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Journal Articles

Predicting Immune Pathology after Hematopoietic Stem Cell Transplant with Transcriptomics: Naïve CD4 T Cell Expansion at Day 100 Predicts Patients with De Novo Chronic Gvhd

Ben Watkins, MD, James Kaminski, Muna Qayed, MDMSc, Kayla Betz, BS, Yvonne Suessmuth, PhD, Brandi Bratrude, Alison Yu, PhD, Victor Tkachev, PhD, Kathryn Pellegrini, Steven Bosinger, PhD, Bruce R. Blazar, MD, John T. Horan, MDMPH, Amelia Langston, MD, Leslie Kean, MD PhD

Blood (2020) 136 (Supplement 1): 38–39.

https://doi.org/10.1182/blood-2020-139488

Published: 2020

Journal Articles

Potent Interaction between CMV Reactivation and Gvhd: Immunologic Evidence for Blunting of CMV-Driven Immune Reconstitution in the Setting of Gvhd

Yvonne Suessmuth, PhD, Kayla Betz, BS, Alison Yu, PhD, Brandi Bratrude, Benjamin Watkins, MD, Muna Qayed, MDMSc, John T. Horan, MDMPH, Leslie Kean, MD PhD, Amelia Langston, MD

Blood (2020) 136 (Supplement 1): 50.

https://doi.org/10.1182/blood-2020-141856

Published: 2020

Journal Articles

Making Progress in Graft-Versus-Host Disease Prophylaxis and Microbiome Analysis in the Blood and Marrow Transplant Clinical Trials Network: Progress III (1703)/MI-Immune (1801)

Shernan Holtan, MD, Ami S. Bhatt, MD PhD, Raphael Fraser, PhD, Miguel-Angel Perales, MD, Leslie Kean, MD PhD, Wael Saber, MD MS, Mehdi Hamadani, MD, Brent R. Logan, Javier Bolaños-Meade, MD

Blood (2019) 134 (Supplement_1): 2005.

https://doi.org/10.1182/blood-2019-122782

Published: 2019

Journal Articles

Transcriptomic Analysis of CD4+ T Cell Dysfunction during Gvhd: Evidence for Profound Reprograming of T Cell Signaling during Acute Gvhd That Is Controlled during CD28:CD80/86 Costimulation Blockade with Abatacept

Benjamin Watkins, Yvonne Suessmuth, Kayla Betz, BS, Alison Yu, PhD, Brandi Bratrude, Muna Qayed, MD MSc, Kathryn Pellegrini, Steven Bosinger, Amelia Langston, MD, John T. Horan, MDMPH, Bruce R. Blazar, MD, Leslie Kean, MD PhD

Blood (2019) 134 (Supplement_1): 596.

https://doi.org/10.1182/blood-2019-131955

Published: 2019

Journal Articles

Equate, a Phase 1b/2 Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of a Novel Targeted Anti-CD6 Therapy, Itolizumab, in Subjects with Newly Diagnosed Acute Graft Versus Host Disease

Blood (2019) 134 (Supplement_1): 4516.

https://doi.org/10.1182/blood-2019-127325

Published: 2019

Journal Articles

An All Antibody Approach for Conditioning Bone Marrow for Hematopoietic Stem Cell Transplantation with Anti-cKIT and Anti-CD47 in Non-Human Primates

Kristopher D Marjon, PhD, James Y Chen, MD PhD, Jiaqi Duan, MS, Timothy S Choi, BS, Kavitha Sompalli, MS, Dongdong Feng, PhD, Ofelia Mata, Sharline Chen, B.S., Leslie Kean, MD PhD, Mwe Mwe Chao, MD, Mark Chao, MD PhD, Chris H Takimoto, MD PhD, Balaji Agoram, PhD, Cynthia E. Dunbar, MD, Ravi Majeti, MD PhD, Irving L Weissman, MD, Jie Liu, PhD MD, Jens-Peter Volkmer, MD

Blood (2019) 134 (Supplement_1): 4428.

