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Journal Articles

Single-cell genomics details the maturation block in BCP-ALL and identifies therapeutic vulnerabilities in DUX4 -r cases

Hanna Thorsson, Rasmus Henningsson, Noelia Puente-Moncada, Pablo Peña-Martínez, Ludvig Sjöström, Helena Ågerstam, Carl Sandén, Marianne Rissler, Anders Castor, Hanne Marquart, Signe Modvig, Kajsa Paulsson, Cornelis Jan Pronk, Kjeld Schmiegelow, Axel Hyrenius-Wittsten, Christina Orsmark-Pietras, Henrik Lilljebjörn, Thoas Fioretos

Blood (2024) 144 (13): 1399–1411.

https://doi.org/10.1182/blood.2023021705

Published: 2024

Includes: Supplemental data

Journal Articles

Single-Cell Genomics Details the Maturation Block in BCP-ALL and Identifies Therapeutic Vulnerabilities in DUX4 -Rearranged Cases

Hanna Thorsson, Rasmus Henningsson, Noelia Puente-Moncada, Ludvig Sjöström, Helena Ågerstam, Pablo Enrique Peña-Martínez, Carl Sandén, Marianne Rissler, Anders Castor, Hanne Vibeke Marquart, Signe Modvig, Kajsa Paulsson, Cornelis Pronk, Kjeld Schmiegelow, Axel Hyrenius Wittsten, Christina Orsmark-Pietras, Henrik PhD Lilljebjörn, Thoas Fioretos

Blood (2023) 142 (Supplement 1): 842.

https://doi.org/10.1182/blood-2023-173350

Published: 2023

Journal Articles

AML Xenografts Undergo Extensive Clonal Competition and Unmask Rare Clones in Patient Samples

Carl Sandén, PhD, Henrik Lilljebjörn, PhD, Christina Orsmark-Pietras, PhD, Karim Saba, MSc, Carl Högberg, PhD, Marianne Rissler, MSc, Vladimir Lazarevic, MD PhD, Gunnar Juliusson, MD PhD, Helena Ågerstam, PhD, Thoas Fioretos, MD PhD

Blood (2018) 132 (Supplement 1): 2621.

https://doi.org/10.1182/blood-2018-99-110497

Published: 2018

Journal Articles

FLT3 N676K drives Myeloid Leukemia in a Xenograft Model of KMT2A-MLLT3 leukemogenesis

Axel Hyrenius Wittsten, MSc, Mattias Pilheden, MSc, Jian Liu, PhD, Helena Ågerstam, PhD, Helena Sturesson, PhD, Anna K. Andersson, PhD

Blood (2017) 130 (Supplement 1): 2499.

https://doi.org/10.1182/blood.V130.Suppl_1.2499.2499

Published: 2017

Journal Articles

IL1RAP antibodies block IL-1–induced expansion of candidate CML stem cells and mediate cell killing in xenograft models

Helena Ågerstam, Nils Hansen, Sofia von Palffy, Carl Sandén, Kristian Reckzeh, Christine Karlsson, Henrik Lilljebjörn, Niklas Landberg, Maria Askmyr, Carl Högberg, Marianne Rissler, Kimmo Porkka, Hans Wadenvik, Satu Mustjoki, Johan Richter, Marcus Järås, Thoas Fioretos

Blood (2016) 128 (23): 2683–2693.

https://doi.org/10.1182/blood-2015-11-679985

Published: 2016

Includes: Supplemental data

Journal Articles

Mutational and Clonal Dynamics in Patient-Derived Xenografts of Acute Myeloid Leukemia

Carl Sandén, Karim Saba, Christina Orsmark-Pietras, Henrik Lilljebjörn, Carl Högberg, Marianne Rissler, Vladimir Lazarevic, Gunnar Juliusson, Helena Ågerstam, Thoas Fioretos

Blood (2016) 128 (22): 1154.

https://doi.org/10.1182/blood.V128.22.1154.1154

Published: 2016

Journal Articles

IL1RAP Antibodies Block IL1-Induced Expansion of Primitive CML Cells and Display Therapeutic Effects in Xenograft Models

Helena Ågerstam, Nils Hansen, Sofia Von Palffy, Carl Sandén, Kristian Reckzeh, Christine Karlsson, Henrik Lilljebjörn, Niklas Landberg, Maria Askmyr, Carl Högberg, Marianne Rissler, Kimmo Porkka, Hans Wadenvik, Satu Mustjoki, Johan Richter, MD, Marcus Järås, Thoas Fioretos

Blood (2016) 128 (22): 1118.

https://doi.org/10.1182/blood.V128.22.1118.1118

Published: 2016

Journal Articles

Modeling Chronic Myeloid Leukemia in Immunodeficient Mice Reveals an Inflammatory State with Expansion of Aberrant Mast Cells and Accumulation of Pre B Cells

