MBA
Journal: Blood
Blood (2017) 130 (Supplement 1): 4369.
https://doi.org/10.1182/blood.V130.Suppl_1.4369.4369
Published: 2017
Journal Articles

PIKfyve Inhibitors for the Treatment of Multiple Myeloma

Free
Cecilia Bonolo De Campos, PhD, Yuan Xiao Zhu, PhD, Chang-Xin Shi, PhD, Laura Ann Bruins, BS, Joachim L Petit, PhD, Alysia N Polito, BS, Meaghen E Sharik, BS, Caleb K Stein, MS, Gregory J Ahmann, BS, Ilsel D Lopez Armenta, BS, Nikolai Sepetov, PhD, Sergei Romanov, PhD, P. Leif Bergsagel, MD, Marta Chesi, PhD, Nathalie Meurice, PhD, A. Keith Stewart, MBChB, MBA
Journal: Blood
Blood (2017) 130 (Supplement 1): 4423.
https://doi.org/10.1182/blood.V130.Suppl_1.4423.4423
Published: 2017
Journal Articles

Multiple myeloma cells’ capacity to decompose H 2 O 2 determines lenalidomide sensitivity

Free
Sinto Sebastian, Yuan X. Zhu, Esteban Braggio, Chang-Xin Shi, Sonali C. Panchabhai, Scott A. Van Wier, Greg J. Ahmann, Marta Chesi, P. Leif Bergsagel, A. Keith Stewart, Rafael Fonseca
Journal: Blood
Blood (2017) 129 (8): 991–1007.
https://doi.org/10.1182/blood-2016-09-738872
Published: 2017
Includes: Supplemental data
Journal Articles

Lenalidomide Inhibits Thioredoxin Reductase (TrxR) in Multiple Myeloma (MM) Cells but Direct Inhibition of Trxr and Thioredoxin (Trx) Can Bypass Requirement of Cereblon (CRBN)

Free
Sinto Sebastian Chirackal, PhD, Esteban Braggio, PhD, Yuan Xiao Zhu, PhD, Chang-Xin Shi, PhD, Scott Van Wier, Gregory Ahmann, Veronica Gonzalez-Calle, MD, Marta Chesi, PhD, Leif Bergsagel, MD, Keith Stewart, M.B., Ch.B., Rafael Fonseca, MD
Journal: Blood
Blood (2016) 128 (22): 4482.
https://doi.org/10.1182/blood.V128.22.4482.4482
Published: 2016
Journal Articles

The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude mice

Free
Zubin Zhang, Jiefei Tong, Xiaowen Tang, Jiaxiang Juan, Biyin Cao, Rose Hurren, Guodong Chen, Paul Taylor, Xin Xu, Chang-xin Shi, Juan Du, Jian Hou, Guanghui Wang, Depei Wu, A. Keith Stewart, Aaron D. Schimmer, Michael F. Moran, Xinliang Mao
Journal: Blood
Blood (2016) 127 (13): 1676–1686.
https://doi.org/10.1182/blood-2015-07-658203
Published: 2016
Includes: Supplemental data
Journal Articles

Crispr Sgrnas Genome-Wide Screen Identifies the Proteasome Regulatory Subunit PSMC6 As a Bortezomib Resistance Gene in Human Multiple Myeloma Cells

Free
Chang-Xin Shi, PhD, Klaus M Kortum, MD, Yuan Xiao Zhu, PhD, Patrick Jedlowski, Esteban Braggio, PhD, Laura Ann Bruins, Patrick G. Votruba, M.S., Moulun Luo, PhD, Robert A. Stewart, Jonathan M. Ahmann, A. Keith Stewart
Journal: Blood
Blood (2015) 126 (23): 450.
https://doi.org/10.1182/blood.V126.23.450.450
Published: 2015
Journal Articles

Immunomodulatory Drugs Inhibit H 2 O 2 Decomposition in Multiple Myeloma Cells and Its Mediated Cytotoxicity Is Determined By Cellular Antioxidative Capacity

Free
Sinto Sebastian Chirackal, PhD, Yuan Xiao Zhu, PhD, Esteban Braggio, PhD, Chang-Xin Shi, PhD, Sonali Panchabhai, MBBS, Gregory Ahmann, BS, Scott A. Van Wier, BS, Marta Chesi, PhD, Leif Bergsagel, MD PhD, Keith Stewart, MD, Rafael Fonseca, MD
Journal: Blood
Blood (2015) 126 (23): 2475.
https://doi.org/10.1182/blood.V126.23.2475.2475
Published: 2015