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Journal Articles

Combination of Menin and IDH Mutant Inhibition in Acute Myeloid Leukemia

James J. Yoon, Hongzhi Miao, Trupta Purohit, Dong Chen, Tomasz Cierpicki, Jolanta Grembecka

Blood (2022) 140 (Supplement 1): 5946.

https://doi.org/10.1182/blood-2022-168834

Published: 2022

Journal Articles

Combinatorial treatment with menin and FLT3 inhibitors induces complete remission in AML models with activating FLT3 mutations

Hongzhi Miao, EunGi Kim, Dong Chen, Trupta Purohit, Katarzyna Kempinska, James Ropa, Szymon Klossowski, Winifred Trotman, Gwenn Danet-Desnoyers, Tomasz Cierpicki, Jolanta Grembecka

Blood (2020) 136 (25): 2958–2963.

https://doi.org/10.1182/blood.2020006575

Published: 2020

Includes: Supplemental data

Journal Articles

The same site on the integrase-binding domain of lens epithelium–derived growth factor is a therapeutic target for MLL leukemia and HIV

Marcelo J. Murai, Jonathan Pollock, Shihan He, Hongzhi Miao, Trupta Purohit, Adam Yokom, Jay L. Hess, Andrew G. Muntean, Jolanta Grembecka, Tomasz Cierpicki

Blood (2014) 124 (25): 3730–3737.

https://doi.org/10.1182/blood-2014-01-550079

Published: 2014

Includes: Supplemental data

Journal Articles

Selective Inhibition of the Leukemia Fusion Protein CBFβ-SMMHC By Small Molecule AI-10-49 in the Treatment of Inv(16) AML

John Anto Pulikkan, PhD, Anuradha Illendula, PhD, Jolanta Grembecka, Liting Xue, Roger Rajewski, Monica L. Guzman, PhD, John H. Bushweller, PhD, Lucio H. Castilla, PhD

Blood (2014) 124 (21): 390.

https://doi.org/10.1182/blood.V124.21.390.390

Published: 2014

Journal Articles

Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia

Aibin Shi, Marcelo J. Murai, Shihan He, George Lund, Thomas Hartley, Trupta Purohit, Gireesh Reddy, Maksymilian Chruszcz, Jolanta Grembecka, Tomasz Cierpicki

Blood (2012) 120 (23): 4461–4469.

https://doi.org/10.1182/blood-2012-05-429274

Published: 2012

Includes: Supplemental data

Journal Articles

A Small Molecule Inhibitor of the CBFβ-SMMHC/RUNX Interaction Attenuates Inv(16) Leukemia in Vivo

John H. Bushweller, PhD, Anuradha Illendula, Ph.D., John Anto Pulikkan, Jolanta Grembecka, PhD, Paul Bradley, Yunpeng Zhou, Ph.D., Liting Xue, Yan Gao, Lucio H. Castilla, PhD

Blood (2012) 120 (21): 286.

https://doi.org/10.1182/blood.V120.21.286.286

Published: 2012

Journal Articles

Targeting Menin-MLL Interaction to Inhibit MLL Fusion Oncoproteins in Leukemia

Jolanta Grembecka, PhD, Shihan He, PhD, Aibin Shi, PhD, Trupta Purohit, Andrew G. Muntean, PhD, Xiaoqin Li, Thomas Hartley, Duxin Sun, PhD, Jay L. Hess, MD, PhD, Tomasz Cierpicki, PhD

Blood (2011) 118 (21): 2497.

https://doi.org/10.1182/blood.V118.21.2497.2497

Published: 2011

Journal Articles

Targeting LEDGF Interactions in MLL Leukemia

Tomasz Cierpicki, PhD, Shihan He, PhD, Trupta Purohit, Marcelo Murai, PhD, Thomas Hartley, Jolanta Grembecka, PhD

Blood (2011) 118 (21): 2500.

https://doi.org/10.1182/blood.V118.21.2500.2500

Published: 2011

Journal Articles

Structural Basis for MLL Cxxc Domain Protection against CpG DNA Methylation and the Essential Role of This Function in MLL-AF9 Leukemia.

Laurie Risner, Tomasz Cierpicki, PhD, Jolanta Grembecka, PhD, Stephen M Lukasik, PhD, Relja Popovic, PhD, David S Shultis, PhD, Nancy J. Zeleznik-Le, PhD, John H. Bushweller, PhD

Blood (2009) 114 (22): 763.

https://doi.org/10.1182/blood.V114.22.763.763

Published: 2009

Journal Articles

Molecular Basis of Menin-MLL Interaction: Implication for Targeted Therapies in MLL Leukemias.

Jolanta Grembecka, Amalia Marie Belcher, Tomasz Cierpicki

Blood (2009) 114 (22): 3775.

https://doi.org/10.1182/blood.V114.22.3775.3775

Published: 2009

Journal Articles

Development of Small Molecule Inhibitors of the CBFβ-SMMHC Oncoprotein.

John H. Bushweller, PhD, Michael J. Gorczynski, PhD, Jolanta Grembecka, PhD, Miki Newman, MS, Takeshi Corpora, BA, Yunpeng Zhou, BS, Yali Kong, PhD, Jae-Pil Jeon, PhD, Pu Paul Liu, PhD, Milton L. Brown, PhD

Blood (2005) 106 (11): 3359.

https://doi.org/10.1182/blood.V106.11.3359.3359

Published: 2005

Journal Articles

Development of Small Molecule Inhibitor of the AML1-ETO Oncoprotein.

Jolanta Grembecka, PhD, Kristin Graf, Miki Newman, Yunpeng Zhou, Mathew Cheney, Nancy A. Speck, PhD, Milton L. Brown, PhD, John H. Bushweller, PhD

Blood (2005) 106 (11): 1515.

https://doi.org/10.1182/blood.V106.11.1515.1515

Published: 2005

NARROW

Combination of Menin and IDH Mutant Inhibition in Acute Myeloid Leukemia

Combinatorial treatment with menin and FLT3 inhibitors induces complete remission in AML models with activating FLT3 mutations

The same site on the integrase-binding domain of lens epithelium–derived growth factor is a therapeutic target for MLL leukemia and HIV

Selective Inhibition of the Leukemia Fusion Protein CBFβ-SMMHC By Small Molecule AI-10-49 in the Treatment of Inv(16) AML

Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia

A Small Molecule Inhibitor of the CBFβ-SMMHC/RUNX Interaction Attenuates Inv(16) Leukemia in Vivo

Targeting Menin-MLL Interaction to Inhibit MLL Fusion Oncoproteins in Leukemia

Targeting LEDGF Interactions in MLL Leukemia

Structural Basis for MLL Cxxc Domain Protection against CpG DNA Methylation and the Essential Role of This Function in MLL-AF9 Leukemia.

Molecular Basis of Menin-MLL Interaction: Implication for Targeted Therapies in MLL Leukemias.

Development of Small Molecule Inhibitors of the CBFβ-SMMHC Oncoprotein.

Development of Small Molecule Inhibitor of the AML1-ETO Oncoprotein.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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