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Journal Articles

8-Oxoguanine DNA Glycosylase 1 Inhibition Suppresses Inflammatory Responses in Sickle Cell Disease

Kang Le, Zenaide Quezado, Sayuri Kamimura, Meghann L. Smith, Yuki Tahara, Yujeong Lee, Laxminath Tumburu, Anna Conrey, Eric T Kool, Swee Lay Thein
Journal: Blood
Blood (2023) 142 (Supplement 1): 2482.
https://doi.org/10.1182/blood-2023-182157
Published: 2023
Journal Articles

Exploring Mitochondrial DNA Heteroplasmy in a Mouse Model of Sickle Cell Disease

Rudra Ray, John Hamre, Kang Le, Xunde Wang, Justin Lack, Yuesheng Li, Zenaide Quezado, Swee Lay Thein
Journal: Blood
Blood (2023) 142 (Supplement 1): 3858.
https://doi.org/10.1182/blood-2023-189660
Published: 2023
Journal Articles

Long-Term Safety and Efficacy of Mitapivat, an Oral Pyruvate Kinase Activator, in Adults with Sickle Cell Disease: Extension of a Phase 1 Dose Escalation Study

Anna Conrey, Ingrid Frey, Nancy Asomaning, Ruth Pierre Charles, Dina Parekh, Julia Xu, Kang Le, Britney Kruah, Quan Li, Emily Dunkelberger, Troy Cellmer, Amber M Yates, Megan Wind-Rotolo, Neal Jeffries, William A Eaton, Swee Lay Thein
Journal: Blood
Blood (2023) 142 (Supplement 1): 273.
https://doi.org/10.1182/blood-2023-180165
Published: 2023
Journal Articles

Functional and Multi-Omics Signatures of Mitapivat Efficacy upon Activation of Pyruvate Kinase in Red Blood Cells from Patients with Sickle Cell Disease

Angelo D'Alessandro, Kang Le, Maureen Lundt, Quan Li, Emily Dunkelberger, Troy Cellmer, Andrew J Worth, Spurthi Patil, Chris Huston, Abby Grier, Monika monikA.dzieciatkow, Daniel Stephenson, William A Eaton, Swee Lay Thein
Journal: Blood
Blood (2023) 142 (Supplement 1): 2485.
https://doi.org/10.1182/blood-2023-181213
Published: 2023
Journal Articles

Activating Pyruvate Kinase Improves Red Blood Cell Integrity By Reducing Band3 Tyrosine Phosphorylation

Kang Le, Xunde Wang, Maureen Lundt, Anna Conrey, Ingrid Frey, Silvia Giannini, Penelope A. Kosinski, John A. Hausman, Philip S. Low, Neal Jeffries, Swee Lay Thein
Journal: Blood
Blood (2022) 140 (Supplement 1): 5395–5396.
https://doi.org/10.1182/blood-2022-160378
Published: 2022
Journal Articles

Towards Predicting Graft Vs Host Disease from Predicted Tissue Specific Minor Histocompatibility Antigens

Max Jameson-Lee, PhD, Amir Ahmed Toor, MBBS, Kang Le, PhD, Vishal Koparde, PhD, Brian Di Pace, PhD, Erin Donahue, PhD, Cathy Roberts, PhD, Gregory Buck, PhD, Michael Neale, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3395.
https://doi.org/10.1182/blood-2018-99-119783
Published: 2018