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Journal Articles

Hydroxycarbamide Plus Aspirin Vs Aspirin Alone in Intermediate Risk Essential Thrombocythemia: Results of the PT-1 International, Prospective, Randomized Clinical Trial

Anna L. Godfrey, BMBCh, PhD MRCP, FRCPath, Peter J Campbell, MD PhD, Cathy MacLean, BSc, MSc, MBA, Georgina Buck, BSc, MSc, Clare L. East, BSc, Julia Cook, BSc, Julie Temple, BSc, Bridget S. Wilkins, MD FRCPath, Keith Wheatley, DPhil, Jyoti Nangalia, MBBChir, MA, MRCP, FRCPath, PhD, Jacob Grinfeld, MBChB, BSc, MRCP, FRCPath, Mary Frances Frances McMullin, MB,Bch BAO, MD FRCPath, Cecily Forsyth, MB BS, Jean-Jacques Kiladjian, MD PhD, Anthony R. Green, FRCP, FRCPath, FMed Sci, Claire N. Harrison, BMBCh, DM, FRCP, FRCPath
Journal: Blood
Blood (2017) 130 (Supplement 1): 319.
https://doi.org/10.1182/blood.V130.Suppl_1.319.319
Published: 2017
Journal Articles

in Philadelphia-Chromosome-Negative Acute Lymphoblastic Leukemia, Late Relapses Are Not Uncommon, Occur Mostly in Patients at Standard Risk and Have a Relatively Favorable Outcome. Results of the International ALL Trial: MRC Ukallxii/ECOG E2993

Chezi Ganzel, Wang Xin Victoria, Adele K. Fielding, MB, BS, PhD, Jacob M. Rowe, MD, Susan M Richards, PhD, Georgina Buck, Rajesh Chopra, PhD, I. Jill Durrant, David Marks, MD PhD, Ian M. Franklin, MD, Andrew K McMilan, Mark R Litzow, MD, Elisabeth Paietta, PhD, Selina Luger, MD, Peter H Wiernik, Dan Douer, MD, Hillard M. Lazarus, MD, Martin S Tallman, MD, Anthony H. Goldstone, FRCP, FRCPath
Journal: Blood
Blood (2015) 126 (23): 795.
https://doi.org/10.1182/blood.V126.23.795.795
Published: 2015
Journal Articles

Delays in Start of Intensification Therapy Are Common for Adults with Acute Lymphoblastic Leukemia, and Are Associated with Decreased Survival in Patients Who Undergo Allogeneic Stem Cell Transplant (SCT)

Anita J. Kumar, MDMS, Phyllis A. Gimotty, PhD, Joel Gelfand, MDMS, Georgina Buck, Jacob M. Rowe, MD, Anthony H Goldstone, MD, Adele Fielding, MB BS, PhD, David I Marks, Mark Litzow, Elisabeth Paietta, PhD, Hillard M. Lazarus, Martin S. Tallman, MD, Selina M. Luger, MD, Alison W. Loren, MDMS
Journal: Blood
Blood (2014) 124 (21): 208.
https://doi.org/10.1182/blood.V124.21.208.208
Published: 2014
Journal Articles

UKALLXII/ECOG2993: addition of imatinib to a standard treatment regimen enhances long-term outcomes in Philadelphia positive acute lymphoblastic leukemia

Clinical Trials & Observations
Adele K. Fielding, Jacob M. Rowe, Georgina Buck, Letizia Foroni, Gareth Gerrard, Mark R. Litzow, Hillard Lazarus, Selina M. Luger, David I. Marks, Andrew K. McMillan, Anthony V. Moorman, Bella Patel, Elisabeth Paietta, Martin S. Tallman, Anthony H. Goldstone
Journal: Blood
Blood (2014) 123 (6): 843–850.
https://doi.org/10.1182/blood-2013-09-529008
Published: 2014
Includes: Supplemental data
Journal Articles

Correlation of blood counts with vascular complications in essential thrombocythemia: analysis of the prospective PT1 cohort

