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Lukas P. Frenzel
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Journal Articles

MARCKS affects cell motility and response to BTK inhibitors in CLL

Laura Beckmann, Valeska Berg, Clarissa Dickhut, Clare Sun, Olaf Merkel, Johannes Bloehdorn, Sandra Robrecht, Marc Seifert, Alexandra da Palma Guerreiro, Julia Claasen, Stefan Loroch, Matteo Oliverio, Chingiz Underbayev, Lauren Vaughn, Daniel Thomalla, Malte F. Hülsemann, Eugen Tausch, Kirsten Fischer, Anna Maria Fink, Barbara Eichhorst, Albert Sickmann, Clemens M. Wendtner, Stephan Stilgenbauer, Michael Hallek, Adrian Wiestner, René P. Zahedi, Lukas P. Frenzel
Journal: Blood
Blood (2021) 138 (7): 544–556.
https://doi.org/10.1182/blood.2020009165
Published: 2021
Includes: Supplemental data
Journal Articles

PI3K/BCL2: illusion or promise for RS?

Lukas P. Frenzel
Journal: Blood
Blood (2021) 137 (24): 3319–3321.
https://doi.org/10.1182/blood.2021011854
Published: 2021
Journal Articles

Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1

Vivien Kohlhaas, Stuart James Blakemore, Mona Al-Maarri, Nadine Nickel, Martin Pal, Andreas Roth, Nadine Hövelmeyer, Stephan C. Schäfer, Gero Knittel, Philipp Lohneis, Milos Nikolic, Janica L. Wiederstein, Marek Franitza, Theodoros Georgomonolis, Nina Reinart, Marco Herling, Carmen Herling, Elena M. Hartmann, Andreas Rosenwald, Wolfram Klapper, Reinhard Büttner, Riccardo Moia, Davide Rossi, Renzo Boldorini, Gianluca Gaidano, Lukas P. Frenzel, Hans Christian Reinhardt, Jens C. Brüning, Michael Hallek, Marcus Krüger, Martin Peifer, Christian P. Pallasch, F. Thomas Wunderlich
Journal: Blood
Blood (2021) 137 (5): 646–660.
https://doi.org/10.1182/blood.2020005734
Published: 2021
Includes: Supplemental data
Journal Articles

A Novel BCL2-Driven Compound Mutant Mouse Model for In Vivo Research on BH3 Mimetics

Ismini Halmer, Alexandra da Palma Guerreiro, PhD, Laura Beckmann, MD, Christian Reinhardt, MD, Hamid Kashkar, Michael Hallek, Lukas P. Frenzel, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39.
https://doi.org/10.1182/blood-2020-142569
Published: 2020
Journal Articles

BIM Regulation Is BTK Dependent and Can be Targeted By Entospletinib in Ibrutinib Refractory Mutants

Laura Beckmann, MD, Valeska Berg, PhD, Clarissa Dickhut, Gunter Krause, PhD, René Zahedi, PhD, Michael Hallek, Lukas P. Frenzel, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1765.
https://doi.org/10.1182/blood-2019-127148
Published: 2019
Journal Articles

FcmR Shapes BCR Signaling in IgM-Positive Leukemia

Alexandra da Palma Guerreiro, PhD, Cornelia Dorweiler, Ismini Halmer, Olaf Merkel, Elena Maria Hartmann, MD, Valeska Berg, PhD, Nina Reinart, Günter Fingerle-Rowson, MD PhD, Gero Knittel, MSc, Christian Pallasch, MD, Andreas Rosenwald, Christian Reinhardt, MD, Clemens-Martin Wendtner, Michael Hallek, MD, Lukas P. Frenzel, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2620.
https://doi.org/10.1182/blood-2018-99-118352
Published: 2018
Journal Articles

Integrated Proteomic and Phosphoproteomic Analysis Reveal Novel Targets and Suggest Rationale for Ibrutinib Efficacy in UM-CLL

Laura Beckmann, MD, Valeska Berg, PhD, Clarissa Dickhut, Johannes Bloehdorn, MD, Jasmin Bahlo, PhD, Sandra Robrecht, PhD, Malte Hülsemann, MD, Stefan Loroch, Olaf Merkel, Kirsten Fischer, MD, Clemens-Martin Wendtner, Stephan Stilgenbauer, Albert Sickmann, PhD, Michael Hallek, René Zahedi, PhD, Lukas P. Frenzel, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 583.
https://doi.org/10.1182/blood-2018-99-118235
Published: 2018
Journal Articles

Increased Palmitoylation Modulates Cytoskeletal Regulators to Enhance CXCR4-Mediated Motility of Malignant B Cells

