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Journal Articles

Narazaciclib, a Differentiated CDK4/6 Antagonist, Prolongs Cell Cycle Arrest and Metabolomic Reprogramming, Enabling Restoration of Ibrutinib Sensitivity in Btki-Resistant Mantle Cell Lymphoma

Nuria Profitos-Peleja, Marcelo Lima Ribeiro, Jeronimo Parra, Miranda Fernandez-Serrano, Pau Marin-Escudero, Joan Josep Bech, Carolina De La Torre, Adar Makovski Silverstein, Steve Cosenza, Steven M. Fruchtman, Manel Esteller, Gael Roue
Journal: Blood
Blood (2023) 142 (Supplement 1): 4181.
https://doi.org/10.1182/blood-2023-189838
Published: 2023
Journal Articles

CARD11 gain of function upregulates BCL2A1 expression and promotes resistance to targeted therapies combination in B-cell lymphoma

Salomé Decombis, Celine Bellanger, Yannick Le Bris, Candice Madiot, Jane Jardine, Juliana Carvalho Santos, Delphine Boulet, Christelle Dousset, Audrey Menard, Charlotte Kervoelen, Elise Douillard, Philippe Moreau, Stephane Minvielle, Agnes Moreau-Aubry, Benoit Tessoulin, Gael Roue, Nicolas Bidère, Steven Le Gouill, Catherine Pellat-Deceunynck, David Chiron
Journal: Blood
Blood (2023) 142 (18): 1543–1555.
https://doi.org/10.1182/blood.2023020211
Published: 2023
Includes: Supplemental data
Journal Articles

Multiomic Characterization of Myelodysplastic Neoplasms (MDS) with Micromegakaryocytes Highlights the Role of EZH2-RUNX1 deregulation in Disease Physiopathology and Response to Targeted Therapies

Miranda Fernandez-Serrano, Alba Mesa, Ignacio Campillo-Marcos, Marta Casado-Pelaez, Shubhra Bhattacharya, Laura Palomo, Wencke Walter, Pau Marin-Escudero, Mar Mallo, Julia Montoro, Francesc Sole, Elisabetta Mereu, Caterina Mata, David Corujo, Torsten Haferlach, Marcus Buschbeck, Manel Esteller, David Valcarcel, Silvia Saumell, Gael Roue
Journal: Blood
Blood (2023) 142 (Supplement 1): 4116.
https://doi.org/10.1182/blood-2023-188848
Published: 2023
Journal Articles

Lymphomagenic Roles of MYC, E2F and Mir-150-5p in Plasmablastic Lymphoma: Therapeutic and Prognostic Implications

Miriam Verdú Bou, Maria Joao Baptista, Aleix Mendez Lopez, Gustavo Tapia, Marcelo Lima Ribeiro, Gaël Roué, Jose Luis Mate, Pau Abrisqueta, Mariana Bastos-Oreiro, Miguel Alcoceba, Eva González Barca, Fina Climent, Antonio Salar, Juan-Manuel Sancho, Fabian Frontzek, Annette M. Staiger, German Ott, Manuel Castro De Moura, Georg Lenz, Jose Tomas Navarro
Journal: Blood
Blood (2022) 140 (Supplement 1): 9266–9268.
https://doi.org/10.1182/blood-2022-168552
Published: 2022
Journal Articles

Distinct roles for PARP-1 and PARP-2 in c-Myc–driven B-cell lymphoma in mice

Miguel A. Galindo-Campos, Nura Lutfi, Sarah Bonnin, Carlos Martínez, Talia Velasco-Hernandez, Violeta García-Hernández, Juan Martín-Caballero, Coral Ampurdanés, Ramón Gimeno, Lluis Colomo, Gaël Roué, Guillaume Guilbaud, Françoise Dantzer, Pilar Navarro, Matilde Murga, Oscar Fernández-Capetillo, Anna Bigas, Pablo Menéndez, Julian E. Sale, José Yélamos
Journal: Blood
Blood (2022) 139 (2): 228–239.
https://doi.org/10.1182/blood.2021012805
Published: 2022
Includes: Supplemental data
Journal Articles

The Ublituximab-Umbralisib (U2) Drug Regimen Potentiates the Activity of the Novel CD47-CD19 Bispecific Antibody, TG-1801, through the Activation of the G Protein-Coupled Receptor EBI2/GPR183

Emmanuel Normant, Marcelo Lima Ribeiro, Nuria Profitos-Peleja, Pedro Blecua, Diana Reyes-Garau, Juliana Carvalho Santos, Marc Armengol, Miranda Fernández-Serrano, Hari P. Miskin, Gael Roue
Journal: Blood
Blood (2021) 138 (Supplement 1): 1196.
https://doi.org/10.1182/blood-2021-150570
Published: 2021
Journal Articles

Morphologic Assessment of Terminal Erythroid Differentiation Predicts Outcomes in Myelodysplastic Syndromes

