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Kristian Helin
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Journal Articles

Inhibition of Topors Ubiquitin Ligase Augments the Efficacy of DNA Hypomethylating Agents through DNMT1 Stabilization

Satoshi Kaito, Kazumasa Aoyama, Motohiko Oshima, Karl Agger, Kristian Helin, Yasuhito Nannya, Seishi Ogawa, Atsuya Nishiyama, Makoto Nakanishi, Atsushi Iwama
Journal: Blood
Blood (2023) 142 (Supplement 1): 414.
https://doi.org/10.1182/blood-2023-179684
Published: 2023
Journal Articles

BMP2/SMAD pathway activation in JAK2/p53-mutant megakaryocyte/erythroid progenitors promotes leukemic transformation

Bing Li, Wenbin An, Hua Wang, Timour Baslan, Shoron Mowla, Aishwarya Krishnan, Wenbin Xiao, Richard P. Koche, Ying Liu, Sheng F. Cai, Zhijian Xiao, Andriy Derkach, Ilaria Iacobucci, Charles G. Mullighan, Kristian Helin, Scott W. Lowe, Ross L. Levine, Raajit K. Rampal
Journal: Blood
Blood (2022) 139 (25): 3630–3646.
https://doi.org/10.1182/blood.2021014465
Published: 2022
Includes: Supplemental data
Journal Articles

Targeting RIOK2 ATPase activity leads to decreased protein synthesis and cell death in acute myeloid leukemia

Jan-Erik Messling, Karl Agger, Kasper L. Andersen, Kristina Kromer, Hanna M. Kuepper, Anders H. Lund, Kristian Helin
Journal: Blood
Blood (2022) 139 (2): 245–255.
https://doi.org/10.1182/blood.2021012629
Published: 2022
Includes: Supplemental data
Journal Articles

The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance

Brief Report
Karl Agger, Koutarou Nishimura, Satoru Miyagi, Jan-Erik Messling, Kasper Dindler Rasmussen, Kristian Helin
Journal: Blood
Blood (2019) 134 (14): 1154–1158.
https://doi.org/10.1182/blood.2019000855
Published: 2019
Includes: Supplemental data
Journal Articles

The chromatin-binding protein Phf6 restricts the self-renewal of hematopoietic stem cells

Satoru Miyagi, Patrycja Sroczynska, Yuko Kato, Yaeko Nakajima-Takagi, Motohiko Oshima, Ola Rizq, Naoya Takayama, Atsunori Saraya, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Yumi Matsuzaki, Jesper Christensen, Kristian Helin, Atsushi Iwama
Journal: Blood
Blood (2019) 133 (23): 2495–2506.
https://doi.org/10.1182/blood.2019000468
Published: 2019
Includes: Supplemental data
Journal Articles

Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2

Takeshi Ueda, Akiko Nagamachi, Keiyo Takubo, Norimasa Yamasaki, Hirotaka Matsui, Akinori Kanai, Yuichiro Nakata, Kenichiro Ikeda, Takaaki Konuma, Hideaki Oda, Linda Wolff, Zen-ichiro Honda, Xudong Wu, Kristian Helin, Atsushi Iwama, Toshio Suda, Toshiya Inaba, Hiroaki Honda
Journal: Blood
Blood (2015) 125 (22): 3437–3446.
https://doi.org/10.1182/blood-2014-03-562694
Published: 2015
Includes: Supplemental data
Journal Articles

The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal in mice

Brief Report
Morag H. Stewart, Mareike Albert, Patrycja Sroczynska, V. Adam Cruickshank, Yanping Guo, Derrick J. Rossi, Kristian Helin, Tariq Enver
Journal: Blood
Blood (2015) 125 (13): 2075–2078.
https://doi.org/10.1182/blood-2014-08-596734
Published: 2015
Includes: Supplemental data
Journal Articles

shRNA screening identifies JMJD1C as being required for leukemia maintenance

Patrycja Sroczynska, V. Adam Cruickshank, John-Paul Bukowski, Satoru Miyagi, Frederik Otzen Bagger, Julian Walfridsson, Mikkel Bruhn Schuster, Bo Porse, Kristian Helin
Journal: Blood
Blood (2014) 123 (12): 1870–1882.
https://doi.org/10.1182/blood-2013-08-522094
Published: 2014
Includes: Supplemental data
Journal Articles

TET Proteins and Histone Modifications in Hematopoiesis

Kristian Helin, PhD, Kasper D. Rasmusssen, Marianne T. Pedersen, Guangshuai Jia, Kristine Williams, Jens V. Johansen, Paul A.C. Cloos, Olivier A. Bernard, Jesper Christensen
Journal: Blood
Blood (2013) 122 (21): SCI-19.
https://doi.org/10.1182/blood.V122.21.SCI-19.SCI-19
Published: 2013
Journal Articles

Loss Of Tet2 Collaborates With AML1-ETO In Inducing Leukemogenesis

Kasper D Rasmussen, PhD, Guangshuai Jia, Jens V. Johansen, Olivier A. Bernard, PhD, Kristian Helin, PhD
Journal: Blood
Blood (2013) 122 (21): 1251.
https://doi.org/10.1182/blood.V122.21.1251.1251
Published: 2013
Journal Articles

TET2 mutations in Diffuse Large B-Cell Lymphoma: The Role of TET2 in the Regulation of Methylation Patterns at TET2 Target Genes

Fazila Asmar, Jesper Christensen, Jens V Johansen, Anders Blåbjerg, Anja Pedersen, Christoffer Hother, Ulrik Ralfkiaer, Kristian Helin, Kirsten Grønbæk
Journal: Blood
Blood (2011) 118 (21): 1364.
https://doi.org/10.1182/blood.V118.21.1364.1364
Published: 2011