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Journal Articles

A p53 score derived from TP53 CRISPR/Cas9 HMCLs predicts survival and reveals a major role of BAX in the response to BH3 mimetics

Blood (2024) 143 (13): 1242–1258.

https://doi.org/10.1182/blood.2023021581

Published: 2024

Includes: Supplemental data

Journal Articles

TP53 CRISPR/Cas9 Reveals Strict BAX Dependence in the Response to BH3 Mimetic Targeting MCL1

Romane Durand, Domitille Costes-Tertrais, Geraldine Descamps, Christelle Dousset, Sophie Maïga, Jean-Baptiste Alberge, Elise Douillard, Jennifer Derrien, Celine Bellanger, David Chiron, Stephane Minvielle, Cyrille Touzeau, Philippe Moreau, Martine Amiot, Patricia Gomez-Bougie, Agnes Moreau-Aubry, Catherine Pellat-Deceunynck

Blood (2022) 140 (Supplement 1): 4198–4199.

https://doi.org/10.1182/blood-2022-155862

Published: 2022

Journal Articles

BH3-mimetic toolkit guides the respective use of BCL2 and MCL1 BH3-mimetics in myeloma treatment

Patricia Gomez-Bougie, Sophie Maiga, Benoît Tessoulin, Jessie Bourcier, Antoine Bonnet, Manuel S. Rodriguez, Steven Le Gouill, Cyrille Touzeau, Philippe Moreau, Catherine Pellat-Deceunynck, Martine Amiot

Blood (2018) 132 (25): 2656–2669.

https://doi.org/10.1182/blood-2018-03-836718

Published: 2018

Includes: Supplemental data

Journal Articles

Respective Place of Venetoclax and MCL1 BH3 Mimetics in Multiple Myeloma Treatment

Patricia Gomez-Bougie, PhD, Sophie Maïga, Benoit Tessoulin, MD, Jessie Bourcier, MD, Antoine Bonnet, MD, Géraldine Descamps, PhD, Carolane Seiller, Cyrille Touzeau, MD PhD, Philippe Moreau, Catherine Pellat-Deceunynck, PhD, Martine Amiot, PhD

Blood (2018) 132 (Supplement 1): 953.

https://doi.org/10.1182/blood-2018-99-109987

Published: 2018

Journal Articles

The Use of a BH3 Mimetic Toolkit Reveals a Switch of Myeloma Patients Dependency from BCL2 at Diagnosis to MCL1 at Relapse

Antoine Bonnet, MD, Jessie Bourcier, MD, Patricia Gomez-Bougie, PhD, Sophie Maïga, Benoit Tessoulin, MD, Philippe Moreau, MDPhD, Steven Le Gouill, MDPhD, Catherine Pellat-Deceunynck, PhD, Cyrille Touzeau, MD PhD, Martine Amiot, PhD

Blood (2017) 130 (Supplement 1): 4383.

https://doi.org/10.1182/blood.V130.Suppl_1.4383.4383

Published: 2017

Journal Articles

Combination Of 2-Deoxy-D-Glucose With ABT-199 Efficiently Kills All Molecular Subgroups Of Myeloma Cells

Maxime Halliez, Sophie Maïga, Cyrille Touzeau, MD, Patricia Gomez-Bougie, PhD, Steven Le Gouill, MD, PhD, Marie-Christine Bene, PharmSciD, PhD, Philippe Moreau, MD, Catherine Pellat-Deceunynck, PhD, Martine Amiot, PhD

Blood (2013) 122 (21): 1921.

https://doi.org/10.1182/blood.V122.21.1921.1921

Published: 2013

Journal Articles

The Cap-Translation Inhibitor 4EGI-1 Induces Apoptosis in Multiple Myeloma Through Noxa Induction and Synergizes with ABT-737

Géraldine Descamps, PhD, Patricia Gomez-Bougie, PhD, Didier Bouscary, MD, PhD, Philippe Moreau, MD, Régis Bataille, PhD, Catherine Pellat-Deceunynck, PhD, Martine Amiot, PhD

Blood (2011) 118 (21): 1832.

https://doi.org/10.1182/blood.V118.21.1832.1832

Published: 2011

Journal Articles

TP53 Is Not Involved in the Apoptosis Induced by RITA

Sylvanie Surget, PhD, in, training, Vincent Normant, Carole Brosseau, PhD, Sophie Maiga, Patricia Gomez-Bougie, Géraldine Descamps, Steven Le Gouill, MD, PhD, Martine Amiot, Catherine Pellat-Deceunynck, PhD

Blood (2011) 118 (21): 1848.