Maria Askmyr, PhD, Helena Agerstam, PhD, Henrik Lilljebjörn, PhD, Nils Hansen, PhD, Christine Karlsson, PhD, Niklas Landberg, Carl Hogberg, PhD, Carin Lassen, Msc, Marianne Rissler, Johan Richter, MD PhD, Mats Ehinger, MD PhD, Marcus Jaras, PhD, Thoas Fioretos, MD PhD

Blood (2014) 124 (21): 3132.

https://doi.org/10.1182/blood.V124.21.3132.3132

Published: 2014

Journal Articles

Upregulation Of IL1RAP On Human Progenitor/Stem Cells Induces Features Of a Myeloproliferative Disorder In Mice

Nils Hansen, Kristian Reckzeh, PhD, Helena Agerstam, PhD, Maria Askmyr, PhD, Sandra Gordon, Marianne Rissler, Carl Högberg, PhD, Johan Richter, MD, PhD, Marcus Järås, PhD, Thoas Fioretos, MD, PhD

Blood (2013) 122 (21): 1650.

https://doi.org/10.1182/blood.V122.21.1650.1650

Published: 2013

Journal Articles

Strong Therapeutic Effect Of Anti-IL1RAP Immunotherapy In a Xenograft Model Of Acute Myeloid Leukemia

Helena Agerstam, PhD, Maria Askmyr, PhD, Nils Hansen, Marianne Rissler, Gunnar Juliusson, MD, PhD, Johan Richter, MD, PhD, Mark Wunderlich, MS, Marcus Järås, PhD, James C. Mulloy, PhD, Thoas Fioretos, MD PhD

Blood (2013) 122 (21): 3954.

https://doi.org/10.1182/blood.V122.21.3954.3954

Published: 2013

Journal Articles

Selective killing of candidate AML stem cells by antibody targeting of IL1RAP

Maria Askmyr, Helena Ågerstam, Nils Hansen, Sandra Gordon, Alexandros Arvanitakis, Marianne Rissler, Gunnar Juliusson, Johan Richter, Marcus Järås, Thoas Fioretos

Blood (2013) 121 (18): 3709–3713.

https://doi.org/10.1182/blood-2012-09-458935

Published: 2013

Includes: Supplemental data

Journal Articles

Socs2 Is Dispensable for BCR/ABL1-Induced Chronic Myeloid Leukemia-Like Disease in Mice and for Normal Hematopoietic Stem Cell Function,

Nils Hansen, Helena Agerstam, PhD, Martin Wahlestedt, Mats Ehinger, MD, PhD, Petra Johnels, PhD, Jun Ishiko, PhD, Junia V. Melo, MD, PhD, Warren S Alexander, PhD, David Bryder, Marcus Järås, PhD, Thoas Fioretos, MD, PhD

Blood (2011) 118 (21): 3743.

https://doi.org/10.1182/blood.V118.21.3743.3743

Published: 2011

Journal Articles

Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice

Helena Ågerstam, Marcus Järås, Anna Andersson, Petra Johnels, Nils Hansen, Carin Lassen, Marianne Rissler, David Gisselsson, Tor Olofsson, Johan Richter, Xiaolong Fan, Mats Ehinger, Thoas Fioretos

Blood (2010) 116 (12): 2103–2111.

https://doi.org/10.1182/blood-2009-05-217182

Published: 2010

Includes: Supplemental data

NARROW

Single-cell genomics details the maturation block in BCP-ALL and identifies therapeutic vulnerabilities in DUX4 -r cases

Single-Cell Genomics Details the Maturation Block in BCP-ALL and Identifies Therapeutic Vulnerabilities in DUX4 -Rearranged Cases

AML Xenografts Undergo Extensive Clonal Competition and Unmask Rare Clones in Patient Samples

FLT3 N676K drives Myeloid Leukemia in a Xenograft Model of KMT2A-MLLT3 leukemogenesis

IL1RAP antibodies block IL-1–induced expansion of candidate CML stem cells and mediate cell killing in xenograft models

Mutational and Clonal Dynamics in Patient-Derived Xenografts of Acute Myeloid Leukemia

IL1RAP Antibodies Block IL1-Induced Expansion of Primitive CML Cells and Display Therapeutic Effects in Xenograft Models

Modeling Chronic Myeloid Leukemia in Immunodeficient Mice Reveals an Inflammatory State with Expansion of Aberrant Mast Cells and Accumulation of Pre B Cells

Upregulation Of IL1RAP On Human Progenitor/Stem Cells Induces Features Of a Myeloproliferative Disorder In Mice

Strong Therapeutic Effect Of Anti-IL1RAP Immunotherapy In a Xenograft Model Of Acute Myeloid Leukemia

Selective killing of candidate AML stem cells by antibody targeting of IL1RAP

Socs2 Is Dispensable for BCR/ABL1-Induced Chronic Myeloid Leukemia-Like Disease in Mice and for Normal Hematopoietic Stem Cell Function,

Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice

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American Society of Hematology

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ASH Publications

American Society of Hematology

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