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Jonathan S Yen
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Journal Articles

Reduced Polycomb Repressor Complex 2 (PRC2) Activity and Increased TP53 Activity Mediate Hematopoietic Stem Cell Dysfunction in RPS19-Mutated Diamond-Blackfan Anemia

Senthil V Bhoopalan, Ruopeng Feng, Thiyagaraj Mayuranathan, Kalin Mayberry, Yoonjeong Jang, Jonathan S Yen, Yu Yao, Lance Palmer, Yong Cheng, Marcin W Wlodarski, Mitchell J. Weiss
Journal: Blood
Blood (2023) 142 (Supplement 1): 2732.
https://doi.org/10.1182/blood-2023-190069
Published: 2023
Journal Articles

Systematic Mapping of Gene-Editable Mutations in GATA2 and SAMD9/SAMD9L Syndromes

Damian Krzyzanowski, Sushree S Sahoo, Lili Kotmayer, Masanori Yoshida, Majd Khiami, Alessandra Giorgetti, Shengdar Q Tsai, Senthil V Bhoopalan, Jonathan S Yen, Marcin W Wlodarski
Journal: Blood
Blood (2023) 142 (Supplement 1): 1362.
https://doi.org/10.1182/blood-2023-190982
Published: 2023
Journal Articles

Efficient and Stable Makassar Base Editing in Nonhuman Primates

Stefan Radtke, Emily Fields, Gregory A. Newby, Jonathan S Yen, Mitchell Weiss, Olivier Humbert, Dnyanada Pande, Mark Enstrom, David Liu, Hans-Peter Kiem
Journal: Blood
Blood (2023) 142 (Supplement 1): 484.
https://doi.org/10.1182/blood-2023-178732
Published: 2023
Journal Articles

Increased Potency and Uniformity of Fetal Hemoglobin Induction from Base Editing Compared to Cas9 Nuclease

Thiyagaraj Mayuranathan, Gregory A. Newby, Ruopeng Feng, Yu Yao, Kalin Mayberry, Guolian Kang, Cicera Lazzarotto, Yichao Li, Rachel Levine, Erin Dempsey, Shaina N. Porter, Phillip A Doerfler, Jingjing Zhang, Yoonjeong Jang, Senthil Bhoopalan, Nikitha Nimmagadda, Akshay Sharma, John Tisdale, Shondra Miller, Yong Cheng, Shengdar Tsai, Mitchell J. Weiss, David R. Liu, Jonathan S Yen
Journal: Blood
Blood (2022) 140 (Supplement 1): 7784–7785.
https://doi.org/10.1182/blood-2022-162639
Published: 2022
Journal Articles

Base Editing for Therapeutic Induction of Fetal Hemoglobin in β-Thalassemia

Georgios E. Christakopoulos, Thiyagaraj Mayuranathan, Alfonso G. Fernandez, Kalin Mayberry, Yu Yao, Rahul Telange, Michael Dudley, Rachel Levine, Erin Dempsey, David R. Liu, Jonathan S Yen, Mitchell J. Weiss
Journal: Blood
Blood (2022) 140 (Supplement 1): 10660–10661.
https://doi.org/10.1182/blood-2022-169391
Published: 2022
Journal Articles

Adenosine Base Editing of γ-Globin Promoters Induces Fetal Hemoglobin and Inhibit Erythroid Sickling

Thiyagaraj Mayuranathan, Jonathan S. Yen, PhD, Gregory A. Newby, PhD, Yu Yao, MD, Shaina N. Porter, PhD, Kaitly J. Woodard, BS, Jingjing Zhang, MS, Kalin Mayberry, BS, Akshay Sharma, MBBS, Shondra M. preutt-Miller, PhD, John F. Tisdale, MD, Shengdar Q. Tsai, PhD, David R. Liu, PhD, Mitchell J. Weiss, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 21–22.
https://doi.org/10.1182/blood-2020-141498
Published: 2020
Journal Articles

Base Editing Eliminates the Sickle Cell Mutation and Pathology in Hematopoietic Stem Cells Derived Erythroid Cells

Jonathan S Yen, PhD, Gregory A. Newby, PhD, Thiyagaraj Mayuranathan, Shaina N. Porter, PhD, Yu Yao, MD, Kaitly J. Woodard, BS, Kalin Mayberry, BS, Kelcee Everette, Jingjing Zhang, MS, Jordana M Henderson, MS, Anton P Mccaffrey, Jonathan Yen, John F. Tisdale, MD, Shengdar Q. Tsai, PhD, David R. Liu, PhD, Mitchell J. Weiss, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 13–14.
https://doi.org/10.1182/blood-2020-139016
Published: 2020