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Thiyagaraj Mayuranathan
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Journal Articles

Reduced Polycomb Repressor Complex 2 (PRC2) Activity and Increased TP53 Activity Mediate Hematopoietic Stem Cell Dysfunction in RPS19-Mutated Diamond-Blackfan Anemia

Senthil V Bhoopalan, Ruopeng Feng, Thiyagaraj Mayuranathan, Kalin Mayberry, Yoonjeong Jang, Jonathan S Yen, Yu Yao, Lance Palmer, Yong Cheng, Marcin W Wlodarski, Mitchell J. Weiss
Journal: Blood
Blood (2023) 142 (Supplement 1): 2732.
https://doi.org/10.1182/blood-2023-190069
Published: 2023
Journal Articles

Base Editing for Therapeutic Induction of Fetal Hemoglobin in β-Thalassemia

Georgios E. Christakopoulos, Thiyagaraj Mayuranathan, Alfonso G. Fernandez, Kalin Mayberry, Yu Yao, Rahul Telange, Michael Dudley, Rachel Levine, Erin Dempsey, David R. Liu, Jonathan S Yen, Mitchell J. Weiss
Journal: Blood
Blood (2022) 140 (Supplement 1): 10660–10661.
https://doi.org/10.1182/blood-2022-169391
Published: 2022
Journal Articles

Increased Potency and Uniformity of Fetal Hemoglobin Induction from Base Editing Compared to Cas9 Nuclease

Thiyagaraj Mayuranathan, Gregory A. Newby, Ruopeng Feng, Yu Yao, Kalin Mayberry, Guolian Kang, Cicera Lazzarotto, Yichao Li, Rachel Levine, Erin Dempsey, Shaina N. Porter, Phillip A Doerfler, Jingjing Zhang, Yoonjeong Jang, Senthil Bhoopalan, Nikitha Nimmagadda, Akshay Sharma, John Tisdale, Shondra Miller, Yong Cheng, Shengdar Tsai, Mitchell J. Weiss, David R. Liu, Jonathan S Yen
Journal: Blood
Blood (2022) 140 (Supplement 1): 7784–7785.
https://doi.org/10.1182/blood-2022-162639
Published: 2022
Journal Articles

Regulation of Fetal Hemoglobin Expression By the VHL-HIF1α Oxygen Sensing System

Ruopeng Feng, Thiyagaraj Mayuranathan, Peng Huang, Phillip A Doerfler, Yichao Li, Yu Yao, Jingjing Zhang, Lance E. Palmer, Peng Xu, Kalin Mayberry, Shaela Wright, Chunliang Li, Yong Cheng, Gerd A. Blobel, M. Celeste Simon, Mitchell J. Weiss
Journal: Blood
Blood (2021) 138 (Supplement 1): 574.
https://doi.org/10.1182/blood-2021-149901
Published: 2021
Journal Articles

A Novel RPS19 -Edited Hematopoietic Stem Cell Model of Diamond-Blackfan Anemia for Development of Lentiviral Vector Gene Therapy

Senthil Velan Bhoopalan, Jonathan Yen, Thiyagaraj Mayuranathan, Yu Yao, Kalin Mayberry, Sheng Zhou, Robert Throm, Marcin W. Wlodarski, Mitchell J. Weiss
Journal: Blood
Blood (2021) 138 (Supplement 1): 859.
https://doi.org/10.1182/blood-2021-147557
Published: 2021
Journal Articles

Adenosine Base Editing of γ-Globin Promoters Induces Fetal Hemoglobin and Inhibit Erythroid Sickling

Thiyagaraj Mayuranathan, Jonathan S. Yen, PhD, Gregory A. Newby, PhD, Yu Yao, MD, Shaina N. Porter, PhD, Kaitly J. Woodard, BS, Jingjing Zhang, MS, Kalin Mayberry, BS, Akshay Sharma, MBBS, Shondra M. preutt-Miller, PhD, John F. Tisdale, MD, Shengdar Q. Tsai, PhD, David R. Liu, PhD, Mitchell J. Weiss, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 21–22.
https://doi.org/10.1182/blood-2020-141498
Published: 2020
Journal Articles

Base Editing Eliminates the Sickle Cell Mutation and Pathology in Hematopoietic Stem Cells Derived Erythroid Cells

