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Christian Michel
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Journal Articles

Efficacy of Ropeginterferon Alpha 2b in Inducing Treatment Free Remission in Chronic Myeloid Leukemia - an International, Randomized Phase III Trial (ENDURE, CML-IX) of the German CML-Study Group

Andreas Burchert, Susanne Saussele, Christian Michel, Stephan K Metzelder, Andreas Hochhaus, Norbert Gattermann, Martina Crysandt, Philippe Schafhausen, Matthias Bormann, Markus P. Radsak, Agnès Guerci-Bresler, Thomas Illmer, Maria E Goebeler, Peter Herhaus, Lino L. Teichmann, Georg-Nikolaus Franke, Fabian Lang, Stefan W. Krause, Robert Möhle, Martine Klausmann, Frank Stegelmann, Christoph Lutz, Gabriel Etienne, Andrea Stoltefuß, Joachim R Göthert, Thomas Ernst, Andreas Neubauer, Rüdiger Hehlmann, Behnaz Aminossadati, Michael Wittenberg, Markus Pfirrmann, Carmen Schade-Brittinger, Philipp le Coutre, Franck E. Nicolini
Journal: Blood
Blood (2022) 140 (Supplement 1): 1501–1503.
https://doi.org/10.1182/blood-2022-169324
Published: 2022
Journal Articles

Immunotherapy: genetically agnostic in BCP-ALL?

Christian Michel Zwaan, Friso G. J. Calkoen
Journal: Blood
Blood (2022) 139 (14): 2093–2094.
https://doi.org/10.1182/blood.2022015618
Published: 2022
Journal Articles

A phase 1 study of inotuzumab ozogamicin in pediatric relapsed/refractory acute lymphoblastic leukemia (ITCC-059 study)

Clinical Trials & Observations
Erica Brivio, Franco Locatelli, Marta Lopez-Yurda, Andrea Malone, Cristina Díaz-de-Heredia, Bella Bielorai, Claudia Rossig, Vincent H. J. van der Velden, Anneke C. J. Ammerlaan, Adriana Thano, Inge M. van der Sluis, Monique L. den Boer, Ying Chen, Barbara Sleight, Benoit Brethon, Karsten Nysom, Lucie Sramkova, Ingrid Øra, Luciana Vinti, Christiane Chen-Santel, Christian Michel Zwaan
Journal: Blood
Blood (2021) 137 (12): 1582–1590.
https://doi.org/10.1182/blood.2020007848
Published: 2021
Includes: Supplemental data
Journal Articles

A Phase II Study of Single-Agent Inotuzumab Ozogamicin in Pediatric CD22-Positive Relapsed/Refractory Acute Lymphoblastic Leukemia: Results of the ITCC-059 Study

Erica Brivio, MD, Franco Locatelli, MD, Adriana Thano, Arnaud Petit, MD PhD, Britta Julia Vormoor, MD, Susana Rives, Bella Bielorai, MD, Claudia Rossig, Carmelo Rizzari, Vincent H.J. Van Der Velden, PhD, Anneke C.J. Ammerlaan, Monique L. Den Boer, PhD, Barbara Sleight, MD, Gernot Engstler, Jan Stary, MD PhD, Francisco José Bautista Sirvent, MD PhD, Christiane Chen-Santel, Bénédicte Bruno, MD, Yves Bertrand, MD, Fanny Rialland, MD, Geneviève Plat, Dirk Reinhardt, MD, Luciana Vinti, MD, Arend von Stackelberg, MD, Christian Michel Zwaan
Journal: Blood
Blood (2020) 136 (Supplement 1): 8–9.
https://doi.org/10.1182/blood-2020-134774
Published: 2020
Journal Articles

Phase 2 study of nilotinib in pediatric patients with Philadelphia chromosome–positive chronic myeloid leukemia

Clinical Trials & Observations
Nobuko Hijiya, Alexey Maschan, Carmelo Rizzari, Hiroyuki Shimada, Carlo Dufour, Hiroaki Goto, Hyoung Jin Kang, Terri Guinipero, Zeynep Karakas, Francisco Bautista, Stéphane Ducassou, Keon Hee Yoo, Christian Michel Zwaan, Frédéric Millot, Paola Aimone, Alex Allepuz, Sara Quenet, Florence Hourcade-Potelleret, Sabine Hertle, Darintr Sosothikul
Journal: Blood
Blood (2019) 134 (23): 2036–2045.
https://doi.org/10.1182/blood.2019000069
Published: 2019
Includes: Supplemental data
Journal Articles

