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Journal Articles

Association of aberrant ASNS imprinting with asparaginase sensitivity and chromosomal abnormality in childhood BCP-ALL

Blood (2020) 136 (20): 2319–2333.

https://doi.org/10.1182/blood.2019004090

Published: 2020

Includes: Supplemental data

Journal Articles

Involvement of Allele-Specific Methylation of Asparagine Synthetase Gene in Asparaginase Sensitivity of BCP-ALL

Atsushi Watanabe, MD PhD, Takeshi Inukai, MD, PhD, Minori Tamai, MD PhD, Tamao Shinohara, MD, Shinpei Somazu, MD, Hiroko Oshiro, MD PhD, Koshi Akahane, MD PhD, Kumiko Goi, MD,PhD, Kunio Miyake, PhD, Kevin Urayama, PhD MPH, Kanji Sugita, MD, PhD

Blood (2016) 128 (22): 3966.

https://doi.org/10.1182/blood.V128.22.3966.3966

Published: 2016

Journal Articles

TGFβ1 Induces MLL -Rearranged Acute Lymphoblastic Leukemia into Chemoresistant Quiescence in a Coordinated Manner with FLT3 Ligand

Minori Tamai, MD,PhD, Yoshiyuki Furuichi, MD, PhD, Shin Kasai, MD, Norie Ando, MD, Kumiko Goi, MD,PhD, Takeshi Inukai, MD, PhD, Masako Abe, Keiko Kagami, Kanji Sugita, MD, PhD

Blood (2016) 128 (22): 3972.

https://doi.org/10.1182/blood.V128.22.3972.3972

Published: 2016

Journal Articles

Molecular Mechanism for Synergistic Anti-Leukemic Activity of Tyrosine Kinase Inhibitors and Glucocorticoids Against Ph+ALL

Meixian Huang, MD, Takeshi Inukai, MD, PhD, Keiko Kagami, BD, Masako Abe, BD, Tamao Shinohara, MD, Atsushi Watanabe, MD PhD, Koshi Akahane, MD PhD, Shinpei Somazu, MD, Hiroko Oshiro, MD PhD, Kumiko Goi, MD PhD, Yasuhiro Maeda, MD PhD, Seiichi Okabe, MD PhD, Shinya Kimura, MD, PhD, Kanji Sugita, MD, PhD

Blood (2016) 128 (22): 1059.

https://doi.org/10.1182/blood.V128.22.1059.1059

Published: 2016

Journal Articles

Lenalidomide Effectively Induces Philadelphia-Chromosome Positive ALL Cells into Apoptosis in Synergy with Tyrosine Kinase Inhibitor

Daisuke Harama, MD PhD, Minori Tamai, MD PhD, Takeshi Inukai, MD, PhD, Kumiko Goi, MD, PhD, Takashi Yahata, PhD, Kiyoshi Ando, Takumi Ito, Hiroshi Handa, MD PhD, Kanji Sugita, MD, PhD

Blood (2016) 128 (22): 1060.

https://doi.org/10.1182/blood.V128.22.1060.1060

Published: 2016

Journal Articles

Triggering of CD44 by Ultra-Low-Molecular-Weight Hyaluronan Induces Cell Death by Autophagy Via Endoplasmic Reticulum Stress in Acute Lymphoblastic Leukemia with MLL Gene Rearrangements

Shin Kasai, Yoshiyuki Furuichi, MD, PhD, Norie Ando, Keiko Kagami, Kumiko Goi, MD, PhD, Takeshi Inukai, MD, PhD, Kanji Sugita, MD, PhD

Blood (2012) 120 (21): 1361.

https://doi.org/10.1182/blood.V120.21.1361.1361

Published: 2012

Journal Articles

Chemosensitivity Is Differentially Regulated by SDF-1/CXCR4 and SDF-1/CXCR7 Axes in Acute Lymphoblastic Leukemia.

Norie Ando, Yoshiyuki Furuichi, MD, PhD, Shin Kasai, Keiko Kagami, Kumiko Goi, MD, PhD, Takeshi Inukai, MD, PhD, Kanji Sugita, MD, PhD

Blood (2012) 120 (21): 2441.

https://doi.org/10.1182/blood.V120.21.2441.2441

Published: 2012

Journal Articles

Extensive gene deletions in Japanese patients with Diamond-Blackfan anemia

Blood (2012) 119 (10): 2376–2384.

https://doi.org/10.1182/blood-2011-07-368662

Published: 2012

Includes: Supplemental data

Journal Articles

BCR-ABL Regulates Death Receptor Expression for TNF-Related Apoptosis-Inducing Ligand (TRAIL) in Philadelphia Chromosome-Positive Leukemia