https://doi.org/10.1182/blood-2019-131490

Published: 2019

Journal Articles

IL2 and Rapamycin Enhance Persistence of Adoptively-Transferred Ex-Vivo Expanded T Regulatory Cells

Scott N Furlan, MD, Christina Lopez, PhD, Victor Tkachev, PhD, Kayla Betz, Daniel J Hunt, James Hibbard, PhD, Bruce R. Blazar, MD, Cole Trapnell, PhD, Leslie Kean, MD PhD

Blood (2018) 132 (Supplement 1): 2049.

https://doi.org/10.1182/blood-2018-99-120254

Published: 2018

Journal Articles

Pharmacologic Blockade of Notch/Delta-like Ligand 4 Signaling Protects from Gastrointestinal Acute Graft-Versus-Host Disease in Non-Human Primates

Victor Tkachev, PhD, Frank Kuhnert, PhD, Scott N Furlan, MD, Hengqi Zheng, MD, Daniel J Hunt, Lucrezia Colonna, PhD, Judith M Carlson, BS, Agne Taraseviciute, MD PhD, Angela Panoskaltsis-Mortari, PhD, Virginia Hoglund, Kayla Betz, Alison Yu, PhD, Bruce R. Blazar, MD, Steve Carpenter, MD PhD, Olivier Harari, MD PhD, Gavin Thurston, PhD, Ivan Maillard, MD PhD, Leslie Kean, MD PhD

Blood (2018) 132 (Supplement 1): 2027.

https://doi.org/10.1182/blood-2018-99-110030

Published: 2018

Journal Articles

Uncovering the Molecular Signature of Pathogenic Tissue-Infiltrating T Cells during Acute Graft-Versus-Host Disease

Victor Tkachev, PhD, Scott N Furlan, MD, E. Lake Potter, Hengqi Zheng, MD, Daniel J Hunt, Lucrezia Colonna, PhD, Agne Taraseviciute, MD PhD, Judith M Carlson, BS, Kayla Betz, Alison Yu, PhD, Michelle Hoffman, MS, Audrey Baldessari, DVM, Sarah Herrin, Joe Olvera, Chad Littlewood, Christopher English, Bruce R. Blazar, MD, Mario Roederer, PhD, Leslie Kean, MD PhD

Blood (2018) 132 (Supplement 1): 805.

https://doi.org/10.1182/blood-2018-99-113652

Published: 2018

Journal Articles

T Cell Costimulation Blockade with Abatacept Nearly Eliminates Early Severe Acute Graft Versus Host Disease after HLA-Mismatched (7/8 HLA Matched) Unrelated Donor Transplant, with a Favorable Impact on Disease-Free and Overall Survival

Blood (2017) 130 (Supplement 1): 212.

https://doi.org/10.1182/blood.V130.Suppl_1.212.212

Published: 2017

Journal Articles

Modeling and Understanding the Biology of Transplant-Mediated HIV Cure in a Non-Human Primate Model

Blood (2017) 130 (Supplement 1): 694.

https://doi.org/10.1182/blood.V130.Suppl_1.694.694

Published: 2017

Journal Articles

In Vitro Induction of Human Regulatory T-Cells (iTregs) Using Conditions of Low Tryptophan Plus Kynurenines

Keli L. Hippen, PhD, Margaret L. MacMillan, MD, Amanda Lemire, BS, Asim Saha, PhD, Eric Hanse, Colin Lord, Ameeta Kelekar, PhD, Roddy S. O'Connor, PhD, James L. Riley, PhD, Carl H June, MD, Leslie Kean, MD PhD, Jeffrey S. Miller, MD, John E. Wagner, MD, David H. Munn, MD, Bruce R. Blazar, MD

Blood (2016) 128 (22): 1229.

https://doi.org/10.1182/blood.V128.22.1229.1229

Published: 2016

Journal Articles

Creation of the First Non-Human Primate Model That Faithfully Recapitulates Chimeric Antigen Receptor (CAR) T Cell-Mediated Cytokine Release Syndrome (CRS) and Neurologic Toxicity Following B Cell-Directed CAR-T Cell Therapy

