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Journal Articles

Novel approaches to identify cellular vulnerabilities in TET2-dependent MDS

Blood (2025) 146 (Supplement 1): 3838.

https://doi.org/10.1182/blood-2025-3838

Published: 2025

Journal Articles

Serum erythropoietin level as a selective pressure in clonal hematopoiesis: Insights into the mutational landscape of myeloid neoplasias

Zachary Brady, Charlotte Zurowski, Felipe de Almeida Sartori, Tariq Kewan, Olivia Hunyadi, Mark Orland, Aashray Mandala, Christopher Haddad, Hetty Carraway, Abhay Singh, Serhan Unlu, Atsushi Marumo, Kartik Lakhotiya, Carmelo Gurnari, Arda Durmaz, Valeria Visconte, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 3174.

https://doi.org/10.1182/blood-2025-3174

Published: 2025

Journal Articles

C-CBL mutations affecting residue 371 confer dismal prognosis in MDS and CMML

Luca Guarnera, Carmelo Gurnari, Zachary Brady, Carlos Bravo-Perez, Matteo D'Addona, Atsushi Marumo, Mark Orland, Praveena Thiagarajan, Serhan Unlu, Christopher Haddad, Aashray Mandala, Eleonora Lumia, Nicole Lelli, Arda Durmaz, Emiliano Fabiani, Maria Teresa Voso, Jaroslaw Maciejewski, Valeria Visconte

Blood (2025) 146 (Supplement 1): 2064.

https://doi.org/10.1182/blood-2025-2064

Published: 2025

Journal Articles

Germline alterations of hematopoietic growth factor receptors and maladaptive somatic genetic rescue leads to myeloid neoplasia

Serhan Unlu, Tariq Kewan, Christopher Haddad, Olisaemeka Ogbue, Asfand Yar Cheema, Zachary Brady, Mark Orland, Praveena Thiagarajan, Aashray Mandala, Matteo D'Addona, Luca Guarnera, Carlos Bravo-Perez, Carmelo Gurnari, Valeria Visconte, Arda Durmaz, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 5614.

https://doi.org/10.1182/blood-2025-5614

Published: 2025

Journal Articles

The basis for the differential impact of BCOR and BCORL1 in aplastic anemia/paroxysmal nocturnal hemoglobinuria and myeloid neoplasia

Atsushi Marumo, Arda Durmaz, Aashray Mandala, Christopher Haddad, Felipe Sartori, Olivia Hunyadi, Ersan Unlu, Serhan Unlu, Zachary Brady, Matteo D Addona, Kartik Lakhotiya, Luca Guarnera, Masanori Yoshida, Mark Orland, Carlos Bravo-Perez, Carmelo Gurnari, Marcin Wlodarski, Valeria Visconte, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 3196.

https://doi.org/10.1182/blood-2025-3196

Published: 2025

Journal Articles

Epidemiologic clues, current management and diagnostic trends in idiopathic budd-chiari syndrome: Implications of PNH and diagnostic testing

Aashray Mandala, Arda Durmaz, Mark Orland, Carlos Bravo-Perez, Zachary Brady, Matteo D'Addona, Kartik Lakhotiya, Christopher Haddad, Praveena Thiagarajan, Serhan Unlu, Felipe de Almeida Sartori, Selin Ilaslan, Valeria Visconte, Carmelo Gurnari, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 1432.

https://doi.org/10.1182/blood-2025-1432

Published: 2025

Journal Articles

Global immunopeptidome remodeling favors piga mutant clones in bone marrow failure

Kartik Lakhotiya, Xiaorong Gu, Arda Durmaz, Aashray Mandala, Matteo D'Addona, Carlos Bravo-Perez, Mark Orland, Zachary Brady, Serhan Unlu, Atsushi Marumo, Praveena Thiagarajan, Christopher Haddad, Felipe de Almeida Sartori, ERSAN UNLU, Valeria Visconte, Carmelo Gurnari, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 3207.

https://doi.org/10.1182/blood-2025-3207

Published: 2025

Journal Articles

A comparative analysis of epigenetic age acceleration across distinct hematopoietic clones in hematologic diseases

Atsushi Marumo, Arda Durmaz, Aashray Mandala, Christopher Haddad, Felipe Sartori, Olivia Hunyadi, Ersan Unlu, Serhan Unlu, Zachary Brady, Matteo D Addona, Kartik Lakhotiya, Luca Guarnera, Mark Orland, Carlos Bravo-Perez, Carmelo Gurnari, Valeria Visconte, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 4945.

https://doi.org/10.1182/blood-2025-4945

Published: 2025

Journal Articles

Machine learning-derived, comprehensive “Geno-Immunome” of bone marrow failure syndromes reveals complex immunogenetic interactions with clinical implications

Aashray Mandala, Carlos Bravo-Perez, Mark Orland, Zachary Brady, Serhan Unlu, Atsushi Marumo, Kartik Lakhotiya, Christopher Haddad, Felipe de Almeida Sartori, Asfand Yar Cheema, Simona Pagliuca, Carmelo Gurnari, Valeria Visconte, Arda Durmaz, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 2583.