Brief Report
Peter J. Campbell, Cathy MacLean, Philip A. Beer, Georgina Buck, Keith Wheatley, Jean-Jacques Kiladjian, Cecily Forsyth, Claire N. Harrison, Anthony R. Green
Journal: Blood
Blood (2012) 120 (7): 1409–1411.
https://doi.org/10.1182/blood-2012-04-424911
Published: 2012
Journal Articles

Inability to Tolerate Standard Therapy Is a Major Reason for Poor Outcome In Older Adults with Acute Lymphoblastic Leukemia (ALL): Results From the International MRC/ECOG Trial

Jonathan I Sive, MBChB, Georgina Buck, Adele Fielding, MBBS, PhD, FRCPath, FRCP, Hillard M. Lazarus, MD, FACP, Mark R. Litzow, MD, Selina Luger, MD, David I. Marks, MBBS, PHD, Andrew McMillan, FRCP, FRCPath, PhD, Susan M Richards, PhD, Jacob M. Rowe, Martin S. Tallman, MD, Anthony H. Goldstone, FRCP, FRCPath
Journal: Blood
Blood (2010) 116 (21): 493.
https://doi.org/10.1182/blood.V116.21.493.493
Published: 2010
Journal Articles

Imatinib Significantly Enhances Long-Term Outcomes In Philadelphia Positive Acute Lymphoblastic Leukaemia; Final Results of the UKALLXII/ECOG2993 Trial

Adele K. Fielding, MBBS, PhD, FRCPath, FRCP, Georgina Buck, Hillard M. Lazarus, MD, FACP, Mark R. Litzow, MD, Selina Luger, MD, David I. Marks, MBBS, PHD, Andrew McMillan, FRCP, FRCPath, PhD, Anthony V. Moorman, PhD, Elisabeth Paietta, PhD, Susan M Richards, PhD, Martin S. Tallman, MD, Jacob M. Rowe, Anthony H. Goldstone, FRCP, FRCPath
Journal: Blood
Blood (2010) 116 (21): 169.
https://doi.org/10.1182/blood.V116.21.169.169
Published: 2010
Journal Articles

Outcome of 1,229 Adult Philadelphia Chromosome Negative B Acute Lymphoblastic Leukemia (B-ALL) Patients (pts) From the International UKALLXII/E2993 Trial: No Difference In Results Between B Cell Immunophenotypic Subgroups

Mark R. Litzow, MD, Georgina Buck, Gordon Dewald, Adele Fielding, MBBS, PhD, FRCPath, FRCP, Rhett Ketterling, Hillard M. Lazarus, MD, FACP, Selina Luger, MD, David I. Marks, MBBS, PHD, Andrew McMillan, FRCP, FRCPath, PhD, Anthony V. Moorman, PhD, Elisabeth Paietta, PhD, Susan M Richards, PhD, Jacob M. Rowe, Martin S. Tallman, MD, Anthony H. Goldstone, FRCP, FRCPath
Journal: Blood
Blood (2010) 116 (21): 524.
https://doi.org/10.1182/blood.V116.21.524.524
Published: 2010
Journal Articles

T-cell acute lymphoblastic leukemia in adults: clinical features, immunophenotype, cytogenetics, and outcome from the large randomized prospective trial (UKALL XII/ECOG 2993)

Clinical Trials & Observations
David I. Marks, Elisabeth M. Paietta, Anthony V. Moorman, Susan M. Richards, Georgina Buck, Gordon DeWald, Adolfo Ferrando, Adele K. Fielding, Anthony H. Goldstone, Rhett P. Ketterling, Mark R. Litzow, Selina M. Luger, Andrew K. McMillan, Marc R. Mansour, Jacob M. Rowe, Martin S. Tallman, Hillard M. Lazarus
Journal: Blood
Blood (2009) 114 (25): 5136–5145.
https://doi.org/10.1182/blood-2009-08-231217
Published: 2009
Journal Articles

Prospective outcome data on 267 unselected adult patients with Philadelphia chromosome–positive acute lymphoblastic leukemia confirms superiority of allogeneic transplantation over chemotherapy in the pre-imatinib era: results from the International ALL Trial MRC UKALLXII/ECOG2993

