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Journal Articles

Core Binding Factor Leukemias Utilize a Physiologic Sense/Antisense Promoter Switch Employed By T-Cells

Blood (2020) 136 (Supplement 1): 40–41.

https://doi.org/10.1182/blood-2020-140776

Published: 2020

Journal Articles

Allele-Specific Expression of GATA2 in AML with CEBPA Biallelic Mutations

Roger Mulet-Lazaro, MSc, Stanley van Herk, B.Sc., Claudia Erpelinck-Verschueren, B.Sc., Mathijs A. Sanders, PhD MSc, Eric Bindels, PhD, Peter Valk, PhD, Michael Rehli, PhD, Claudia Gebhard, PhD, Ruud Delwel, PhD, B.J. Wouters

Blood (2019) 134 (Supplement_1): 1235.

https://doi.org/10.1182/blood-2019-129766

Published: 2019

Journal Articles

Integrated Analysis of Global DNA Methylation and Transcription Reveals a Leukemia Subtype with Extreme Hypermethylation Associated with Silencing of Regulators of Differentiation

Claudia Gebhard, PhD, Roger Mulet-Lazaro, B.Sc., Lucia Schwarzfischer, Dagmar Glatz, Margit Nuetzel, Daniel Heudobler, MD, Sandra Pohl, Wolfgang Herr, MD, Gerhard Ehninger, MD, Claudia Erpelinck-Verschueren, B.Sc., Stanley van Herk, B.Sc., B.J. Wouters, Christian Thiede, MD, Ruud Delwel, PhD, Michael Rehli, PhD

Blood (2018) 132 (Supplement 1): 2608.

https://doi.org/10.1182/blood-2018-99-118521

Published: 2018

Journal Articles

Complex 3q26/EVI1 Rearrangements Genocopy Inv(3)/t(3;3) Acute Myeloid Leukemias By Enhancer Hijacking, EVI1 Overexpression, Absent MDS1-EVI1 and Low GATA2 Expression

Sophie Ottema, MSc, Roger Mulet-Lazaro, B.Sc., Berna Beverloo, PhD, Marije Havermans, Ir, Claudia Erpelinck-Verschueren, B.Sc., Tim Grob, MD, Peter Valk, PhD, Eric Bindels, PhD, Torsten Haferlach, MD, Claudia Haferlach, MD, Leonie Smeenk, PhD, Ruud Delwel, PhD

Blood (2018) 132 (Supplement 1): 2766.

https://doi.org/10.1182/blood-2018-99-113339

Published: 2018

Journal Articles

Genetically-Defined AML Subgroups Represent Diverse Epigenetic Heterogeneity Landscape

Sheng Li, PhD, Xiaowen Chen, PhD, Jihui Wang, MS, Cem Meydan, PhD, Jacob L Glass, MDPhD, Alan H. Shih, MD PhD, Peter J.M. Valk, PhD, Ruud Delwel, PhD, Ross L. Levine, MD, Christopher Mason, PhD, Ari Melnick, MD

Blood (2017) 130 (Supplement 1): 243.

https://doi.org/10.1182/blood.V130.Suppl_1.243.243

Published: 2017

Journal Articles

Lineage Deconvolution Using Chromatin Accessibility and DNA Methylation Shows a Spectrum of Lineage Characteristics and Differentiation States across Acute Leukemias

Jacob L Glass, MDPhD, Alyson J Palia, Francine E. Garrett-Bakelman, MDPhD, Richard Koche, PhD, Ross L. Levine, MD, Martin S. Tallman, MD, Richard James Dillon, MA, PhD MRCP, FRCPath, David Grimwade, Adolfo A. Ferrando, MD PhD, Peter J.M. Valk, PhD, Ruud Delwel, PhD, Maria E. Figueroa, MD, Ari Melnick, MD, Olivier Elemento, PhD

Blood (2017) 130 (Supplement 1): 1208.

https://doi.org/10.1182/blood.V130.Suppl_1.1208.1208

Published: 2017

Journal Articles

Divergent Dynamics of Epigenetic and Genetic Heterogeneity in Relapsed Acute Myeloid Leukemia

Blood (2015) 126 (23): 306.

https://doi.org/10.1182/blood.V126.23.306.306

Published: 2015

Journal Articles

Integrative Analysis of Lincrna Expression and Clinical Annotations Reveals a Signature of 17 Genes with Prognostic Significance in Acute Myeloid Leukemia (AML)

Dominik Beck, PhD, Cintia Palu, MSc, Anushi Shah, PhD, Tobias Herold, MD, Jake Olivier, PhD, Peter J.M. Valk, PhD, Ruud Delwel, PhD, Stefan K Bohlander, MD, Jason W Wong, DPhil, John E Pimanda, MD PhD

Blood (2014) 124 (21): 483.