Agne Taraseviciute, MD PhD, Leslie Kean, MD PhD, Michael C Jensen, MD

Blood (2016) 128 (22): 651.

https://doi.org/10.1182/blood.V128.22.651.651

Published: 2016

Journal Articles

Striking Clinical, Molecular and Immunological Outcomes in Non-Human Primate Hematopoietic Stem Cell Transplantation Using a Novel OX40L Blockade Agent, KY1005, Combined with Rapamycin

Victor Tkachev, PhD, Scott N. Furlan, MD, Ben Watkins, MD, Betty Zheng, MD, Daniel Hunt, Angela Panoskaltsis-Mortari, PhD, Kayla Betz, Melanie Brown, Katie Zeleski, Alison Yu, PhD, Bruce R. Blazar, MD, Duncan Casson, Ian Kirby, Phil Bland-Ward, Leslie Kean, MD PhD

Blood (2016) 128 (22): 3341.

https://doi.org/10.1182/blood.V128.22.3341.3341

Published: 2016

Journal Articles

Th17/Th22 Cells Mediate Breakthrough Graft-Versus-Host-Disease

Scott N. Furlan, MD, Victor Tkachev, PhD, Ben Watkins, MD, Kayla Betz, Angela Panoskaltsis-Mortari, PhD, Bruce R. Blazar, MD, Leslie Kean, MD PhD

Blood (2015) 126 (23): 1878.

https://doi.org/10.1182/blood.V126.23.1878.1878

Published: 2015

Journal Articles

Loss of Programmed Death Ligand-1 Expression on Donor T Cells Lessens Acute Graft-Versus-Host Disease Lethality

Blood (2015) 126 (23): 147.

https://doi.org/10.1182/blood.V126.23.147.147

Published: 2015

Journal Articles

T Stem Cell Memory Dynamics during Acute Graft-Versus-Host Disease

Victor Tkachev, PhD, Scott N. Furlan, MD, Ben Watkins, MD, Angela Panoskaltsis-Mortari, PhD, Bruce R. Blazar, MD, Leslie Kean, MD PhD

Blood (2015) 126 (23): 3079.

https://doi.org/10.1182/blood.V126.23.3079.3079

Published: 2015

Journal Articles

Evidence for Quantitative and Functional Immune Deviation in Pediatric Patients with Sickle Cell Disease

Leslie Kean, MD, PHD, Sharon Sen, Martha Ann Felder, CRA, VIN Tangpricha, MD, PHD, Olufolake Adisa, MD, Angelica JAMES-Herry, MD, Iris Buchanan, MD, MSC, Thomas Ziegler, Jessica Alvarez, RD, PhD, Jonathan Beus, Diana Worthington-White, RN, CRA, Jennifer Robertson, PhD, Jackie George, BS, Joshua Cetron, Solomon Fiifi Ofori-Acquah, PhD, Ifeyinwa Osunkwo, MD, MPH

Blood (2011) 118 (21): 1054.

https://doi.org/10.1182/blood.V118.21.1054.1054

Published: 2011

Journal Articles

Sirolimus and GvHD Control: the Rhesus Macaque GvHD Model Reveals That Sirolimus Preferentially Inhibits T Cell Proliferation While Permitting Breakthrough T cell Activation After MHC-Mismatched Hematopoietic Stem Cell Transplantation

Karnail Singh, Swetha Srinivasan, Angela Panoskaltsis-Mortari, PhD, Sharon Sen, Kelly Hamby, Taylor Deane, Linda Stempora, Frank Leopardi, John Shires, Jonathan Beus, Benjamin Byrd, Bruce R. Blazar, MD, Leslie Kean, MD, PhD

Blood (2010) 116 (21): 2549.

https://doi.org/10.1182/blood.V116.21.2549.2549

Published: 2010

Journal Articles

GvHD After Haploidentical Transplant: A Novel, MHC-Defined Rhesus Macaque Model Identifies CD28-Negative CD8+ T Cells as a Reservoir of Breakthrough T Cell Proliferation During Costimulation Blockade and Sirolimus-Based Immunosuppression