https://doi.org/10.1182/blood-2025-2583

Published: 2025

Journal Articles

GLP‑1 receptor agonists and clonal hematopoiesis: Early human signals of anti‑inflammatory clone mitigation and lower MDS‑to‑AML progression

Mark Orland, Asfand Yar Cheema, Zachary Brady, Aashray Mandala, Felipe de Almeida Sartori, Luca Guarnera, Christopher Haddad, Kartik Lakhotiya, Carlos Bravo-Perez, Carmelo Gurnari, Valeria Visconte, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 1385.

https://doi.org/10.1182/blood-2025-1385

Published: 2025

Journal Articles

Could Somatic Gene Rescue Explain Frequency of Compound Heterozygous and Concurrent Receptor Tyrosine Kinase Mutations in Hematological Diseases?

Serhan Unlu, Christopher Haddad, Tariq Kewan, Olisaemeka Ogbue, Arda Durmaz, Waled Bahaj, Arooj Ahmed, Carlos Bravo-Perez, Luca Guarnera, Hetty E. Carraway, Yasuo Kubota, Carmelo Gurnari, Torsten Haferlach, Valeria Visconte, Jaroslaw Maciejewski

Blood (2024) 144 (Supplement 1): 3199.

https://doi.org/10.1182/blood-2024-205865

Published: 2024

Journal Articles

Budd-Chiari Syndrome: Pathogenetic Factors and Completeness of Screening for Paroxysmal Nocturnal Hemoglobinuria

Aashray Mandala, Carlos Bravo-Perez, Zachary Brady, Matteo D'Addona, Arda Durmaz, Mark Orland, Kartik Lakhotiya, Christopher Haddad, Praveena Thiagarajan, Valeria Visconte, Carmelo Gurnari, Jaroslaw Maciejewski

Blood (2024) 144 (Supplement 1): 1254.

https://doi.org/10.1182/blood-2024-211609

Published: 2024

Journal Articles

Low-Count T-/NK-Large Granular Lymphocytic Leukemia: A Nosologically Distinct Disease Subtype at the Crossroads between Lymphoproliferation, Autoimmunity and Immunodeficiency

Carlos Bravo-Perez, Carmelo Gurnari, Arooj Ahmed, Naomi Kawashima, Zachary Brady, Matteo D'Addona, Luca Guarnera, Aashray Mandala, Kartik Lakhotiya, Christopher Haddad, Serhan Unlu, Mark Orland, Praveena Thiagarajan, Arda Durmaz, Valeria Visconte, Jaroslaw Maciejewski

Blood (2024) 144 (Supplement 1): 1688.

https://doi.org/10.1182/blood-2024-209437

Published: 2024

Journal Articles

LGL Versus MGUS: Clonal Immune Pathogenetic Culprits in Hyporegenerative Anemias and Red Cell Aplasia

Carlos Bravo-Perez, Carmelo Gurnari, Zachary Brady, Arooj Ahmed, Matteo D'Addona, Luca Guarnera, Aashray Mandala, Christopher Haddad, Kartik Lakhotiya, Praveena Thiagarajan, Megan Nakashima, Hetty E. Carraway, Heesun J. Rogers, Arda Durmaz, Valeria Visconte, Jaroslaw Maciejewski

Blood (2024) 144 (Supplement 1): 5234.

https://doi.org/10.1182/blood-2024-209314

Published: 2024

Journal Articles

First Results of High Throughput Pipeline for Serotypic and TCR Clonotypic Specificities in Aplastic Anemia and Large Granular Lymphocyte Leukemia Uncovering Antigenic Peptides Relevant to Disease Etiology

Kartik Lakhotiya, Carmelo Gurnari, Carlos Bravo-Perez, Aashray Mandala, Matteo D'Addona, Christopher Haddad, Mark Orland, Zachary Brady, Luca Guarnera, Praveena Thiagarajan, Ishani Nautiyal, Simona Pagliuca, Hari Krishnamurthy, Karthik Krishna, Vasanth Jayaraman, Valeria Visconte, Jaroslaw Maciejewski, Arda Durmaz

Blood (2024) 144 (Supplement 1): 35.

https://doi.org/10.1182/blood-2024-210990

Published: 2024

Journal Articles

Molecular Landscape of Multiple STAG2 Mutant Myeloid Malignancies

Matteo D'Addona, Eno-Obong B. Udoh, Luca Guarnera, Carlos Bravo-Perez, Serhan Unlu, Zachary Brady, Kartik Lakhotiya, Hussein Awada, Christopher Haddad, Aashray Mandala, Mark Orland, Arda Durmaz, Carmelo Gurnari, Aaron D. Viny, Jaroslaw Maciejewski, Valeria Visconte

Blood (2024) 144 (Supplement 1): 6696.

https://doi.org/10.1182/blood-2024-207614

Published: 2024

Journal Articles

An Immunogenetic Perspective on Bone Marrow Failure Syndromes: The KIR-HLA System