Clinical Trials & Observations
Adele K. Fielding, Jacob M. Rowe, Susan M. Richards, Georgina Buck, Anthony V. Moorman, I. Jill Durrant, David I. Marks, Andrew K. McMillan, Mark R. Litzow, Hillard M. Lazarus, Letizia Foroni, Gordon Dewald, Ian M. Franklin, Selina M. Luger, Elisabeth Paietta, Peter H. Wiernik, Martin S. Tallman, Anthony H. Goldstone
Journal: Blood
Blood (2009) 113 (19): 4489–4496.
https://doi.org/10.1182/blood-2009-01-199380
Published: 2009
Journal Articles

Standard Consolidation/Maintenance Chemotherapy Is Consistently Superior to a Single Autologous Transplant for Adult Patients with Acute Lymphoblastic Leukemia: Results of the International ALL Trial (MRC UKALL XII/ECOG E2993)

Jacob M. Rowe, MD, Georgina Buck, Anthony V Moorman, MD, Martin S Tallman, MD, Susan M Richards, Ph.D, Adele K Fielding, MD, Ph.D, Alan K. Burnett, MD, FRCP, Ian M Franklin, MD, Peter H. Wiernik, MD, Hillard M Lazarus, MD, Elisabeth Paietta, PhD, Mark R. Litzow, MD, David I Marks, MD, Selina Luger, MD, Gordon W. Dewald, PhD, PhD, FACMG, Anthony H. Goldstone, FRCP, FRCPath
Journal: Blood
Blood (2008) 112 (11): 3314.
https://doi.org/10.1182/blood.V112.11.3314.3314
Published: 2008
Journal Articles

Unlike Paediatric T-ALL, Notch-1 and FBXW7 Mutations Do Not Seem to Predict a Better Outcome in Adult Patients: Data from the UKALLXII/ECOG2993 Protocol

Marc R Mansour, MBChB, MRCP, Maria Luisa Sulis, Veronique Duke, PhD, Letizia Foroni, Sarah Jenkinson, Christopher G Allen, Rosemary E Gale, Georgina Buck, Sue Richards, Elisabeth Paietta, Martin Tallman, Anthony H Goldstone, FRCP, FRCPath, Jacob M. Rowe, MD, Adolfo A. Ferrando, MD, PhD, David C Linch
Journal: Blood
Blood (2008) 112 (11): 2548.
https://doi.org/10.1182/blood.V112.11.2548.2548
Published: 2008
Journal Articles

MPL mutations in myeloproliferative disorders: analysis of the PT-1 cohort

Philip A. Beer, Peter J. Campbell, Linda M. Scott, Anthony J. Bench, Wendy N. Erber, David Bareford, Bridget S. Wilkins, John T. Reilly, Hans C. Hasselbalch, Richard Bowman, Keith Wheatley, Georgina Buck, Claire N. Harrison, Anthony R. Green
Journal: Blood
Blood (2008) 112 (1): 141–149.
https://doi.org/10.1182/blood-2008-01-131664
Published: 2008
Includes: Supplemental data
Journal Articles

In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/maintenance chemotherapy in all patients: final results of the International ALL Trial (MRC UKALL XII/ECOG E2993)

Clinical Trials & Observations
Anthony H. Goldstone, Susan M. Richards, Hillard M. Lazarus, Martin S. Tallman, Georgina Buck, Adele K. Fielding, Alan K. Burnett, Raj Chopra, Peter H. Wiernik, Letizia Foroni, Elisabeth Paietta, Mark R. Litzow, David I. Marks, Jill Durrant, Andrew McMillan, Ian M. Franklin, Selina Luger, Niculae Ciobanu, Jacob M. Rowe
Journal: Blood
Blood (2008) 111 (4): 1827–1833.
https://doi.org/10.1182/blood-2007-10-116582
Published: 2008
Includes: Supplemental data
Journal Articles

Bone marrow pathology in essential thrombocythemia: interobserver reliability and utility for identifying disease subtypes

Clinical Trials & Observations
Bridget S. Wilkins, Wendy N. Erber, David Bareford, Georgina Buck, Keith Wheatley, Clare L. East, Beverley Paul, Claire N. Harrison, Anthony R. Green, Peter J. Campbell
Journal: Blood
Blood (2008) 111 (1): 60–70.
https://doi.org/10.1182/blood-2007-05-091850
Published: 2008
Journal Articles

Impact of Platelet Glycoprotein Polymorphisms upon Clinical Events in Essential Thrombocythaemia Patients Enrolled in the PT1 Trial.