Andrea Haerzschel, PhD, Dunja Baatout, PhD, Valeska Berg, PhD, Manuela Paunovic, Karin Oberascher, PhD, Hubert Kerschbaum, PhD, Richard Greil, MD, Michael J. Hallek, MD, Tanja N. Hartmann, PhD, Lukas P. Frenzel, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3988.
https://doi.org/10.1182/blood.V130.Suppl_1.3988.3988
Published: 2017
Journal Articles

Mechanisms of Venetoclax Resistance in Chronic Lymphocytic Leukemia

Lukas P. Frenzel, MD, Carmen D. Herling, MD PhD, Nima Abedpour, PhD, Jonathan Weiss, PhD, Petra Mayer, Maria Cartolano, PhD, Valeska Berg, PhD, Nadine Kutsch, MD, Paula Cramer, MD, Clemens-Martin Wendtner, MD, Thorsten Persigehl, MD, Andreas Saleh, MD, Janine Altmüller, PhD, Peter Nürnberg, PhD, Christian Pallasch, MD, Viktor Achter, PhD, Ulrich Lang, PhD, Barbara F. Eichhorst, MD, Roberta Castiglione, MD, Stephan C. Schaefer, MD, Reinhard Buettner, MD, Karl-Anton Kreuzer, MD, Hans Christian Reinhardt, MD, Michael J. Hallek, MD, Martin Peifer, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 263.
https://doi.org/10.1182/blood.V130.Suppl_1.263.263
Published: 2017
Journal Articles

APT1-Mediated Cross-Talk Between Palmitoylation and Phosphorylation Events of the BCR Pathway Sensitizes CLL Cells Towards BCR-Associated Kinase Inhibitors

Valeska Berg, PhD, Dunja Baatout, M.Sc., Clemens Wendtner, MD, Michael Hallek, Lukas P. Frenzel, MD
Journal: Blood
Blood (2016) 128 (22): 4361.
https://doi.org/10.1182/blood.V128.22.4361.4361
Published: 2016
Journal Articles

Loss of TOSO Promotes Richter's Transformation of TCL1A Driven CLL

Alexandra da Palma Guerreiro, PhD, Cornelia Dorweiler, Laurent Kintzelé, Dunja Baatout, M.Sc., Malte Huelsemann, Valeska Berg, PhD, Olaf Merkel, Nina Reinart, PhD, Guenter Fingerle-Rowson, MD PhD, Gero Knittel, Christian Pallasch, MD, Hans Christian Reinhardt, Clemens Martin Wendtner, MD, Michael Hallek, Lukas P. Frenzel, MD
Journal: Blood
Blood (2016) 128 (22): 354.
https://doi.org/10.1182/blood.V128.22.354.354
Published: 2016
Journal Articles

Chimeric antigen receptor T cells targeting Fc μ receptor selectively eliminate CLL cells while sparing healthy B cells

Elena Faitschuk, Andreas A. Hombach, Lukas P. Frenzel, Clemens-Martin Wendtner, Hinrich Abken
Journal: Blood
Blood (2016) 128 (13): 1711–1722.
https://doi.org/10.1182/blood-2016-01-692046
Published: 2016
Journal Articles

B-cell–specific conditional expression of Myd88 p.L252P leads to the development of diffuse large B-cell lymphoma in mice

Gero Knittel, Paul Liedgens, Darya Korovkina, Jens M. Seeger, Yussor Al-Baldawi, Mona Al-Maarri, Christian Fritz, Katerina Vlantis, Svetlana Bezhanova, Andreas H. Scheel, Olaf-Oliver Wolz, Maurice Reimann, Peter Möller, Cristina López, Matthias Schlesner, Philipp Lohneis, Alexander N. R. Weber, Lorenz Trümper, German International Cancer Genome Consortium Molecular Mechanisms in Malignant Lymphoma by Sequencing Project Consortium, Louis M. Staudt, Monika Ortmann, Manolis Pasparakis, Reiner Siebert, Clemens A. Schmitt, Andreas R. Klatt, F. Thomas Wunderlich, Stephan C. Schäfer, Thorsten Persigehl, Manuel Montesinos-Rongen, Margarete Odenthal, Reinhard Büttner, Lukas P. Frenzel, Hamid Kashkar, H. Christian Reinhardt
Journal: Blood
Blood (2016) 127 (22): 2732–2741.
https://doi.org/10.1182/blood-2015-11-684183
Published: 2016
Includes: Supplemental data
Journal Articles

miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL

Valeska Berg, Marion Rusch, Nachiket Vartak, Christian Jüngst, Astrid Schauss, Herbert Waldmann, Christian Hedberg, Christian P. Pallasch, Philippe I. H. Bastiaens, Michael Hallek, Clemens-Martin Wendtner, Lukas P. Frenzel
Journal: Blood
Blood (2015) 125 (19): 2948–2957.
https://doi.org/10.1182/blood-2014-07-586511
Published: 2015
Includes: Supplemental data
Journal Articles

p38 MAPK Controls Sensitivity Towards BH3 Mimetics By Regulating Mcl-1 Expression of Chronic Lymphocytic Leukemia in Hypoxia and Acquired Resistance