Itaru Kuroda, MD, PhD, Takeshi Inukai, MD, PhD, Xiaochun Zhang, MD, PhD, Jiro Kikuchi, Yusuke Furukawa, Atsushi Nemoto, MD, PhD, Koshi Akahane, MD, PhD, Kinuko Hirose, MD, PhD, Hiroko Honna- Oshiro, MD, PhD, Kumiko Goi, MD, PhD, Keiko Kagami, Hideo Yagita, PhD, Tetsuzo Tauchi, M.D., Yasuhiro Maeda, MD, PhD, Kanji Sugita, MD, PhD

Blood (2011) 118 (21): 2740.

https://doi.org/10.1182/blood.V118.21.2740.2740

Published: 2011

Journal Articles

PD0332991, a CDK4/6 Inhibitor, Has An Anti-Leukemic Activity Against Lymphoid Crisis of CML and Ph+ALL Even with T315I Mutation in BCR-Abl; in Vitro Analysis

Atsushi Nemoto, MD, PhD, Takeshi Inukai, MD, PhD, Koshi Akahane, MD, PhD, Hiroko Honna- Oshiro, MD, PhD, Kumiko Goi, MD, PhD, Keiko Kagami, Yasuhiro Maeda, MD, PhD, Tetsuzo Tauchi, M.D., Shinya Kimura, MD, PhD, Kanji Sugita, MD, PhD

Blood (2011) 118 (21): 1511.

https://doi.org/10.1182/blood.V118.21.1511.1511

Published: 2011

Journal Articles

Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19)

Blood (2010) 116 (6): 962–970.

https://doi.org/10.1182/blood-2009-09-244673

Published: 2010

Includes: Supplemental data

Journal Articles

KIRs Expression and Cytotoxic Activities of Cord Blood Natural Killer Cells Against Acute Lymphoblastic Leukemia with MLL Gene Rearrangement.

Hiroko Honna, MD, Kumiko Goi, MD, Kinuko Hirose, MD, Itaru Kuroda, MD, Takeshi Inukai, MD, Keiko Kagami, Kanji Sugita, MD

Blood (2007) 110 (11): 2803.

https://doi.org/10.1182/blood.V110.11.2803.2803

Published: 2007

Journal Articles

Induction of Death Receptors for TRAIL, a Cytotoxic Factor for GVL Effect, by Oncogenic Fusion E2A-HLF Derived from t(17;19)-Positive Acute Lymphoblastic Leukemia.

Xiaochun Zhang, Takeshi Inukai, Koshi Akahane, Kinuko Hirose, Itaru Kuroda, Hiroko Honna, Kumiko Goi, Keiko Kagami, Toshiya Inaba, Hidemitsu Kurosawa, Hiroaki Goto, Mikiya Endo, Hideo Yagita, A. Thomas Look, Kanji Sugita

Blood (2007) 110 (11): 2785.

https://doi.org/10.1182/blood.V110.11.2785.2785

Published: 2007

Journal Articles

Analysis of NK Cell Alloreactivity Against Acute Leukemia Cells with MLL Gene Rearramgement.

Hiroko Honna, MD, Kumiko Goi, M.D., Kinuko Hirose, M.D., Itaru Kuroda, M.D., Takeshi Inukai, M.D., Keiko Kagami, Shinpei Nakazawa, M.D., Kanji Sugita, M.D.

Blood (2006) 108 (11): 5169.

https://doi.org/10.1182/blood.V108.11.5169.5169

Published: 2006

Journal Articles

E2A-HLF Fusion Transcription Factor Mediating Aberrant Expression of LMO2 in B-Precursor ALL with t(17;19).

Kinuko Hirose, Takeshi Inukai, Koshi Akahane, Xiaochun Zhang, Itaru Kuroda, Hiroko Honna, Kumiko Goi, Toshiya Inaba, A. Thomas Look, Shinpei Nakazawa, Kanji Sugita

Blood (2006) 108 (11): 1832.

https://doi.org/10.1182/blood.V108.11.1832.1832

Published: 2006

Journal Articles

Induction of CD33 Expression in B-Precursor ALL by E2A-HLF Fusion Transcription Factor Derived from t(17;19).

Koshi Akahane, MD, Takeshi Inukai, MD, Toshiya Inaba, MD, Hidemitsu Kurosawa, MD, Mikiya Endo, MD, Hiroaki Goto, MD, Nobutaka Kiyokawa, MD, A. Thomas Look, MD, Kumiko Goi, MD, Kanji Sugita, MD, Shinpei Nakazawa, MD

Blood (2005) 106 (11): 851.

https://doi.org/10.1182/blood.V106.11.851.851

Published: 2005

Journal Articles

TEF, an antiapoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by down-regulating expression of the common β chain of cytokine receptors

Takeshi Inukai, Toshiya Inaba, Jinjun Dang, Ryoko Kuribara, Keiya Ozawa, Atsushi Miyajima, Wenshu Wu, A. Thomas Look, Yojiro Arinobu, Hiromi Iwasaki, Koichi Akashi, Keiko Kagami, Kumiko Goi, Kanji Sugita, Shinpei Nakazawa

Blood (2005) 105 (11): 4437–4444.

https://doi.org/10.1182/blood-2004-08-2976

Published: 2005

Journal Articles

PKC412, a FLT3 Inhibitor, Effectively Induces Apoptosis of Leukemia Cells with 11q23 Translocation Particularly Having D835 Mutation.