Aashray Mandala, Carlos Bravo-Perez, Matteo D'Addona, Zachary Brady, Mark Orland, Luca Guarnera, Kartik Lakhotiya, Christopher Haddad, Praveena Thiagarajan, Arooj Ahmed, Simona Pagliuca, Carmelo Gurnari, Valeria Visconte, Arda Durmaz, Jaroslaw Maciejewski

Blood (2024) 144 (Supplement 1): 4084.

https://doi.org/10.1182/blood-2024-210304

Published: 2024

Journal Articles

Distinct Phenotypes of Myeloid Neoplasia Associated with Truncating C-CBL Mutations

Luca Guarnera, Carmelo Gurnari, Carlos Bravo-Perez, Arda Durmaz, Nakisha D Williams, Hussein Awada, Matteo D'Addona, Naomi Kawashima, Arooj Ahmed, Serhan Unlu, Olisaemeka Ogbue, Christopher Haddad, Aashray Mandala, Yasuo Kubota, Juraj Bodo, Genevieve M Crane, Heesun J. Rogers, Jaroslaw Maciejewski, Valeria Visconte

Blood (2024) 144 (Supplement 1): 2920.

https://doi.org/10.1182/blood-2024-209834

Published: 2024

Journal Articles

Genomic Landscape of Germline RUNX1 variants in Adult Myeloid Neoplasia According to Functional Impact

Christopher Haddad, Luca Guarnera, Yasuo Kubota, Carlos Bravo-Perez, Carmelo Gurnari, Olisaemeka Ogbue, Arda Durmaz, Serhan Unlu, Aashray Mandala, Mark Orland, Zachary Brady, Kartik Lakhotiya, Matteo D'Addona, Ishani Nautiyal, David S. Bosler, Hetty E. Carraway, Yogen Saunthararajah, Valeria Visconte, Jaroslaw Maciejewski

Blood (2024) 144 (Supplement 1): 1328.

https://doi.org/10.1182/blood-2024-210419

Published: 2024

Journal Articles

Elucidating the Somatic Genetic Rescue Underlying Del(20q) Myeloid Neoplasms

Mark Orland, Arda Durmaz, Carlos Bravo-Perez, Carmelo Gurnari, Luca Guarnera, Matteo D'Addona, Aashray Mandala, Christopher Haddad, Kartik Lakhotiya, Valeria Visconte, Jaroslaw Maciejewski

Blood (2024) 144 (Supplement 1): 4573.

https://doi.org/10.1182/blood-2024-208520

Published: 2024

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Novel approaches to identify cellular vulnerabilities in TET2-dependent MDS

Serum erythropoietin level as a selective pressure in clonal hematopoiesis: Insights into the mutational landscape of myeloid neoplasias

C-CBL mutations affecting residue 371 confer dismal prognosis in MDS and CMML

Germline alterations of hematopoietic growth factor receptors and maladaptive somatic genetic rescue leads to myeloid neoplasia

The basis for the differential impact of BCOR and BCORL1 in aplastic anemia/paroxysmal nocturnal hemoglobinuria and myeloid neoplasia

Epidemiologic clues, current management and diagnostic trends in idiopathic budd-chiari syndrome: Implications of PNH and diagnostic testing

Global immunopeptidome remodeling favors piga mutant clones in bone marrow failure

A comparative analysis of epigenetic age acceleration across distinct hematopoietic clones in hematologic diseases

Machine learning-derived, comprehensive “Geno-Immunome” of bone marrow failure syndromes reveals complex immunogenetic interactions with clinical implications

GLP‑1 receptor agonists and clonal hematopoiesis: Early human signals of anti‑inflammatory clone mitigation and lower MDS‑to‑AML progression

Could Somatic Gene Rescue Explain Frequency of Compound Heterozygous and Concurrent Receptor Tyrosine Kinase Mutations in Hematological Diseases?

Budd-Chiari Syndrome: Pathogenetic Factors and Completeness of Screening for Paroxysmal Nocturnal Hemoglobinuria

Low-Count T-/NK-Large Granular Lymphocytic Leukemia: A Nosologically Distinct Disease Subtype at the Crossroads between Lymphoproliferation, Autoimmunity and Immunodeficiency

LGL Versus MGUS: Clonal Immune Pathogenetic Culprits in Hyporegenerative Anemias and Red Cell Aplasia

First Results of High Throughput Pipeline for Serotypic and TCR Clonotypic Specificities in Aplastic Anemia and Large Granular Lymphocyte Leukemia Uncovering Antigenic Peptides Relevant to Disease Etiology

Molecular Landscape of Multiple STAG2 Mutant Myeloid Malignancies

An Immunogenetic Perspective on Bone Marrow Failure Syndromes: The KIR-HLA System

Distinct Phenotypes of Myeloid Neoplasia Associated with Truncating C-CBL Mutations

Genomic Landscape of Germline RUNX1 variants in Adult Myeloid Neoplasia According to Functional Impact

Elucidating the Somatic Genetic Rescue Underlying Del(20q) Myeloid Neoplasms

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American Society of Hematology

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