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Journal Articles

Combination of Menin and IDH Mutant Inhibition in Acute Myeloid Leukemia

James J. Yoon, Hongzhi Miao, Trupta Purohit, Dong Chen, Tomasz Cierpicki, Jolanta Grembecka

Blood (2022) 140 (Supplement 1): 5946.

https://doi.org/10.1182/blood-2022-168834

Published: 2022

Journal Articles

Combinatorial treatment with menin and FLT3 inhibitors induces complete remission in AML models with activating FLT3 mutations

Hongzhi Miao, EunGi Kim, Dong Chen, Trupta Purohit, Katarzyna Kempinska, James Ropa, Szymon Klossowski, Winifred Trotman, Gwenn Danet-Desnoyers, Tomasz Cierpicki, Jolanta Grembecka

Blood (2020) 136 (25): 2958–2963.

https://doi.org/10.1182/blood.2020006575

Published: 2020

Includes: Supplemental data

Journal Articles

Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development

Qing Wang, Ran Yan, Nancy Pinnell, Anna C. McCarter, Yeonjoo Oh, Yiran Liu, Cher Sha, Noah F. Garber, Yitong Chen, Qingqing Wu, Chia-Jui Ku, Ivy Tran, Amparo Serna Alarcon, Rork Kuick, James Douglas Engel, Ivan Maillard, Tomasz Cierpicki, Mark Y. Chiang

Blood (2018) 132 (12): 1279–1292.

https://doi.org/10.1182/blood-2018-02-835850

Published: 2018

Includes: Supplemental data

Journal Articles

The Direct Notch1 Cofactor Zmiz1 Differentially Regulates Notch1 Signals in a Stage-Specific Manner to Preserve Early T-Cell Precursors and Expand Committed T Cells

Qing Wang, Ran Yan, Nancy Pinnell, Yiran Liu, Amparo Serna Alarcon, Jason Qin, Yitong Chen, Erin Kim, Noah Garber, Ivan Maillard, MD PhD, Tomasz Cierpicki, PhD, Mark Chiang, MD PhD

Blood (2016) 128 (22): 426.

https://doi.org/10.1182/blood.V128.22.426.426

Published: 2016

Journal Articles

The same site on the integrase-binding domain of lens epithelium–derived growth factor is a therapeutic target for MLL leukemia and HIV

Marcelo J. Murai, Jonathan Pollock, Shihan He, Hongzhi Miao, Trupta Purohit, Adam Yokom, Jay L. Hess, Andrew G. Muntean, Jolanta Grembecka, Tomasz Cierpicki

Blood (2014) 124 (25): 3730–3737.

https://doi.org/10.1182/blood-2014-01-550079

Published: 2014

Includes: Supplemental data

Journal Articles

Direct Coregulation of Notch1 By Zmiz1 in T-Cell Development and Leukemia

Nancy Pinnell, Ran Yan, Hyoje Cho, PhD, Paula Jeon, Theresa Keeley, Jordan McHugh, Yiran Liu, Kojo S.J. Elenitoba-Johnson, MD, Ivan Maillard, MD PhD, Linda C. Samuelson, PhD, Tomasz Cierpicki, PhD, Mark Y. Chiang, MD PhD

Blood (2014) 124 (21): 55.

https://doi.org/10.1182/blood.V124.21.55.55

Published: 2014

Journal Articles

Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia

Aibin Shi, Marcelo J. Murai, Shihan He, George Lund, Thomas Hartley, Trupta Purohit, Gireesh Reddy, Maksymilian Chruszcz, Jolanta Grembecka, Tomasz Cierpicki

Blood (2012) 120 (23): 4461–4469.

https://doi.org/10.1182/blood-2012-05-429274

Published: 2012

Includes: Supplemental data

Journal Articles

The Pias-Like Coactivator ZMIZ1 Drives C-MYC Induction in Collaboration with NOTCH1 in T-Cell Acute Lymphoblastic Leukemia.

