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Journal Articles

Evaluation of Red Cell Deformability in Sickle Cell Disease Patients, Sickle Cell Carriers, and Healthy Controls Using Lorrca-Derived Parameters

Nancy Asomaning, Xunde Wang, Maureen Lundt, Britney Kruah, Mai Hill, Anna Conrey, Ruth Pierre Charles, Ingrid Frey, Megan Wind-Rotolo, Chris Huston, Neal Jeffries, Swee Lay Thein
Journal: Blood
Blood (2023) 142 (Supplement 1): 5262.
https://doi.org/10.1182/blood-2023-184834
Published: 2023
Journal Articles

Exploring Mitochondrial DNA Heteroplasmy in a Mouse Model of Sickle Cell Disease

Rudra Ray, John Hamre, Kang Le, Xunde Wang, Justin Lack, Yuesheng Li, Zenaide Quezado, Swee Lay Thein
Journal: Blood
Blood (2023) 142 (Supplement 1): 3858.
https://doi.org/10.1182/blood-2023-189660
Published: 2023
Journal Articles

Activating Pyruvate Kinase Improves Red Blood Cell Integrity By Reducing Band3 Tyrosine Phosphorylation

Kang Le, Xunde Wang, Maureen Lundt, Anna Conrey, Ingrid Frey, Silvia Giannini, Penelope A. Kosinski, John A. Hausman, Philip S. Low, Neal Jeffries, Swee Lay Thein
Journal: Blood
Blood (2022) 140 (Supplement 1): 5395–5396.
https://doi.org/10.1182/blood-2022-160378
Published: 2022
Journal Articles

The Pyruvate Kinase Activator Mitapivat Improves Red Blood Cell Deformability and Sickling Kinetics in Adult Patients with Sickle Cell Disease

Maureen Lundt, Nancy Asomaning, Ingrid Frey, Xunde Wang, Anna Conrey, Julia Z Xu, Quan Li, Emily B Dunkelberger, Neal Jeffries, William Eaton, Swee Lay Thein
Journal: Blood
Blood (2022) 140 (Supplement 1): 2508–2509.
https://doi.org/10.1182/blood-2022-170010
Published: 2022
Journal Articles

HBB rs334 , ABO R s8176703 and Plasmodium Falciparum Positivity at Enrollment Are Independently Associated with Lower Risk for Endemic Burkitt Lymphoma in Uganda, Tanzania, Kenya, and Malawi

Hyokyoung G Hong, Mateus H Gouveia, Martin Ogwang, Patrick Kerchan, Steven Reynolds, Constance N Tenge, Pamela A Were, Robert T Kuremu, Walter N Wekesa, Nestory Masalu, Esther Kawira, Tobias Kinyera, Xunde Wang, Jiefu Zhou, Isaac Otim, Ismail D Legason, Hadijah Nabalende, Herry Dhudha, Mediatrix Mumia, Francine G Baker, Temi Okusolubo, Leona W Ayers, Kishor Bhatia, James J Goedert, Joshua G Woo, Nathan Cole, Wen Luo, Belynda Hicks, Adebowale A Adeyemo, Ludmila Prokunina-Olsson, Daniel N. Shriner, Charles N Rotimi, George Chagaluka, W Thomas Johnston, Nora Mutalima, Eric Borgstein, George N Liomba, Steve Kamiza, Nyengo Mkandawire, Collins Mitambo, Collins Mitambo, Elizabeth Molyneux, Robert Newton, Michelle Manning, Joseph F Fraumeni, Jr., Ruth M Pfeiffer, Amy Hutchinson, Meredith Yeager, Swee Lay Thein, Stephen J. Chanock, Sam M. Mbulaiteye
Journal: Blood
Blood (2022) 140 (Supplement 1): 9314–9316.
https://doi.org/10.1182/blood-2022-170410
Published: 2022
Journal Articles

Pklr Variants Associated with Acute Pain in Sickle Cell Disease Influence ATP Concentrations in Red Blood Cells

Xunde Wang, Yi-Ping Fu, Quan Li, Emily B Dunkelberger, Mickias Tegegn, Penelope A. Kosinski, Heidi Mangus, John Hamre, Sam M. Mbulaiteye, Ludmila Prokunina-Olsson, Stephen J. Chanock, Nancy Asomaning, Neal Jeffries, William Eaton, Swee Lay Thein
Journal: Blood
Blood (2022) 140 (Supplement 1): 954–956.
https://doi.org/10.1182/blood-2022-167296
Published: 2022
Journal Articles