Maria Julia Montoro, MD, Ana Perez, MD, Silvia Saumell, MD PhD, Maida Navarrete, MD, Gael Roue, PhD, Moraima Jimenez, MD, Margarita Ortega, PhD, Bárbara Tazón, PhD, Antonieta Molero, MD, Olga Salamero, MD, Francesc Bosch, MD PhD, David Valcarcel, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3011.
https://doi.org/10.1182/blood-2019-123185
Published: 2019
Journal Articles

Acute Myeloid Leukemia with Myelodisplasia-Related Changes (AML-MRC) Defined Only By Morphological Findings May Not Represent a Poor Prognosis AML

Ana Pérez, MD, Olga Salamero, MD, Helena Pomares, MD PhD, Maria Julia Montoro, MD, Montserrat Arnan Sangerman, MD PhD, Laura Gallur, MD, María Laura Fox, MD, Elisa Roldan, MD, Antonieta Molero, MD, Guillermo Ortí, MD, Mayda Navarrete, MD, Esther Alonso, MD, Bárbara Tazón, PhD, M Moraima Jimenez, MD, Margarita Ortega, PhD, Adoración Blanco, PhD, Gael Roue, PhD, Pere Barba, MD PhD, Silvia Saumell, MD PhD, David Valcárcel, MD PhD, Francesc Bosch, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2612.
https://doi.org/10.1182/blood-2019-129153
Published: 2019
Journal Articles

Favorable Outcome in Patients with Acute Myeloblastic Leukemia (AML) with NPM1 Mutation Who Present an Inadequate Clearance or Relapse of Minimal/Measurable Residual Disease (MRD): Results of a Preemptive Intervention Policy (CETLAM-2012 Protocol)

Alex Bataller Torralba, MD, Marina Diaz-Beyá, MD, Ana Garrido, MD, Susana Vives, MD, Mar Tormo, MD PhD, Montserrat Arnan Sangerman, MD, Olga Salamero, MD, Antonia Sampol, MD PhD, Rosa Coll, MD, Monica Lopez-Guerra, PhD, Marta Pratcorona, MD PhD, Lurdes Zamora, PhD, Eva Villamón, PhD, Gael Roue, PhD, Adoración Blanco, PhD, Aina Oliver-Caldes, MD, Josep F Nomdedeu, MD, Dolors Colomer, PhD, Salut Brunet, MD PhD, Jorge Sierra, MD, Jordi Esteve, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1385.
https://doi.org/10.1182/blood-2018-99-110895
Published: 2018
Journal Articles

The BET Inhibitor GS-626510 Converges with Idelalisib through the Inhibition of Tumor-Macrophage Crosstalk and Cytokine Production in Diffuse Large B-Cell Lymphoma

Juan G Valero, PhD, Aranzazu Chamorro-Jorganes, PhD, Katie Walker, PhD, Martina Guerrero-Hernandez, MSc, Vanina Rodriguez, Clara Recasens-Zorzo, MSc, Anna Esteve-Arenys, MSc, Eriong Lee-Verges, MSc, Alba Matas-Cespedes, PhD, Neus Serrat, PhD, Dolors Colomer, PhD, Armando Lopez-Guillermo, Stacey Tannheimer, PhD, Patricia Pérez-Galán, PhD, Gael Roue, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4108.
https://doi.org/10.1182/blood.V130.Suppl_1.4108.4108
Published: 2017
Journal Articles

Idelalisib Interferes with the Crosstalk of Follicular Lymphoma and Its Immune Microenvironment and Potentiates the Activity of ABT-199

Martina Guerrero-Hernandez, MSc, Alba Matas-Cespedes, PhD, Neus Serrat, PhD, Anella Yahiaoui, BS, Juan G Valero, PhD, Laura Magnano, MD, Alfredo Rivas-Delgado, MD, Dolors Colomer, PhD, Elias Campo, MD PhD, Armando Lopez-Guillermo, Gael Roue, PhD, Stacey Tannheimer, PhD, Patricia Pérez-Galán, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2813.
https://doi.org/10.1182/blood.V130.Suppl_1.2813.2813
Published: 2017
Journal Articles

BET Bromodomain Blockade Enhances Ikaros Inhibition By Lenalidomide Therapy Providing Additional Activity in I n Vitro and In Vivo Models of Multiple Myeloma

Carlos Fernández de Larrea, Tania Díaz, Vanina Rodriguez, Ester Lozano, Patricia Pérez-Galán, Mari-Pau Mena, Marcos Calderón, Laura Rosiñol, Antonio Martínez, MD PhD, Natalia Tovar, Gael Roue, Joan Bladé
Journal: Blood
Blood (2016) 128 (22): 308.
https://doi.org/10.1182/blood.V128.22.308.308
Published: 2016
Journal Articles

Daratumumab, a Novel Anti-CD38 Monoclonal Antibody Shows Anti-Tumor Activity in CLL and hampers Leukemia-Microenvironment Interactions

Alba Matas-Céspedes, MS, Anna Vidal-Crespo, MS, Vanina Rodriguez, Julio Delgado, MD PhD, Neus Villamor, MD PhD, Gael Roue, PhD, Elías Campo, MD PhD, Dolors Colomer, PhD, Parul Doshi, PhD, Adrian Wiestner, MD PhD, Paul W.H.I. Parren, PhD, Jeroen Lammerts van Bueren, PhD, Patricia Pérez-Galán, PhD
Journal: Blood
Blood (2014) 124 (21): 4680.
https://doi.org/10.1182/blood.V124.21.4680.4680
Published: 2014
Journal Articles