Swetha Srinivasan, Weston P. Miller IV, MD, Angela Panoskalltsis-Mortari, Sharon Sen, Kelly Hamby, Taylor Deane, Linda Stempora, Karnail Singh, Jonathan Beus, Bruce R. Blazar, MD, Leslie Kean, MD, PhD

Blood (2010) 116 (21): 2550.

https://doi.org/10.1182/blood.V116.21.2550.2550

Published: 2010

NARROW

Predicting Immune Pathology after Hematopoietic Stem Cell Transplant with Transcriptomics: Naïve CD4 T Cell Expansion at Day 100 Predicts Patients with De Novo Chronic Gvhd

Potent Interaction between CMV Reactivation and Gvhd: Immunologic Evidence for Blunting of CMV-Driven Immune Reconstitution in the Setting of Gvhd

Making Progress in Graft-Versus-Host Disease Prophylaxis and Microbiome Analysis in the Blood and Marrow Transplant Clinical Trials Network: Progress III (1703)/MI-Immune (1801)

Transcriptomic Analysis of CD4+ T Cell Dysfunction during Gvhd: Evidence for Profound Reprograming of T Cell Signaling during Acute Gvhd That Is Controlled during CD28:CD80/86 Costimulation Blockade with Abatacept

Equate, a Phase 1b/2 Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of a Novel Targeted Anti-CD6 Therapy, Itolizumab, in Subjects with Newly Diagnosed Acute Graft Versus Host Disease

An All Antibody Approach for Conditioning Bone Marrow for Hematopoietic Stem Cell Transplantation with Anti-cKIT and Anti-CD47 in Non-Human Primates

IL2 and Rapamycin Enhance Persistence of Adoptively-Transferred Ex-Vivo Expanded T Regulatory Cells

Pharmacologic Blockade of Notch/Delta-like Ligand 4 Signaling Protects from Gastrointestinal Acute Graft-Versus-Host Disease in Non-Human Primates

Uncovering the Molecular Signature of Pathogenic Tissue-Infiltrating T Cells during Acute Graft-Versus-Host Disease

T Cell Costimulation Blockade with Abatacept Nearly Eliminates Early Severe Acute Graft Versus Host Disease after HLA-Mismatched (7/8 HLA Matched) Unrelated Donor Transplant, with a Favorable Impact on Disease-Free and Overall Survival

Modeling and Understanding the Biology of Transplant-Mediated HIV Cure in a Non-Human Primate Model

In Vitro Induction of Human Regulatory T-Cells (iTregs) Using Conditions of Low Tryptophan Plus Kynurenines

Creation of the First Non-Human Primate Model That Faithfully Recapitulates Chimeric Antigen Receptor (CAR) T Cell-Mediated Cytokine Release Syndrome (CRS) and Neurologic Toxicity Following B Cell-Directed CAR-T Cell Therapy

Striking Clinical, Molecular and Immunological Outcomes in Non-Human Primate Hematopoietic Stem Cell Transplantation Using a Novel OX40L Blockade Agent, KY1005, Combined with Rapamycin

Th17/Th22 Cells Mediate Breakthrough Graft-Versus-Host-Disease

Loss of Programmed Death Ligand-1 Expression on Donor T Cells Lessens Acute Graft-Versus-Host Disease Lethality

T Stem Cell Memory Dynamics during Acute Graft-Versus-Host Disease

Evidence for Quantitative and Functional Immune Deviation in Pediatric Patients with Sickle Cell Disease

Sirolimus and GvHD Control: the Rhesus Macaque GvHD Model Reveals That Sirolimus Preferentially Inhibits T Cell Proliferation While Permitting Breakthrough T cell Activation After MHC-Mismatched Hematopoietic Stem Cell Transplantation

GvHD After Haploidentical Transplant: A Novel, MHC-Defined Rhesus Macaque Model Identifies CD28-Negative CD8+ T Cells as a Reservoir of Breakthrough T Cell Proliferation During Costimulation Blockade and Sirolimus-Based Immunosuppression

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American Society of Hematology

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American Society of Hematology

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