Susan E. Robinson, MSc, MRCPath, Peter J. Campbell, FRCPA, PhD, Georgina Buck, MSc, Keith Wheatley, DPhil, Jacqueline A. Cutler, BSc, Ruth B. Wheeler, BSc, PhD, Savita Rangarajan, FRCP, FRCPath, Beverley J. Hunt, RCPath, Anthony R. Green, FRCPath, FMedSci, Claire N. Harrison, MD, FRCPath
Journal: Blood
Blood (2007) 110 (11): 2543.
https://doi.org/10.1182/blood.V110.11.2543.2543
Published: 2007
Journal Articles

Clinical Significance of MPL Mutations in Essential Thrombocythemia: Analysis of the PT-1 Cohort.

Philip Beer, Peter Campbell, Wendy Erber, Linda Scott, Anthony Bench, David Bareford, Wilkins Bridget, Keith Wheatley, Georgina Buck, Claire Harrison, Anthony Green
Journal: Blood
Blood (2007) 110 (11): 677.
https://doi.org/10.1182/blood.V110.11.677.677
Published: 2007
Journal Articles

In Adults with Standard-Risk Acute Lymphoblastic Leukemia (ALL) the Greatest Benefit Is Achieved from an Allogeneic Transplant in First Complete Remission (CR) and an Autologous Transplant Is Less Effective Than Conventional Consolidation/Maintenance Chemotherapy: Final Results of the International ALL Trial (MRC UKALL XII/ECOG E2993).

Jacob M. Rowe, MD, Georgina Buck, PhD, Adele Fielding, MD, Martin S. Tallman, MD, Alan K. Burnett, MD, Raj Chopra, MD, Peter H. Wiernik, MD, Susan M. Richards, PhD, Hillard M. Lazarus, MD, Letizia Foroni, MD, Elisabeth Paietta, PhD, Mark R. Litzow, MD, David Marks, MD, Jill Durrant, MD, Anthony H. Goldstone, MD
Journal: Blood
Blood (2006) 108 (11): 2.
https://doi.org/10.1182/blood.V108.11.2.2
Published: 2006
Journal Articles

Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); an MRC UKALL12/ECOG 2993 study

Clinical Trials & Observations
Adele K. Fielding, Susan M. Richards, Rajesh Chopra, Hillard M. Lazarus, Mark R. Litzow, Georgina Buck, I. Jill Durrant, Selina M. Luger, David I. Marks, Ian M. Franklin, Andrew K. McMillan, Martin S. Tallman, Jacob M. Rowe, Anthony H. Goldstone, Medical Research Council of the United Kingdom Adult ALL Working Party and the Eastern Cooperative Oncology Group
Journal: Blood
Blood (2006) 109 (3): 944–950.
https://doi.org/10.1182/blood-2006-05-018192
Published: 2006
Journal Articles

Central nervous system involvement in adult acute lymphoblastic leukemia at diagnosis: results from the international ALL trial MRC UKALL XII/ECOG E2993

Clinical Trials & Observations
Hillard M. Lazarus, Susan M. Richards, Raj Chopra, Mark R. Litzow, Alan K. Burnett, Peter H. Wiernik, Ian M. Franklin, Martin S. Tallman, Lucy Cook, Georgina Buck, I. Jill Durrant, Jacob M. Rowe, Anthony H. Goldstone, for the Medical Research Council (MRC)/National Cancer Research Institute (NCRI) Adult Leukaemia Working Party of the United Kingdom and the Eastern Cooperative Oncology Group
Journal: Blood
Blood (2006) 108 (2): 465–472.
https://doi.org/10.1182/blood-2005-11-4666
Published: 2006