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Maureen Lundt
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Journal Articles

Functional and Multi-Omics Signatures of Mitapivat Efficacy upon Activation of Pyruvate Kinase in Red Blood Cells from Patients with Sickle Cell Disease

Angelo D'Alessandro, Kang Le, Maureen Lundt, Quan Li, Emily Dunkelberger, Troy Cellmer, Andrew J Worth, Spurthi Patil, Chris Huston, Abby Grier, Monika monikA.dzieciatkow, Daniel Stephenson, William A Eaton, Swee Lay Thein
Journal: Blood
Blood (2023) 142 (Supplement 1): 2485.
https://doi.org/10.1182/blood-2023-181213
Published: 2023
Journal Articles

Evaluation of Red Cell Deformability in Sickle Cell Disease Patients, Sickle Cell Carriers, and Healthy Controls Using Lorrca-Derived Parameters

Nancy Asomaning, Xunde Wang, Maureen Lundt, Britney Kruah, Mai Hill, Anna Conrey, Ruth Pierre Charles, Ingrid Frey, Megan Wind-Rotolo, Chris Huston, Neal Jeffries, Swee Lay Thein
Journal: Blood
Blood (2023) 142 (Supplement 1): 5262.
https://doi.org/10.1182/blood-2023-184834
Published: 2023
Journal Articles

Activating Pyruvate Kinase Improves Red Blood Cell Integrity By Reducing Band3 Tyrosine Phosphorylation

Kang Le, Xunde Wang, Maureen Lundt, Anna Conrey, Ingrid Frey, Silvia Giannini, Penelope A. Kosinski, John A. Hausman, Philip S. Low, Neal Jeffries, Swee Lay Thein
Journal: Blood
Blood (2022) 140 (Supplement 1): 5395–5396.
https://doi.org/10.1182/blood-2022-160378
Published: 2022
Journal Articles

The Pyruvate Kinase Activator Mitapivat Improves Red Blood Cell Deformability and Sickling Kinetics in Adult Patients with Sickle Cell Disease

Maureen Lundt, Nancy Asomaning, Ingrid Frey, Xunde Wang, Anna Conrey, Julia Z Xu, Quan Li, Emily B Dunkelberger, Neal Jeffries, William Eaton, Swee Lay Thein
Journal: Blood
Blood (2022) 140 (Supplement 1): 2508–2509.
https://doi.org/10.1182/blood-2022-170010
Published: 2022
Journal Articles

A phase 1 dose escalation study of the pyruvate kinase activator mitapivat (AG-348) in sickle cell disease

Clinical Trials & Observations
Julia Z. Xu, Anna Conrey, Ingrid Frey, Eveline Gwaabe, Laurel A. Menapace, Laxminath Tumburu, Maureen Lundt, Timothy Lequang, Quan Li, Kristen Glass, Emily B. Dunkelberger, Varsha Iyer, Heidi Mangus, Charles Kung, Lenny Dang, Penelope A. Kosinski, Peter Hawkins, Neal Jeffries, William A. Eaton, Swee Lay Thein
Journal: Blood
Blood (2022) 140 (19): 2053–2062.
https://doi.org/10.1182/blood.2022015403
Published: 2022
Includes: Supplemental data
Journal Articles

Mitapivat (AG-348) Demonstrates Safety, Tolerability, and Improvements in Anemia, Hemolysis, Oxygen Affinity, and Hemoglobin S Polymerization Kinetics in Adults with Sickle Cell Disease: A Phase 1 Dose Escalation Study

Julia Z. Xu, Anna Conrey, Ingrid Frey, Eveline Gwaabe, Laurel A Menapace, Laxminath Tumburu, Maureen Lundt, Quan Li, Kristen Glass, Varsha Iyer, Heidi Mangus, Charles Kung, Lenny Dang, Penelope A. Kosinski, Peter Hawkins, Neal Jeffries, William Eaton, Swee Lay Thein
Journal: Blood
Blood (2021) 138 (Supplement 1): 10.
https://doi.org/10.1182/blood-2021-145398
Published: 2021