Margaret Decker, Choi Li, Lesley A Rakowski, Tomasz Cierpicki, PhD, Mark Y. Chiang, MD, PhD

Blood (2012) 120 (21): 2380.

https://doi.org/10.1182/blood.V120.21.2380.2380

Published: 2012

Journal Articles

Targeting Menin-MLL Interaction to Inhibit MLL Fusion Oncoproteins in Leukemia

Jolanta Grembecka, PhD, Shihan He, PhD, Aibin Shi, PhD, Trupta Purohit, Andrew G. Muntean, PhD, Xiaoqin Li, Thomas Hartley, Duxin Sun, PhD, Jay L. Hess, MD, PhD, Tomasz Cierpicki, PhD

Blood (2011) 118 (21): 2497.

https://doi.org/10.1182/blood.V118.21.2497.2497

Published: 2011

Journal Articles

Targeting LEDGF Interactions in MLL Leukemia

Tomasz Cierpicki, PhD, Shihan He, PhD, Trupta Purohit, Marcelo Murai, PhD, Thomas Hartley, Jolanta Grembecka, PhD

Blood (2011) 118 (21): 2500.

https://doi.org/10.1182/blood.V118.21.2500.2500

Published: 2011

Journal Articles

The Role of the Intrinsically Disordered and Multifunctional AF9 C-Terminal Domain in MLL-AF9 Leukemia,

John H. Bushweller, PhD, Benjamin Leach, Ming-jin Chang, Bhavna Lumba, Tomasz Cierpicki, PhD, Nancy J. Zeleznik-Le, PhD, Charles S. Hemenway, MD, PhD

Blood (2011) 118 (21): 3464.

https://doi.org/10.1182/blood.V118.21.3464.3464

Published: 2011

Journal Articles

Molecular Basis of Menin-MLL Interaction: Implication for Targeted Therapies in MLL Leukemias.

Jolanta Grembecka, Amalia Marie Belcher, Tomasz Cierpicki

Blood (2009) 114 (22): 3775.

https://doi.org/10.1182/blood.V114.22.3775.3775

Published: 2009

Journal Articles

Structural Basis for MLL Cxxc Domain Protection against CpG DNA Methylation and the Essential Role of This Function in MLL-AF9 Leukemia.

Laurie Risner, Tomasz Cierpicki, PhD, Jolanta Grembecka, PhD, Stephen M Lukasik, PhD, Relja Popovic, PhD, David S Shultis, PhD, Nancy J. Zeleznik-Le, PhD, John H. Bushweller, PhD

Blood (2009) 114 (22): 763.

https://doi.org/10.1182/blood.V114.22.763.763

Published: 2009

Journal Articles

Structure of the AML1-ETO eTAFH domain–HEB peptide complex and its contribution to AML1-ETO activity

Sangho Park, Wei Chen, Tomasz Cierpicki, Marco Tonelli, Xiongwei Cai, Nancy A. Speck, John H. Bushweller

Blood (2009) 113 (15): 3558–3567.

https://doi.org/10.1182/blood-2008-06-161307

Published: 2009

Includes: Supplemental data

Journal Articles

Development of Small Molecule Inhibitors of the AML1-ETO and CBFβ-SMMHC Oncoproteins.

Jolanta E. Grembecka, PhD, Kristin Graf, Yali Kong, PhD, Michael Douvas, MD, Tomasz Cierpicki, PhD, Anuradha Illendula, PhD, Gwen Baber, Izabela Bielnicka, Liya Roudaia, Nancy A. Speck, PhD, Milton L. Brown, PhD, MD, John H. Bushweller, PhD

Blood (2007) 110 (11): 1591.

https://doi.org/10.1182/blood.V110.11.1591.1591

Published: 2007

NARROW

Combination of Menin and IDH Mutant Inhibition in Acute Myeloid Leukemia

Combinatorial treatment with menin and FLT3 inhibitors induces complete remission in AML models with activating FLT3 mutations

Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development

The Direct Notch1 Cofactor Zmiz1 Differentially Regulates Notch1 Signals in a Stage-Specific Manner to Preserve Early T-Cell Precursors and Expand Committed T Cells

The same site on the integrase-binding domain of lens epithelium–derived growth factor is a therapeutic target for MLL leukemia and HIV

Direct Coregulation of Notch1 By Zmiz1 in T-Cell Development and Leukemia

Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia

The Pias-Like Coactivator ZMIZ1 Drives C-MYC Induction in Collaboration with NOTCH1 in T-Cell Acute Lymphoblastic Leukemia.

Targeting Menin-MLL Interaction to Inhibit MLL Fusion Oncoproteins in Leukemia

Targeting LEDGF Interactions in MLL Leukemia

The Role of the Intrinsically Disordered and Multifunctional AF9 C-Terminal Domain in MLL-AF9 Leukemia,

Molecular Basis of Menin-MLL Interaction: Implication for Targeted Therapies in MLL Leukemias.

Structural Basis for MLL Cxxc Domain Protection against CpG DNA Methylation and the Essential Role of This Function in MLL-AF9 Leukemia.

Structure of the AML1-ETO eTAFH domain–HEB peptide complex and its contribution to AML1-ETO activity

Development of Small Molecule Inhibitors of the AML1-ETO and CBFβ-SMMHC Oncoproteins.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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