https://doi.org/10.1182/blood.V118.21.1848.1848

Published: 2011

Journal Articles

ABT-737 is highly effective against molecular subgroups of multiple myeloma

Linda Bodet, Patricia Gomez-Bougie, Cyrille Touzeau, Christelle Dousset, Géraldine Descamps, Sophie Maïga, Hervé Avet-Loiseau, Régis Bataille, Philippe Moreau, Steven Le Gouill, Catherine Pellat-Deceunynck, Martine Amiot

Blood (2011) 118 (14): 3901–3910.

https://doi.org/10.1182/blood-2010-11-317438

Published: 2011

Includes: Supplemental data

Journal Articles

Rational for the Use of a Targeted-Therapy Using ABT-737 In Mantle-Cell Lymphoma

Cyrille Touzeau, Christelle Dousset, Lynda Bodet, Stephanie Bonnaud, Patricia Gomez-Bougie, Thomas Gastinne, Soraya Wuilleme, Anne Moreau, Philippe Moreau, Catherine Pellat-Deceunynck, PhD, Martine Amiot, Steven Le Gouill

Blood (2010) 116 (21): 770.

https://doi.org/10.1182/blood.V116.21.770.770

Published: 2010

Journal Articles

High Bcl-2/Mcl-1 Gene Expression Ratio Identifies Molecular Sub-Groups of Multiple Myeloma Patients Extremely Sensitive to ABT-737

Linda Bodet, Catherine Pellat-Deceunynck, PhD, Patricia Gomez-Bougie, PhD, Christelle Dousset, Cyrille Touzeau, Steven Le Gouill, MD, PhD, Hervé Avet-Loiseau, MD, PhD, Regis Bataille, MD, PhD, Martine Amiot, PhD

Blood (2010) 116 (21): 4061.

https://doi.org/10.1182/blood.V116.21.4061.4061

Published: 2010

Journal Articles

TP53 Positively Regulates Cell Death through TRAILR2 (DR5) but Negatively through TRAILR1 (DR4) In Myeloma Cells

Sylvanie Surget, PhD, in, training, Patricia Gomez-Bougie, David Chiron, PhD, in, training, Robin Humphreys, PhD, Philippe Moreau, Steven Le Gouill, Jean-Luc Harousseau, Regis Bataille, MD, PhD, Martine Amiot, Catherine Pellat-Deceunynck, PhD

Blood (2010) 116 (21): 136.

https://doi.org/10.1182/blood.V116.21.136.136

Published: 2010

Journal Articles

Agonist Anti-TRAILR1 Human Mab, Hgs-ETR1, Induces Myeloma Cell Death Mainly through the Intrinsic Pathway of Apoptosis.

Emmanuelle Ménoret, Sylvanie Surget, Patricia Gomez-Bougie, Régis Bataille, Martine Amiot, Catherine Pellat-Deceunynck

Blood (2008) 112 (11): 1713.

https://doi.org/10.1182/blood.V112.11.1713.1713

Published: 2008

Journal Articles

The Pan-Bcl-2 Inhibitor GX15-O70 Induces Apoptosis in Human Myeloma Cells by Noxa Induction and Strongly Enhances Melphalan, Bortezomib or TRAIL-R1 Antibody Apoptotic Effect.

Patricia Gomez-Bougie, MD, PhD, Sophie Maïga, BSc, Catherine Pellat-Deceunynck, PhD, Sandrine Jouan, MSc, Regis Bataille, MD PhD, Martine Amiot, PhD

Blood (2006) 108 (11): 3476.

https://doi.org/10.1182/blood.V108.11.3476.3476

Published: 2006

Journal Articles

A Humanized Anti-IGF-1R Monoclonal Antibody (AVE1642) Synergizes with Bortezomib To Induce Apoptosis in CD45neg Myeloma Cells.

Geraldine Descamps, PhD, Soraya Wuilleme-Toumi, MD, Patricia Gomez-Bougie, MD, PhD, Corinne Venot, PhD, Friedhelm Bladt Bladt, PhD, Regis Bataille, MD, PhD, Martine Amiot, PhD

Blood (2006) 108 (11): 845.

https://doi.org/10.1182/blood.V108.11.845.845

Published: 2006

Journal Articles

Mcl-1L cleavage is involved in TRAIL-R1– and TRAIL-R2–mediated apoptosis induced by HGS-ETR1 and HGS-ETR2 human mAbs in myeloma cells

Emmanuelle Menoret, Patricia Gomez-Bougie, Alexandrine Geffroy-Luseau, Sylvanne Daniels, Philippe Moreau, Steven Le Gouill, Jean-Luc Harousseau, Regis Bataille, Martine Amiot, Catherine Pellat-Deceunynck

Blood (2006) 108 (4): 1346–1352.

https://doi.org/10.1182/blood-2005-12-007971

Published: 2006

Journal Articles

TRAILR Triggering by Human Antibodies Induces Apoptosis through an Early Cleavage of Mcl-1 and Caspase 3 in Myeloma Cells.