Follicular Dendrytic Cells Deliver Angiogenesis Signaling To Follicular Lymphoma Cells That Is Hampered By The Pan-PI3K Inhibitor NVP-BKM120

Alba Matas-Céspedes, MS, Vanina Rodriguez, Susana Kalko, PhD, Eva Gine, MD, PhD, Elias Campo, MD, PhD, Gael Roue, PhD, Armando Lopez-Guillermo, MD, PhD, Dolors Colomer, PhD, Perez-Galan Patricia, PhD
Journal: Blood
Blood (2013) 122 (21): 3072.
https://doi.org/10.1182/blood.V122.21.3072.3072
Published: 2013
Journal Articles

Daratumumab, a Novel Human Anti-CD38 Monoclonal antibody shows Anti-Tumor Activity In Mouse Models Of MCL, FL and CLL

Alba Matas-Céspedes, MS, Anna Vidal Crespo, MS, Vanina Rodriguez, Gael Roue, PhD, Armando Lopez-Guillermo, MD, PhD, Elias Campo, MD, PhD, Dolors Colomer, PhD, Jeroen Lammerts van Bueren, PhD, Joost M Bakker, PhD, Adrian Wiestner, MD, PhD, Paul W.H.I. Parren, PhD, Patricia Perez-Galan, PhD
Journal: Blood
Blood (2013) 122 (21): 378.
https://doi.org/10.1182/blood.V122.21.378.378
Published: 2013
Journal Articles

SOX11 regulates PAX5 expression and blocks terminal B-cell differentiation in aggressive mantle cell lymphoma

Maria Carmela Vegliante, Jara Palomero, Patricia Pérez-Galán, Gaël Roué, Giancarlo Castellano, Alba Navarro, Guillem Clot, Alexandra Moros, Helena Suárez-Cisneros, Sílvia Beà, Luis Hernández, Anna Enjuanes, Pedro Jares, Neus Villamor, Dolors Colomer, José Ignacio Martín-Subero, Elias Campo, Virginia Amador
Journal: Blood
Blood (2013) 121 (12): 2175–2185.
https://doi.org/10.1182/blood-2012-06-438937
Published: 2013
Includes: Supplemental data
Journal Articles

The Multi-Kinase Inhibitor Sorafenib Blocks Migration, BCR Survival Signals, Protein Translation and Stroma-Mediated Bortezomib Resistance in Mantle Cell Lymphoma

Silvia Xargay-Torrent, BS, Monica López-Guerra, PhD, Ifigènia Saborit-Villarroya, PhD, Laia Rosich, BS, Alba Navarro, BS, Neus Villamor, MD, PhD, Marta Aymerich, MD, PhD, Patricia Perez-Galan, PhD, Gael Roue, PhD, Elias Campo, MD, PhD, Dolors Colomer, PhD
Journal: Blood
Blood (2012) 120 (21): 1647.
https://doi.org/10.1182/blood.V120.21.1647.1647
Published: 2012
Journal Articles

Daratumumab, a Novel Human Anti-CD38 Monoclonal Antibody for the Treatment of Chronic Lymphocytic Leukemia and B-Cell Non–Hodgkin Lymphoma

Alba Matas-Céspedes, BS, Anna Vidal-Crespo, BS, Vanina Rodriguez, Gael Roue, PhD, Elias Campo, MD, PhD, Dolors Colomer, PhD, Jeroen Lammerts van Bueren, PhD, Joost M Bakker, PhD, Adrian Wiestner, MD, PhD, Paul W.H.I. Parren, PhD, Patricia Perez-Galan, PhD
Journal: Blood
Blood (2012) 120 (21): 3935.
https://doi.org/10.1182/blood.V120.21.3935.3935
Published: 2012
Journal Articles

Expression Profile and Regulation of BAFF and APRIL Receptors in Chronic Lymphocytic Leukemia,

Gerardo Ferrer, Msc, Kate E Hodgson, MBBS, MRCP, FRCPath, Victor Ciria, Tycho Baumann, MD, Gael Roue, Dolors Colomer, MD. PhD, Emili Montserrat, MD. PhD, Carol Moreno, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 3880.
https://doi.org/10.1182/blood.V118.21.3880.3880
Published: 2011
Journal Articles

The Hsp90 inhibitor IPI-504 overcomes bortezomib resistance in mantle cell lymphoma in vitro and in vivo by down-regulation of the prosurvival ER chaperone BiP/Grp78

Gaël Roué, Patricia Pérez-Galán, Ana Mozos, Mónica López-Guerra, Sílvia Xargay-Torrent, Laia Rosich, Ifigènia Saborit-Villarroya, Emmanuel Normant, Elias Campo, Dolors Colomer
Journal: Blood
Blood (2011) 117 (4): 1270–1279.
https://doi.org/10.1182/blood-2010-04-278853
Published: 2011
Includes: Supplemental data