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Gerulf Hänel
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Journal Articles

Accomplices in Cure: Blinatumomab + Dasatinib Reduces TCR Signaling and Effector Function Stronger Than Ponatinib and Ameliorates T-Cell Exhaustion

Nora Philipp, Anetta Marcinek, Gerulf Hänel, Daniel Nixdorf, Veit L. Buecklein, Marion Subklewe
Journal: Blood
Blood (2023) 142 (Supplement 1): 1511.
https://doi.org/10.1182/blood-2023-179286
Published: 2023
Journal Articles

Two Players, One Goal: BiTE ® Vs CART Targeting FLT3 in AML

Lisa Rohrbacher, Daniel Nixdorf, Helena Stadler, Bettina Brauchle, Florian Märkl, Nora Philipp, Gerulf Hänel, Anetta Marcinek, Maryam Kazerani, Alica Joana Emhardt, Giulia Magno, Rebecca L. Goldstein, Tobias Straub, Sebastian Kobold, Tara L. Chapman-Arvedson, Veit L. Buecklein, Marion Subklewe
Journal: Blood
Blood (2023) 142 (Supplement 1): 3444.
https://doi.org/10.1182/blood-2023-177922
Published: 2023
Journal Articles

Beyond Mitigating Immune-Related Adverse Events: Glucocorticoids Ameliorate Bispecific Antibody-Mediated T-Cell Exhaustion I n Vitro

Amelie Muth, Nora Philipp, Anetta Marcinek, Tobias Straub, Lis Winter, Gerulf Hänel, Daniel Nixdorf, Lisa Rohrbacher, Veit L. Buecklein, Marion Subklewe
Journal: Blood
Blood (2023) 142 (Supplement 1): 5389.
https://doi.org/10.1182/blood-2023-174258
Published: 2023
Journal Articles

Fine Tuning Bispecific Activity in CLL: Harmonizing a CD19/20-T Cell Bispecific with a CD28 or 4-1BBL Costimulatory Bispecific

Giulia Petra Rappa, Monika Sponheimer, Gerulf Hänel, Anne-Sophie Neumann, Nora Philipp, Koorosh Korfi, Sylvia Herter, Johannes Sam, Franz Schuler, Christian Klein, Marina Bacac, Pablo Umana, Marion Subklewe
Journal: Blood
Blood (2023) 142 (Supplement 1): 2058.
https://doi.org/10.1182/blood-2023-180785
Published: 2023
Journal Articles

The Race Is on: BiTE Vs CART As FLT3-Directed Immunotherapies in AML

Lisa Rohrbacher, Daniel Nixdorf, Helena Stadler, Bettina Brauchle, Florian Märkl, Nora Phillip, Gerulf Hänel, Anetta Marcinek, Maryam Kazerani, Rebecca Goldstein, Michael von Bergwelt, Sebastian Kobold, Veit L Buecklein, Tara Chapman-Arvedson, Marion Subklewe
Journal: Blood
Blood (2022) 140 (Supplement 1): 10233–10234.
https://doi.org/10.1182/blood-2022-158452
Published: 2022
Journal Articles

T-cell exhaustion induced by continuous bispecific molecule exposure is ameliorated by treatment-free intervals

Nora Philipp, Maryam Kazerani, Alyssa Nicholls, Binje Vick, Jan Wulf, Tobias Straub, Michaela Scheurer, Amelie Muth, Gerulf Hänel, Daniel Nixdorf, Monika Sponheimer, Malte Ohlmeyer, Sonja M. Lacher, Bettina Brauchle, Anetta Marcinek, Lisa Rohrbacher, Alexandra Leutbecher, Kai Rejeski, Oliver Weigert, Michael von Bergwelt-Baildon, Sebastian Theurich, Roman Kischel, Irmela Jeremias, Veit Bücklein, Marion Subklewe
Journal: Blood
Blood (2022) 140 (10): 1104–1118.
https://doi.org/10.1182/blood.2022015956
Published: 2022
Includes: Supplemental data
Journal Articles

Targeting intracellular WT1 in AML with a novel RMF-peptide-MHC-specific T-cell bispecific antibody