A Retrospective Study on Inotuzumab Ozogamicin in Infants and Young Children with Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL)

Erica Brivio, MD, Raoull Hoogendijk, MSc, Christophe Chantrain, MD PhD, Fanny Rialland, MD, Audrey Contet, Sarah Elitzur, MD, Luciano Dalla-Pozza, MBBS FRACP, Krisztian Kallay, MD, Chi Kong Li, MBBS,MD, Motohiro Kato, MD PhD, Inna V Markova, Dr., Kjeld Schmiegelow, Professor MD DMSc., Nicole Bodmer, Rob Pieters, MDPhDMSc, Christian Michel Zwaan, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3890.
https://doi.org/10.1182/blood-2019-126472
Published: 2019
Journal Articles

Phase II Study of Midostaurin + Chemotherapy in Pediatric Patients with Untreated, Newly Diagnosed, FLT3 -Mutated Acute Myeloid Leukemia (AML)

Dirk Reinhardt, MD, Christian Michel Zwaan, Albert Hoenekopp, Julie Niolat, Sophie Ifrah, Florence Noel-Baron, Franco Locatelli, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3835.
https://doi.org/10.1182/blood-2019-128043
Published: 2019
Journal Articles

Safety, Efficacy, and PK of the BCL2 Inhibitor Venetoclax in Combination with Chemotherapy in Pediatric and Young Adult Patients with Relapsed/Refractory Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia: Phase 1 Study

Seth E Karol, MD, Todd M Cooper, DO, Henrique Bittencourt, Lia Gore, MD, Maureen M O'Brien, MD, Christopher Fraser, MD, Marion Gambart, MD, Gunnar Cario, MD PhD, Christian Michel Zwaan, MD PhD, Jean-Pierre Bourquin, MD PhD, Mignon L. Loh, MD, Hubert Caron, MD PhD, Betty Prine, Ahmed Hamed Salem, PhD FCP, Kristina Unnebrink, Bo Tong, PhD, Tammy Palenski, PhD, Andrew E. Place, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2649.
https://doi.org/10.1182/blood-2019-129805
Published: 2019
Journal Articles

A Phase I Study of Single-Agent Inotuzumab Ozogamicin in Pediatric CD22-Positive Relapsed/Refractory Acute Lymphoblastic Leukemia: Preliminary Results of the ITCC-059 Study

Erica Brivio, MD, Marta Lopez-Yurda, PhD, Cormac Ownes, MD, Cristina Díaz de Heredia, MD PhD, Bella Bielorai, MD, Claudia Rossig, Vincent van der Velden, PhD, Anneke C.J. Ammerlaan, Inge M. van der Sluis, MD PhD, Monique L. Den Boer, PhD, Ying Chen, Barbara Sleight, MD, Benoit Brethon, MD, Karsten Nysom, Jan Stary, Prof., MD PhD, Ingrid Øra, Christiane Chen-Santel, Luciana Vinti, MD, Franco Locatelli, MD PhD, Christian Michel Zwaan, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2629.
https://doi.org/10.1182/blood-2019-122411
Published: 2019
Journal Articles

Integrative Analysis of Pediatric Acute Leukemia Identifies Immature Subtypes That Span a T Lineage and Myeloid Continuum with Distinct Prognoses

Tanja A. Gruber, MD PhD, Jing Ma, PhD, Sanne Noort, MD MSc, Yu Liu, PhD, Michael P Walsh, PhD, Stephanie Nance, PhD, Yanling Liu, PhD, Yuanyuan Wang, PhD, Guangchun Song, PhD, Tamara Lamprecht, BS, John Easton, PhD, Martina Pigazzi, PhD, Marie Jarosova, PhD, Kelaidi Charikleia, MD, Jeffrey Rubnitz, MD PhD, Dirk Reinhardt, MD, Marry M. van den Heuvel-Eibrink, Prof, MD PhD, Franco Locatelli, MD PhD, Henrik Hasle, Jeffery M. Klco, MD PhD, James R. Downing, MD, Stanley Pounds, PhD, Jinghui Zhang, PhD, Christian Michel Zwaan, MD PhD, Maarten Fornerod, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 918.
https://doi.org/10.1182/blood-2019-127411
Published: 2019
Journal Articles

