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Ingrid Frey
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Journal Articles

Longitudinal Characterization of Hemodynamic Changes with Multimodal Optical Techniques in Patients with Sickle Cell Disease Treated with Mitapivat

Timothy Quang, Ingrid Frey, Julia Xu, Golnar Mostashari, Anna Conrey, Dina S. Parekh, Ruth Pierre Charles, Brian Hill, Swee Lay Thein, Bruce J Tromberg
Journal: Blood
Blood (2023) 142 (Supplement 1): 2492.
https://doi.org/10.1182/blood-2023-174227
Published: 2023
Journal Articles

Long-Term Safety and Efficacy of Mitapivat, an Oral Pyruvate Kinase Activator, in Adults with Sickle Cell Disease: Extension of a Phase 1 Dose Escalation Study

Anna Conrey, Ingrid Frey, Nancy Asomaning, Ruth Pierre Charles, Dina Parekh, Julia Xu, Kang Le, Britney Kruah, Quan Li, Emily Dunkelberger, Troy Cellmer, Amber M Yates, Megan Wind-Rotolo, Neal Jeffries, William A Eaton, Swee Lay Thein
Journal: Blood
Blood (2023) 142 (Supplement 1): 273.
https://doi.org/10.1182/blood-2023-180165
Published: 2023
Journal Articles

Evaluation of Red Cell Deformability in Sickle Cell Disease Patients, Sickle Cell Carriers, and Healthy Controls Using Lorrca-Derived Parameters

Nancy Asomaning, Xunde Wang, Maureen Lundt, Britney Kruah, Mai Hill, Anna Conrey, Ruth Pierre Charles, Ingrid Frey, Megan Wind-Rotolo, Chris Huston, Neal Jeffries, Swee Lay Thein
Journal: Blood
Blood (2023) 142 (Supplement 1): 5262.
https://doi.org/10.1182/blood-2023-184834
Published: 2023
Journal Articles

Feasibility of Near-Infrared Spectroscopy for Monitoring Hemodynamic Changes in Patients with Sickle Cell Disease Treated with Mitapivat

Timothy Quang, Julia Z Xu, Ingrid Frey, Kathryn Jaroszynski, Elise M. Berning, Anna Conrey, Ruth Pierre Charles, Brian Y Hill, Neal Jeffries, Swee Lay Thein, Bruce J. Tromberg
Journal: Blood
Blood (2022) 140 (Supplement 1): 2526–2527.
https://doi.org/10.1182/blood-2022-159559
Published: 2022
Journal Articles

The Pyruvate Kinase Activator Mitapivat Improves Red Blood Cell Deformability and Sickling Kinetics in Adult Patients with Sickle Cell Disease

Maureen Lundt, Nancy Asomaning, Ingrid Frey, Xunde Wang, Anna Conrey, Julia Z Xu, Quan Li, Emily B Dunkelberger, Neal Jeffries, William Eaton, Swee Lay Thein
Journal: Blood
Blood (2022) 140 (Supplement 1): 2508–2509.
https://doi.org/10.1182/blood-2022-170010
Published: 2022
Journal Articles

Activating Pyruvate Kinase Improves Red Blood Cell Integrity By Reducing Band3 Tyrosine Phosphorylation

Kang Le, Xunde Wang, Maureen Lundt, Anna Conrey, Ingrid Frey, Silvia Giannini, Penelope A. Kosinski, John A. Hausman, Philip S. Low, Neal Jeffries, Swee Lay Thein
Journal: Blood
Blood (2022) 140 (Supplement 1): 5395–5396.
https://doi.org/10.1182/blood-2022-160378
Published: 2022
Journal Articles

A phase 1 dose escalation study of the pyruvate kinase activator mitapivat (AG-348) in sickle cell disease

Clinical Trials & Observations
Julia Z. Xu, Anna Conrey, Ingrid Frey, Eveline Gwaabe, Laurel A. Menapace, Laxminath Tumburu, Maureen Lundt, Timothy Lequang, Quan Li, Kristen Glass, Emily B. Dunkelberger, Varsha Iyer, Heidi Mangus, Charles Kung, Lenny Dang, Penelope A. Kosinski, Peter Hawkins, Neal Jeffries, William A. Eaton, Swee Lay Thein
Journal: Blood
Blood (2022) 140 (19): 2053–2062.
https://doi.org/10.1182/blood.2022015403
Published: 2022
Includes: Supplemental data
Journal Articles

Mitapivat (AG-348) Demonstrates Safety, Tolerability, and Improvements in Anemia, Hemolysis, Oxygen Affinity, and Hemoglobin S Polymerization Kinetics in Adults with Sickle Cell Disease: A Phase 1 Dose Escalation Study

Julia Z. Xu, Anna Conrey, Ingrid Frey, Eveline Gwaabe, Laurel A Menapace, Laxminath Tumburu, Maureen Lundt, Quan Li, Kristen Glass, Varsha Iyer, Heidi Mangus, Charles Kung, Lenny Dang, Penelope A. Kosinski, Peter Hawkins, Neal Jeffries, William Eaton, Swee Lay Thein
Journal: Blood
Blood (2021) 138 (Supplement 1): 10.
https://doi.org/10.1182/blood-2021-145398
Published: 2021
Journal Articles

Phase 1 Multiple Ascending Dose Study of Safety, Tolerability, and Pharmacokinetics/Pharmacodynamics of Mitapivat (AG-348) in Subjects with Sickle Cell Disease

Julia Z. Xu, MDMS, Anna Conrey, NP, Ingrid Frey, RN, BSN, MS, James Nichols, RN, Laurel A Menapace, MD, Laxminath Tumburu, PhD, Timothy Lequang, MSc, Quan Li, PhD, Emily Dunkelberger, PhD, Eric Henry, PhD, Troy Cellmer, PhD, Varsha Iyer, Heidi Mangus, BS, Charles Kung, PhD, Lenny Dang, PhD, Penelope A. Kosinski, MS, Peter Hawkins, PhD, Neal Jeffries, PhD, William Eaton, MD, Swee Lay Thein, DSc, FRCP, MBBS, MRCP
Journal: Blood
Blood (2020) 136 (Supplement 1): 21–22.
https://doi.org/10.1182/blood-2020-137716
Published: 2020