Catherine Pellat-Deceunynck, PhD, Patricia Gomez-Bougie, MD, Sylvanne Daniels, Alexandrine Geffroy-Luseau, Regis Bataille, MD, PhD, Martine Amiot, PhD

Blood (2005) 106 (11): 3397.

https://doi.org/10.1182/blood.V106.11.3397.3397

Published: 2005

Journal Articles

The Complex Mcl-1/Bim Regulates the Sensitivity of Human Myeloma Cells to Melphalan.

Patricia Gomez-Bougie, MD, Lisa Oliver, PhD, Emmanuelle Menoret, Steven Le Gouill, MD, Régis Bataille, PHD, MD, Martine Amiot, PHD

Blood (2005) 106 (11): 357.

https://doi.org/10.1182/blood.V106.11.357.357

Published: 2005

Journal Articles

Mcl-1 Sequesters Pro-Apoptotic BH3-Only Bim To Inhibit Its Collaboration with Bax in Myeloma Cells.

Patricia Gomez-Bougie, MD, Monique Clement, PhD, Philipe Juin, PhD, Regis Bataille, MD, Martine Amiot, PhD

Blood (2004) 104 (11): 789.

https://doi.org/10.1182/blood.V104.11.789.789

Published: 2004

Journal Articles

Mcl-1 Is Overexpressed in Multiple Myeloma and Correlates with Disease Severity.

Soraya Wuilleme-Toumi, MD, Nelly Robillard, PhD, Patricia Gomez-Bougie, MD, Philippe Moreau, MD, Steven Le Gouill, MD, Herve Avet-Loiseau, MD, PhD, Jean-Luc Harousseau, MD, Martine Amiot, PhD, Regis Bataille, MD, PhD

Blood (2004) 104 (11): 1419.

https://doi.org/10.1182/blood.V104.11.1419.1419

Published: 2004

NARROW

A p53 score derived from TP53 CRISPR/Cas9 HMCLs predicts survival and reveals a major role of BAX in the response to BH3 mimetics

TP53 CRISPR/Cas9 Reveals Strict BAX Dependence in the Response to BH3 Mimetic Targeting MCL1

BH3-mimetic toolkit guides the respective use of BCL2 and MCL1 BH3-mimetics in myeloma treatment

Respective Place of Venetoclax and MCL1 BH3 Mimetics in Multiple Myeloma Treatment

The Use of a BH3 Mimetic Toolkit Reveals a Switch of Myeloma Patients Dependency from BCL2 at Diagnosis to MCL1 at Relapse

Combination Of 2-Deoxy-D-Glucose With ABT-199 Efficiently Kills All Molecular Subgroups Of Myeloma Cells

The Cap-Translation Inhibitor 4EGI-1 Induces Apoptosis in Multiple Myeloma Through Noxa Induction and Synergizes with ABT-737

TP53 Is Not Involved in the Apoptosis Induced by RITA

ABT-737 is highly effective against molecular subgroups of multiple myeloma

Rational for the Use of a Targeted-Therapy Using ABT-737 In Mantle-Cell Lymphoma

High Bcl-2/Mcl-1 Gene Expression Ratio Identifies Molecular Sub-Groups of Multiple Myeloma Patients Extremely Sensitive to ABT-737

TP53 Positively Regulates Cell Death through TRAILR2 (DR5) but Negatively through TRAILR1 (DR4) In Myeloma Cells

Agonist Anti-TRAILR1 Human Mab, Hgs-ETR1, Induces Myeloma Cell Death Mainly through the Intrinsic Pathway of Apoptosis.

The Pan-Bcl-2 Inhibitor GX15-O70 Induces Apoptosis in Human Myeloma Cells by Noxa Induction and Strongly Enhances Melphalan, Bortezomib or TRAIL-R1 Antibody Apoptotic Effect.

A Humanized Anti-IGF-1R Monoclonal Antibody (AVE1642) Synergizes with Bortezomib To Induce Apoptosis in CD45neg Myeloma Cells.

Mcl-1L cleavage is involved in TRAIL-R1– and TRAIL-R2–mediated apoptosis induced by HGS-ETR1 and HGS-ETR2 human mAbs in myeloma cells

TRAILR Triggering by Human Antibodies Induces Apoptosis through an Early Cleavage of Mcl-1 and Caspase 3 in Myeloma Cells.

The Complex Mcl-1/Bim Regulates the Sensitivity of Human Myeloma Cells to Melphalan.

Mcl-1 Sequesters Pro-Apoptotic BH3-Only Bim To Inhibit Its Collaboration with Bax in Myeloma Cells.

Mcl-1 Is Overexpressed in Multiple Myeloma and Correlates with Disease Severity.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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