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Nancy Asomaning
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Journal Articles

Sickle cell disease is associated with early-onset clonal hematopoiesis involving DNA damage response pathway mutations

Free
Lachelle Weeks, Courtney Fitzhugh, Sam Pollock, Miriam Osei, Micah Rickles-Young, H. Moses Murdock, Megan Townsend, Christopher Reilly, Carla Dinardo, Ester Sabino, Mark Fleharty, Matthew DeFelice, Azeet Narayan, Donna Neuberg, Robert Redd, Lakshmanan Krishnamurti, David Williams, Pablo Bartolucci, Carrie Cibulskis, Julia Smith, Milena Batchvarova, Nancy Asomaning, Brian Custer, Kolapo Oyebola, Carlo Brugnara, Russell Ware, Vivien Sheehan, Jeffrey Glassberg, Shannon Kelly, Swee Lay Thein, Allison Ashley-Koch, Marilyn Telen, Guillaume Lettre, Niall Lennon, R. Coleman Lindsley
Journal: Blood
Blood (2025) 146 (Supplement 1): 8.
https://doi.org/10.1182/blood-2025-8
Published: 2025
Journal Articles

Advancing risk prediction in sickle cell disease through multi-task deep learning of mortality and intermediate risk factors

Free
Gefei Lin, Rui Miao, Xin Tian, Nancy Asomaning, Colin Wu, Swee Lay Thein
Journal: Blood
Blood (2025) 146 (Supplement 1): 295.
https://doi.org/10.1182/blood-2025-295
Published: 2025
Journal Articles

A pilot study evaluating the feasibility and usability of an mHealth application: SCD warrior

Free
Nancy Asomaning, Matthew Xu, Ingrid Frey, Raquel Andres, Swee Lay Thein
Journal: Blood
Blood (2025) 146 (Supplement 1): 4366.
https://doi.org/10.1182/blood-2025-4366
Published: 2025
Journal Articles

Machine Learning–Guided identification of survival-associated genetic variants in sickle cell disease

Free
Shijinqiu Gao, Haiou Li, Xin Tian, Xunde Wang, Nancy Asomaning, Anna Conrey, Britney Kruah, Kylie Haymaker, Colin Wu, Swee Lay Thein
Journal: Blood
Blood (2025) 146 (Supplement 1): 4703.
https://doi.org/10.1182/blood-2025-4703
Published: 2025
Journal Articles

Mitapivat-Induced Improvements in RBC Deformability and Membrane Integrity in Patients with Sickle Cell Disease Are Sustained during Extended Therapy

Free
Xunde Wang, Yechan Cho, Nancy Asomaning, Maureen Lundt, Anna Conrey, Britney Kruah, Amber M Yates, Megan Wind-Rotolo, Haiou Li, Kang Le, Swee Lay Thein
Journal: Blood
Blood (2024) 144 (Supplement 1): 2491.
https://doi.org/10.1182/blood-2024-206051
Published: 2024
Journal Articles

A Machine Learning-Based Workflow for Predicting Transplant Outcome in Patients with Sickle Cell Disease

Free
Haiou Li, Vandana Sachdev, Xin Tian, My-Le Nguyen, Matthew Hsieh, Courtney D. Fitzhugh, Emily Limerick, Wynona Coles, Nancy Asomaning, Anna Conrey, Colin O. Wu, Swee Lay Thein
Journal: Blood
Blood (2024) 144 (Supplement 1): 177.
https://doi.org/10.1182/blood-2024-194897
Published: 2024
Journal Articles

Acquired Mutations in the Mitochondrial Genome As Prognostic Markers in Sickle Cell Disease

Free
Rudra Ray, Haiou Li, Nancy Asomaning, Kang Le, Xunde Wang, Justin Lack, Yuesheng Li, Sayuri Kamimura, Zenaide Quezado, Swee Lay Thein
Journal: Blood
Blood (2024) 144 (Supplement 1): 2485.
https://doi.org/10.1182/blood-2024-203373
Published: 2024
Journal Articles

The Amyloidogenic Transthyretin V122I Variant Increase Severity of Cardiac Phenotype and Mortality in Sickle Cell Disease

Free
Haiou Li, Xunde Wang, Nancy Asomaning, Anna Conrey, Britney Kruah, Kylie Haymaker, Colin O. Wu, Vandana Sachdev, Swee Lay Thein
Journal: Blood
Blood (2024) 144 (Supplement 1): 800.
https://doi.org/10.1182/blood-2024-197909
Published: 2024
Journal Articles

Evaluation of Red Cell Deformability in Sickle Cell Disease Patients, Sickle Cell Carriers, and Healthy Controls Using Lorrca-Derived Parameters

Free
Nancy Asomaning, Xunde Wang, Maureen Lundt, Britney Kruah, Mai Hill, Anna Conrey, Ruth Pierre Charles, Ingrid Frey, Megan Wind-Rotolo, Chris Huston, Neal Jeffries, Swee Lay Thein
Journal: Blood
Blood (2023) 142 (Supplement 1): 5262.
https://doi.org/10.1182/blood-2023-184834
Published: 2023
Journal Articles

Long-Term Safety and Efficacy of Mitapivat, an Oral Pyruvate Kinase Activator, in Adults with Sickle Cell Disease: Extension of a Phase 1 Dose Escalation Study

Free
Anna Conrey, Ingrid Frey, Nancy Asomaning, Ruth Pierre Charles, Dina Parekh, Julia Xu, Kang Le, Britney Kruah, Quan Li, Emily Dunkelberger, Troy Cellmer, Amber M Yates, Megan Wind-Rotolo, Neal Jeffries, William A Eaton, Swee Lay Thein
Journal: Blood
Blood (2023) 142 (Supplement 1): 273.
https://doi.org/10.1182/blood-2023-180165
Published: 2023
Journal Articles

Pklr Variants Associated with Acute Pain in Sickle Cell Disease Influence ATP Concentrations in Red Blood Cells

Free
Xunde Wang, Yi-Ping Fu, Quan Li, Emily B Dunkelberger, Mickias Tegegn, Penelope A. Kosinski, Heidi Mangus, John Hamre, Sam M. Mbulaiteye, Ludmila Prokunina-Olsson, Stephen J. Chanock, Nancy Asomaning, Neal Jeffries, William Eaton, Swee Lay Thein
Journal: Blood
Blood (2022) 140 (Supplement 1): 954–956.
https://doi.org/10.1182/blood-2022-167296
Published: 2022
Journal Articles

The Pyruvate Kinase Activator Mitapivat Improves Red Blood Cell Deformability and Sickling Kinetics in Adult Patients with Sickle Cell Disease

Free
Maureen Lundt, Nancy Asomaning, Ingrid Frey, Xunde Wang, Anna Conrey, Julia Z Xu, Quan Li, Emily B Dunkelberger, Neal Jeffries, William Eaton, Swee Lay Thein
Journal: Blood
Blood (2022) 140 (Supplement 1): 2508–2509.
https://doi.org/10.1182/blood-2022-170010
Published: 2022