Malte F Huelsemann, Michaela Patz, PhD, Laura Beckmann, Kerstin Brinkmann, Teresa Otto, Joachim Fandrey, MD, Hans Jiro Becker, Sebastian Theurich, MD, Michael S. von Bergwelt-Baildon, MD PhD, Christian P. Pallasch, MD, Réne P. Zahedi, Hamid Kashkar, PhD, Christian Reinhardt, MD, Michael Hallek, MD, Clemens-Martin Wendtner, MD, Lukas P. Frenzel, MD
Journal: Blood
Blood (2014) 124 (21): 1947.
https://doi.org/10.1182/blood.V124.21.1947.1947
Published: 2014
Journal Articles

Mirs-138 and -424 Control Palmitoylation-Dependent CD95-Mediated Cell Death By Targeting Acyl Protein Thioesterases 1 and 2 in Chronic Lymphocytic Leukemia

Valeska Berg, Marion Rusch, PhD, Nachiket Vartak, PhD, Christian Juengst, Astrid Schauss, Herbert Waldmann, PhD, Christian Hedberg, PhD, Christian P. Pallasch, MD, Philippe Bastiaens, PhD, Michael Hallek, MD, Clemens-Martin Wendtner, MD, Lukas P. Frenzel, MD
Journal: Blood
Blood (2014) 124 (21): 1953.
https://doi.org/10.1182/blood.V124.21.1953.1953
Published: 2014
Journal Articles

A Complex Molecular Network Controls Palmitoylation-Dependant CD95 Sensitivity Of CLL Cells

Valeska Berg, Nachiket Vartak, PhD, Rainer Claus, MD, Julia Claasen, Marion Rusch, PhD, Christian P. Pallasch, MD, Herbert Waldmann, PhD, Christopher Plass, PhD, Philippe Bastiaens, PhD, Michael Hallek, MD, Christian Hedberg, PhD, Clemens Wendtner, MD, Lukas P. Frenzel, MD
Journal: Blood
Blood (2013) 122 (21): 4148.
https://doi.org/10.1182/blood.V122.21.4148.4148
Published: 2013
Journal Articles

Increased Functional T Cell Defects in Patients with low CD4 Counts after Allogeneic Hematopoietic Stem Cell Transplantation

Udo Holtick, MD PhD, Lukas P. Frenzel, MD, Shimabukuro-Vornhagen Alexander, MD, Sebastian Theurich, MD, Julia Claasen, Christof Scheid, MD, PhD, Michael von-Bergwelt-Baildon, MD PhD, Michael Hallek, MD PhD, Clemens Wendtner, MD, Jens M. Chemnitz, MD
Journal: Blood
Blood (2013) 122 (21): 4588.
https://doi.org/10.1182/blood.V122.21.4588.4588
Published: 2013
Journal Articles

Drug-Induced Cytokine Release Sensitizes Protective Tumor Microenvironments to Antibody- Mediated Therapy

Christian P. Pallasch, MD, Leskov Ilya, MD, PhD, Yadira M Soto, Christian J. Braun, MD, Nadine Kutsch, MD, Adam Drake, PhD, Lukas P. Frenzel, MD, Bettina Iliopoulou, PhD, Nico van Rooijen, PhD, Clemens Wendtner, MD, Michael Hallek, MD, Jianzhu Chen, PhD, Michael T Hemann, PhD
Journal: Blood
Blood (2012) 120 (21): 1335.
https://doi.org/10.1182/blood.V120.21.1335.1335
Published: 2012
Journal Articles

Impact of Hypoxia As Novel Microenvironmental Factor On Drug Susceptibility of Primary CLL Cells

Malte Huelsemann, Lukas P. Frenzel, MD, Dunja Baatout, M.Sc., Julia Claasen, Sebastian Theurich, MD, Laurent Kintzelé, Hans Jiro Becker, Michaela Patz, PhD, Christian P. Pallasch, MD, Michael S. von Bergwelt-Baildon, MD, PhD, Michael Hallek, MD, Clemens-Martin Wendtner, MD
Journal: Blood
Blood (2012) 120 (21): 3918.
https://doi.org/10.1182/blood.V120.21.3918.3918
Published: 2012