Jonathan S Yen, PhD, Gregory A. Newby, PhD, Thiyagaraj Mayuranathan, Shaina N. Porter, PhD, Yu Yao, MD, Kaitly J. Woodard, BS, Kalin Mayberry, BS, Kelcee Everette, Jingjing Zhang, MS, Jordana M Henderson, MS, Anton P Mccaffrey, Jonathan Yen, John F. Tisdale, MD, Shengdar Q. Tsai, PhD, David R. Liu, PhD, Mitchell J. Weiss, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 13–14.
https://doi.org/10.1182/blood-2020-139016
Published: 2020
Journal Articles

Control of Fetal Hemoglobin Levels By NFI Transcription Factors

Kunhua Qin, Peng Huang, PhD, Anran Huang, BS, Ruopeng Feng, PhD, Thiyagaraj Mayuranathan, Cheryl A. Keller, PhD, Belinda Giardine, Ross C. Hardison, PhD, Mitchell J. Weiss, MD PhD, Junwei Shi, PhD, Gerd A. Blobel, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 54.
https://doi.org/10.1182/blood-2020-136167
Published: 2020
Journal Articles

ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression

Xianjiang Lan, PhD, Ren Ren, PhD, Ruopeng Feng, PhD, Lana C Ly, Yemin Lan, PhD, Zhe Zhang, PhD, Nicholas Aboreden, Kunhua Qin, John R Horton, Jeremy D. Grevet, PhD, Thiyagaraj Mayuranathan, Osheiza Abdulmalik, DVM, Cheryl A. Keller, PhD, Belinda Giardine, Ross C. Hardison, PhD, Merlin Crossley, PhD, Mitchell J. Weiss, MD PhD, Xiaodong Cheng, PhD, Junwei Shi, PhD, Gerd A. Blobel, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 54.
https://doi.org/10.1182/blood-2020-137564
Published: 2020
Journal Articles

CRISPR-Cas9 Genome Editing of γ-Globin Promoters in Human Hematopoietic Stem Cells to Induce Erythrocyte Fetal Hemoglobin for Treatment of β-Hemoglobinopathies

Jean-Yves Metais, PhD, Phillip A Doerfler, PhD, Thiyagaraj Mayuranathan, Daniel E. Bauer, MD PhD, Stephanie Fowler, Matthew Hsieh, MD, Varun Katta, Sagar Keriwala, Cicera Lazzarotto, Kevin Luk, Michael Neel, Scott Perry, Shaina Porter, Byoung Y. Ryu, PhD, Akshay Sharma, MBBS, Devlin Shea, Samuel Peters, John F. Tisdale, MD, Scot A. Wolfe, PhD, Kaitly Jensen Woodard, BS, Naoya Uchida, MD, Yuxuan Wu, PhD, Yu Yao, MD, Jing Zeng, MD, Shondra M. Pruett-Miller, PhD, Shengdar Q. Tsai, PhD, Mitchell J. Weiss, MD, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2066.
https://doi.org/10.1182/blood-2019-131318
Published: 2019
Journal Articles

Identification of Erythroid Specific Enhancers By Analyzing Genome Wide Association of Transcriptional Co-Activators CBP and P300

Thiyagaraj Mayuranathan, BSc,MSc,MPhil, Janakiram Rayabaram, BSc,MSc, Aneesha Nath, BSc., MSc, Shaji R Velayudhan, PhD
Journal: Blood
Blood (2015) 126 (23): 3330.
https://doi.org/10.1182/blood.V126.23.3330.3330
Published: 2015
Journal Articles

A Robust Ex-Vivo Erythropoiesis System For Studying Transcriptional Regulation Of Globin Genes In Thalassaemia

Janakiram Rayabaram, MSc, Thiyagaraj Mayuranathan, MSc, Divya Jayasree, MSc, Neeraj Arora, MD, Eunice Sindhuvi Edison, Ph.D, Alok Srivastava, MD, Shaji Velayudhan, PhD
Journal: Blood
Blood (2013) 122 (21): 2259.
https://doi.org/10.1182/blood.V122.21.2259.2259
Published: 2013
Journal Articles

Molecular Basis Of (δβ) 0 Thalassaemia and HPFH In Indian Population and The Role Of Non-Coding Transcripts In Increased Foetal Hemoglobin In Adults

Thiyagaraj Mayuranathan, MSc, Janakiram Rayabaram, MSc, Reena Das, MD, Neeraj Arora, MD, Eunice Sindhuvi Edison, Ph.D, Alok Srivastava, MD, Shaji Velayudhan, PhD
Journal: Blood
Blood (2013) 122 (21): 3446.
https://doi.org/10.1182/blood.V122.21.3446.3446
Published: 2013