Kazuya Takahashi, MD, Kumiko Goi, MD, Yoshiyuki Furuichi, MD, Takeshi Inukai, MD, Kanji Sugita, MD, Shinpei Nakazawa, MD

Blood (2004) 104 (11): 1886.

https://doi.org/10.1182/blood.V104.11.1886.1886

Published: 2004

Journal Articles

Ligand Activation of FLT3 Induces Cell Cycle Arrest in Acute Lymphoblastic Leukemia with 11q23 Translocation.

Yoshiyuki Furuichi, M.D., Kanji Sugita, M.D., Takeshi Inukai, M.D., Kumiko Goi, M.D., Kazuya Takahashi, M.D., Shinpei Nakazawa, M.D.

Blood (2004) 104 (11): 1888.

https://doi.org/10.1182/blood.V104.11.1888.1888

Published: 2004

Journal Articles

TNF-related apoptosis-inducing ligand (TRAIL) frequently induces apoptosis in Philadelphia chromosome–positive leukemia cells

Kanako Uno, Takeshi Inukai, Nobuhiko Kayagaki, Kumiko Goi, Hiroki Sato, Atsushi Nemoto, Kazuya Takahashi, Keiko Kagami, Noriko Yamaguchi, Hideo Yagita, Ko Okumura, Toshiko Koyama-Okazaki, Toshio Suzuki, Kanji Sugita, Shinpei Nakazawa

Blood (2003) 101 (9): 3658–3667.

https://doi.org/10.1182/blood-2002-06-1770

Published: 2003

NARROW

Association of aberrant ASNS imprinting with asparaginase sensitivity and chromosomal abnormality in childhood BCP-ALL

Involvement of Allele-Specific Methylation of Asparagine Synthetase Gene in Asparaginase Sensitivity of BCP-ALL

TGFβ1 Induces MLL -Rearranged Acute Lymphoblastic Leukemia into Chemoresistant Quiescence in a Coordinated Manner with FLT3 Ligand

Molecular Mechanism for Synergistic Anti-Leukemic Activity of Tyrosine Kinase Inhibitors and Glucocorticoids Against Ph+ALL

Lenalidomide Effectively Induces Philadelphia-Chromosome Positive ALL Cells into Apoptosis in Synergy with Tyrosine Kinase Inhibitor

Triggering of CD44 by Ultra-Low-Molecular-Weight Hyaluronan Induces Cell Death by Autophagy Via Endoplasmic Reticulum Stress in Acute Lymphoblastic Leukemia with MLL Gene Rearrangements

Chemosensitivity Is Differentially Regulated by SDF-1/CXCR4 and SDF-1/CXCR7 Axes in Acute Lymphoblastic Leukemia.

Extensive gene deletions in Japanese patients with Diamond-Blackfan anemia

BCR-ABL Regulates Death Receptor Expression for TNF-Related Apoptosis-Inducing Ligand (TRAIL) in Philadelphia Chromosome-Positive Leukemia

PD0332991, a CDK4/6 Inhibitor, Has An Anti-Leukemic Activity Against Lymphoid Crisis of CML and Ph+ALL Even with T315I Mutation in BCR-Abl; in Vitro Analysis

Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19)

KIRs Expression and Cytotoxic Activities of Cord Blood Natural Killer Cells Against Acute Lymphoblastic Leukemia with MLL Gene Rearrangement.

Induction of Death Receptors for TRAIL, a Cytotoxic Factor for GVL Effect, by Oncogenic Fusion E2A-HLF Derived from t(17;19)-Positive Acute Lymphoblastic Leukemia.

Analysis of NK Cell Alloreactivity Against Acute Leukemia Cells with MLL Gene Rearramgement.

E2A-HLF Fusion Transcription Factor Mediating Aberrant Expression of LMO2 in B-Precursor ALL with t(17;19).

Induction of CD33 Expression in B-Precursor ALL by E2A-HLF Fusion Transcription Factor Derived from t(17;19).

TEF, an antiapoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by down-regulating expression of the common β chain of cytokine receptors

PKC412, a FLT3 Inhibitor, Effectively Induces Apoptosis of Leukemia Cells with 11q23 Translocation Particularly Having D835 Mutation.

Ligand Activation of FLT3 Induces Cell Cycle Arrest in Acute Lymphoblastic Leukemia with 11q23 Translocation.

TNF-related apoptosis-inducing ligand (TRAIL) frequently induces apoptosis in Philadelphia chromosome–positive leukemia cells

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American Society of Hematology

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American Society of Hematology

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