Christian Augsberger, Gerulf Hänel, Wei Xu, Vesna Pulko, Lydia Jasmin Hanisch, Angelique Augustin, John Challier, Katharina Hunt, Binje Vick, Pier Eduardo Rovatti, Christina Krupka, Maurine Rothe, Anne Schönle, Johannes Sam, Emmanuelle Lezan, Axel Ducret, Daniela Ortiz-Franyuti, Antje-Christine Walz, Jörg Benz, Alexander Bujotzek, Felix S. Lichtenegger, Christian Gassner, Alejandro Carpy, Victor Lyamichev, Jigar Patel, Nikola Konstandin, Antje Tunger, Marc Schmitz, Michael von Bergwelt-Baildon, Karsten Spiekermann, Luca Vago, Irmela Jeremias, Estelle Marrer-Berger, Pablo Umaña, Christian Klein, Marion Subklewe
Journal: Blood
Blood (2021) 138 (25): 2655–2669.
https://doi.org/10.1182/blood.2020010477
Published: 2021
Includes: Supplemental data
Journal Articles

Treatment-Free Intervals during CD19xCD3 BiTE ® Construct-Mediated T-Cell Stimulation Induce Functional Reinvigoration and Transcriptional Reprogramming of Exhausted T Cells

Nora Zieger, Maryam Kazerani Pasikhani, Tobias Straub, Alyssa Nicholls, Gerulf Hänel, Jan Wulf, Michaela Scheurer, Daniel Nixdorf, Monika Sponheimer, Sonja M Lacher, Bettina Brauchle, Anetta Marcinek, Lisa Rohrbacher, Alexandra Leutbecher, Michael von Bergwelt, Karsten Spiekermann, Oliver Weigert, Sebastian Theurich, Veit L Buecklein, Roman Kischel, Marion Subklewe
Journal: Blood
Blood (2021) 138 (Supplement 1): 513.
https://doi.org/10.1182/blood-2021-150178
Published: 2021
Journal Articles

CD33 BiTE ® Construct Mediated Immunological Synapse Formation and Downstream Signaling in T Cells Is Dependent on Expression of Costimulatory Molecules on Target Cells

Anetta Marcinek, Bettina Brauchle, Gerulf Hänel, Sonja M Lacher, Nora Zieger, Roman Kischel, Michael von Bergwelt, Karsten Spiekermann, Sebastian Theurich, John R James, Veit L Buecklein, Marion Subklewe
Journal: Blood
Blood (2021) 138 (Supplement 1): 2237.
https://doi.org/10.1182/blood-2021-146488
Published: 2021
Journal Articles

Augmenting Efficacy of T-Cell Bispecific Antibodies in AML through a Tumor Stroma-Targeted 4-1BB Agonist

Gerulf Hänel, Anne-Sophie Neumann, Vesna Pulko, Christina Claus, Alexandra Leutbecher, Anetta Marcinek, Nora Zieger, Veit L Buecklein, Pablo Umana, Christian Klein, Marion Subklewe
Journal: Blood
Blood (2021) 138 (Supplement 1): 1178.
https://doi.org/10.1182/blood-2021-146762
Published: 2021
Journal Articles

Treatment-Free Intervals Mitigate T-Cell Exhaustion Induced By Continuous CD19xCD3-BiTE® Construct Stimulation in Vitro

Nora Zieger, Alyssa Nicholls, Jan Wulf, Gerulf Hänel, Maryam Kazerani Pasikhani, Veit Buecklein, MD, Bettina Brauchle, Anetta Marcinek, Daniel Nixdorf, Lisa Rohrbacher, Michaela Scheurer, Roman Kischel, MD, Karsten Spiekermann, MD, Oliver Weigert, MD, Sebastian Theurich, MD, Michael von Bergwelt, MD PhD, Marion Subklewe, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 44–45.
https://doi.org/10.1182/blood-2020-137421
Published: 2020
Journal Articles

Targeting Intracellular WT1 in AML Utilizing a T Cell Bispecific Antibody Construct: Augmenting Efficacy through Combination with Lenalidomide

Christian Klein, PhD, Christian Augsberger, Wei Xu, MD PhD, Christina Heitmüller, PhD, Lydia Hanisch, PhD, Johannes Sam, PhD, Vesna Pulko, PhD, Anne Schönle, John Challier, PhD, Alejandro Carpy, PhD, Nikola Konstandin, PhD, Maurine Rothe, Gerulf Hänel, Veit Bücklein, MD, Felix S. Lichtenegger, MD, Antje Tunger, PhD, Marc Schmitz, MD, Michael von Bergwelt, Karsten Spiekermann, MD, Pablo Umana, PhD, Marion Subklewe, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4450.
https://doi.org/10.1182/blood-2019-130121
Published: 2019