Pklr Is a Genetic Modifier of Sickle Cell Disease

Xunde Wang, Mickias Tegegn, Fayaz Seifuddin, Stephan Menzel, Hamel Patel, Yi-Ping Fu, Neal Jeffries, Mehdi Pirooznia, Kate Gardner, Swee Lay Thein
Journal: Blood
Blood (2021) 138 (Supplement 1): 953.
https://doi.org/10.1182/blood-2021-151842
Published: 2021
Journal Articles

RNA Seq Profiles and Bioinformatics Validation in a Large Sample of Sickle Cell Disease Patients

Jen Judy, PhDMS, Xunde Wang, PhD, Fayaz Seifuddin, PhD, Laxminath Tumburu, PhD, Mehdi Pirooznia, MD PhD, Swee Lay Thein, DSc, FRCP, MBBS, MRCP
Journal: Blood
Blood (2020) 136 (Supplement 1): 13–14.
https://doi.org/10.1182/blood-2020-139382
Published: 2020
Journal Articles

Platelet Phenotype Prediction from Whole Genome Sequencing in 621 Sickle Cell Disease Patients

Celina Montemayor Garcia, MD PhD, Julie K. Weisman, MD, Xunde Wang, PhD, Divya Gandla, James Owen Long, MD, Clifton L. Dalgard, PhD, Mehdi Pirooznia, MD PhD, Harvey Klein, MD, Swee Lay Thein, DSc, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 2295.
https://doi.org/10.1182/blood-2019-131640
Published: 2019
Journal Articles

The NLRP3 Inflammasome in Platelets Is Upregulated in Sickle Cell Disease and Promotes Platelet Aggregation and In Vitro Thrombosis

Sebastian Vogel, MD PhD, Taruna Arora, MD, Xunde Wang, PhD, Luis E. Almeida, MD PhD, Zenaide Quezado, MD, Swee Lay Thein, DSc,FRCP,FRCPath,MBBS,MRCPath,MRCP
Journal: Blood
Blood (2017) 130 (Supplement 1): 2234.
https://doi.org/10.1182/blood.V130.Suppl_1.2234.2234
Published: 2017
Journal Articles

Characterisation of Three Unique Head-to-Tail Alpha Globin Cluster Duplications Contributing to Beta Thalassemia Intermedia in 3 Families

Barnaby E. Clark, PhD, Claire C. Shooter, Frances Smith, David Brawand, Laura Steedman, Matthew Oakley, Peter Rushton, Helen Rooks, Xunde Wang, PhD, Anthi Drousiotou, Andriani Kyrri, Xenia Felekis, Miranda Petrou, Andrew M Will, MD, Chris Fisher, PhD, Douglas R. Higgs, FRS, Cornelius Harteveld, Marion Phylipsen, Marina Kleanthous, PhD, Swee Lay Thein, MD DSc
Journal: Blood
Blood (2015) 126 (23): 3375.
https://doi.org/10.1182/blood.V126.23.3375.3375
Published: 2015
Journal Articles

Erythrocytosis in Chronic Mountain Sickness (CMS) in Andeans

Xunde Wang, PhD, David Callacondo, MD, Jose Rojas, MD, Jose Quesada-Olarte, Alan T. Remaley, Irina Maric, MD, John F. Tisdale, MD, Fabiola Leon-Velarde, MD, Francisco Villafuerte, PhD, Matthew Hsieh, MD
Journal: Blood
Blood (2014) 124 (21): 4873.
https://doi.org/10.1182/blood.V124.21.4873.4873
Published: 2014
Journal Articles

Stimulation of Nitric Oxide Synthase Activity By Plasma Apolipoproteins: a Biomarker of Endothelial Function in Adults with Sickle Cell Disease

Xunde Wang, PhD, Laurel Mendelsohn, BS, Lita Freeman, PhD, Boris Vaisman, PhD, Alan Remaley, MD, Gregory J. Kato, MD
Journal: Blood
Blood (2014) 124 (21): 4015.
https://doi.org/10.1182/blood.V124.21.4015.4015
Published: 2014
Journal Articles

Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor

Xunde Wang, Laurel Mendelsohn, Heather Rogers, Susan Leitman, Nalini Raghavachari, Yanqin Yang, Yu Ying Yau, Michael Tallack, Andrew Perkins, James G. Taylor, VI, Constance Tom Noguchi, Gregory J. Kato
Journal: Blood
Blood (2014) 124 (6): 946–954.
https://doi.org/10.1182/blood-2013-11-539718
Published: 2014
Journal Articles

The Anti-Sickling Agent Aes-103 Decreases Sickle Erythrocyte Fragility, Hypoxia-Induced Sickling and Hemolysis In Vitro

Laurel G. Mendelsohn, B.S., Leah Pedoeim, B.S., Yekai Kevin Wang, B.S., Rehan Saiyed, B.S., Christine A. Brantner, PhD, Mathew P. Daniels, PhD, James S. Nichols, RN, Xunde Wang, Ph.D., Eduard J. van Beers, MD, PhD, Gregory J. Kato, M.D.
Journal: Blood
Blood (2013) 122 (21): 940.
https://doi.org/10.1182/blood.V122.21.940.940
Published: 2013
Journal Articles

Placenta Growth Factor Is Regulated By Heme-Bound Iron Via Erythroid Krüppel-Like Factor In Erythroid Cells and Is Linked To Iron Status In Vivo In Sickle Cell Disease and Hereditary Hemochromatosis

Xunde Wang, PH.D., Laurel G. Mendelsohn, B.S., Heather Marie Rogers, MS, Susan F. Leitman, MD, Andrew Perkins, PhD, Michael Tallack, PhD, James G Taylor, MD, Constance Tom Noguchi, PhD, Gregory J. Kato, M.D.
Journal: Blood
Blood (2013) 122 (21): 432.
https://doi.org/10.1182/blood.V122.21.432.432
Published: 2013
Journal Articles

Phase 1 Clinical Trial Of The Candidate Anti-Sickling Agent Aes-103 In Adults With Sickle Cell Anemia

Gregory J. Kato, M.D., Marlene Peters Lawrence, R.N., Laurel G. Mendelsohn, B.S., Rehan Saiyed, B.S., Xunde Wang, Ph.D., Anna K. Conrey, RN, Judith M. Starling, Pharm.D., George Grimes, Pharm.D., James G Taylor, MD, John McKew, Ph.D., Caterina P. Minniti, M.D., Warren Stern, Ph.D.
Journal: Blood
Blood (2013) 122 (21): 1009.
https://doi.org/10.1182/blood.V122.21.1009.1009
Published: 2013
Journal Articles

Association of Plasma Cell-Free Hemoglobin with Physiological Measures of Nitric Oxide Responsiveness and Estimated Pulmonary Artery Systolic Pressure: Requirement for Rigorously Optimized Blood Processing Variables

Laurel G. Mendelsohn, M.S., Susan Yuditskaya, M.D., Xunde Wang, Ph.D., Wasnard Victor, M.S., Katherine Corbin, Shoaib Alam, M.D., Darlene Allen, C.L.T., Caterina P. Minniti, M.D., James G. Taylor, M.D., Gregory J. Kato, M.D.
Journal: Blood
Blood (2012) 120 (21): 3253.
https://doi.org/10.1182/blood.V120.21.3253.3253
Published: 2012
Journal Articles

Effect of Aes-103 Anti-Sickling Agent On Oxygen Affinity and Stability of Red Blood Cells From Patients with Sickle Cell Anemia

Laurel G. Mendelsohn, M.S., Leah Pedoeim, BS, Eduard J. van Beers, MD, PhD, Rehan Saiyed, BS, James S Nichols, RN, Xunde Wang, Ph.D., Gregory J. Kato, M.D.
Journal: Blood
Blood (2012) 120 (21): 85.
https://doi.org/10.1182/blood.V120.21.85.85
Published: 2012
Journal Articles

Iron Containing Compound Stimulates Expression of Pulmonary Hypertension Promoting Factor PlGF

Xunde Wang, Gregory J. Kato, MD, Laurel Mendelsohn
Journal: Blood
Blood (2011) 118 (21): 900.
https://doi.org/10.1182/blood.V118.21.900.900
Published: 2011