Nuclear NFATc1 Causes Development of Fms-like Receptor Tyrosine Kinase 3 Receptor (FLT3) Internal Tandem Duplication Mutation-Positive (FLT3-ITD) Acute Myeloid Leukemia (AML) and Mediates Drug Resistance

Maria A. Solovey, Ying Wang, MD, Stefan Gattenloehner, MD, Elisabeth Hessmann, MD, Stephan Metzelder, MD, Christian Michel, MD, Volker Ellenrieder, MD, Joachim R. Goethert, MD, Andreas Neubauer, Andreas Burchert, MD
Journal: Blood
Blood (2016) 128 (22): 1722.
https://doi.org/10.1182/blood.V128.22.1722.1722
Published: 2016
Journal Articles

Ibrutinib Abrogates TREM-1 Mediated Neutrophil Activation

Nicole Stadler, Astrid Hasibeder, Pamela Aranda Lopez, Alexander Desuki, Oliver Kriege, Alexander N.R. Weber, Christian Michel, Daniel Teschner, Georg Hess, MD, Matthias Theobald, MD, Markus Radsak, MD
Journal: Blood
Blood (2016) 128 (22): 3691.
https://doi.org/10.1182/blood.V128.22.3691.3691
Published: 2016
Journal Articles

Idelalisib Impairs TREM-1 and TLR Mediated Neutrophil Activation

Astrid Hasibeder, Nicole Stadler, Pamela Aranda Lopez, Alexander Desuki, Oliver Kriege, Alexander N.R. Weber, Christian Michel, Daniel Teschner, Georg Hess, MD, Matthias Theobald, MD, Markus Radsak, MD
Journal: Blood
Blood (2016) 128 (22): 2510.
https://doi.org/10.1182/blood.V128.22.2510.2510
Published: 2016
Journal Articles

The Impact of NFAT Inhibition on Neutrophil Effector Functions in Patients after Allogeneic Hematopoietic Stem Cell Transplantation and on Neutrophil Antifungal Defense and Myelopoiesis in Cyclosporin Α Treated and NFATc1 LysM Mice

Daniel Teschner, Katharina Plein, Christian Michel, Steve Pruefer, PhD, Matthias Bros, PhD, Eva Maria Wagner, MD, Matthias Theobald, MD, Hansjoerg Schild, PhD Prof., Markus Radsak, MD
Journal: Blood
Blood (2016) 128 (22): 3679.
https://doi.org/10.1182/blood.V128.22.3679.3679
Published: 2016
Journal Articles

The Impact of NFAT Inhibition on Neutrophil Antifungal Defense and Myelopoiesis in Cyclosporine A Treated and NFATc1 LysM Mice

Daniel Teschner, MD, Christian Michel, MD, Steve Pruefer, PhD, Matthias Theobald, MD PhD, Hansjoerg Schild, PhD Prof., Markus Radsak, MD
Journal: Blood
Blood (2015) 126 (23): 1007.
https://doi.org/10.1182/blood.V126.23.1007.1007
Published: 2015
Journal Articles

A Role for NFAT in Innate Immunity: Neutrophil Effector Functions in Patients after Allogeneic Hematopoietic Stem Cell Transplantation Under Cyclosporine Α Treatment

Katharina Plein, Daniel Teschner, MD, Christian Michel, MD, Eva-Maria Wagner, MD, Pamela Stein, PhD, Matthias Theobald, MD Prof., Hansjoerg Schild, MD Prof., Markus Radsak, MD
Journal: Blood
Blood (2014) 124 (21): 2495.
https://doi.org/10.1182/blood.V124.21.2495.2495
Published: 2014
Journal Articles

CEBPA resembles Roman god Janus

Iris H. I. M. Hollink, Marry M. van den Heuvel-Eibrink, Christian Michel Zwaan
Journal: Blood
Blood (2009) 113 (26): 6501–6502.
https://doi.org/10.1182/blood-2009-04-214296
Published: 2009
Journal Articles

Does modulation of P-glycoprotein have clinical relevance in pediatric acute myeloid leukemia?

Christian Michel Zwaan, Monique L. den Boer, Karin M. Kazemier, Karel Hählen, Anne H. Loonen, Dirk Reinhardt, Ursula Creutzig, Gertjan J. L. Kaspers, Rob Pieters
Journal: Blood
Blood (2006) 107 (12): 4975–4977.
https://doi.org/10.1182/blood-2006-01-0309
Published: 2006