https://doi.org/10.1182/blood.V124.21.483.483

Published: 2014

Journal Articles

Defects in the RAS/RTK Signaling Pathways Predominate the Mutational Spectrum of EVI1/GATA2 Rearranged Myeloid Malignancies with Inv(3)/t(3;3)

Mathijs A. Sanders, MSc, Stefan Gröschel, Remco M. Hoogenboezem, Annelieke Zeilemaker, Marije Havermans, Claudia Erpelinck, Eric M. J. Bindels, PhD, Berna Beverloo, PhD, Hartmut Döhner, MD, Bob Löwenberg, MD PhD, Konstanze Döhner, MD, Ruud Delwel, PhD, Peter J.M. Valk, PhD

Blood (2014) 124 (21): 701.

https://doi.org/10.1182/blood.V124.21.701.701

Published: 2014

Journal Articles

A Myeloid-Specific Gene-Dosage Regulator for CEBPA Expression in Myeloid Cells Is Commonly Targeted By Onco-Proteins in AML

Roberto Avellino, Stefan M Groschel, MD, Harmen Van de Werken, Mathijs A. Sanders, MSc, Remco M. Hoogenboezem, Claudia Erpelinck, Marije Havermans, Eric Bindels, Ruud Delwel, PhD

Blood (2014) 124 (21): 2205.

https://doi.org/10.1182/blood.V124.21.2205.2205

Published: 2014

Journal Articles

Identification of Sox4 As Key Oncogene in Leukemias with Mutated or Silenced C/EBPα

Hong Zhang, PhD, Min Ye, PhD, Meritxell Alberich-Jordà, PhD, Giovanni Amabile, PhD, Philipp B. Staber, M.D., Peter J. M. Valk, PhD, Ruud Delwel, PhD, Véronique Lefebvre, PhD, Constanze Bonifer, PhD, Daniel G. Tenen, MD

Blood (2012) 120 (21): 114.

https://doi.org/10.1182/blood.V120.21.114.114

Published: 2012

Journal Articles

The HOXA/PBX3 Pathway Is an Attractive Therapeutic Target in MLL -Rearranged Acute Leukemia

Blood (2012) 120 (21): 3522.

https://doi.org/10.1182/blood.V120.21.3522.3522

Published: 2012

Journal Articles

Overexpression of Sharp-1 in MLL-AF6-Positive Acute Myeloid Leukemia

Akira Kawasaki, MD, PhD, Reshma Taneja, Ruud Delwel, PhD, Daniel G. Tenen, MD

Blood (2012) 120 (21): 3493.

https://doi.org/10.1182/blood.V120.21.3493.3493

Published: 2012

Journal Articles

The Impact of Novel Molecular Markers on Risk Stratification in Acute Myeloid Leukemia

Bob Löwenberg, MD, PhD, Peter Valk, PhD, Ivo P. Touw, PhD, Ruud Delwel, PhD

Blood (2012) 120 (21): SCI-33.

https://doi.org/10.1182/blood.V120.21.SCI-33.SCI-33

Published: 2012

Journal Articles

Hoxa9 Suppresses Cellular Senescence and Sustains the Development of Leukemic Stem Cells Induced by Fusion Proteins In the Absence of Bmi1.

Lan-Lan Smith, Jenny Yeung, PhD, Bernd B Zeisig, PhD, Ivo Huijbers, PhD, Nik Popov, PhD, Josephine Barnes, PhD, Amanda J Wilson, Sanne Lugthart, PhD, Ruud Delwel, PhD, Jesus Gil, PhD, Maarten van Lohuizen, PhD, Chi Wai Eric So, PhD

Blood (2010) 116 (21): 1578.

https://doi.org/10.1182/blood.V116.21.1578.1578

Published: 2010

Journal Articles

An Insertional Mutagenesis Screen for Genes That Cooperate with Mll-AF9 in Leukemogenesis.

Rachel Joy Bergerson, Lara S Collier, PhD, Sanne Lugthart, MD, Raha Allaei, Molly J Nixon, Kevin A.T. Silverstein, PhD, Aaron Sarver, PhD, Danhua Flora Fan, PhD, Anne-Francoise J Lamblin, PhD, Linda Wolff, PhD, John H. Kersey, MD, M. Gerard O'Sullivan, MVB, PhD, Ruud Delwel, PhD, Scott C. Kogan, MD, David J Adams, PhD, David Largaespada, PhD

Blood (2009) 114 (22): 3962.

https://doi.org/10.1182/blood.V114.22.3962.3962

Published: 2009

Journal Articles

VEGFC Predicts Poor Outcome in Pediatric as Well as Adult Acute Myeloid Leukemia: Insights in Associated Gene Expression Profiles.

Hendrik JM de Jonge, Peter Valk, PhD, Kim R Kampen, Arja ter Elst, PhD, Gertjan Kaspers, MD, PhD, Jacqueline Cloos, PhD, C. Michel Zwaan, MD, PhD, Marry M van den Heuvel-Eibrink, MD, PhD, Willem A. Kamps, MD, PhD, Ruud Delwel, PhD, Bob Lowenberg, MD, PhD, Eveline S de Bont, MD, PhD

Blood (2009) 114 (22): 997.

https://doi.org/10.1182/blood.V114.22.997.997

Published: 2009

Journal Articles

DNA Methylation Profiling Predicts Clinical Outcomes and Reveals Unique Insights Into the Molecular Complexity of Acute Myeloid Leukemia.

Maria E Figueroa, MD, Sanne Lugthart, MD, Yushan Li, Claudia Erpelinck-Verschueren, Xutao Deng, Paul J. Christos, PhD, Elizabeth Schifano, Jim Booth, Lucy Skrabanek, Fabien Campagne, Madhu Mazumdar, PhD, John Greally, MB, PhD, Peter Valk, Bob Lowenberg, MD, PhD, Ruud Delwel, PhD, Ari Melnick

Blood (2009) 114 (22): 707.

https://doi.org/10.1182/blood.V114.22.707.707

Published: 2009

Journal Articles

Genome-Wide Epigenetics in Myeloid Leukemias.

Maria Eugenia Figueroa, MD, John Greally, MB, PhD, Ruud Delwel, PhD, Ari M. Melnick, MD

Blood (2008) 112 (11): sci-35.

https://doi.org/10.1182/blood.V112.11.sci-35.sci-35

Published: 2008

Journal Articles

Epigenetic Signatures Identify New Clinically Relevant Subtypes and Define Gene Regulatory Patterns in Patients with Acute Myeloid Leukemia (AML)

Maria E Figueroa, MD, Sanne Lugthart, MD, Yushan Li, Claudia Erpelinck-Verschueren, Paul J Christos, MS, MPH, Madhu Mazumdar, PhD, Bob Löwenberg, MD, PhD, John Greally, MB, PhD, Peter JM Valk, PhD, Ruud Delwel, PhD, Ari Melnick, MD

Blood (2008) 112 (11): 756.

https://doi.org/10.1182/blood.V112.11.756.756

Published: 2008

NARROW

Core Binding Factor Leukemias Utilize a Physiologic Sense/Antisense Promoter Switch Employed By T-Cells

Allele-Specific Expression of GATA2 in AML with CEBPA Biallelic Mutations

Integrated Analysis of Global DNA Methylation and Transcription Reveals a Leukemia Subtype with Extreme Hypermethylation Associated with Silencing of Regulators of Differentiation

Complex 3q26/EVI1 Rearrangements Genocopy Inv(3)/t(3;3) Acute Myeloid Leukemias By Enhancer Hijacking, EVI1 Overexpression, Absent MDS1-EVI1 and Low GATA2 Expression

Genetically-Defined AML Subgroups Represent Diverse Epigenetic Heterogeneity Landscape

Lineage Deconvolution Using Chromatin Accessibility and DNA Methylation Shows a Spectrum of Lineage Characteristics and Differentiation States across Acute Leukemias

Divergent Dynamics of Epigenetic and Genetic Heterogeneity in Relapsed Acute Myeloid Leukemia

Integrative Analysis of Lincrna Expression and Clinical Annotations Reveals a Signature of 17 Genes with Prognostic Significance in Acute Myeloid Leukemia (AML)

Defects in the RAS/RTK Signaling Pathways Predominate the Mutational Spectrum of EVI1/GATA2 Rearranged Myeloid Malignancies with Inv(3)/t(3;3)

A Myeloid-Specific Gene-Dosage Regulator for CEBPA Expression in Myeloid Cells Is Commonly Targeted By Onco-Proteins in AML

Identification of Sox4 As Key Oncogene in Leukemias with Mutated or Silenced C/EBPα

The HOXA/PBX3 Pathway Is an Attractive Therapeutic Target in MLL -Rearranged Acute Leukemia

Overexpression of Sharp-1 in MLL-AF6-Positive Acute Myeloid Leukemia

The Impact of Novel Molecular Markers on Risk Stratification in Acute Myeloid Leukemia

Hoxa9 Suppresses Cellular Senescence and Sustains the Development of Leukemic Stem Cells Induced by Fusion Proteins In the Absence of Bmi1.

An Insertional Mutagenesis Screen for Genes That Cooperate with Mll-AF9 in Leukemogenesis.

VEGFC Predicts Poor Outcome in Pediatric as Well as Adult Acute Myeloid Leukemia: Insights in Associated Gene Expression Profiles.

DNA Methylation Profiling Predicts Clinical Outcomes and Reveals Unique Insights Into the Molecular Complexity of Acute Myeloid Leukemia.

Genome-Wide Epigenetics in Myeloid Leukemias.

Epigenetic Signatures Identify New Clinically Relevant Subtypes and Define Gene Regulatory Patterns in Patients with Acute Myeloid Leukemia (AML)

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American Society of Hematology

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American Society of Hematology

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